A Contrastive Appraisal Study on Modern Evolution of Female's Non-prototype Characteristics——A Case Study of Different Wu Zetian's Biographical Versions

Within the framework of Appraisal theory,this thesis attempts to do the discourse analysis of modern evolution of fe males'non-prototype characteristics through six versions of biographies of Wu Zetian(included Lin Yutang's Lady Wu,and Yuan Baidai's Wu Zetian) in modern times,which aims to uncover the implicit relationship of language and ideology of these different Wu Zetian's biographical versions composed by different authors with different genders and nationalities,which can evoke the readers resonance and affection towards them and reflect the interpersonal function between them by means of excavat ing the regularity of Attitude,Engagement and Graduation resources distribution.

肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Analysis of the Variations of Body Build of Middle-and Old-aged and Research on the Prototype

The characteristics of body build of middle - and old -aged women and its rule of variations as well as the basic sizes of various parts are discussed. All these are based on the body measurements of this age group, and also on the statistical studies of the measurement data. By setting the regression equation, the calculating formulae of various control parts are obtained, thus establishing the prototype of this age group for women.

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

FAREY SEQUENCE OF NONLINEAR DIFFERENTIAL DYNAMIC SYSTEM IN TWO DIMENSIONS

In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle) to the circle m ap .

Prototype for 5G New Air Interface Technology SCMA and Performance Evaluation

Sparse code multiple access(SCMA) is a novel non-orthogonal multiple access scheme proposed to meet the challenging demand of the future 5G communications, especially in support of the massive connections. The coded bits from each data stream will be directly mapped as multi-dimensional SCMA codeword in complex domain and then spread onto the physical resource elements in a sparse manner. The number of codewords that can be nonorthogonally multiplexed in one SCMA block can be made much larger than the number of orthogonal resource elements therein, resulting in an overloaded system. The sparsity in the spreading pattern and the design in the multidimensional modulator jointly ensure the SCMA codewords can be robustly decoded with low complexity. In this paper, we focus on the low complexity receiver design and verified the superior of an SCMA system via simulations and real-time prototyping. Lab tests and field tests all show that SCMA is a promising candidate for 5G non-orthogonal multiple access which can provide up to 300% overloading that triples the whole system throughput while still enjoying the link performance close to orthogonal transmissions.

Ways to Overcome Anxiety in the English Listening Class in College (SUN JING-YU KE SU-FEN)

In my ten-yeat experience of tenching English as major in college , I feel that students experience more difficulties in listening lessons than in other lessons. What, then, prevents students from achieving success in the listening class? I suggest that anxiety is one of the major factors, which interferes with students listening comprehension. And I would agree with writers such as Gardner and Horwitz et al. (1991)that anxiety may impede learner’s ability to perform successfully in all aspects of learning a foreign language. I feet it is particularly significant for listening.

基于形体特征层次分析的概念设计原型评价与演化方法

为对概念设计原型进行定量评价,实现具有形位公差需求的机械零件成形时间与制造质量之间的均衡,提出一种基于形体特征层次分析(Shape Feature Hierarchical Analysis,SFHA)的概念设计原型评价与演化方法。针对概念设计形体的孔和轴的形态特性,采用最大内切圆柱和最小外接圆柱构建特征模型,计算由分层策略所导致偏移的实际轴线位置,推算圆柱度误差大小。进行基于形位公差的自适应分层,在保证圆柱度等公差满足设计需求的情况下尽可能减少所需层数。通过改进粒子群算法进行非凸优化求解,遴选出最优的分层序列。计算特征层次化模型向正平面V(XOZ)和侧平面W(YOZ)的平行正投影面积及绝对梯度变化,实现基于SFHA的概念设计原型特征定量化描述与动态演化。以典型支座零件为例进行验证,采用熔融沉积成形设备进行物理试验,基于高精度结构光三维扫描仪获取原型零件的圆柱度误差,相较于均匀分层方法,所提出的SFHA方法制造时间可减少26.97%。

Bioinformatics analysis of the association between miR-942-5p–induced downregulation of PIEZO-type mechanosensitive ion channel component 1 and poor prognosis in non–small cell lung cancer mediated by the mitogen-activated protein kinase pathway signaling pathway

Background:Non–small cell lung cancer(NSCLC)is a common malignant tumor with an increasing incidence.PIEZO-type mechanosensitive ion channel component 1(PIEZO1)is a mechanosensitive ion channel whose expression has been implicated in various cancers.However,its expression patterns,prognostic implications,and specific molecular mechanisms of action in NSCLC remain un-clear.This study aimed to characterize the expression profile of PIEZO1 in NSCLC in vitro and using bioinformatics analyses.Methods:To determine the expression profile of PIEZO1 in normal and cancerous human tissues and the mRNA expression of PIEZO1 in NSCLC,we analyzed data from The Cancer Genome Atlas.Various bioinformatics analyses were performed for correlation analyses,construction of survival curves,and identification of upstream mRNA targets and genes coexpressed with PIEZO1.Furthermore,the coexpressed genes were functionally annotated with Gene Ontology and subjected to pathway enrichment analyses.Additionally,we an-alyzed and compared PIEZO1 expression in normal and cancerous human tissue samples in vitro.Results:NSCLC tissue samples had lower PIEZO1 expression than adjacent tissues.PIEZO1 overexpression inhibited NSCLC progres-sion and cell migration and correlated with improved survival outcomes,as revealed by bioinformatics analyses.Additionally,analysis using the OncomiR database revealed that miR-942-5p upregulation contributed to the downregulation of PIEZO1 in NSCLC.Mechanistic in-vestigations suggested that PIEZO1 modulates NSCLC by regulating the mitogen-activated protein kinase pathway,particularly by targeting FLNA,RRAS,and MAP3K6.Bioinformatics analyses highlighted the potential of PIEZO1 as a therapeutic target and prognostic indicator of NSCLC.Conclusions:These novel findings reveal the expression profile of PIEZO1 in NSCLC and highlight the potential of PIEZO1 and miR-942-5p as diagnostic and therapeutic biomarkers of NSCLC and other cancer types.

氨基酸与钠离子非共价键相互作用的电喷雾质谱研究

实验研究中常常观察到钠离子与一些多肽或蛋白质有较强的非共价键结合能力,这种非共价键相互作用可能与生物的一些功能和活性有关.为了进一步了解这一结合作用,我们应用电喷雾质谱研究了常见的20种氨基酸与钠离子在溶液中的非共价键相互作用.实验研究中发现脯氨酸和苯丙胺酸与钠离子有较强的非共价键结合能力.……

英汉被动句的认知对比分析

本文从认知语言学的角度出发 ,对英语和汉语中典型和特殊的被动句式进行了有代表性的对比分析 ,发现无施事被动句因符合EICM而应被视为被动态的原型 ,而有施事的被动句因偏离了EICM而成为被动态的特殊形式。英汉语在被动句原型和特殊形式方面 ,既相似又相异 ,我们把这种现象看成是认知语义结构基底的表层变体。

316L不锈钢选区激光熔化成型非水平悬垂面研究

为了提高选区激光熔化直接成型非水平悬垂面的能力,通过实验研究了影响悬垂面极限成型角度的工艺因素.实验使用316L不锈钢粉末,设计了不同倾斜角度的悬垂平面模型和悬垂曲面模型.结果表明:提高预置粉末密度可以提高悬垂面成型的极限角度;在25μm的成型厚度下,激光扫描能量输入在0.15～0.2 J/mm时悬垂面成型精度最高,悬垂面翘曲最小,成型完整悬垂表面的倾斜角度达到30°.最后,通过成型带有悬垂结构的个性化零件对研究结果进行验证.成型件悬垂结构在成型方向和水平方面上的尺寸精度分别达到0.1 mm以下和0.01 mm.本研究从工艺和设计的角度为选区激光熔化技术直接成型非水平悬垂面提出了基本的控制和优化方法.

概率聚类技术应用于变压器DGA数据故障诊断

传统的最优聚类、分类技术,需要对聚类原型做球形假设,若将其应用于溶解气体分析(DGA)数据表诊断故障分类问题将存在不符合聚类本质的问题。为此将密度聚类方法引入DGA数据的故障诊断,取消了对聚类原型做形状假设,实现了DGA样本聚类的无监督型分析。该方法实现如下:①利用非参数密度估计方法估计样本空间概率密度函数,并以概率密度函数作为聚类依据,密度函数值较大的区域将有可能作为类簇原型区;②利用非参数估计方法直接估计出概率密度函数的梯度场;③依据概率密度函数的梯度分布确定聚类原型,进而利用峡谷搜索法思想建立聚类划分;④最后利用类簇划分的边界确定变压器故障的区分边界。试验结果表明,该方法实现了基于密度的自然值域划分,能够做到比现有的人工划分方式更加细致地划分,为研究DGA样本表特性提供了一种新的可行途径。

涡轮叶片锥束体积CT检测系统软件原型

给出了检测系统软件原型的总体结构和数据流设计。研究了图像序列快速重建、高精度图像边缘检测、叶片点云模型与CAD设计模型配准、叶片壁厚检测与铸造缺陷分析等关键模块的实现方法。软件原型由C++6.0编程实现。仿真测试表明该软件可基于空心涡轮叶片的锥束体积CT扫描数据对叶片的外型轮廓偏差、壁厚和铸造缺陷进行检测分析。

照明用LED光学系统的计算机辅助设计

介绍了LED在照明领域的应用前景,提出了利用计算机辅助非序列光线追迹设计照明用LED的光学系统的分析方法,以达到计算机虚拟试制LED的目的。

神:语言构筑的世界——再论语言非工具论

语言是人类文化传统和认知方式的最典型表征。从语言的本质特征和人类认知思维的特点出发,可以把"成人讲故事,儿童听故事"的信息交流过程形象地称为Fairy Tale Model(童话模式),将其作为一种具有普遍意义的人类语言信息交换模式和认知方式确立下来。本文探讨人类通过童话模式对神的世界的描述,说明建构语言的世界在人类认知的趋同特征,同时也说明这个世界存在于语言中,是语言非工具性特征的代表性表征。