Third-order modified coeffcient scheme based on essentially non-oscillatory scheme

A third-order numerical scheme is presented to give approximate solutions to multi-dimensional hyperbolic conservation laws only using modified coefficients of an essentially non-oscillatory （MCENO） scheme without increasing the base points during construction of the scheme. The construction process shows that the modified coefficient approach preserves favourable properties inherent in the original essentially nonoscillatory （ENO） scheme for its essential non-oscillation, total variation bounded （TVB）, etc. The new scheme improves accuracy by one order compared to the original one. The proposed MCENO scheme is applied to simulate two-dimensional Rayleigh-Taylor （RT） instability with densities 1：3 and 1：100, and solve the Lax shock-wave tube numerically. The ratio of CPU time used to implement MCENO, the .third-order ENO and fifth-order weighed ENO （WENO） schemes is 0.62：1：2.19. This indicates that MCENO improves accuracy in smooth regions and has higher accuracy and better efficiency compared to the original ENO scheme.

APPLICATION OF WEIGHTED NONOSCILLATORY AND NON-FREE-PARAMETER DISSIPATION DIFFERENCE SCHEME IN CALCULATING THE FLOW OF VIBRATING FLAT CASCADE

A dual-time method is introduced to calculate the unsteady flow in a certain vibrating flat cascade. An implicit lower-upper symmetric-gauss-seidel scheme（LU-SGS） is applied for time stepping in pseudo time domains, and the convection items are discretized with the spatial three-order weighted non-oscillatory and non-free-parameter dissipation difference （WNND） scheme. The turbulence model adopts q-co low-Reynolds-number model. The frequency specmuns of lift coefficients and the unsteady pressure-difference coefficients at different spanwise heights as well as the entropy contours at blade tips on different vibrating instants, are obtained. By the analysis of frequency specmuns of lift coefficients at three spanwise heights, it is considered that there exist obvious non-linear perturbations in the flow induced by the vibrating, and the perturbation frequencies are higher than the basic frequency. The entropy contours at blade tips at different times display an intensively unsteady attribute of the flow under large amplitudes.

肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

Oscillation Criteria of second Order Non-Linear Differential Equations

In this paper we are concerned with the oscillation criteria of second order non-linear homogeneous differential equation. Example have been given to illustrate the results.

无创高频振荡通气在中-重度慢性阻塞性肺疾病急性加重期伴呼吸衰竭患者中的应用

目的研究无创高频振荡通气治疗对中-重度慢性阻塞性肺疾病急性加重期(AECOPD)伴呼吸衰竭患者炎性指标及痰液性状的影响。方法选取2019年1月至2020年6月在绵阳市第三人民医院·四川省精神卫生中心呼吸与危重症医学科就诊的100例中-重度AECOPD伴呼吸衰竭患者为研究对象,按随机数字表法分为双相气道正压通气(BiPAP)组和无创高频振荡通气(NHFOV)组,每组50例。两组于治疗前及治疗后72 h采集清晨空腹静脉血,经全自动血液分析仪检测白细胞(WBC)水平,透射比浊法检测患者C-反应蛋白(CRP)水平,电化学发光法检测患者降钙素原(PCT)水平,比较两组WBC、CRP、PCT等炎症指标;痰液量、性状及颜色改变。结果治疗后,NHFOV组PCT、CRP值明显低于BiPAP组(P<0.05);两组WBC比较,差异无统计学意义(P>0.05);NHFOV组痰液性状改变时间、平均24 h排痰量较BiPAP组明显降低(P<0.05)。结论在中-重度AECOPD伴呼吸衰竭患者治疗中,NHFOV较常规BiPAP更能减轻炎性反应,减少痰液量,改善患者症状。

经鼻无创高频振荡通气联合TcPCO_(2)和TcPO_(2)监测在早产儿呼吸窘迫综合征中的应用

目的分析经鼻无创高频震荡通气联合经皮二氧化碳分压(TcPCO_(2))和经皮氧分压(TcPO_(2))监测在早产儿呼吸窘迫综合征中的应用。方法选择2019年10月至2021年10月收治的新生儿呼吸窘迫综合征无创呼吸支持治疗的早产儿80例,采用随机数字法分为改良组(经鼻无创高频震荡通气)和对照组(经鼻持续正压通气)。每组40例。2组均联合TcPCO_(2)和TcPO_(2)监测。观察2组通气0、6、12、24 h后的pH值、TcPCO_(2)/TcPO_(2)指标、无创通气时间、治疗失败转为气管插管机械通气率、并发症发生率及病死率。结果通气0 h,2组血液pH值、TcPCO_(2)、TcPO_(2)比较差异无统计学意义(P>0.05);与对照组比较,改良组通气6、12、24 h血液pH值、TcPO_(2)均明显升高,TcPCO_(2)均明显降低(P<0.05)。与对照组比较,无创通气时间和治疗失败转为气管插管机械通气率均明显降低(P<0.05)。2组气漏、腹胀、鼻部损伤、肺出血、感染性肺炎等并发症发生率比较差异无统计学意义(P>0.05)。对照组病死率为5.00%(2/40),改良组病死率为2.50%(1/40),差异无统计学意义(P>0.05)。结论经鼻无创高频震荡通气联合TcPCO_(2)和TcPO_(2)监测在早产儿呼吸窘迫综合征中应用价值较高,可改善患儿呼吸功能,降低气管插管机械通气率,且不会增加并发症的发生。

基于Additive Runge-Kutta方法的激波聚焦起爆高精度数值模拟

基于详细氢氧化学动力学模型,建立了描述氢氧爆轰的多组分反应欧拉方程组.针对建立的反应欧拉方程组,数值方法上采用3阶Additive Runge-Kutta方法对时间项进行积分,采用5阶精度的加权本质无振荡(WENO)格式对空间对流项进行离散,自主研发了大规模高精度计算程序.该程序能够处理化学反应源项引起的刚性问题,且能节省计算时间和计算内存.对半球型、半椭球型、圆锥型3种结构形式凹面腔内的激波聚焦起爆过程进行了数值模拟,数值模拟研究得到了不同结构形式凹面腔内的激波聚焦起爆过程.

Doppler Effect: A Look from Biology Aging

The Doppler effect can be defined as the frequency shift suffered by a wave phenomenon, when there is a difference in relative speed between the waves generated and their source. We know that it occurs in the case of mechanical and electromagnetic waves. We propose to generalize the Doppler effect to the case of frequency changes of certain oscillatory variables in biology before and after puberty, starting from the basis that a metabolically accelerated system is equivalent to a mechanically accelerated system. We then established the following objectives: To verify if there is an average difference in heart and respiratory rates, before and after puberty. To verify the association of these frequency differences with the metabolic activity estimated as basal metabolic rate or BMR. We studied heart and respiratory rate data from healthy people of both sexes, verifying the frequency distribution before and after puberty. We also study the relationship of the frequency distribution with the evolution of the basal metabolic rate throughout life. Analysis of the results shows that the highest heart and respiratory rates occur before puberty, while the lowest rates occur after puberty. A high correlation of the evolution of the variables studied with the evolution of the metabolic acceleration of the system throughout life is also evident. Taking into account that a mechanically accelerated system is equivalent to a metabolically accelerated system, we can conclude that the frequency distribution found is the expression of a generalization of the Doppler effect in the case of biological physical systems.

无创高频振荡通气在新生儿呼吸窘迫综合征中的应用效果

目的:观察无创高频振荡通气在新生儿呼吸窘迫综合征中的应用效果。方法:选取2021年8月至2023年8月该院收治的70例新生儿呼吸窘迫综合征患儿进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各35例。对照组采用无创呼吸机通气,研究组采用无创高频振荡通气。比较两组无创通气时间、氧依赖时间、住院时间,治疗前后呼吸参数(潮气量、呼吸频率)、血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、pH]水平,以及并发症发生率。结果:研究组无创通气时间、氧依赖时间、住院时间均短于对照组,差异有统计学意义(P<0.05);两组潮气量均高于治疗前,且研究组高于对照组,两组呼吸频率均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组PaO_(2)、pH水平均高于治疗前,且研究组高于对照组,两组PaCO_(2)水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组并发症发生率为2.86%(1/35),低于对照组的22.86%(8/35),差异有统计学意义(P<0.05)。结论:无创高频振荡通气应用于新生儿呼吸窘迫综合征,可缩短无创通气时间、氧依赖时间和住院时间,提高潮气量,改善血气分析指标,降低呼吸频率和并发症发生率,效果优于无创呼吸机通气。

无创高频振荡通气治疗新生儿呼吸窘迫综合征早产儿的临床效果及对血气分析指标的影响

目的分析无创高频振荡通气(nHFOV)治疗新生儿呼吸窘迫综合征(NRDS)早产儿的临床效果及对血气分析指标的影响。方法选择2018年1月至2021年12月我院收治的120例NRDS早产儿作为研究对象,以随机法将其分为常规组和观察组,每组60例。常规组开展持续气道正压通气治疗,观察组开展nHFOV治疗。比较两组的治疗效果。结果观察组的通气治疗时长、住院时长短于常规组,一次撤机成功率高于常规组,呼吸暂停、高碳酸血症、低氧血症、支气管肺发育不良发生率低于常规组(P<0.05)。治疗6、24 h后及治疗结束后,观察组的血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))显著高于常规组,动脉血二氧化碳分压(PaCO_(2))、二氧化碳总量(TCO_(2))显著低于常规组(P<0.05)。治疗6、24 h后及治疗结束后,观察组的吸入氧浓度(FiO_(2))、平均动脉压(MAP)高于常规组,氧合指数(P/F)低于常规组(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、降钙素原(PCT)水平低于常规组(P<0.05)。结论nHFOV治疗NRDS早产儿可取得理想的治疗效果,能降低不良事件发生率,并快速改善动脉血气、氧合指标及炎症指标。

FAREY SEQUENCE OF NONLINEAR DIFFERENTIAL DYNAMIC SYSTEM IN TWO DIMENSIONS

In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle) to the circle m ap .

Hamilton-Jacobi方程的高分辨率解法

Ham ilton-Jacob i方程经常应用于控制论和微分对策等方面.它与双曲型守恒律有非常紧密的联系,在一维的情形下,两者几乎完全相同.在多维的空间中,类似的情形依然存在.因此,可以通过这种联系来设计不同的近似算法来求解Ham ilton-Jacob i方程.本文利用CWENO算法成功地求解了包括控制最优化问题在内的许多标量问题,结果表明,这种算法在解的光滑区域具有很高的精度,并能很好地解决具有不连续偏导数的计算问题,数值算例结果也表明这种算法是收敛的.

非结构网格上求解二维H-J方程的一种WENO格式

基于WENO(Weighted Essentially Non-Oscillatory)的思想,提出了一种在非结构网格上求解二维Hamilton-Jacobi(简称H-J)方程的数值方法.该方法利用Abgrall提出的数值通量,在每个三角形单元上构造三次加权插值多项式,得到了一个求解H-J方程的高阶精度格式.数值实验结果表明,该方法计算速度较快,具有较高的精度,而且对导数间断有较高的分辨率.

Hypersonic Shock Wave/Boundary Layer Interactions by a Third-Order Optimized Symmetric WENO Scheme

A novel third-order optimized symmetric weighted essentially non-oscillatory(WENO-OS3)scheme is used to simulate the hypersonic shock wave/boundary layer interactions.Firstly,the scheme is presented with the achievement of low dissipation in smooth region and robust shock-capturing capabilities in discontinuities.The Maxwell slip boundary conditions are employed to consider the rarefied effect near the surface.Secondly,several validating tests are given to show the good resolution of the WENO-OS3 scheme and the feasibility of the Maxwell slip boundary conditions.Finally,hypersonic flows around the hollow cylinder truncated flare(HCTF)and the25°/55°sharp double cone are studied.Discussions are made on the characteristics of the hypersonic shock wave/boundary layer interactions with and without the consideration of the slip effect.The results indicate that the scheme has a good capability in predicting heat transfer with a high resolution for describing fluid structures.With the slip boundary conditions,the separation region at the corner is smaller and the prediction is more accurate than that with no-slip boundary conditions.

Ways to Overcome Anxiety in the English Listening Class in College (SUN JING-YU KE SU-FEN)

In my ten-yeat experience of tenching English as major in college , I feel that students experience more difficulties in listening lessons than in other lessons. What, then, prevents students from achieving success in the listening class? I suggest that anxiety is one of the major factors, which interferes with students listening comprehension. And I would agree with writers such as Gardner and Horwitz et al. (1991)that anxiety may impede learner’s ability to perform successfully in all aspects of learning a foreign language. I feet it is particularly significant for listening.