Progress in the Study of Inflammatory Bowel Disease Patients with Primary Non-Responsiveness

Inflammatory bowel disease (IBD) is a group of chronic, nonspecific intestinal inflammatory disorders characterized by localized and systemic inflammation. The use of biologic agents in the treatment of IBD patients is widespread, and the occurrence of primary non-responsiveness during treatment is also significant. This review briefly summarizes the possible reasons for primary non-responsiveness in IBD patients, as well as predictive markers and current strategies to address it, providing a theoretical reference for early identification and management of IBD patients who do not respond to treatment.

Outcome after Discharge from Hospital of Children with Complicated Severe Acute Malnutrition and Predictors Factors of Non-Response during Outpatient Treatment, in Senegal

Introduction: Malnutrition is a public health problem. It is responsible for high morbidity and mortality in children aged 6 - 59 months. The aim of this study was to determine the outcome of children with complicated severe acute malnutrition after hospital discharge. Methods: This is a descriptive and analytical cross-sectional study conducted from March 1 to November 31, 2021 at the Albert Royer Children’s Hospital. Children discharged from hospital for complicated severe acute malnutrition were included. Results: A total of 103 children were included. The mean age of children at hospitalization was 16.41 ± 10.11 months and mean duration of follow-up after hospital discharge was 29.63 ± 8.59 months. Three children (2.91%) died after hospital discharge. The mean z-score of the weight-for-current height was -1.34 ± 1.08. Almost a quarter (24.27%) of the children remain acute malnourished with 3.88% of severe acute malnutrition (SAM). The predictors’ factors associated with non-response were weaning before 2 years of age (ORaj: 12.21;95% CI [6.82 - 18.44];p = 0.04) and tuberculosis (ORaj: 21.06;95% CI [12.54 - 41.09];p = 0.03). Conclusion: The rate of recovery of nutritional status in children with complicated severe acute malnutrition is satisfactory. Ablactation before the age of two and the existence of tuberculosis are significantly associated with non-recovery of nutritional status.

Proprotein convertase subtilisin/kexin type 9 inhibitor non responses in an adult with a history of coronary revascularization:A case report

BACKGROUND Familial hypercholesterolemia(FH)is an autosomal dominant disorder that is characterized by severely increased low-density lipoprotein(LDL)cholesterol levels.At the same time,elevated LDL levels accelerated the development of coronary heart disease.Several classes of drugs are currently in use to treat FH.Proprotein convertase subtilisin/kexin type 9 inhibitor(PCSK9i)is novel one of these.CASE SUMMARY This manuscript reports a case of FH that responded modestly after treatment with PCSK9i and statin drugs.Of even more concern is that the patient frequently admitted to the hospital during a 12-year follow-up period.Subsequently,we identified a heterozygous mutation,1448G>A(W483X)of the LDL receptor(LDLR)in this patient.The serum levels of PCSK9(proprotein convertase subtilisin/kexin type 9)in the patient was 71.30±26.66 ng/mL,which is close the average level reported in the literature.This LDLR mutation affects LDLR metabolism or structure,which may make it unsuitable for use of PCSK9i.CONCLUSION Our outcome demonstrates that LDLR-W483X represents a partial loss-of-function LDLR and may contribute to PCSK9i ineffective. In the meanwhile, additional measures aretherefore required (particularly with gene sequencing or change the treatment plan) must beinitiated as early as possible. Genetic testing for clinically challenging cases who do not respond toPCSK9i therapy is very helpful.

Predictors of non-response to cardiac resynchronization therapy implantation in patients with class Ⅰ indications: the markedly dilated left ventricular end-diastolic dimension and the presence of fragmented QRS

Background Cardiac resynchronization therapy(CRT)is a highly effective treatment in patients with a class I recommendation.However,a small proportion of the strictly selected patients still fail to respond.This study was designed to identify predictors of non-response in patients with class I indications for CRT and determine the non-response probability of the patients.Methods A total of 296 consecutive patients with a class I recommendation received CRT from January 2009 to January 2017 were retrospectively analyzed.Multivariate logistic regression analysis was performed to identify predictors for non-response(defined as cardiac death,heart transplantation,or HF hospitalization during 1-year follow-up).Results Among 296 patients,30(10.1%)met non-response.Multivariate analysis demonstrated that non-response to CRT was associated with a fragmented QRS(odd ratio(OR)=2.86,95%CI:1.14–7.12;P=0.025)and left ventricular end-diastolic dimension(LVEDD)≥77 mm(OR=3.02,95%CI:1.17–7.82;P=0.022).Patients with both of the predictors had a non-response probability of 46.2%(95%CI:19.1%–73.3%).Conclusion In patients with left bundle branch block and wider QRS duration,the proportion of non-response to CRT is not low in real world.The presence of the dilated LVEDD or fragmented QRS is a strong predictor of non-response to CRT.The probability of non-response in the patients with the two predictors was 46.2%.

A METHOD FOR THE ANALYSIS OF DYNAMIC RESPONSE OF STRUCTURE CONTAINING NON-SMOOTH CONTACTABLE INTERFACES

A novel single-step method is proposed for the analysis of dynamic response of visco-elastic structures containing non-smooth contactable interfaces. In the method, a two-level algorithm is employed for dealing with a nonlinear boundary condition caused by the dynamic contact of interfaces. At the first level, an explicit method is adopted to calculate nodal displacements of global viscoelastic system without considering the effect of dynamic contact of interfaces and at the second level, by introducing contact conditions of interfaces, a group of equations of lower order is derived to calculate dynamic contact normal and shear forces on the interfaces. The method is convenient and efficient for the analysis of problems of dynamic contact. The accuracy of the method is of the second order and the numerical stability condition is wider than that of other explicit methods.

THE NON-AXISYMMETRICAL DYNAMIC RESPONSE OF TRANSVERSELY ISOTROPIC SATURATED POROELASTIC MEDIA

The Blot's wave equations of transversely isotropic saturated poroelastic media excited hy non-axisymmetrical harmonic source were solved by means of Fourier expansion and Hankel transform. Then the components of total stress in porous media are expressed with the solutions of Biot's wave equations. The method of research on non-axisymmetrical dynamic response of saturated porous media is discussed, and a numerical result is presented.

A time-domain nonlinear effective-stress non-Masing approach of ground response analysis of Guwahati city, India

The response of subsoil strata subjected to seismic excitations plays an important role in governing the response of the overlying superstructures at any site. Ground response analysis(GRA) helps to assess the influence of soil characteristics on the propagating seismic stress waves from the bedrock level to the ground surface during an earthquake. For the northeastern region of India, located in the highest seismic zone in the country, conducting an extensive GRA study is of prime importance. Conventionally, most of the GRA studies are carried out using the equivalent linear method, which, being a simplistic approach, cannot capture the nonlinear behavior of soil during seismic shaking. This paper presents the outcomes of a one-dimensional effective stress based nonlinear GRA conducted for Guwahati city(located in northeast India) incorporating the non-Masing load/unload/reload characteristics. The various ground response parameters evaluated from this study help in assessing the ground shaking, soil amplification, and site responses expected in this region. 2D contour maps, which are representative of the distribution of some of these parameters throughout Guwahati city, are also developed. The results presented herein can serve as guidelines for the design of foundations and superstructures in this region.

A method for stochastic seismic response analysis of non-classically damped structures

A method to calculate the stationary random response of a non-classically damped structure is proposed that features clearly-defined physical meaning and simple expression. The method is developed in the frequency domain. The expression of the proposed method consists of three terms, i.e., modal velocity response, modal displacement response, and coupled (between modal velocity and modal displacement response). Numerical results from the parametric study and three example structures reveal that the modal velocity response term and the coupled term are important to structural response estimates only for a dynamic system with a tuned mass damper. In typical cases, the modal displacement term can provide response estimates with satisfactory accuracy by itself, so that the modal velocity term and coupled term may be ignored without loss of accuracy. This is used to simplify the response computation of non-classically damped structures. For the white noise excitation, three modal correlation coefficients in closed form are derived. To consider the modal velocity response term and the coupled term, a simplified approximation based on white noise excitation is developed for the case when the modal velocity response is important to the structural responses. Numerical results show that the approximate expression based on white noise excitation can provide structural responses with satisfactory accuracy.

NONLINEAR TRANSIENT RESPONSE OF STAY CABLE WITH VISCOELASTICITY DAMPER IN CABLE-STAYED BRIDGE

Taking the bending stiffness, static sag, and geometric non-linearity into consideration, the space nonlinear vibration partial differential equations were derived. The partical differential equations were discretized in space by finite center difference approximation, then the nonlinear ordinal differential equations were obtained. A hybrid method involving the combination of the Newmark method and the pseudo-force strategy was proposed to analyze the nonlinear transient response of the inclined cable-dampers system subjected to arbitrary dynamic loading. As an example, two typical stay cables were calculated by the present method. The results reveal both the validity and the deficiency of the viscoelasticity damper for vibration control of stay cables. The efficiency and accuracy of the proposed method is also verified by comparing the results with those obtained by using Runge-Kutta direct integration technique. A new time history analysis method is provided for the research on the stay cable vibration control.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

Dynamics Response and Non⁃linear Characteristics Analysis of Complex Planar 2⁃DOF Mechanism with Revolute Clearances

There are clearances in mechanism because of manufacture and assembly error,which reduces operation life and working accuracy of mechanism and has a great impact on dynamical responses.At the moment,research in this area mainly focuses on single degree⁃of⁃freedom mechanism considering one clearance,while research of multi⁃DOF mechanism considering multi⁃clearance is less.With the purpose of studying the dynamical characteristics of complex multi⁃DOF mechanism with multi⁃clearances,a dynamic model was developed.The dynamic responses of 2⁃DOF mechanism with two clearances under different positions,values,and numbers of clearance were analyzed.The displacement,velocity,acceleration,collision force,and the axis trajectory at clearance were then given.In addition,there is a limited amount of literature on chaotic phenomena,which mainly focuses on the chaotic phenomena of end⁃effector of mechanism.But in this paper,the non⁃linear characteristics were analyzed by chaotic phenomenon of clearance joint,then chaotic phenomenon was identified by Poincarémappings and phase diagrams.Bifurcation diagrams were given.The results will offer a reliable technical support for the study of dynamical responses of planar mechanisms and the analysis of chaotic phenomena.

Characteristics of seismic responses at liquefied and non-liquefied sites with same site conditions

To understand the characteristics of seismic response at liquefied sites, a liquefiable site and a non-liquefiable site were selected, separated by about 500 m and having the same site conditions as Class D in the National Earthquake Hazards Reduction Program （NEHRP）. A suite of earthquake records on rock sites are selected and scaled to the spectrum of the Joyner, Boore, and Fumal （JBF） attenuation model for a magnitude 7.5 earthquake at a distance of 50 km. The scaled records were then used to excite the two sites. The effect of pore-water pressure was investigated using the effective stress analysis method, and nonlinear soil behavior was modeled by a soil bounding surface model. Comparisons for spectra, peak ground acceleration （PGA）, peak ground displacement （PGD） and permanent displacement were performed. Results show that the mean ground response spectrum at the non-liquefied site is close to the estimated ground response spectrum from the JBF model, but the mean ground response spectrum at the liquefied site is much lower than the estimated ground response spectrum from the JBF model for periods of up to 1.3 s. The mean PGA at the non-liquefied site is about 1.6-1.7 times as large as that at the liquefied site, but the mean peak ground displacement （PGD） at the non-liquefied site has a slight difference with that at the liquefied site. The mean permanent displacements at the liquefied site are larger than those at the non-liquefied site, particularly at the liquefied layer.

Numerical Calculation of Dynamic Response for Multi-Span Non-Uniform Beam Subjected to Moving Mass with Friction

In order to simulate the coupling vibration of a vehicle or train moves on a multi-span continuous bridge with non-uniform cross sections, a moving mass model is used according to the Finite Element Method, the effect of the inertial force, Coriolis force and centrifugal force are considered by means of the additive matrices. For a non-uniform rectangular section beam with both linear and parabolic variable heights in a plane, the stiffness and mass matrices of the beam elements are presented. For a non-uniform box girder, Romberg numerical integral scheme is adopted, each coefficient of the stiffness matrix is obtained by means of a normal numerical computation. By applying these elements to calculate the non-uniform beam, the computational accuracy and efficiency are improved. The finite element method program is worked out and an entire dynamic response process of the beam with non-uniform cross sections subjected to a moving mass is simulated numerically, the results are compared to those previously published for some simple examples. For some complex multi-span bridges subjected to some moving vehicles with changeable velocity and friction, the computational results, which can be regarded as a reference for engineering design and scientific research, are also given simultaneously.

The Long-Lived Photon Echo Response Locking Effect in the Presence of External Non-Resonant Laser Pulses with a Different Spatial Orientation

The correlation of the inhomogeneous broadening of the resonance transition at different time intervals and the efficiency of long-lived photon echo response locking by the action of standing waves of non-resonant laser pulses are considered. It is shown that the long-lived photon echo response locking effect may be observed even at the angles of the relative orientation of the non-resonant standing wave laser pulses of less than one degree, due to the change in the correlation coefficient of inhomogeneous broadening at time intervals between the first and the second and after the third resonant laser pulses.

STOCHASTIC OPTIMAL CONTROL FOR THE RESPONSE OF QUASI NON-INTEGRABLE HAMILTONIAN SYSTEMS

A strategy is proposed based on the stochastic averaging method for quasi non- integrable Hamiltonian systems and the stochastic dynamical programming principle.The pro- posed strategy can be used to design nonlinear stochastic optimal control to minimize the response of quasi non-integrable Hamiltonian systems subject to Gaussian white noise excitation.By using the stochastic averaging method for quasi non-integrable Hamiltonian systems the equations of motion of a controlled quasi non-integrable Hamiltonian system is reduced to a one-dimensional av- eraged It stochastic differential equation.By using the stochastic dynamical programming princi- ple the dynamical programming equation for minimizing the response of the system is formulated. The optimal control law is derived from the dynamical programming equation and the bounded control constraints.The response of optimally controlled systems is predicted through solving the FPK equation associated with It stochastic differential equation.An example is worked out in detail to illustrate the application of the control strategy proposed.

Modified non-rectangular hyperbola equation with plant height for photosynthetic light-response curves of Potentilla anserina and Elymus nutans at various growth phases in the Heihe River Basin, Northwest China

The non-rectangular hyperbola(NRH)equation is the most popular method that plots the photosynthetic light-response(PLR)curve and helps to identify plant photosynthetic capability.However,the PLR curve can't be plotted well by the NRH equation at different plant growth phases due to the variations of plant development.Recently,plant physiological parameters have been considered into the NRH equation to establish the modified NRH equation,but plant height(H),an important parameter in plant growth phases,is not taken into account.In this study,H was incorporated into the NRH equation to establish the modified NRH equation,which could be used to estimate photosynthetic capability of herbage at different growth phases.To explore photosynthetic capability of herbage,we selected the dominant herbage species Potentilla anserina L.and Elymus nutans Griseb.in the Heihe River Basin,Northwest China as the research materials.Totally,twenty-four PLR curves and H at different growth phases were measured during the growing season in 2016.Results showed that the maximum net photosynthetic rate and the initial slope of PLR curve linearly increased with H.The modified NRH equation,which is established by introducing H and an H-based adjustment factor into the NRH equation,described better the PLR curves of P.anserina and E.nutans than the original ones.The results may provide an effective method to estimate the net primary productivity of grasslands in the study area.

Using a Suppression Subtractive Library-Based Approach to Identify Non-Heading Chinese Cabbage Genes Up-Regulated in Early Response to Elicitor PB90

Monitoring expression at the transcriptional level is the first essential step for the functional analysis of plant genes. Genes-encoding proteins directly involved in early response to elicitor constitute only a small fraction of all the genes affected by elicitor. Transcriptional responses to various elicitors have been extensively studied in different plants including Nicotiana and Arabidopsis thaliana; however, corresponding data aren＇t available for non-heading Chinese cabbage. To address this problem, we describe a suppression subtractive library-based approach to isolate the plant＇s ESTs up-regulated in the early induction/execution of the HR induced by elicitor PB90 from Phytophthora boehmeriae. According to their putative identification in BLAST searches against the three genome databases, 70 up-regulated genes were classified into 9 parts： some aspect of primary ＇metabolism＇ or ＇energy＇ production; ＇protein synthesis＇ or ＇protein fate＇; cellular communication/signal transduction mechanism; cell fates including Beclin, SPT1, and SPT2; HLA-B and AGO1 which participate in transcription; cellular transport and hypothetical proteins or proteins for which a function has yet to be determined. Seven selected genes such as Beclin, thioredoxin, HLA-B, MAP3K, SPT1, SPT2, and AGO1 were up-regulated induced by PB90, suggesting that the genes may play an important role in PB90-triggered HR.

Estimating a Finite Population Mean under Random Non-Response in Two Stage Cluster Sampling with Replacement

Non-response is a regular occurrence in Sample Surveys. Developing estimators when non-response exists may result in large biases when estimating population parameters. In this paper, a finite population mean is estimated when non-response exists randomly under two stage cluster sampling with replacement. It is assumed that non-response arises in the survey variable in the second stage of cluster sampling. Weighting method of compensating for non-response is applied. Asymptotic properties of the proposed estimator of the population mean are derived. Under mild assumptions, the estimator is shown to be asymptotically consistent.

Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge

Background: Pathogenesis of type 2 diabetes (T2DM) involves defects in β-cell function with impaired first and second phase insulin response, and reduced insulin sensitivity. Diabetic dyslipidemia is an important and common risk factor for coronary heart disease (CHD). Aims: This study examined the effect of glycemic control on post prandial insulin and lipid parameters in response to a standardised meal challenge among Type 2 diabetes patients with good and poor glycemic control. Methods: We cross-sectionally studied 31 T2DM patients with good glycemic control and 32 T2DM patients with poor glycemic control. Subjects were given, after minimum 10 hours of fasting, a standard meal containing 58% fat. Fasting and serial postprandial blood samples were taken over 8 hours to determine levels of triglyceride, direct LDL-C, apoB lipoprotein, non-esterified-fatty-acid, insulin and blood glucose. Results: Post prandial NEFA was significantly higher in poor controlled diabetes patients compared to good control diabetes patients (p = 0.019), and post-hoc analysis showed significant difference from 3 hours post prandial to 4 hours post prandial, where p= 0.021. Although the difference in insulin between the 2 groups did not reach statistical significance (p =0.058), post-hoc analysis showed significant difference between the 2 groups from fasting to 1 hour post prandial (p = 0.034) despite postprandial glucose being significantly higher in poor controlled diabetes patients (p < 0.001), throughout the postprandial period. Conclusion: T2DM patients with good glycemic control have improved insulin response with lower non-esterified fatty acid.

Compromise Allocation for Combined Ratio Estimates of Population Means of a Multivariate Stratified Population Using Double Sampling in Presence of Non-Response

This paper is an attempt to work out a compromise allocation to construct combined ratio estimates under multivariate double sampling design in presence of non-response when the population mean of the auxiliary variable is unknown. The problem has been formulated as a multi-objective integer non-linear programming problem. Two solution procedures are developed using goal programming and fuzzy programming techniques. A numerical example is also worked out to illustrate the computational details. A comparison of the two methods is also carried out.