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Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis
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作者 Qiang Zou Hao-Wen Wang +2 位作者 Xi-Liang Di Yuan Li Hui Gao 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1547-1563,共17页
BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found t... BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is unclear.Ultrasound targeted microbubble destruction mediated gene transfection is a new method to overexpress genes.AIM To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of HCC.METHODS In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,respectively.In addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell behavior.Next,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and EMT.In vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation ability.RESULTS We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of UTMBs.Additionally,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of TIMP2.And miR-873-5p mimic counteracted the impact of HAND2-AS1.Further,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to UTMBs.We discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/MMP9.In vivo results showed that HAND2-AS1 silencing significantly inhibited tumor formation in mice.CONCLUSION LncRNA HAND2-AS1 promotes TIMP2 expression by targeting miR-873-5p to inhibit HepG2 cell growth and delay HCC progression. 展开更多
关键词 Hepatocellular carcinoma Ultrasound microbubbles Long noncoding RNA hand2-AS1 miR-873-5p Tissue inhibitor of matrix metalloproteinase-2
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The Silent Language of Fingers and Hands—The Role of Finger and Hand Motions in Non-verbal Communication
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作者 周樱 《海外英语》 2013年第3X期223-225,共3页
This paper engages in the discussion about nonverbal intercultural communication from the perspective of hand and finger gestures,probing into the functions of non-verbal cues in cross-cultural interaction,talking ove... This paper engages in the discussion about nonverbal intercultural communication from the perspective of hand and finger gestures,probing into the functions of non-verbal cues in cross-cultural interaction,talking over two different attitudes toward gestures,and giving a detailed analysis about the silent language of some specific gestures with fingers and hands in different cultures. 展开更多
关键词 non-VERBAL COMMUNICATION INTERCULTURAL communicati
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Abnormal Secondary Growth and Histochemical Localization of Alkaloids in Root System of Aconitum flavum Hand.-Mazz.
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作者 祁建钊 郭继元 徐青 《Agricultural Science & Technology》 CAS 2011年第9期1313-1317,共5页
[Objective] The purpose of this study was to clarify the structure,growth pattern and histochemical localization of alkaloids in root system of Aconitum flavum Hand.-Mazz.[Method] Paraffin sectioning and histochemistr... [Objective] The purpose of this study was to clarify the structure,growth pattern and histochemical localization of alkaloids in root system of Aconitum flavum Hand.-Mazz.[Method] Paraffin sectioning and histochemistry were employed for performing the analysis in this study.[Result] The root system of Aconitum flavum Hand.-Mazz.consists of taproot,lateral root and adventitious root.The primary structure of root system is normal,but secondary structure shows abnormal.The cambium and the extra cambium of taproot form a "U"-shaped secondary vascular bundle and tertiary bundle in abnormal secondary structure.The sieve tube group is made of little sieve tube group which is differentiated from primary phloem and cambium.Meanwhile,the secondary xylem in tuberous root also appears to be a "U" shape.Parenchyma cells of secondary phloem occupy most of the tuberous root.The sieve tube group of tuberous root is mainly differentiated from parenchyma cell of secondary phloem.[Conclusion] The difference in abnormal secondary structure of taproot and tuberous root are attributed to their varied cambium compose and activity pattern.Alkaloids are mainly accumulated in parenchyma cell of the inside cortex and between bundle in taproot,while parenchyma of secondary phloem and pith in tuberous root. 展开更多
关键词 Aconitum flavum hand. - Mazz. Root system Abnormal secondary growth ALKALOIDS Histochemical localization
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肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系 被引量:4
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作者 焦朝艳 刘戈力 +4 位作者 鲍鹏丽 魏莹 杨箐岩 郑荣秀 赵菁 《天津医科大学学报》 2014年第1期25-28,共4页
目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体... 目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。 展开更多
关键词 儿童肥胖 亚临床动脉粥样硬化 non—HDL—C REMNANT CHOLESTEROL 血浆致动脉粥样硬化指数 颈动脉内膜-中层厚度
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Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer: a meta-analysis 被引量:13
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作者 Qiang Zhang Yi-Huan Fan +2 位作者 Teng Zhang Xiao-Lan Qin Ji-Fang Song 《TMR Integrative Medicine》 2017年第2期68-78,共11页
Objective: To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin(GP) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: we performed a syst... Objective: To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin(GP) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials (RCT) of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results: Eight trials were included including a total of 701 patients. Meta-analysisresults: Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC (OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001) and clinical treatment efficacy (OR =(OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia (OR = .31, 95%CI [0.20,0.47], P 〈 0.0001),thrombocytopenia (OR = 0.58, 95%CI [0.37, 0.91], P = 0.020), hemoglobin decline ((OR = 0.31, 95%CI [0.16,0.59], P = 0.0004) and incidence of gastrointestinal reactions (OR = 0.58,P 〈 0.05) could be reduced. Conclusion:Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove. 展开更多
关键词 Shenqi Fuzheng GP chemotherapy Advanced non - small cell lung cancer Meta analysis
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Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field
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作者 Hong-tao Zheng Zhi-yong Tan +2 位作者 Hai-ou Sun Chun-liang Zhou Zhi-ming Li 《Journal of Marine Science and Application》 2002年第1期26-34,共9页
Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved... Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec- 展开更多
关键词 plasma GENERATOR CHEMISTRY non - EQUILIBRIUM IGNITION technique numerical calculation
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On the Influence Factors of Second-hand House Prices in First-tier Cities——Empirical Analysis Based on Panel Data
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作者 Dong Fan Zheng Xuefeng 《学术界》 CSSCI 北大核心 2018年第2期225-236,共12页
With the arrival of the "housing stock" in first - tier cities, the second - handhousing^market will become the dominant property market. This ardcle aim to the first - tiercities of second - hand housing prices and... With the arrival of the "housing stock" in first - tier cities, the second - handhousing^market will become the dominant property market. This ardcle aim to the first - tiercities of second - hand housing prices and new home price index for the empirical analysis, thedata related to the cointegration analysis found that the result of the first -tier cities real estatemarket in China, the new home price index is the significant factors influencing the second -hand house price indexi For Beijing, Shanghai second - hand housing and new home price in-dex time series johans test, found that there exists cointegration relationship between two varia-bles,the new city real estate market prices out of a line on the secondary market have clearguide. Therefore, the real estate market regulation aiming at the first -tier cities and the"housing stock" should take the second - hand housing market as the main direction, startingwith the sale price and influencing factors of new houses. At the same time, in different cities,we should adhere to the city' s policies, reflect the policy differentiation, promote the reformof the real estate supply side, and promote the return of housing properties. 展开更多
关键词 first - tier CITIES second - hand house HOUSING PRICE panel data cointegra-tion johansTest
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Optimization of post-warranty sequential inspection for second-hand products 被引量:1
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作者 Dae-Kyung Kim Jae-Hak Lim Dong Ho Park 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第4期793-800,共8页
This paper considers an optimal sequential inspection schedule for a second-hand product after that the free nonrenewable warranty is expired. The length of warranty is prespecified and during the warranty period, the... This paper considers an optimal sequential inspection schedule for a second-hand product after that the free nonrenewable warranty is expired. The length of warranty is prespecified and during the warranty period, the product is minimally repaired by the dealer when it fails. Following the expiration of the non-renewing warranty, the product is inspected and upgraded sequentially a fixed number of times at the expenses of the customer.At each inspection, the failure rate of the product is reduced proportionally so that the product is upgraded. The product is assumed to deteriorate as it ages and the replacement of the product occurs when a fixed number of inspections are rendered. In addition,the intervals between two successive inspections are assumed to decrease monotonically. The main objective of this paper is to determine the optimal improvement level to upgrade the product at each inspection so that the expected maintenance cost during the life cycle of the product is minimized from the perspective of the customer. Under the given cost structures, we derive an explicit formula to obtain the expected maintenance cost incurred during the life cycle of the product and discuss the method to find the optimal level of the improvement analytically in case the failure times follow the Weibull distribution. Numerical results are analyzed to observe the impact of relevant parameters on the optimal solution. 展开更多
关键词 second-hand product sequential inspection upgrade action life cycle of the product expected maintenance cost free non-renewable warranty
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Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes
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作者 程隆棣 黄秀宝 于修业 《Journal of China Textile University(English Edition)》 EI CAS 2000年第3期57-59,共3页
The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and prac... The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality. 展开更多
关键词 WET - laid non - woven fiber PULP FLOW TURBULENT FLOW layer FLUID occluded FLUID .
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CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer
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作者 Kashif Iqbal 《The Chinese-German Journal of Clinical Oncology》 CAS 2007年第3期250-253,共4页
Objective: In an era of ever evolving, promising new therapies for advanced non small cell lung cancer (NSCLC), early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum... Objective: In an era of ever evolving, promising new therapies for advanced non small cell lung cancer (NSCLC), early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods: 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer (Elecsys 2000; Roche Diagnostics). Response was evaluated using Response evaluation criteria in solid tumors (RECIST) criteria. Results: 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 (72%) patients had an elevated baseline value of CYFRA 21-1.62% patients (18/29) had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant (P = 0.002; 95% CI, from 0.8369 to 3.49464; t test). 8 out of 10 (80%) patients with partial response had a reduction in their 2nd reading of. CYFRA (P = 0.019; 95% CI, from 0.81965 to 7.20035; t test) which was significant. We also observed that 6/9 (66%) patients whose disease remains stable also had a decrease in their subsequent reading (P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test), though it was not significant statistically. Although 5 out of 9 (55%) patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant (P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest). 14 out of 19 (73%) who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically (P = 0.004; 95% CI, from 0.74792 to 3.50208; t test). We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease (P = 0.001), which was statistically significant. Conclusion: We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC. 展开更多
关键词 CYFRA 21-1 non small cell lung cancer CHEMOTHERAPY RESPONSE
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MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2
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作者 JUNQI GUO YUN YANG +6 位作者 WEI ZHAO ZHONGHAI YAN XIA YANG YUNFEI YAN RUIMIN HAO JINXIA HU FEI JIAO 《BIOCELL》 SCIE 2021年第3期627-638,共12页
Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are... Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients. 展开更多
关键词 miR-16-5p non–small-cell lung cancer(NSCLC) Fermitin family member 2(FERMT2) APOPTOSIS INVASION Overall survival(OS)
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非药物治疗脑卒中后肩手综合征有效性的网状Meta分析
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作者 黄腾佳 曹曦 +2 位作者 陈蕾 李子滢 秦莉花 《中国全科医学》 CAS 北大核心 2024年第23期2921-2930,共10页
背景肩手综合征是脑卒中患者致残的主要因素之一,严重影响患者身心健康及生活质量。目前,治疗脑卒中后肩手综合征的非药物干预方式众多,但临床上优选何种非药物治疗方式尚有一定困扰。目的使用网状Meta分析评价7种非药物治疗方式改善脑... 背景肩手综合征是脑卒中患者致残的主要因素之一,严重影响患者身心健康及生活质量。目前,治疗脑卒中后肩手综合征的非药物干预方式众多,但临床上优选何种非药物治疗方式尚有一定困扰。目的使用网状Meta分析评价7种非药物治疗方式改善脑卒中后肩手综合征疗效、疼痛视觉模拟评分(VAS)及简式肢体运动功能量表(FMA)评分的差异,为临床决策提供循证支持。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统、PubMed、Embase、CochraneLibrary数据库中有关非药物治疗脑卒中后肩手综合征的随机对照试验,检索时间设定为建库至2023年6月。由2名研究员根据研究设计独立筛查文献与数据提取,使用RevMan 5.3、Stata 15.0软件进行网状Meta分析。结果共纳入62项研究,共5090例患者,干预措施包含针灸疗法、中药熏蒸疗法、体外冲击波疗法、艾灸疗法、热敷疗法、电刺激疗法、中药泡洗疗法。网状Meta分析结果显示:7种非药物治疗方式在改善肩手综合征患者总有效率、FMA评分方面均优于对照组(P<0.05);除艾灸疗法外,6种非药物治疗方式在改善肩手综合征患者VAS评分方面均优于对照组(P<0.05)。7种非药物治疗方式改善总有效率的累积排序概率图下面积(SUCRA)依次为:针灸疗法(86.1%)>中药泡洗疗法(77.1%)>中药熏蒸疗法(54.7%)>体外冲击波疗法(53.1%)>热敷疗法(49.0%)>电刺激疗法(48.4%)>艾灸疗法(31.1%)>常规对照治疗(0.4%)。7种非药物治疗方式改善VAS评分的SUCRA依次为:热敷疗法(81.3%)>中药泡洗疗法(78.4%)>针灸疗法(76.7%)>电刺激疗法(58.4%)>中药熏蒸疗法(52.7%)>体外冲击波疗法(32.9%)>艾灸疗法(18.1%)>常规对照治疗(1.5%)。7种非药物治疗改善FMA评分的SUCRA依次为:中药泡洗疗法(90.6%)>针灸疗法(83.5%)>中药熏蒸疗法(59.9%)>电刺激疗法(59.8%)>体外冲击波疗法(42.3%)>艾灸疗法(39.7%)>热敷疗法(24.1%)>常规对照治疗(0.2%)。结论与常规治疗相比,使用或联合非药物治疗方式在治疗脑卒中后肩手综合征的疗效更佳,由于受到原始研究限制,以上结论仍需开展更多临床试验以期论证。 展开更多
关键词 肩手综合征 非药物治疗 脑卒中 随机对照试验 网状Meta分析
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有无双遣与下学上达——论邹守益的工夫路径
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作者 董甲河 毛莉婷 《赣南师范大学学报》 2024年第1期89-93,共5页
邹守益在青原梦见朱子而意识到阳明后学工夫路径有下学不上达与上达不下学两种弊端。他采取有无双遣方式救弊:用“无声无臭独知时,此是乾坤万有基”纠正下学不上达,批评朱子舍心逐物之弊,主张不可滞于有,而是回到无声无臭独知,在良知的... 邹守益在青原梦见朱子而意识到阳明后学工夫路径有下学不上达与上达不下学两种弊端。他采取有无双遣方式救弊:用“无声无臭独知时,此是乾坤万有基”纠正下学不上达,批评朱子舍心逐物之弊,主张不可滞于有,而是回到无声无臭独知,在良知的观照之下,避免义袭之学;用“不离日用常行内,直造先天未画前”纠正上达不下学,批评王畿空悟本体之弊,主张不可陷于无,而是于日用常行处做致知工夫。他由有无双遣方式救弊,最终落实于下学上达工夫路径。他纠正下学不上达之弊,有助于使学人意识到心学与俗学的差异,由俗学转向心学,为学人修行指明正道;纠正上达不下学之弊,有助于扭转学人竞谈玄虚之风。邹守益主张从下学入手致良知,是救治上达不下学与下学不上达之弊的良药,体现了高超的中道智慧,有助于阳明后学的传播。 展开更多
关键词 邹守益 下学不上达 上达不下学 有无双遣 下学上达
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SHEA/IDSA/APIC实践建议:预防医院感染策略纲要(2022年更新版)
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作者 肖园园 谭彩霞(译) +3 位作者 吴安华(审校) Yokoe DA Advani SD Anderson DJ 《中国感染控制杂志》 CAS CSCD 北大核心 2024年第5期652-660,共9页
美国医疗保健流行病学学会/美国感染病协会/感染控制和流行病学专业人员协会(SHEA/IDSA/APIC)2022年更新了“急诊医院医疗保健相关感染的预防策略纲要”,内容包括“导尿管相关尿路感染(CAUTI)的预防策略”“中央导管相关血流感染(CLABSI... 美国医疗保健流行病学学会/美国感染病协会/感染控制和流行病学专业人员协会(SHEA/IDSA/APIC)2022年更新了“急诊医院医疗保健相关感染的预防策略纲要”,内容包括“导尿管相关尿路感染(CAUTI)的预防策略”“中央导管相关血流感染(CLABSI)的预防策略”“艰难梭菌感染(CDI)的预防策略”“预防耐甲氧西林金黄色葡萄球菌(MRSA)传播和感染的策略”“手术部位感染(SSI)的预防策略”“呼吸机相关肺炎(VAP)和呼吸机相关事件(VAE)的预防策略”“预防非呼吸机医院获得性肺炎(NV-HAP)的策略”“通过手卫生预防医疗保健相关感染的策略”“实施预防医疗保健相关感染的策略”九部分。 展开更多
关键词 医院感染 导尿管相关尿路感染 中央导管相关血流感染 艰难梭菌感染 耐甲氧西林金黄色葡萄球菌 手术部位感染 呼吸机相关肺炎 呼吸机相关事件 非呼吸机医院获得性肺炎 手卫生 医疗保健相关感染 预防策略
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2022年重庆市巴南区成人烟草使用监测结果分析
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作者 杨笑语 潘冬梅 +1 位作者 陈鹏 苏耀 《黑龙江科学》 2024年第17期32-34,共3页
为了解2022年重庆市巴南区成人烟草使用现状,分析相关影响因素,为控烟策略或政策的有效制定与改进提供科学依据,结合多阶段分层整群随机抽样法、PPS抽样调研法及简单随机抽样法对重庆市巴南区居民进行调查,统计其人口学特征、吸烟率、... 为了解2022年重庆市巴南区成人烟草使用现状,分析相关影响因素,为控烟策略或政策的有效制定与改进提供科学依据,结合多阶段分层整群随机抽样法、PPS抽样调研法及简单随机抽样法对重庆市巴南区居民进行调查,统计其人口学特征、吸烟率、戒烟率、电子烟知晓率、非吸烟者二手烟暴露率等信息。调查结果显示,巴南区居民吸烟率为19.35%,不同性别间的差异具有统计学意义,性别是影响巴南区居民吸烟率的主要因素。非吸烟者二手烟暴露率为34.67%,不同年龄、文化程度及城乡间的差异具有统计学意义。吸烟率与非吸烟者二手烟暴露率均显著低于2020年监测指标及国内平均水平。戒烟率及电子烟知晓率分别为24.38%、39.8%,不同年龄、文化程度受访者的电子烟知晓率差异具有统计学意义。基于此,应加强宣传,完善相关法律法规,完善戒烟服务体系,从而使居民有效控烟戒烟。 展开更多
关键词 烟草监测 吸烟率 二手烟暴露率 戒烟率 电子烟知晓率
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富血小板血浆局部注射治疗手部创面不愈合的临床疗效观察
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作者 金宇晗 《农垦医学》 2024年第2期116-120,共5页
目的:观察手部创面不愈合治疗中富血小板血浆局部注射的临床疗效。方法:回顾性选取2020年2月-2022年2月本院手部创面不愈合患者100例,依据手术彻底清创术后处理方法分为富血小板血浆局部注射治疗组(富血小板血浆组)、常规换药处理组两组... 目的:观察手部创面不愈合治疗中富血小板血浆局部注射的临床疗效。方法:回顾性选取2020年2月-2022年2月本院手部创面不愈合患者100例,依据手术彻底清创术后处理方法分为富血小板血浆局部注射治疗组(富血小板血浆组)、常规换药处理组两组,各50例。统计分析两组疼痛程度、创面愈合情况、瘢痕增生情况、日常自理情况、生活质量、创面生长因子浓度、创面愈合率、创面感染率、临床疗效、换药次数、创面愈合时间、住院时间、住院费用、不良反应发生情况、外观满意度。结果:富血小板血浆组患者的VAS评分、BWAT评分、VSS评分均低于常规换药处理组(P<0.05),ADL评分、SF-36评分、创面VEGF、EGF、TGF-β、PDGF、IGF浓度均高于常规换药处理组(P<0.05),创面愈合率高于常规换药处理组(P<0.05),创面感染率低于常规换药处理组(P<0.05),总有效率高于常规换药处理组(P<0.05),换药次数少于常规换药处理组(P<0.05),创面愈合时间、住院时间均短于常规换药处理组(P<0.05),住院费用低于常规换药处理组(P<0.05),不良反应发生率低于常规换药处理组(P<0.05),外观满意度高于常规换药处理组(P<0.05)。结论:手部创面不愈合治疗中富血小板血浆局部注射的临床疗效较常规换药显著。 展开更多
关键词 手部创面不愈合 常规换药 富血小板血浆 局部注射 创面愈合 不良反应
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基于特征分离的复杂环境三维手部姿态估计算法研究
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作者 高鲲 张皓洋 +2 位作者 李达 闫野 印二威 《智能安全》 2024年第3期54-65,共12页
基于视觉的三维手部姿态估计是实现人机交互的重要技术手段。目前,视觉手部姿态估计算法易受光照变化、遮挡和环境噪声等复杂环境因素干扰,导致模型的鲁棒性无法得到保障。这些多变的环境因素使得传统的深度学习方法在真实场景中难以取... 基于视觉的三维手部姿态估计是实现人机交互的重要技术手段。目前,视觉手部姿态估计算法易受光照变化、遮挡和环境噪声等复杂环境因素干扰,导致模型的鲁棒性无法得到保障。这些多变的环境因素使得传统的深度学习方法在真实场景中难以取得令人满意的结果。针对这一难题,本文提出了一种基于特征分离的手部姿态估计算法,通过对手部图像中的关键特征进行精炼来提升模型在不同环境中的鲁棒性。首先,对编码器进行基于频域增强的预训练,从而减少环境噪声对于底层视觉特征提取的影响;其次,在解码阶段提出了一种用于分离因果特征和非因果特征的双分支结构,通过减少非因果特征对于姿态估计任务的影响以提高模型应对复杂环境的能力;最后,通过融合全局姿态信息和局部关节信息,实现了不同尺度的统一优化,并基于两个公开数据集的定量分析和定性分析,验证了本文所提出方法的准确性和鲁棒性。 展开更多
关键词 特征分离 复杂环境 三维手部姿态估计 因果-非因果特征解耦 全局-局部信息融合
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含非竞争性内标四重荧光RT-PCR方法检测手足口肠道病毒方法的研究 被引量:1
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作者 周冬根 孙大为 +3 位作者 王燕 倪敏君 张升 翟敏 《生物技术通报》 CAS CSCD 北大核心 2012年第5期144-150,共7页
旨在了解手足口病的流行和感染情况,并进行快速准确的检测。建立了含非竞争性内标的同时检测肠道病毒通用型、肠道病毒EV71型及柯萨奇病毒CA16型的四重荧光RT-PCR方法,对该方法的特异性、灵敏度等进行评价,并对多份临床样本进行应用检... 旨在了解手足口病的流行和感染情况,并进行快速准确的检测。建立了含非竞争性内标的同时检测肠道病毒通用型、肠道病毒EV71型及柯萨奇病毒CA16型的四重荧光RT-PCR方法,对该方法的特异性、灵敏度等进行评价,并对多份临床样本进行应用检测。结果表明,该检测方法特异性强,对肠道病毒及其他人类非肠道病毒进行检测,显示了良好的特异性;该检测方法对EV71型和CA16型的检测灵敏度分别达到31.25 TCID50和1.25×102TCID50;将浓度为1×104TCID50及5×102TCID50的EV71样本进行重复性试验,其变异系数均小于1.5%;将浓度为5×102-5×105TCID50的EV71和CA16样本进行线性试验,其相关系数R2值在0.982-0.998之间。采用本研究建立的方法检测40份疑似临床样本,最后检出31份肠道病毒阳性样本,其中8例EV71型阳性,13例CA16阳性。另外,试验数据表明,内标对监控PCR抑制物的存在具有重要作用。本方法能同时快速检测所有肠道病毒并进行EV71型及CA16型的分型,并且灵敏度高、特异性好、扩增效率高,由于加入了内标,能有效地监控假阴性的出现,适合于手足口病的临床检测。 展开更多
关键词 四重荧光RT-PCR 非竞争性内标 手足口 肠道病毒 检测
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毫米波3D-MCM中垂直互联的设计 被引量:2
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作者 罗鑫 黄建 赵青 《电子元件与材料》 CAS CSCD 北大核心 2020年第11期73-78,共6页
3D-MCM是新一代有源相控阵共形天线的核心部件,设计小型化、低插入损耗和高可靠的垂直互联结构是实现3D-MCM关键技术之一。以小型化、连接可靠性、易集成、易加工为目的,提出一种应用于毫米波频段,基于左手传输线的同轴型非接触式垂直... 3D-MCM是新一代有源相控阵共形天线的核心部件,设计小型化、低插入损耗和高可靠的垂直互联结构是实现3D-MCM关键技术之一。以小型化、连接可靠性、易集成、易加工为目的,提出一种应用于毫米波频段,基于左手传输线的同轴型非接触式垂直互联结构,使得不同功能模块之间通过电磁耦合的方式实现了信号的垂直传输。利用低温共烧陶瓷(LTCC)制造工艺,制作了背靠背同轴型非接触式垂直互联实物,单个垂直互联接口面积约3.14 mm^2,经测试在35~43 GHz频段内单个垂直互联插入损耗小于0.7 dB,带内平坦度优于±0.75 dB,回波损耗优于-12 dB。 展开更多
关键词 3D-MCM 左手传输线 垂直互联 非接触式 毫米波 低插入损耗
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FAREY SEQUENCE OF NONLINEAR DIFFERENTIAL DYNAMIC SYSTEM IN TWO DIMENSIONS 被引量:1
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作者 H. Q. Jin and S. N. Xu Shenyang Institute of Technology , Shenyang 110015 , China 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 1999年第5期1234-1236,共3页
In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle)... In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle) to the circle m ap . 展开更多
关键词 non - linearity Farey sequence phase lock CHAOS
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