Rational solutions of Painlevé-Ⅱequation as Gram determinant

Under the Flaschka-Newell Lax pair,the Darboux transformation for the Painlevé-Ⅱequation is constructed by the limiting technique.With the aid of the Darboux transformation,the rational solutions are represented by the Gram determinant,and then we give the large y asymptotics of the determinant and the rational solutions.Finally,the solution of the corresponding Riemann-Hilbert problem is obtained from the Darboux matrices.

某院非小细胞肺癌治疗中EGFR-TKI使用情况分析

目的 分析医院近三年表皮生长因子受体-酪氨酸激酶抑制剂(EGFR-TKI)在非小细胞肺癌(NSCLC)治疗中的使用情况,为临床安全合理用药提供参考。方法 应用限定日剂量(DDD)法回顾性统计分析2020~2022年医院EGFR-TKI的销售金额、用药频度(DDDs)、限定日费用(DDC)及排序比等情况。结果 三年来我院EGFR-TKI的总销售额和DDDs稳步增长,一代EGFR-TKI的销售额、DDDs和占比逐年走低,以奥希替尼为代表的三代EGFR-TKI同期指标大幅上升,且排序比同步性良好。结论 我院近三年EGFR-TKI使用较为合理,其用药趋势与文献报道的情况基本相符,但仍需加强医保适应症审批制度,确保临床用药的安全、经济和有效。

The Mathematical and Physical Theory of Rational Human Intelligence: Complete Empirical-Digital Properties;Full Electrochemical-Mechanical Model (Part I: Mathematical Foundations)

The design of this paper is to present the first installment of a complete and final theory of rational human intelligence. The theory is mathematical in the strictest possible sense. The mathematics involved is strictly digital—not quantitative in the manner that what is usually thought of as mathematics is quantitative. It is anticipated at this time that the exclusively digital nature of rational human intelligence exhibits four flavors of digitality, apparently no more, and that each flavor will require a lengthy study in its own right. (For more information,please refer to the PDF.)

STUDY ON THE METHOD OF CONSTRUCTING RATIONAL CUBIC CURVES AND CURVED SURFACE INCLUDING CONTROLLING PARAMETERS

By adopting the method of controlling parameters this paper describes the construction of various kinds of cubic curve segment and curved surface fragment with rational and non rational parameters, and discusses the relationship between controlling parameters, weighted factors and types, kinds and characteristics of curve segments and curved surface fragments. A mathematical method is provided for CAGD with abundant connotations, broad covering region, convenience, flexibility and direct simplicity.

基于Granada-Ⅱ分类法评价利伐沙班用于非瓣膜性心房颤动药物相关问题

目的探讨利伐沙班用于非瓣膜性心房颤动(简称房颤)患者的药物相关问题(DRPs),以促进临床合理使用。方法抽取医院心内科2022年1月至10月使用利伐沙班的非瓣膜性房颤住院患者的病历127份,以利伐沙班药品说明书为基础,参考相关指南、共识和文献,采用Granada-Ⅱ分类法对患者使用利伐沙班的必要性(包括DRP1和DRP2)、有效性(包括DRP3和DRP4)、安全性(包括DRP5和DRP6)进行评价。结果共纳入127例使用利伐沙班的非瓣膜性房颤患者,其中55例(43.31%)发生了DRPs,包括46例(36.22%)DRP4,7例(5.51%)DRP5,2例(1.57%)DRP6。结论该院心内科非瓣膜性房颤患者使用利伐沙班的DRPs主要为有效性问题。需加强合理用药培训及干预,促进利伐沙班在非瓣膜性房颤患者中的合理使用。

肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

VALUE DISTRIBUTION OF MEROMORPHIC SOLUTIONS OF CERTAIN NON-LINEAR DIFFERENCE EQUATIONS

In this article, we consider the non-linear difference equation(f(z + 1)f(z)-1)(f(z)f(z-1)-1) =P(z, f(z))/Q(z, f(z)),where P(z, f(z)) and Q(z, f(z)) are relatively prime polynomials in f(z) with rational coefficients. For the above equation, the order of growth, the exponents of convergence of zeros and poles of its transcendental meromorphic solution f(z), and the exponents of convergence of poles of difference △f(z) and divided difference △f(z)/f(z)are estimated. Furthermore, we study the forms of rational solutions of the above equation.

Polynomial Functions Composed of Terms with Non-Integer Powers

Polynomial functions containing terms with non-integer powers are studied to disclose possible approaches for obtaining their roots as well as employing them for curve-fitting purposes. Several special cases representing equations from different categories are investigated for their roots. Curve-fitting applications to physically meaningful data by the use of fractional functions are worked out in detail. Relevance of this rarely worked subject to solutions of fractional differential equations is pointed out and existing potential in related future work is emphasized.

现代历史小说叙事策略研究

现代历史小说以现代艺术模式呈现历史文本,使其具有现代独特的艺术理想与艺术规范。对非理性思维领域的延伸是现代历史小说自由文学表现力的一个层面,也是在历史小说领域建构现代价值体系的探索。现代历史小说家对史实进行艺术化处理,发掘出历史小说在现代独特的艺术美感。自由的文学表现力说明文学性回归历史话语领域,增强了现代历史小说文学地位的独立性,也对中国新文学呼唤“人”的全面解放做了有力的回应。

阿美替尼上市后不良反应分析

目的分析第三代表皮生长因子受体-酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI)阿美替尼不良反应发生的规律及特点,为该药临床安全使用提供参考。方法计算机检索PubMed、Embase、Web of Science、The Cochrane Library、中国知网、万方数据和中国生物医学文献服务系统数据库,对阿美替尼上市后不良反应文献进行分析,检索时限为建库至2024年1月16日。结果共纳入12篇文献,收集263名患者的安全性数据,据文献数据统计,阿美替尼所致不良反应共246例次,主要表现为皮疹/痤疮样皮疹(17.9%)、转氨酶增高(12.6%)、血液及淋巴系统疾病(6.1%)、全身乏力(5.7%)、甲沟炎(7.3%)等,共发生11例≥3级的不良反应,预后良好。结论阿美替尼的不良反应表现多样,对皮肤和肝功能的影响较为明显,应持续加强用药监测,警惕其不良反应发生。

技术理性批判与非压抑性文明的重建——西方马克思主义的非压抑性文明观及其当代价值

西方马克思主义的技术理性批判从哲学文化和现实维度揭示了技术理性盛行的根源及其后果,同时也揭示了由于资本追求利润的本性和资本主义生产目的的不正义,使得科学技术成为控制自然,进而控制人的工具,最终导致人们处于总体异化和受支配的生存状态,因此资本主义文明本质上属于压抑性文明。而强调只有重新摆正科学与哲学、科学与价值的关系,或者通过培育工人阶级成熟的阶级意识,或者通过艺术审美和爱的培育,恢复人的自我意识与独立人格,才能克服技术理性的过度膨胀所建立的非压抑性文明,实现了人的自由全面发展。西方马克思主义的技术理性批判和对非压抑性文明的探索,继承和发展了马克思、恩格斯对资本主义文明悖论的分析,深化了马克思、恩格斯对科学技术的作用与社会效应问题的探索,在技术理性和算法盛行的现时代,具有重要的理论与现实意义。

眼镜镜片尖边轮廓的五轴数控加工

为了改善和优化眼镜镜片的加工流程,避免镜片尖边加工过程中刀轴矢量变化剧烈、影响工件表面的加工质量,提出了一种基于UG NX的五轴数控加工路径。利用智能镜框扫描仪对镜框边缘进行扫描,获得镜框凹槽点云数据文件,编写相应程序对符合眼镜片加工标准的OMA文件中的球坐标数据进行坐标及格式转换等处理。基于NURBS曲线拟合算法,实现刀路轨迹的连续性并保证拟合曲线的精度。设计和建立一种控制刀轴矢量平滑变化的刀轴驱动约束方法,依靠曲线驱动刀轴及镜片曲面法向量约束刀轴使刀头平滑进给,并将刀轨文件经过后处理转换为NC文件。最后,对加工后的镜片进行误差测量,结果表明,通过点云数据拟合刀路曲线的方法提高了加工面的精确度和光滑性,有效缩减了加工流程,提高了加工效率。

NURBS-UTD方法的爬行波射线寻迹算法

针对一致性几何绕射理论方法不能处理任意弯曲模型这一缺陷,研究了基于任意曲面模型的一致性几何绕射理论方法,采用数值的微分几何手段提出了基于非均匀有理B样条建模技术的一致性几何绕射理论方法中在暗区占主要地位的爬行波射线的寻迹算法,使得一致性几何绕射理论方法可应用到复杂电磁目标的分析中.这种算法可以应用于已有的板、柱、锥模型,并且可以有效地处理以往无法操作的任意光滑凸曲面.

康替唑胺在非结核分枝杆菌患者的应用管理

目的分析康替唑胺对非结核分枝杆菌患者的有效性和安全性,并探讨其临床应用管理的方法,为临床合理应用提供参考。方法对非结核分枝杆菌肺病患者病例进行分析,患者在使用利奈唑胺等常用抗非结核分枝杆菌药物后出现下肢麻木、心率降低等不良反应,采用康替唑胺作为新治疗药物之一,观察治疗效果和不良反应。结果明确患者出现外周神经炎是由利奈唑胺引起,替换为康替唑胺治疗后,症状好转,肺部病灶吸收,未出现不良反应。有必要对康替唑胺开展研究者发起的临床研究,充实超说明书用药证据。结论康替唑胺具有与利奈唑胺相似的抗菌活性,且经过药物结构改造后,毒副作用更低,在非结核分枝杆菌治疗中有很好的应用前景,有望成为长期用药时利奈唑胺的替代药物。

基于NURBS建模技术的迭代MoM-PO方法分析电大尺寸平台天线方向图

本文采用基于非均匀有理B样条(NURBS,Non-Uniform Rational Bezier Spline)曲面建模技术的物理光学方法结合矩量法(Method of Moments-Physical Optics)分析位于电大尺寸平台附近天线的辐射方向图.文章推导了基于有理贝齐尔曲面的物理光学散射场计算公式.采用驻相法计算有理贝齐尔曲面上的物理光学感应电流积分.利用物理光学散射场迭代矩量法区域的电压矩阵.通过与传统平面片建模的物理光学方法的计算结果对比,说明本文方法的有效性和优点.