Background Cardiac resynchronization therapy(CRT)is a highly effective treatment in patients with a class I recommendation.However,a small proportion of the strictly selected patients still fail to respond.This study ...Background Cardiac resynchronization therapy(CRT)is a highly effective treatment in patients with a class I recommendation.However,a small proportion of the strictly selected patients still fail to respond.This study was designed to identify predictors of non-response in patients with class I indications for CRT and determine the non-response probability of the patients.Methods A total of 296 consecutive patients with a class I recommendation received CRT from January 2009 to January 2017 were retrospectively analyzed.Multivariate logistic regression analysis was performed to identify predictors for non-response(defined as cardiac death,heart transplantation,or HF hospitalization during 1-year follow-up).Results Among 296 patients,30(10.1%)met non-response.Multivariate analysis demonstrated that non-response to CRT was associated with a fragmented QRS(odd ratio(OR)=2.86,95%CI:1.14–7.12;P=0.025)and left ventricular end-diastolic dimension(LVEDD)≥77 mm(OR=3.02,95%CI:1.17–7.82;P=0.022).Patients with both of the predictors had a non-response probability of 46.2%(95%CI:19.1%–73.3%).Conclusion In patients with left bundle branch block and wider QRS duration,the proportion of non-response to CRT is not low in real world.The presence of the dilated LVEDD or fragmented QRS is a strong predictor of non-response to CRT.The probability of non-response in the patients with the two predictors was 46.2%.展开更多
In this paper, we obtain an explicit formula of general solution for a class of the non-homogeneous recurrence of variable coefficients with two indices.
The concern on climate change and on the limitations of fossil fuels is leading to the promotion of renewable-based energy options. However, the assessment of the energy profitability of a technology is still a contro...The concern on climate change and on the limitations of fossil fuels is leading to the promotion of renewable-based energy options. However, the assessment of the energy profitability of a technology is still a controversial topic, especially when renewable-based systems are compared with non-renewable ones and when the depletion of the stocks of available resources is not accounted properly. As a matter of fact, some popular energy indicators do not seem to cover all the aspects of the problem, with the risk of drawing ambiguous conclusions. A set of life cycle-based indicators is proposed in order to establish a more reliable approach to the assessment of energy products which decouples the different contributions given by renewable and non-renewable resources. The proposed set of indicators has been quantified for different groups of energy products and compared with an energy indicator frequently used (i.e. EROI). A coherent assessment of the depletion of energy resources and of the energy profitability of the products is presented. The indicators could even contribute to understand the feasibility of energy projects and plans by evaluating their impact on the stock of energy resources.展开更多
基金financially supported by the National Natural Science Foundation of China(81570370)CAMS Innovation Fund for Medical Sciences(2017-I2M-1-009)
文摘Background Cardiac resynchronization therapy(CRT)is a highly effective treatment in patients with a class I recommendation.However,a small proportion of the strictly selected patients still fail to respond.This study was designed to identify predictors of non-response in patients with class I indications for CRT and determine the non-response probability of the patients.Methods A total of 296 consecutive patients with a class I recommendation received CRT from January 2009 to January 2017 were retrospectively analyzed.Multivariate logistic regression analysis was performed to identify predictors for non-response(defined as cardiac death,heart transplantation,or HF hospitalization during 1-year follow-up).Results Among 296 patients,30(10.1%)met non-response.Multivariate analysis demonstrated that non-response to CRT was associated with a fragmented QRS(odd ratio(OR)=2.86,95%CI:1.14–7.12;P=0.025)and left ventricular end-diastolic dimension(LVEDD)≥77 mm(OR=3.02,95%CI:1.17–7.82;P=0.022).Patients with both of the predictors had a non-response probability of 46.2%(95%CI:19.1%–73.3%).Conclusion In patients with left bundle branch block and wider QRS duration,the proportion of non-response to CRT is not low in real world.The presence of the dilated LVEDD or fragmented QRS is a strong predictor of non-response to CRT.The probability of non-response in the patients with the two predictors was 46.2%.
基金Supported by the National Natural Science Foundation of China(19771063)
文摘In this paper, we obtain an explicit formula of general solution for a class of the non-homogeneous recurrence of variable coefficients with two indices.
文摘The concern on climate change and on the limitations of fossil fuels is leading to the promotion of renewable-based energy options. However, the assessment of the energy profitability of a technology is still a controversial topic, especially when renewable-based systems are compared with non-renewable ones and when the depletion of the stocks of available resources is not accounted properly. As a matter of fact, some popular energy indicators do not seem to cover all the aspects of the problem, with the risk of drawing ambiguous conclusions. A set of life cycle-based indicators is proposed in order to establish a more reliable approach to the assessment of energy products which decouples the different contributions given by renewable and non-renewable resources. The proposed set of indicators has been quantified for different groups of energy products and compared with an energy indicator frequently used (i.e. EROI). A coherent assessment of the depletion of energy resources and of the energy profitability of the products is presented. The indicators could even contribute to understand the feasibility of energy projects and plans by evaluating their impact on the stock of energy resources.
文摘目的 探讨不同吻合术在行腹腔镜远端胃癌根治术(laparoscopic distal radical gastrectomy,LDRG)患者中的应用效果。方法 选取2020年3月—2022年3月于福鼎市医院行LDRG的58例患者。采用随机数字表法分为观察组29例与对照组29例。对照组术后接受Roux-en-Y吻合术,观察组患者术后接受非离断Roux-en-Y吻合术。比较2组患者手术指标、术后并发症发生率以及患者生活质量。结果 观察组排气时间短于对照组(P<0.05),2组手术时间、吻合时间、住院时间、术中出血量、淋巴结清扫数目比较,差异无统计学意义(P>0.05)。观察组患者术后6个月ROUX淤滞综合征(ROUX stasis syndrome,RSS)发生率为3.45%,低于对照组的27.59%(P<0.05);2组吻合口出血、胃食管反流、吻合口溃疡、吻合口瘘、腹腔感染发生率比较,差异无统计学意义(P>0.05)。术后2组患者各项健康调查简表(the MOS item short from health survey,SF-36)评分高于术前,且术后观察组各项SF-36量表评分均高于对照组(P<0.05)。结论 对LDRG患者术后采用非离断Rouxen-Y吻合术可降低患者排气时间,降低RSS的发生率,同时不会增加其他并发症发生,并改善患者生活质量。
