肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

带有两个物体的Burridge-Knopoff模型的stick-slip运动

Burridge-Knopoff模型是研究地震机理的一种摩擦动力系统模型。考察了具有两个自由度的Burridge-Knopoff模型的摩擦激振问题。系统带有两个摩擦接触面,摩擦采用带有负斜率的速度依赖型摩擦曲线。因为摩擦引入的非光滑性,给系统的直接求解带来了很大的困难;又因为具有两个摩擦接触面,运动情况会更加复杂:物体一的2种形式stick或slip,物体二具有同样的2种形式,从而可组合成4种运动形式的交替运动。首先找到各个运动形式的显式解,再根据各运动形式的跃迁点即可得系统总体的运动。在小的驱动速度下把速度依赖型的摩擦对速度取平均值,近似为动摩擦系数;把位移和速度表达为时间的显式函数。再按位移和速度处于不同运动形式进行迭代求解待定系数。最后由确定的待定系数判断系统运动的性质(周期运动或是混沌运动)。

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

基于Lennard-Jones势的界面摩擦黏滑行为动力学研究

目的研究界面摩擦过程中,原子间的相互作用关系及规律。方法基于Lennard-Jones（L-J）势理论,建立界面摩擦黏滑行为的非线弹性振子模型,并以α-Fe晶体为例进行仿真分析。结果在假设条件下,质块振动主振频率约为16 Hz;运动端宏观速度v=1×10-3m/s是主振幅值增大的临界值;刚度系数k和阻尼系数c分别在1.0~100 N/m,1.0×10-4~1.0×10-1N/（m/s）范围内变化时,粘滑频率和主振频率分别随二者的增大而提高;摩擦界面真实接触面积S在1.0×10-18~1.0×10-14m2内变化时,增大摩擦界面间的法向压力将导致黏滑强度增大。仿真计算表明：摩擦界面单个原子受到的激励力与原子间作用势及晶格常数有关,质块的黏滑行为与激励力、相对滑动速度、质块质量、系统刚度系数、系统阻尼系数及真实接触面积等内外因素有关。结论相对滑动速度或真实接触面积增大时,黏滑强度增强;质块质量、系统刚度系数、系统阻尼系数增大时,黏滑强度减弱。系统刚度系数、系统阻尼系数增大时,黏滑频率增大;质块质量增大时,黏滑频率减小;相对滑动速度、真实接触面积对黏滑频率的影响不显著。

两自由度的Burridge-Knopoff模型的一种近似分析方法

Burridge-Knopoff模型是速度驱动的多质量的质量弹簧系统。它是用来进行地震机理研究的一种摩擦动力系统的模型。本文考查了具有两个自由度的Burridge-Knopoff模型的摩擦激振问题。摩擦的不光滑性给系统的求解带来了很大的困难。又系统带有两个摩擦接触面,运动情况更加复杂。本文通过对摩擦力取平均的方法,得到了系统在各个运动形式下的通解,采用半解析的方法对此两自由度的系统进行了研究。通过以上方法,给出了一种周期运动的具体运动形式以及位移和速度的时程关系;并且发现在不同驱动速度的情况下,随着驱动速度的增大,系统的运动形式存在简单和复杂交替出现的现象,并给出了不同系统参数下的分岔图。

LCP method for a planar passive dynamic walker based on an event-driven scheme

The main purpose of this paper is to present a linear complementarity problem （LCP） method for a planar passive dynamic walker with round feet based on an event-driven scheme. The passive dynamic walker is treated as a planar multi-rigid-body system. The dynamic equations of the passive dynamic walker are obtained by using Lagrange＇s equations of the second kind. The normal forces and frictional forces acting on the feet of the passive walker are described based on a modified Hertz contact model and Coulomb＇s law of dry friction. The state transition problem of stick-slip between feet and floor is formulated as an LCR which is solved with an event-driven scheme. Finally, to validate the methodology, four gaits of the walker are simulated： the stance leg neither slips nor bounces; the stance leg slips without bouncing; the stance leg bounces without slipping; the walker stands after walking several steps.

FAREY SEQUENCE OF NONLINEAR DIFFERENTIAL DYNAMIC SYSTEM IN TWO DIMENSIONS

In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle) to the circle m ap .

Ways to Overcome Anxiety in the English Listening Class in College (SUN JING-YU KE SU-FEN)

In my ten-yeat experience of tenching English as major in college , I feel that students experience more difficulties in listening lessons than in other lessons. What, then, prevents students from achieving success in the listening class? I suggest that anxiety is one of the major factors, which interferes with students listening comprehension. And I would agree with writers such as Gardner and Horwitz et al. (1991)that anxiety may impede learner’s ability to perform successfully in all aspects of learning a foreign language. I feet it is particularly significant for listening.

一种不粘轮乳化沥青的制备方法及其性能研究

在高温环境下,乳化沥青粘层会粘附在施工车辆的轮胎上,进而导致沥青路面层间粘结失效。为了解决这一问题,通过不同的基质沥青进行混合来制备不粘轮乳化沥青,对其进行了一系列性能测试,包括恩格拉粘度、储存稳定性以及蒸发残留物的软化点等指标。同时,通过黏附率试验来检验不粘轮乳化沥青的粘轮性能,与市场上销售的普通乳化沥青粘层油相比,在高温环境下,不粘轮乳化沥青有着显著的不粘轮效应。通过对两种乳化沥青的层间粘结力进行了研究,并分析了不同环境温度下对乳化沥青粘结力的影响水平。研究结果显示,无论在是室温还是高温环境下,不粘轮乳化沥青的层间剪切强度均优于市售普通乳化沥青,并且在高温环境下,不粘轮乳化沥青的层间粘结作用能够得到更好的发挥。不粘轮乳化沥青的各项指标符合规范要求,它可以减少施工时间,延长道路使用寿命,降低维修频次,降低工程造价的目标。

用于不粘领域氟树脂替代问题的解决方案研究

文章综述了氟树脂在不粘领域内的使用现状,并针对PFAS禁令,文章给出了在不粘领域里六种未来可能用到的解决问题方案,包括陶瓷涂料、PEEK树脂、硅烷、氮化硼粉体等,最后对未来在不粘领域可能用到的新材料前景进行了展望。

道路标线用涂料不粘胎时间测定仪校准方法及评定研究

文章介绍了道路标线用涂料不粘胎时间测定仪的工作原理和用途,建立了道路标线用涂料不粘胎时间测定仪校准结果的测量模型,分析了不确定度分量主要来源,结合测量实例具体数据,分析评定了扩展不确定度,最终可得出该项目的校准测量能力,为道路交通设备检测行业的质量控制起到重要作用。

水基高分子不粘轮乳化沥青应用效果评价研究

水基高分子不粘轮乳化沥青作为一种新型高性能路面层间粘结材料,与普通乳化沥青相比,具有生产施工工艺简单、破乳速度快、粘结强度高等优点。文章通过中试生产,铺筑实体工程,跟踪观测实际使用效果,并对中试生产的水基高分子不粘轮乳化沥青进行技术指标、不粘轮性能及粘结强度检测。检测分析认为,该产品具有良好的不粘轮性能和粘结强度,可有效解决普通粘层施工中破乳速度慢、成型慢导致的施工低效和环境污染问题,有助于推动异步施工薄层罩面技术的推广应用。

棍针联合走罐治疗寒湿性非特异性下腰痛的临床疗效分析

目的分析棍针联合走罐治疗寒湿性非特异性下腰痛的临床疗效。方法简单随机选取2021年11月-2023年3月亳州市中医院收治的60例寒湿性非特异性下腰痛患者为研究对象,按照随机数表法分为两组,每组30例,对照组予常规针刺治疗,观察组在对照组治疗基础上采用棍针联合走罐治疗,比较两组治疗总有效率,疼痛视觉模拟评分(Visual Analogue Scale/Score,VAS),腰痛功能障碍指数评分(Oswestry Disabity Index,ODI)及日本骨科协会评分(Japanese Orthopaedic Association Scores,JOA)。结果观察组治疗总有效率为93.33%显著高于对照组的73.33%,差异有统计学意义(χ^(2)=4.320,P=0.038)。治疗后,两组患者ODI评分与VAS评分均低于干预前,且观察组显著低于对照组,差异有统计学意义(P均<0.05)。两组患者JOA评分高于干预前,且观察组显著高于对照组,差异有统计学意义(P均<0.05)。结论寒湿性非特异性下腰痛患者采用棍针联合走罐治疗效果较好,能够有效改善患者腰部功能,减轻活动障碍。

Bioinformatics analysis of the association between miR-942-5p–induced downregulation of PIEZO-type mechanosensitive ion channel component 1 and poor prognosis in non–small cell lung cancer mediated by the mitogen-activated protein kinase pathway signaling pathway

Background:Non–small cell lung cancer(NSCLC)is a common malignant tumor with an increasing incidence.PIEZO-type mechanosensitive ion channel component 1(PIEZO1)is a mechanosensitive ion channel whose expression has been implicated in various cancers.However,its expression patterns,prognostic implications,and specific molecular mechanisms of action in NSCLC remain un-clear.This study aimed to characterize the expression profile of PIEZO1 in NSCLC in vitro and using bioinformatics analyses.Methods:To determine the expression profile of PIEZO1 in normal and cancerous human tissues and the mRNA expression of PIEZO1 in NSCLC,we analyzed data from The Cancer Genome Atlas.Various bioinformatics analyses were performed for correlation analyses,construction of survival curves,and identification of upstream mRNA targets and genes coexpressed with PIEZO1.Furthermore,the coexpressed genes were functionally annotated with Gene Ontology and subjected to pathway enrichment analyses.Additionally,we an-alyzed and compared PIEZO1 expression in normal and cancerous human tissue samples in vitro.Results:NSCLC tissue samples had lower PIEZO1 expression than adjacent tissues.PIEZO1 overexpression inhibited NSCLC progres-sion and cell migration and correlated with improved survival outcomes,as revealed by bioinformatics analyses.Additionally,analysis using the OncomiR database revealed that miR-942-5p upregulation contributed to the downregulation of PIEZO1 in NSCLC.Mechanistic in-vestigations suggested that PIEZO1 modulates NSCLC by regulating the mitogen-activated protein kinase pathway,particularly by targeting FLNA,RRAS,and MAP3K6.Bioinformatics analyses highlighted the potential of PIEZO1 as a therapeutic target and prognostic indicator of NSCLC.Conclusions:These novel findings reveal the expression profile of PIEZO1 in NSCLC and highlight the potential of PIEZO1 and miR-942-5p as diagnostic and therapeutic biomarkers of NSCLC and other cancer types.

干摩擦阻尼系统的非粘结受迫振动分析

对于谐波激励下干摩擦振荡的非粘结振动的稳态周期解,本文在D en H artog和H K Hong的工作基础上,弱化了导出结论所需要的假设,得到了解的对称性,给出了最大速度的理论解答。分析表明,最大速度可表示为放大因子B、固有频率ωn、激振力幅值作用下的静变形p0/k三者的乘积。并用数值分析验证了最大速度的解答。

低温固化氟碳复合不粘涂料的耐粘性研究

在FEVE涂料中加入改性微粉,获得低表面能氟碳复合涂料。采用测试疏液角脱模力及表面粘结力的方法研究氟碳复合涂料的耐粘性,结果表明改性微粉和助剂的加入,显著增强了FEVE涂料的耐粘性。而红外跟踪分析及表面微观结构分析得出30%微粉含量的复合涂层具有最佳的不粘性能。