Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Objective: In the manuscript titled Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinsons Disease: A Systematic Review and Meta-Analysis, the objective was to conduct a systematic review with meta-analysis to investigate the effects that Rasagiline has on motor and non-motor symptoms in individuals with PD. Introduction: Rasagiline is a second-generation monoamine oxidase-B (MAO-B) inhibitor used both as monotherapy and adjunctive therapy for Parkinsons Disease (PD). Methods: A systematic literature search and meta-analysis were performed with randomized control trials that investigated the effects of Rasagiline on motor and non-motor symptoms in individuals with PD. The systematic search was conducted in PubMed, Cochrane, and EBSCO databases. Methodological quality was assessed using the Cochrane Grading Recommendations Assessment, Development and Evaluation approach. Results: Fourteen studies were included in our review. There were trivial to small and statistically significant improvements in motor symptoms for individuals with PD treated with Rasagiline compared to placebo. Non-motor symptoms showed no significant improvement with Rasagiline compared to placebo in five of six meta-analyses. Results were based on very low to moderate certainty of evidence. Conclusion: 1 mg/day Rasagiline significantly improved Parkinsonian motor symptoms in individuals with PD compared with placebo. For all outcomes, the 1 mg/day Rasagiline group was favored over the placebo group.

Liquid Subcutaneous Levodopa-Carbidopa ND0612 Effects on Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to conduct a systematic review with meta-analysis to investigate the effects ND0612 24-hour dosing regimen has on motor symptoms in individuals with Parkinson’s Disease (PD). Introduction: ND0612 is a novel minimally invasive continuous subcutaneous delivery system of liquid Levodopa-Carbidopa being investigated for the treatment of PD in individuals experiencing motor symptoms. Methods: A systematic literature search was conducted in PubMed, Cochrane, and EBSCO databases to identify randomized controlled trials investigating the effects of ND0612 on motor symptoms in individuals with PD. Outcomes included the Unified Parkinson’s Disease Rating Scale (UPDRS) Part II and Part III scores. Methodological quality was assessed using the Cochrane Grading of Recommendations Assessment, Development, and Evaluation approach. Meta-analysis was performed using a random effects model with the DerSimonian and Laird method to estimate the effects of the ND0612 24-hour dosing regimen on UPDRS Part II and Part III scores. Results: Three studies were included in our review. There were statistically significant reductions in UPDRS Part II scores (mean difference (MD) −3.299;95% confidence interval (CI) −3.438, −3.159) and in UPDRS Part III scores (MD −12.695;95% CI −24.428, −0.962) in the ND0612 24-hour dosing regimen. Results were based on very low certainty of evidence. Conclusion: Based on very low certainty evidence, the ND0612 24-hour dosing regimen is effective at improving motor symptoms in individuals with PD. Our findings suggest that ND0612 is more effective at improving UPDRS Part II and Part III scores in individuals with PD than other pharmacological and non-pharmacological treatments, warranting further study.

Effects of a Cocktail Supplement of Ginkgo Biloba and Acai Extract on Cognitive Symptoms of Parkinson’s Disease

Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects and potential for dependency. This study investigates the effects of a natural supplement combination of Ginkgo Biloba and Acai Extract on cognitive symptoms in a 77-year-old male with PD. The participant underwent a three-month supplementation regimen, with cognitive function assessed using the Montreal Cognitive Assessment (MoCA) test before and after the intervention. The results indicated an improvement in cognitive scores, suggesting that the combination of Ginkgo Biloba and Acai Extract may offer a promising alternative or adjunct to conventional PD treatments. This study highlights the potential of natural supplements in managing PD symptoms and calls for further research with larger sample sizes to confirm these findings. Human data was performed in accordance with the Declaration of Helsinki by the Roxbury District IRB Board (IRB Number: IRB00011767).

Factors Influence Hanoians’ Choice of Non-Motorized Transport Mode to Access Bus Stations

Hanoi’s rapid urbanization has led to a surge in private vehicle ownership, particularly motorcycles, amidst inadequate public transportation infrastructure. Despite government efforts, many still prefer motorized transport, citing mobility and safety concerns, exacerbated by insufficient pedestrian infrastructure. This study examines the motivations behind this reliance on motorized vehicles, particularly motorcycles, in Hanoi. Findings reveal safety and convenience as primary factors driving motorized transport use, especially for accessing bus stations. Economic incentives could promote non-motorized travel and public transport adoption. Policy implications highlight the importance of addressing economic factors and improving access infrastructure to manage motorized vehicle reliance and foster sustainable urban mobility in Hanoi.

Non-motor signs and symptoms in Parkinson’s disease

Motor symptoms are cardinal clinical features of Parkinson’s disease (PD). Progress in drug therapy and rehabilitation has been presenting beneficial effect for motor symptoms. However, non-motor symptoms and signs in PD have been accumulated growing attentions and its amelioration may also give beneficial effect for PD patients’ and their care givers’ quality of life. In this mini-review, I overviewed non-motor symptoms and signs in PD.

Non-Motor Symptoms in Parkinson’s Disease Patients—An Observational Study

Background: Parkinson’s disease (PD) remains a challenge for neurologists, particularly in its advanced stages when non-motor symptoms become a burden for the patient. While motor symptoms may be satisfactorily controlled with levodopa therapy or continuous levodopa/carbidopa intestinal gel (LCIG) administration, autonomic, sleep and mental disorders are hard to treat. During the last years, researchers have shifted their interest more to non-motor symptoms, PD being now considered a complex multiorgan impairment. Objective: The aim of this study was to describe non-motor symptoms in 40 Romanian patients diagnosed with PD, under conventional and LCIG administration treatment. Methods: A cross-sectional observational study was conducted, consisting of two groups of 20 patients each: the first group comprised PD patients who received conventional Levodopa treatment, while the second group was formed of patients receiving LCIG therapy. Various data concerning patient’s age, gender, duration of illness, comorbidities, motor and non-motor symptoms were recorded. The data were processed in SPSS v.20. Results: Subjects under continuous LCIG administration, although showing amelioration of motor symptoms, complained more frequently of constipation, mental, and sleeping disorders (statistically significant). Regarding anosmia, orthostatic hypotension, hypersalivation, urinary incontinence and restless legs syndrome, no statistical significant difference was observed between the two groups (p > 0.05). Conclusion: Nowadays, more research is conducted on non-motor symptoms in PD patients, as therapeutic measures try to limit these burdens, in order to improve patient’s quality of life.

Perception of Menopausal Symptoms among Educated versus Non Educated Women by Using Menopausal Rating Scale (MRS)

Background: A cross sectional comparative study was conducted in a well populated city named Rawalpindi, which is located in the Northern part of Pakistan. Objectives: This study was aimed to document the comparison of menopausal-related symptoms among educated and non educated women of Rawalpindi, Pakistan. Methods: MRS was used to measure the intensity of menopausal symptoms. 100 educated and 100 uneducated women were selected for study purpose. Pakistan Institute of Medical Sciences, Military Hospital and Combined Military Hospital were selected as a study setting. Findings: Correlation & Fisher exact test was applied for statistical analysis. The intensity of symptoms reported by Educated women as: sleeping problems (93.0%);heart discomfort (80.0%);hot flushes and sweating (70.0%);joint and muscular pain (52.0);depressive mood (63.0%);irritability (42%);anxiety (60.0%). physical and mental exhaustion;(48.0%);sexual problem (61.0%);dryness of vagina (57.0%);and bladder problem (65.0%). The severity of symptoms in uneducated women;sleeping problems (77.0%);heart discomfort (73.0%);hot flushes (69.0%);joint and muscular pain (66.0);depressive mood (71.0%);irritability (58%);anxiety (80.0%). physical and mental exhaustion (70.0%);sexual problem (66.0%);dryness of vagina (70.0%);and bladder problem (83.0%). Conclusions: Somatic symptoms were high in educated women as compare to uneducated women while the prevalence of psychological and Urogenital symptoms were high in uneducated women as compare to educated women.

Research on the Control for the Planar Motor by Non-symmetric and Unilateral Driven

与由四组线圈单元驱动方式相比，三组线圈单元驱动的平面电机属于单边非质心驱动模型。为提高平面电机系统的伺服性能，需要准确的力解耦模型以及有效的控制算法。由于实际中存在建模误差，如永磁体线圈加工误差引起的推力误差、气隙厚度不均匀、外部不确定扰动等，使得基于名义模型的系统无法有效解耦。同时建模误差的存在使得闭环系统误差方程的等号右侧不为0，无法确保跟踪误差的收敛。因此，必须利用控制器对建模误差进行补偿。以三组线圈单元且x方向为单边非质心驱动的平面电机作为研究对象。为提高其轨迹跟踪与定位能力，提出一种非线性控制算法。在逆动力学控制算法的基础上增加鲁棒项，对建模误差进行有效补偿。采用李雅普诺夫（Lyapunov）理论证明了该算法的稳定性。实验结果表明，轨迹跟踪误差小于1．5μm，可见通过对建模误差的补偿，减小了多自由度间耦合作用对运动精度的影响，提高了平面电机伺服性能。

Working Mechanism of a Kind of Non-resonant Linear Piezoelectric Motor with Flexible Driving End

A non-resonant piezoelectric linear motor with a flexible driving end,which has an extensive working frequency range and good operation stability,is studied theoretically and experimentally.Based on the microscopic vibration characteristics of the motor stator,the longitudinal vibration model is established for the whole motor system.According to the Coulomb friction model and the motor vibration model,the friction mechanism of the nonresonant piezoelectric linear motor is investigated by dynamical analysis of the whole motor system.Furthermore,the vibration characteristics and mechanical output characteristics of the stator are simulated and experimentally studied on the basis of the friction drive mechanism model.Finally,both the simulation and experimental results show that this kind of motor remain stable in the frequency domain from 2.2 kHz to 3.5 kHz and that when the pre-stress is 4 Nand the driving voltage is 90 V,the maximum velocity of the motor is above 4 mm/s and the maximum thrust is nearly 0.5 N.

Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxelbased lesion symptom mapping study

Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuro- nal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.

Non-erosive and uncomplicated erosive reflux diseases:Difference in physiopathological and symptom pattern

AIM:To investigate differences in the physiopathological findings(manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease(NERD) and erosive reflux disease(ERD) found positive at 24 h pH monitoring. METHODS:For a total of 670 patients who underwent 24 h pH monitoring,esophageal manometry and upper endoscopy were retrospectively evaluated,assessing the reflux symptoms,manometric characteristics of the lower esophageal sphincter(LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study,patients had to have NERD or ERD and be found positive on pH monitoring(NERD+) . Patients with Gastroesophageal reflux disease(GERD) complicated by stenosis,ulcers or Barrett's esophagus were ruled out. RESULTS:214 patients were involved in the study,i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender-or age-related differences between the two groups. The ERD group had more cases of hiatal hernia(P = 0.02) and more acid reflux,both in terms of number of reflux episodes(P = 0.01) and as a percentage of the total time with a pH < 4(P = 0.00) ,when upright(P = 0.007) and supine(P = 0.00) . The NERD+ cases had more reflux episodes while upright(P = 0.02) and the ERD cases while supine(P = 0.01) . The LES pressure was higher in cases of NERD+(P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group(P >0.05) . The NERD+ patients presented more often with atypical symptoms(P = 0.01) . CONCLUSION:The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position(unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments.

Modeling Bicycle Conflict on Non-Motorized Paths on Suburban College Campuses

Bicycling is an important way for college students and employees to get around campuses. With a rise in bicycling on campuses there comes a rise in bicycle collisions with pedestrians walking to and from classes and work. The literature review showed many papers involving bicycle conflict modeling but on roads with motor vehicles. While some aspects of this research can be applied to non-motorized paths, there is a lack of research strictly focusing on only bicycles and pedestrians. This study aims to fill this knowledge gap by developing a model to identify locations on roads and paths (hotspots) on college campuses that are likely to have a bicycle collision and predict the likelihood of a serious bicycle crash on a non-motorized path based on the characteristics of the path. This study identifies those interactions between bicyclists and pedestrians on non-motorized paths on a suburban college campus in Newark, USA. Findings suggest that pedestrian density of a path is a major factor in the maximum speed bicyclists can achieve. The wider the path is, the higher the maximum speed is that a bicyclist can obtain. This is because a wider path width decreases the pedestrian density. The grade of the path has little effect on bicycle speeds. The results of the models were displayed on a GIS map that is visually appealing to a viewer. The paths were color coded based on their level of safety, so it is easy to observe problematic areas of the network. This technique can be applied to the entire campus network of non-motorized paths to study the whole system. This can then be used by planners and designers to identify areas that need upgrading and improve the overall safety of the non-motorized path system.

Experimental study of noncontact ultrasonic motor with non-symmetrical electrode

We have proposed a novel noncontact ultrasonic motor based on non-syinmetrical electrode driving. The configuration of this electrode and the fabrication process of rotors are presented. Its vibration characteristics are computed and analysed by using the finite element method and studied experimentally. Good agreement between them is obtained. Moreover, it is also shown that this noncontact ultrasonic motor is operated in antisymmetric radial vibration mode of B21 mode. The maximum revolution speed for three-blade and six-blade rotors are 5100 and 3700r/min at an input voltage of 20V, respectively. Also, the noncontact high-speed revolution of the rotors can be realized by the parts of Ⅰ, Ⅲ of the electrode or Ⅱ, Ⅳ of the electrode. The levitation distance between the s tator and rotor is about 140μm according to the theoretical calculation and the experimental measurement.

Temporal Stability and Transferability of Non-Motorized and Total Trip Generation Models

Transportation systems provide a means for moving people and the goods from which they are spatially separated. Of the two means of surface transportation, the motorized mode is used extensively for utilitarian travel in developed countries. The increasing reliance on motorized travel has contributed to increased traffic congestion, air pollution, and greenhouse emissions. Non-motorized travel has recently received significant attention as a means to reduce congestion and environmental problems and improve human health. However, non-motorized modeling is generally underdeveloped. This study investigated some changes in non-motorized and total travel and the characteristics of the traveling public in 1990, 1995, 2001, and 2009 using a national travel survey. The study also investigated the temporal transferability of linear-regression trip generation models for non-motorized and total travel under such changes. High-income households made fewer non-motorized trips in 1990 and 1995 compared to 2001 and 2009. Persons aged 50 and over showed an increased demand for non-motorized travel, whereas children aged 0 - 15 showed a decreasing preference for non-motorized travel over time. Regarding temporal stability, only the coefficient for single-adult households with no children was stable across all of the analysis years. For both non-motorized and total travel, most model parameter estimates were stable short term but not long term. In general, the total travel models transferred better than non-motorized models, both short term and long term. Despite not finding universal stability in model parameter estimates, the models were marginally able to replicate travel in 2009 relative to the locally estimated 2009 model.

Evaluation of visual stress symptoms in age-matched dyslexic, Meares-Irlen syndrome and normal adults

AIM： To examine the prevalence of dyslexia and Meares-Irlen syndrome（MIS） among female students and determine their level of visual stress in comparison with normal subjects.·METHODS： A random sample of 450 female medical students of King Saud University Riyadh（age range, 18-30y） responded to a wide range of questions designed to accomplish the aims of this study. The detailed questionnaire consisted of 54 questions with 12 questions enquiring on ocular history and demography of participants while 42 questions were on visual symptoms. Items were categorized into critical and non-critical questions（CQ and NCQ） and were rated on four point Likert scale. Based on the responses obtained, the subjects were grouped into normal（control）, dyslexic with or without MIS（Group 1） and subjects with MIS only（Group 2）. Responses were analysed as averages and mean scores were calculated and compared between groups using one way analysis of variance to evaluate total visual stress score（TVSS =NCQ ＋CQ）, critical and non-critical visual stress scores. The relationship between categorical variables such as age, handedness and condition were assessed with Chi-square test.·RESULTS： The completion rate was 97.6% and majority of the respondents（92%） were normal readers, 2%dyslexic and 6% had MIS. They were age-matched. More than half of the participants had visited an eye care practitioner in the last 2y. About 13% were recommendedeye exercises and one participant experienced pattern glare. Hand preference was not associated with any condition but Group 1 subjects（3/9, 33%） were significantly more likely to be diagnosed of lazy eye than Group 2（2/27, 7%） and control（27/414, 7%） subjects. The mean±SD of TVSS responses were 63±14 and it was 44±9for CQ and 19 ±5 for NCQ. Responses from all three variables were normally distributed but the CQ responses were on the average more positive（82%） in Group 2 and less positive（46%） in Group 1 than control. With NCQ,the responses were equally less positive in Group 1 and2 than control. Group 2 subjects showed significantly higher TVSS（P =0.002）, NCQ（P =0.006） and CQ（P =0.008）visual stress scores than control but no difference between Group 1 and control subjects, was observed for all scores（P 〉0.05, for all comparisons）.·CONCLUSION： The prevalence of dyslexia and MIS among Saudi female students was 2% and 6%,respectively. Critical questions performed best for assessing visual stress symptoms in dyslexic and MIS subjects. Generally, students with MIS were more sensitive to visual stress than normal students but dyslexics were more likely to present with a lazy eye than MIS and normal readers.

帕金森病神经突触损伤及中药干预研究进展

帕金森病(PD)是一种常见的神经退行性疾病,临床表现主要分为运动症状和非运动症状。运动症状是PD的终末核心特征之一,与黑质致密部多巴胺能神经元丢失直接相关。而PD运动症状出现之前往往会表现出嗅觉障碍、视觉障碍、睡眠障碍、抑郁、认知障碍等非运动症状,严重影响患者的生活质量。这些症状的产生与大脑特定部位神经突触损伤及功能变化有关,围绕PD突触损伤进行早期诊断和干预是防止PD进行性加重的重要环节。传统中医药在治疗神经退行性疾病方面具有丰富的理论知识和临床经验,中药是常用手段,且其对突触保护凸显出独特的作用。本文综述了神经突触损伤在PD相关症状发生发展过程中扮演的角色,突触损伤的机制和中药对突触损伤的干预作用及潜在机制,以期为神经退行性疾病的有效防治提供新的思路。

论“醉驾”新规下醉酒型危险驾驶罪中机动车的新标准

《关于办理醉酒危险驾驶刑事案件的意见》将有效解决醉酒型危险驾驶罪处罚范围过宽问题,但其第5条对机动车的解释延续了之前解释的立场,老问题的延续需要新的解决方案。正在来临的电动车时代使得电动车逐渐冲击燃油车时代围绕技术属性形成的机动车技术性标准,由此这一传统标准的缺陷逐步显现,援引这一标准难免出现“醉驾”刑法惩处上的乱象。其根本原因在于我国正在形成一套侧重规范属性的机动车规范性标准,形式上这两套标准都不缺乏相应的规范依据,但它们划定的机动车范围不尽一致,实质上它们是替代关系。我国的机动车认定标准应契合电动车时代发展潮流,在行政机关对电动车采取机动车管理持谨慎立场、“电动车不是机动车”是普遍性社会认知、对不法行为惩处泛刑化进行限缩等原因推动下,促进电动车时代我国机动车认定标准的升级,以规范性标准替代传统的技术性标准,进一步限缩该罪的犯罪圈。

基于轨迹数据的非机动车左转信号灯安全效应评估

【目的】对城市交叉口采用的左转非机动车信号灯设施进行交通安全性量化评估。【方法】提出一种基于拓展碰撞时间(extended time to collision,ETTC)指标的左转非机动车信号灯安全效应评估方法。针对现有的碰撞时间(time to collision,TTC)指标不适于评估交叉口左转非机动车冲突的问题,考虑非机动车车辆尺寸与加速度对交通冲突的影响,采用拓展碰撞时间指标,评估交叉口非机动车交通冲突。收集长沙市4个信号交叉口的视频大数据,利用视频软件Tracker提取车辆微观轨迹后,开展案例分析。【结果】左转非机动车信号灯在时间上明确了非机动车的通行权,其设置能显著降低非机动车冲突率,在平峰、高峰时段非机动车冲突率分别降低了40.11%、25.27%。在直行相位末期、左转相位即将启亮时,设置组的左转非机动车在待行区等待,冲突率降为0;而对比组近50%的非机动车违规左转,冲突严重。设置左转非机动车信号灯的改善效果随非机动车流量的增大呈先增加后降低趋势,而随机动车流量的增大呈逐步波动下降趋势。【结论】本研究揭示了非机动车左转信号灯的设置对减少交叉口交通冲突的影响,可为城市交叉口非机动车交通安全管控提供有益参考。

帕金森病、特发性震颤患者的震颤分析及非运动症状差异

目的:分析帕金森病、特发性震颤患者震颤分析、非运动症状差异及其影响因素。方法:将2022年3月~2023年3月我院收治的帕金森病患者82例纳入帕金森组,特发性震颤患者68例纳入特发性震颤组,回顾性收集患者临床资料。分析两组一般资料、震颤分析及非运动症状差异,并分析其影响因素。结果:年龄>60岁、震颤部位单侧肢体、谐波现象、嗅觉减退为帕金森病的危险因素(P<0.05),姿势震颤频率、周围波为帕金森病的保护因素(P<0.05)。结论:帕金森病、特发性震颤患者震颤分析、非运动症状存在差异,其影响因素较多,可为其临床鉴别提供依据。

普拉克索联合多巴丝肼治疗帕金森病患者的效果

目的:观察普拉克索联合多巴丝肼治疗帕金森病患者的效果。方法:选取2021年3月至2023年3月该院收治的86例帕金森病患者进行前瞻性研究,按随机数字表法将其分为研究组和对照组各43例,对照组予以多巴丝肼治疗,研究组在对照组基础上联合普拉克索治疗,比较两组临床疗效,治疗前后Hoehn-Yahr分级、非运动症状控制[非运动症状评价量表(NMSS)]评分、血清miR-124和miR-137水平、认知功能[蒙特利尔认知量表(MOCA)]评分和生命质量[帕金森患者生活质量问卷(PDQ-39)]评分,以及不良反应发生率。结果:研究组治疗总有效率为95.35%(41/43),高于对照组的81.40%(35/43),差异有统计学意义(P<0.05);治疗后,研究组Hoehn-Yahr分级优于对照组,差异有统计学意义(P<0.05);研究组病情严重程度、发生频率等NMSS评分均低于对照组,差异有统计学意义(P<0.05);研究组血清miR-124水平高于对照组,血清miR-137水平低于对照组,差异均有统计学意义(P<0.05);研究组MOCA评分高于对照组,PDQ-39评分低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:普拉克索联合多巴丝肼治疗帕金森病患者可提高治疗总有效率、血清miR-124水平和MOCA评分,降低血清miR-137水平、NMSS评分和PDQ-39评分,改善Hoehn-Yahr分级,效果优于单纯多巴丝肼治疗。