肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Relationship between Beating and Setting-on Place

In this paper,what causes the setting-on place of woven fabrics without adopting tension compensation is explained by means of experimental methods.Owing to that the main shaft speed and the beating speed of reed can not attain the normal values at setting-on,the warp tension and the beating force of the reed can neither reach the normal level.Therefore,the relative slippage movement of the weft against the warp during beating will be less,while the common movement of the weft together with the warp will be bigger than those at nor-mal running.As a result,the setting-on place is

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

向非公立机构“购买学位”发展学前教育——以美国幼儿班(Pre-K)项目为例

在公共教育资源不足时,向非公立学前教育机构"购买学位",获得学生入学位置,是当前国内外一些地方政府采取的做法。美国3-4岁儿童早期教育项目实施了购买学位的政策,明确了向谁购买、为谁购买、以什么形式购买和如何进行监督、评价等关键问题。我国地方政府在制定和实施相关政策时,应审慎考虑国外的经验、教训。

“地方”观念的转变与建筑学在行动

20世纪下半叶,全球向后工业甚至“超工业”的转型,伴随着深度工业化,将世界纳入流动体系,但也蔓延危机。地方观念从“场所”开始,经历“无地方”“无地方感”“非地”三次观念转型,对应后工业文化批判(1950—1970年代)、后现代主义(1980年代)、超现代全球化(1990年代至今)等时代问题。建筑学以行动意识直面危机,重构人地交互。解读地方观念转变,识别空间-人本主义、行为-身份认同、时间-人机互构三种建筑学行动路径,以及抵抗型再地方、敞开型再地方和速度中继三类应对策略,重申建筑学行动潜能。

非遗旅游街区旅游者地方认同的建构及验证——基于表征与非表征的双重视角

基于表征和非表征双重视角,以西安永兴坊为研究案例,以物质景观吸引力、非物质文化氛围和消费空间在地化3个方面代表非遗旅游街区文化表征体系下的符号感知,以人际互动、共同生产和个性化经历3个方面代表非表征的旅游者实践,建立非遗旅游街区旅游者地方认同的研究模型。结果表明:(1)物质景观吸引力、非物质文化氛围和旅游消费空间在地化对旅游者实践的影响不同。其中,物质景观吸引力对旅游者实践的3个方面都有显著正向影响,非物质文化氛围只对共同生产有显著正向影响,消费空间在地化对人际互动和个性化经历有显著正向影响。(2)人际互动、共同生产和个性化经历对旅游者地方认同都有显著正向影响。(3)旅游者实践在符号感知与旅游者地方认同的关系中发挥完全中介作用。研究结果可为历史文化街区引入非遗项目、提升旅游者地方认同提供理论依据。

无预应力钢绞线笼灌注桩设计与施工技术研究

传统灌注桩的钢筋笼一般分为多节,通过多次焊接将上下节连接,难免影响施工质量和施工效率。结合某改扩建具体项目,提出一种钢绞线笼灌注桩,选取无预应力钢绞线作为主筋,采用螺旋箍筋及加劲筋提高整体刚度,并给出了钢绞线笼灌注桩的设计方案及设计方法,通过有限元模拟对比分析了普通钢筋笼灌注桩与钢绞线笼灌注桩在轴拉与轴压下的受力及变形机理。基于优化设计结果,进行了现场工艺试验,形成了灌注桩超长钢绞线笼同步制作下放工艺,可为以后类似工程提供借鉴。

让-菲利普·图森小说中的城市过渡空间

图森小说中的城市过渡空间首先传达了现代城市复杂的、令人迷惑和不安的一面,又是打开城市缺口、打破日常和已知、激荡想象力的地带。其次,它体现了矛盾的社交关系,既在孤立的个体间建立了联系,甚至助推亲密关系的建立,又在关系中设置屏障,使人与人无法真正地靠近。它建立了一种程式化、契约式的人际关系,揭示了人和他人、人和自我不可弥合的距离。最后,城市过渡空间集中体现了现代社会对速度和效率的追求。个体在此过程中采取了不同的方式,或是超越或是抵抗或是顺应高速运动。人们既渴望在速度中获得亢奋的感官体验,又希望恢复慢与静止,在运动中获得永恒的片刻。

非杆件结构体系弹性应力配筋法--关于转换层厚板的研究

本文以转换层厚板为例来探讨非杆件结构体系按照弹性应力图形进行配筋的方法.通过一个工程实例,运用应力配筋法对转换层厚板作了比较详细的整体应力分析和应力配筋计算.通过分析比较一般设计方法与应力配筋方法的共同点及差异性,表明了此方法的合理性和实用性.

FAREY SEQUENCE OF NONLINEAR DIFFERENTIAL DYNAMIC SYSTEM IN TWO DIMENSIONS

In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle) to the circle m ap .

文化遗产的品牌个性感知--以广东江门启明里为例

基于非表征理论和启动效应范式实验方法,以广东省江门市启明里的地方品牌为例,通过对比居民与非居民内隐感知差异、本地居民外显和内隐感知的差异,分析人们内隐感知对于地方品牌建构的影响。研究发现:1)受到日常生活经验的影响,本地居民与非本地居民对启明里的品牌个性的内隐感知存在差异,二者对启明里的品牌个性建构起不同的意义,本地居民将日常生活的记忆和体验融入其中,而非本地居民仅将其视为城市更新的工程;2)本地居民对启明里地方品牌外显和内隐感知的差异表明启明里地方品牌对于本地居民而言只是一种“快餐式”的消费和自我表达的工具,缺乏情感、价值观念层面的认同;3)地方品牌化不能只关注符号性景观构建,而需要重视本地居民日常生活中内隐的、非表征的空间邂逅的作用,这有助于为地方品牌注入可持续的价值提升动力,增进本地居民对品牌的认同和自信。

Ways to Overcome Anxiety in the English Listening Class in College (SUN JING-YU KE SU-FEN)

In my ten-yeat experience of tenching English as major in college , I feel that students experience more difficulties in listening lessons than in other lessons. What, then, prevents students from achieving success in the listening class? I suggest that anxiety is one of the major factors, which interferes with students listening comprehension. And I would agree with writers such as Gardner and Horwitz et al. (1991)that anxiety may impede learner’s ability to perform successfully in all aspects of learning a foreign language. I feet it is particularly significant for listening.

行走在景观的边缘

今天的城市景观,正日益从地方向无地方转变。如何在二者之间重建创造性的关联,而并非单纯陷入二元对立的束缚和框架,成为一个关键的议题。回归中国古代造园传统之中的三重“之间”的手法和意境,或许是一条可行的途径。人作与天成之间的“宛若”之境最终意在令自然呈现其自身,静与动之间的行走之境则试图敞开身体与空间的密切交织,而真与假之间的幻境更是指向着从有限向无限的跃变。对于日趋数字化和智能化的城市景观设计,这些古老的传统并未过时,而是更激活着直面现实的启示。

道路、空间与文化图式——基于湘西边城的民族志研究

道路是一个充满流动性的空间,现代道路的修筑使其沿线出现了许多与地方文化传统迥然相异的“非地方”。马克·欧杰的“非地方”理论概念和国内路学研究对流动性议题有着充分观照,但疏于分析道路所潜藏的文化图式及其转换逻辑。以湘西边城作为田野点,从道路的实体和虚体两个层面讨论传统与现代的遭遇、碰撞和调适,并借由当地人的地势观念剖析道路连带的“玉带环腰”“镰刀煞”和“阴阳之隔”等文化图式的转换过程。研究表明,现代道路造就了格式化、标准化和高流动性的“非地方”,但地方意义和感知结构并不易被取代,相反,地方社会也会从其传统中调用资源赋予道路新的文化意涵。

青岛重点公共场所室内空气化学污染物健康风险评估

目的了解青岛市重点公共场所室内空气中化学污染物污染状况,评估其健康风险,为青岛市公共场所卫生管理和从业人员健康提供科学依据和技术支持。方法分析青岛市2017—2020年的重点公共场所室内空气中甲醛、苯、甲苯、二甲苯及氨暴露水平,按照《公共场所卫生检验方法第2部分:化学污染物》进行检测,采用美国国家环境保护署(United States Environmental Protection Agency,USEPA)经典“四步法”健康风险评估模型评估化学污染物经吸入途径的致癌风险和非致癌风险。结果宾馆(酒店)、美容店、理发店三类场所室内空气中甲醛、苯、甲苯、二甲苯及氨的中位数浓度均低于国家标准规定的卫生限值。其中,甲醛的中位数浓度的致癌风险介于1.0×10-6~1.0×10-4,最高浓度的致癌风险大于1.0×10-4;中位数及以上浓度的慢性非致癌风险值>1。结论青岛市宾馆(酒店)、理发店和美容店从业人员室内空气中甲醛暴露存在慢性非致癌风险和较高的致癌风险,宜重点关注;苯暴露存在一定的致癌风险,宜引起关注。

日本《街道设计导则》解读及对中国的启示

中国的街道设计工作正在从早期重视单一的交通功能向交通功能与空间场所功能并重的阶段转型。日本拥有与中国相近的文化特征,在《街道设计导则》(以下简称《导则》)编制以及相关工程实践领域取得了显著成就,对中国有一定借鉴价值。首先,回顾日本街道设计的发展历程和《导则》的编制背景。然后,梳理日本相较于其他国家或城市独特的《导则》编制目的、研究范围及内容框架。同时,从街道设计的构成要素、交通环境建设与管理措施、制度设计等方面对《导则》核心内容展开解读。最后,基于日本的成功经验进一步反思街道设计工作的原则与初衷,提出对中国编制、修订街道设计导则以及项目实践的启示。