HIV- 1 RT is an important target for the treatment of AIDS. There are two major classes of antiviral agents that inhibit HIV- 1 RT have been identified, nucleoside RT inhibitors （NRTIs） and non-nucleoside RT inhibit...HIV- 1 RT is an important target for the treatment of AIDS. There are two major classes of antiviral agents that inhibit HIV- 1 RT have been identified, nucleoside RT inhibitors （NRTIs） and non-nucleoside RT inhibitors （NNRTIs）. In this report, a noval class of non-nucleoside compound with potential RT inhibitory activity were found from the traditional Chinese medicines database （TCMD） using a combination of virtual screening, docking, molecular dynamic simulations, where results were ranked by scoring function of the docking tool. The result indicates that M4753 （a compound derived from TCMD） has not only the lowest bonding energy but also the best match in geometric conformation with the forthcoming NNRTIs. Accordingly M4753 might possibly become a promising lead compound of NNRTIs for AIDS therapy.展开更多
Based on double pulse welding process characteristics, expert database structure and work flow are designed. Further, multiple outstanding specifications of 1.0 ram-diameter wire are obtained through a large number of...Based on double pulse welding process characteristics, expert database structure and work flow are designed. Further, multiple outstanding specifications of 1.0 ram-diameter wire are obtained through a large number of experiments. By making non-linear regression analysis on these groups of standards, the relationship between average welding current and other pulse parameters can be found out. Polynomial regression equation is set up for further realization of＂ parameter estimation function of the expert database. Finally, the preliminary developed expert database is tested. The result indicates that the unified adjusting and parameters estimation of the expert database leads to stable welding process and good weld appearance.展开更多
This paper proposes a quantitative security evaluation for software system from the vulnerability data consisting of discovery date, solution date and exploit publish date based on a stochastic model. More precisely, ...This paper proposes a quantitative security evaluation for software system from the vulnerability data consisting of discovery date, solution date and exploit publish date based on a stochastic model. More precisely, our model considers a vulnerability life-cycle model and represents the vulnerability discovery process as a non-homogeneous Poisson process. In a numerical example, we show the quantitative measures for contents management system of an open source project.展开更多
With the rising interest in the regulatory functions of long non-coding RNAs （IncRNAs） in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensiv...With the rising interest in the regulatory functions of long non-coding RNAs （IncRNAs） in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensive and integrative data for all aspects of these versatile molecules. Recently, a variety of public data repositories that specialized in lncRNAs have been developed, which make use of huge high-throughput data particularly from next-generation sequencing （NGS） approaches. Here, we provide an overview of current IncRNA databases covering basic and functional annotation, IncRNA expression and regulation, interactions with other biomolecules, and genomic variants influencing the structure and function of lncRNAs. The prominent IncRNA antisense noncoding RNA in the INK4 locus （ANRIL）, which has been unequivocally associated with coronary artery disease through genome-wide association studies （GWAS）, serves as an example to demonstrate the features of each individual database.展开更多
基金supported by the grants from Chinese National Science Foundation(No.30472166)the Tianjin Commission of Sciences and Technology under the Contract(No.06YFGZSH07000)
文摘HIV- 1 RT is an important target for the treatment of AIDS. There are two major classes of antiviral agents that inhibit HIV- 1 RT have been identified, nucleoside RT inhibitors （NRTIs） and non-nucleoside RT inhibitors （NNRTIs）. In this report, a noval class of non-nucleoside compound with potential RT inhibitory activity were found from the traditional Chinese medicines database （TCMD） using a combination of virtual screening, docking, molecular dynamic simulations, where results were ranked by scoring function of the docking tool. The result indicates that M4753 （a compound derived from TCMD） has not only the lowest bonding energy but also the best match in geometric conformation with the forthcoming NNRTIs. Accordingly M4753 might possibly become a promising lead compound of NNRTIs for AIDS therapy.
基金This work was supported by National Natural Science Foundation of China （No. 50875088） and Foundation h）r Distinguished Young Talents in Higher Education of Guaugdong （ No. LYM09099）.
文摘Based on double pulse welding process characteristics, expert database structure and work flow are designed. Further, multiple outstanding specifications of 1.0 ram-diameter wire are obtained through a large number of experiments. By making non-linear regression analysis on these groups of standards, the relationship between average welding current and other pulse parameters can be found out. Polynomial regression equation is set up for further realization of＂ parameter estimation function of the expert database. Finally, the preliminary developed expert database is tested. The result indicates that the unified adjusting and parameters estimation of the expert database leads to stable welding process and good weld appearance.
文摘This paper proposes a quantitative security evaluation for software system from the vulnerability data consisting of discovery date, solution date and exploit publish date based on a stochastic model. More precisely, our model considers a vulnerability life-cycle model and represents the vulnerability discovery process as a non-homogeneous Poisson process. In a numerical example, we show the quantitative measures for contents management system of an open source project.
文摘With the rising interest in the regulatory functions of long non-coding RNAs （IncRNAs） in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensive and integrative data for all aspects of these versatile molecules. Recently, a variety of public data repositories that specialized in lncRNAs have been developed, which make use of huge high-throughput data particularly from next-generation sequencing （NGS） approaches. Here, we provide an overview of current IncRNA databases covering basic and functional annotation, IncRNA expression and regulation, interactions with other biomolecules, and genomic variants influencing the structure and function of lncRNAs. The prominent IncRNA antisense noncoding RNA in the INK4 locus （ANRIL）, which has been unequivocally associated with coronary artery disease through genome-wide association studies （GWAS）, serves as an example to demonstrate the features of each individual database.
