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Research on the Impact of BYD Group’s Green Innovation on Corporate Financial Performance under the Background of“Dual Carbon”
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作者 Ziyue Liao 《Proceedings of Business and Economic Studies》 2024年第4期207-213,共7页
With the increasingly severe global climate change problem,the“dual carbon”goals(peak carbon emissions and carbon neutrality)have become a common focus of international attention.The report of the 20th National Cong... With the increasingly severe global climate change problem,the“dual carbon”goals(peak carbon emissions and carbon neutrality)have become a common focus of international attention.The report of the 20th National Congress of the Communist Party of China clearly emphasizes the need to accelerate the green transformation of development models,implement comprehensive strategies for frugal development,support the growth of green and low-carbon industries,and promote the concept of green consumption.At the same time,“Made in China 2025”also elaborates on the strategic concept of innovation-driven and green development centered,and strives for breakthroughs in key industries such as new energy vehicles.In such a macro environment,adopting green innovation measures by enterprises not only contributes to ecological protection but also has an undeniable impact on their economic performance and overall value.This article takes BYD Group as a case study to explore in detail the positive effects of green innovation on its economic performance.We first systematically organized and analyzed BYD’s specific practices in green innovation;Then,by examining three key financial indicators,BYD’s current financial situation was analyzed in depth;On this basis,combined with research data,the positive impact of green innovation on BYD’s financial performance was revealed;Finally,based on the analysis results,relevant suggestions are proposed to provide reference for the sustainable development of enterprises in the context of“dual carbon.” 展开更多
关键词 Dual carbon target BYD Group Green innovation Corporate financial performance
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Research on Financial Targets Sequence of Impacting on Business Value—— Based on Data Analysis from Chinese High-tech Listed Firms of Unmodified Auditing Opinions 被引量:1
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作者 Aidong Liu He Wang 《Chinese Business Review》 2004年第7期60-65,共6页
The high-tech listed firms are not only representative for mainstream of nongovernmental businesses, but also afflux new livingness into the capital market development in China. By considering our country's high-tech... The high-tech listed firms are not only representative for mainstream of nongovernmental businesses, but also afflux new livingness into the capital market development in China. By considering our country's high-tech listed firms as study object, we have disclosed different degree between diverse financial targets and business value, built a financial targets sequence model of impact on business value. The study supplies a certain extent reference to valid supervising and exalting of firms' financial core. 展开更多
关键词 high-tech enterprise business value financial target sequence evidential study
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A Study on Financial Strategy for Determining the Target Enterprise of Merger and Acquisition
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作者 Xiliang Song Yihong Chu 《Journal of Modern Accounting and Auditing》 2006年第4期55-60,共6页
To enhance the success rate of merger and acquisition, the acquiring party should make due diligence investigation into the target enterprise's counting materials and financial situations when filtering the target en... To enhance the success rate of merger and acquisition, the acquiring party should make due diligence investigation into the target enterprise's counting materials and financial situations when filtering the target enterprises. Meanwhile, the acquiring party must thoroughly analyze the target enterprise's motive for selling, making sure that all the financial resources of the target enterprise well satisfy its acquisition criteria. Thus, the acquiring party can determine the most appropriate target enterprise. This paper tends to define the financial features of the target enterprise and the primary factors that affect the filtration of target enterprise in order to provide suggestions for the acquiring party to filter the target enterprise that satisfy its acquisition criteria. 展开更多
关键词 financial resource fit financial synergy target enterprise
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Assessment of Barriers and Challenges to the Screening and Linkages of Non-Communicable Diseases by Community Health Volunteers in Nyeri County, Kenya
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作者 Kenneth Mugambi Jackline Nyaberi Elizabeth Echoka 《Open Journal of Preventive Medicine》 2024年第5期90-109,共20页
Non-communicable diseases (NCDs) are a significant global health challenge, contributing to 50% of worldwide morbidity and 63% of mortality. The burden is particularly substantial in low—and middle-income countries (... Non-communicable diseases (NCDs) are a significant global health challenge, contributing to 50% of worldwide morbidity and 63% of mortality. The burden is particularly substantial in low—and middle-income countries (LMICs), where 80% of NCD-related deaths occur. A quasi-experimental study addressed this challenge from May 2022 to March 2023. This study utilized a non-equivalent pre-and post-test design, with 300 participants in the quantitative and 70 in the qualitative. The study employed multistage cluster and random sampling to select ten community units, resulting in 150 community health volunteers (CHVs) in the control unit and 150 in the intervention group. Data collection was facilitated through the KOBO app. Qualitative data analysis involved six homogeneous focus group discussions (FGDs) and ten key informant interviews (KIIs), audio-recorded, transcribed, and analyzed using N-Vivo 12. Despite efforts to implement screening programs and improve linkages to care, significant barriers persist. This article reviews these barriers, drawing on current literature and empirical evidence. Key obstacles identified include limited awareness, inadequate healthcare infrastructure, cultural beliefs, financial constraints, fragmented healthcare systems, and challenges linking individuals to appropriate care services. The article explores strategies to overcome these barriers, emphasizing the importance of collaborative approaches involving stakeholders at various levels. Addressing these challenges aims to strengthen NCD screening and linkages to care, ultimately improving health outcomes for populations globally. Several recommendations emerge from the study’s findings and literature review. Raising awareness about NCDs and preventive measures is crucial and can be achieved through targeted health education campaigns and community outreach programs. Addressing healthcare infrastructure deficiencies, such as inadequate facilities and workforce shortages, is essential to ensure access to quality care. Cultural beliefs and practices also play a significant role in shaping health-seeking behavior. Engaging with local communities and incorporating cultural sensitivity into healthcare delivery can help bridge the gap between traditional beliefs and modern healthcare practices. Financial constraints pose a significant barrier to healthcare services, particularly in LMICs. Innovative financing mechanisms, such as health insurance schemes or subsidies, can help alleviate this burden and improve access to care. Furthermore, the fragmented nature of healthcare systems can hinder effective NCD management. Enhancing coordination and integration between primary care providers, specialists, and community health workers is essential to ensure seamless care delivery and patient follow-up. Finally, strengthening linkages between screening programs and care services is critical for the timely diagnosis and management of NCDs. This requires establishing robust referral systems and ensuring continuity of care for patients throughout their healthcare journey. In conclusion, addressing the multifaceted barriers to NCD screening and care linkage is essential for improving health outcomes globally. By implementing targeted interventions and fostering collaboration among stakeholders, progress can be made towards reducing the burden of NCDs and promoting population health. 展开更多
关键词 non-Communicable Diseases Barriers CHALLENGES Healthcare Infrastructure AWARENESS Cultural Beliefs financial Constraints
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A Method to Obtain the Moving Speed of Uncooperative Target Based on Only Two Measurements
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作者 Tao Yu 《Advances in Aerospace Science and Technology》 2024年第1期1-9,共9页
The existing research results show that a fixed single station must conduct three consecutive frequency shift measurements and obtain the target’s moving speed by constructing two frequency difference equations. This... The existing research results show that a fixed single station must conduct three consecutive frequency shift measurements and obtain the target’s moving speed by constructing two frequency difference equations. This article proposes a new method that requires only two consecutive measurements. While using the azimuth measurement to obtain the angular difference between two radial distances, it also conducts two consecutive Doppler frequency shift measurements at the same target azimuth. On the basis of this measurement, a frequency difference equation is first constructed and solved jointly with the Doppler frequency shift equation. By eliminating the velocity variable and using the measured angular difference to obtain the target’s lead angle, the target’s velocity can be solved by using the Doppler frequency shift equation again. The new method avoids the condition that the target must move equidistantly, which not only provides an achievable method for engineering applications but also lays a good foundation for further exploring the use of steady-state signals to achieve passive positioning. 展开更多
关键词 Moving Speed non-Cooperative target Doppler Frequency Shift Frequency Difference Equation AZIMUTH Steady-State Signal Passive Location
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Safety Evaluation of Myricetin and Crude Extract from Myrica rubra Leaves on Non-target Organisms
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作者 李桥 徐静 +2 位作者 张绍勇 张旭 陈安良 《Plant Diseases and Pests》 CAS 2010年第4期46-50,共5页
[ Objective] The study aimed to supply important basis for developing environment-friendly pesticides with myricetin and crude extract of Myrica rubra leaves as effective components. [ Method] According to "Test guid... [ Objective] The study aimed to supply important basis for developing environment-friendly pesticides with myricetin and crude extract of Myrica rubra leaves as effective components. [ Method] According to "Test guidelines for environmental safety evaluation on chemical pesticides", the toxicity of myricetin and crude extract of M. rubra leaves on non-target organisms was determined and the safety evaluation was carried out. [Result] MyriceUn and crude extract of M. rubra leaves had low toxicity on non-target organisms, such as earthworm, silkworm and soil microbes. Myricetin showed low toxicity and the crude extract of M. rubra leaves showed middle toxicity on tadpole. The high-concentration crude extract of M. rubra leaves had some antifeedant effect on silkworm. [ Conclusion] Myricetin and crude extract of M. rubra leaves had low toxicity on non-tar- get organisms in environment and they were relatively safe. 展开更多
关键词 MYRICETIN Crude extract of M. rubra leaves non-target organisms Safety evaluation
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Effects of Transgenic Bt+CpTI Cotton on Field Abundance of Non-Target Pests and Predators in Xinjiang, China 被引量:10
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作者 XUYao WU Kong-ming +7 位作者 LI Hao-bing LIU Jian DING Rui-feng WANG Fei Ahtam Uwayis LI Hai-qiang WANG Dong-mei CHEN Xue-xin 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2012年第9期1493-1499,共7页
Transgenic insect-resistant cotton is being increasingly planted in Xinjiang cotton-planting regions, where geographical climate conditions and species composition of pests and natural enemies are greatly unique in Ch... Transgenic insect-resistant cotton is being increasingly planted in Xinjiang cotton-planting regions, where geographical climate conditions and species composition of pests and natural enemies are greatly unique in China. Limited studies have been conducted on the ecological impacts of transgenic insect-resistant cotton, especially for transgenic double genes (Bt+CpTI) cotton, in this region. In this study, the potential effects of transgenic Bt+CpTI cotton on the seasonal abundance of non-target pests and predators were assessed from 2009 to 2011 in Korla, Xinjiang. The results showed that species composition and seasonal abundance of 5 groups of pests and 5 groups of predators were not significantly different between transgenic Bt+CpTI cotton and non-transgenic cotton every year. It suggests that transgenic Bt+CpTI cotton per se does not affect the population dynamics of non-target pests and predators on this crop in Xinjiang. 展开更多
关键词 transgenic Bt+CpTI cotton non-target pests predators XINJIANG
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Robust detector for range-spread targets in non-Gaussian background 被引量:5
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作者 Tao Jian You He +2 位作者 Feng Su Dianfa Ping Xiaodong Huang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第3期355-363,共9页
Based on the target scatterer density, the range-spread target detection of high-resolution radar is addressed in additive non-Gaussian clutter, which is modeled as a spherically invariant random vector. Firstly, for ... Based on the target scatterer density, the range-spread target detection of high-resolution radar is addressed in additive non-Gaussian clutter, which is modeled as a spherically invariant random vector. Firstly, for sparse scatterer density, the detection of target scatterer in each range cell is derived, and then an M/K detector is proposed to detect the whole range-spread target. Se- condly, an integrating detector is devised to detect a range-spread target with dense scatterer density. Finally, to make the best of the advantages of M/K detector and integrating detector, a robust detector based on scatterer density (DBSD) is designed, which can reduce the probable collapsing loss or quantization error ef- fectively. Moreover, the density decision factor of DBSD is also determined. The formula of the false alarm probability is derived for DBSD. It is proved that the DBSD ensures a constant false alarm rate property. Furthermore, the computational results indi- cate that the DBSD is robust to different clutter one-lag correlations and target scatterer densities. It is also shown that the DBSD out- performs the existing scatterer-density-dependent detector. 展开更多
关键词 non-Gaussian clutter range-spread target robust de- tection quantization error collapsing loss target scatterer.
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Design of a Non-cooperative Target Capture Mechanism 被引量:2
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作者 WANG Chen NIE Hong +1 位作者 CHEN Jinbao PAN Zhengwei 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2019年第1期146-153,共8页
A passive compliant non-cooperative target capture mechanism is designed to maintain the non-cooperative target on-orbit. When the relative position between capture mechanism and satellite is confirmed,a pair of four-... A passive compliant non-cooperative target capture mechanism is designed to maintain the non-cooperative target on-orbit. When the relative position between capture mechanism and satellite is confirmed,a pair of four-bar linkages lock the docking ring,which is used for connecting the satellite and the rocket. The mathematical model of capture mechanism and capture space is built by the Denavit-Hartenberg(D-H)method,and the torque of each joint is analyzed by the Lagrange dynamic equation. Besides,the capture condition and the torque of every joint under different capture conditions are analyzed by simulation in MSC. Adams. The results indicate that the mechanism can capture the non-cooperative target satellite in a wide range. During the process of capture,the passive compliant mechanism at the bottom can increase capture space,thereby reducing the difficulty and enhance stability of the capture. 展开更多
关键词 non-COOPERATIVE target passive COMPLIANCE CAPTURE MECHANISM KINEMATICS ANALYSIS dynamics ANALYSIS
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Non-target-site and target-site resistance to AHAS inhibitors in American sloughgrass(Beckmannia syzigachne) 被引量:2
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作者 WANG Jing-jing LI Xiang-ju +4 位作者 LI Dan HAN Yu-jiao LI Zheng YU Hui-lin CUI Hai-lan 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2018年第12期2714-2723,共10页
American sloughgrass(Beckmannia syzigachne(Steud.) Fernald) is one of the most competitive and malignant weeds in rice-wheat rotation fields in China. American sloughgrass populations in the Jiangsu Province of China ... American sloughgrass(Beckmannia syzigachne(Steud.) Fernald) is one of the most competitive and malignant weeds in rice-wheat rotation fields in China. American sloughgrass populations in the Jiangsu Province of China became less sensitive to acetohydroxyacid synthase(AHAS) inhibitors after repeated application for many years in these areas. Two suspected resistant American sloughgrass populations(R1 and R2) collected in the field were detected the resistance to inhibitors of AHAS in whole-plant dose-response assays, compared to the susceptible(S) population. These assays indicated that R1 showed low resistance to mesosulfuron-methyl(3.32-fold), imazapic(2.84-fold) and pyroxsulam(1.55-fold), moderate resistance to flazasulfuron(4.67-fold) and pyribenzoxim(7.41-fold), and high resistance to flucarbazone(11.73-fold). However, using a combination of the cytochrome P450 inhibitor, malathion, with mesosulfuron-methyl resulted in a reduction in R1 resistance relative to mesosulfuron-methyl alone. Furthermore, R2 was highly resistant to flazasulfuron(34.90-fold), imazapic(11.30-fold), flucarbazone(49.20-fold), pyribenzoxim(12.94-fold), moderately resistant to mesosulfuron-methyl(9.77-fold) and pyroxsulam(6.26-fold), and malathion had no effect on R2 resistance to mesosulfuron-methyl. The fulllength of AHAS genes was sequenced and the AHAS enzymes were assayed in vitro in order to clarify the mechanism of resistance to AHAS inhibitors in R1 and R2 populations. The results demonstrated that R2 had a Pro-197-Ser mutation in the AHAS gene, and the sensitivity of R2 to the five AHAS inhibitors was decreased, which may result in R2 resistance to AHAS inhibitors. There was no mutation in the AHAS gene of R1, and there were no significant differences in enzyme sensitivity between susceptible(S) and resistant(R1) populations. An enhanced metabolism may be the main mechanism of R1 resistance to AHAS inhibitors. 展开更多
关键词 American sloughgrass CROSS-RESISTANCE gene mutation non-target-site resistance
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Non-fluctuating target detection in low-grazing angle with MIMO radar 被引量:2
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作者 丁锦灿 陈浩文 +2 位作者 王宏强 黎湘 庄钊文 《Journal of Central South University》 SCIE EI CAS 2013年第10期2728-2734,共7页
The non-fluctuating target detection in low-grazing angle using multiple-input multiple-output(MIMO) radar systems was studied, where the multipath effects are very abundant. The performance of detection can be improv... The non-fluctuating target detection in low-grazing angle using multiple-input multiple-output(MIMO) radar systems was studied, where the multipath effects are very abundant. The performance of detection can be improved via utilizing the multipath echoes. First, the reflection coefficient considering the curved earth effect is derived. Then, the general signal model for MIMO radar is introduced for non-fluctuating target in low-grazing angle. Using the generalized likelihood ratio test(GLRT) criterion, the detector of non-fluctuating target with multipath was analyzed. The simulation results demonstrate that the MIMO radar outperforms the conventional radar in non-fluctuating target detection and show that the performance can be enhanced markedly when the multipath effects are considered. 展开更多
关键词 low-grazing angle MULTIPLE-INPUT multiple-output(MIMO) radar non-fluctuating target MULTIPATH
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Impact Assessments of Transgenic cry1Ab Rice on the Population Dynamics of Five Non-Target Thrips Species and Their General Predatory Flower Bug in Bt and Non-Bt Rice Fields Using Color Sticky Card Traps 被引量:9
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作者 Akhtar Zunnu Raen YE Gong-yin +4 位作者 LU Zeng-bin CHANG Xue SHEN Xiao-jing PENG Yu-fa HU Cui 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2013年第10期1807-1815,共9页
A 2-yr field study was conducted to assess the effects of transgenic japonica rice(KMD1 and KMD2) with a synthetic cry1 Ab gene from Bacillus thuingiensis Berliner on population dynamics and seasonal average densiti... A 2-yr field study was conducted to assess the effects of transgenic japonica rice(KMD1 and KMD2) with a synthetic cry1 Ab gene from Bacillus thuingiensis Berliner on population dynamics and seasonal average densities of five thrips species including Stenchaetothrips biformis(Bagnall),Frankliniella intonsa(Trybom),F.tenuicornis(Uzel),Haplothrips aculeatus(Fabricius),Haplothrips tritici(Kurd) and their general predatory flower bug,Orius similis Zheng as compared to the parental control rice line using the white,blue and yellow sticky card traps.Population dynamics and seasonal average densities of these five thrips species and their general predatory flower bug were not significantly affected by rice type.Additionally,the white sticky card trap was suggested to be the most suitable for monitoring the population of these five thrips species and their general predator.These results show that our tested Bt rice lines do not interrupt the population of non-target thrips species and their general predatory flower bug in the field,and also cannot result in more occurrence of these thrips species in the rice ecosystem. 展开更多
关键词 rice thrips predatory flower bug non-target effects Bt rice risk assessment
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Non-target Screening and Quantitation of Organic Chlorides in Oilfield Chemicals with Comprehensive Two Dimensional Gas Chromatography Coupled with Time of Flight Mass Spectrometry 被引量:1
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作者 Zheng Kewen Guo Rui +5 位作者 Ren Guofa Xia Lingyan Xiong Wei Zhang Jin Chu Xiaodong Yu Zhiqiang 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2017年第4期65-71,共7页
Advanced analytical methodology based on comprehensive two-dimensional gas chromatography-time of flight mass spectrometry(GC×GC-TOFMS) is proposed for investigation of organic chlorides in different oilfield che... Advanced analytical methodology based on comprehensive two-dimensional gas chromatography-time of flight mass spectrometry(GC×GC-TOFMS) is proposed for investigation of organic chlorides in different oilfield chemicals.The target screening was initially carried out on 8 suspected organic chlorides by evaluating the capability of the enhanced separation and reliable identification at a trace concentration. GC×GC-TOFMS allowed for the fast and automated analysis of organic chlorides at a level of 200 μg/L. This method was subsequently applied for non-target screening of organic chlorides in different oilfield chemicals at various locations across China. 22 organic chlorides were identified and verified by comparison with pure standards in the mixed sample. Finally, this method was used to determine the content of the organic chlorides in individual samples. The result showed that the organic chloride levels in 19 of the 39 tested oilfield chemicals were above the threshold limit of 1.0 mg/L. 展开更多
关键词 GC×GC-TOFMS non-target SCREENING OILFIELD chemicals organic chlorides QUANTITATION
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Financial Poverty Alleviation in Rural Areas of Hubei Province
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作者 Lu TAN 《Asian Agricultural Research》 2017年第10期20-22,25,共4页
In order to find out the various restrictions and difficulties of financial poverty alleviation in rural areas,taking Hubei Province as an example,this paper firstly introduced current situations of financial poverty ... In order to find out the various restrictions and difficulties of financial poverty alleviation in rural areas,taking Hubei Province as an example,this paper firstly introduced current situations of financial poverty alleviation in rural areas of Hubei Province. Then,it analyzed problems confronted by financial poverty alleviation in rural areas of Hubei Province:( i) subjects of financial poverty alleviation not mature and poverty alleviation risks increased,( ii) backward agricultural insurance system,( iii) rural credit system not perfect,and( iv) weak guiding policies of financial poverty alleviation. Finally,it came up with pertinent recommendations: improving rural financial environment,actively developing the innovation mode of financial poverty alleviation,and strengthening relevant supervision efforts. 展开更多
关键词 Rural areas financial poverty alleviation targeted poverty alleviation Rural areas of Hubei Province
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Molecularly targeted therapies for advanced or metastatic non-small-cell lung carcinoma 被引量:8
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作者 Soley Bayraktar Caio M Rocha-Lima 《World Journal of Clinical Oncology》 CAS 2013年第2期29-42,共14页
Non-small-cell lung cancer(NSCLC)remains the leading cause of cancer-related death in both men and women in the United States.Platinum-based doublet chemotherapy has been a standard for patients with advanced stage di... Non-small-cell lung cancer(NSCLC)remains the leading cause of cancer-related death in both men and women in the United States.Platinum-based doublet chemotherapy has been a standard for patients with advanced stage disease.Improvements in overall survival and quality of life have been modest.Improved knowledge of the aberrant molecular signaling pathways found in NSCLC has led to the development of biomarkers with associated targeted therapeutics,thus changing the treatment paradigm for many NSCLC patients.In this review,we present a summary of many of the currently investigated biologic targets in NSCLC,discuss their current clinical trial status,and also discuss the potential for development of other targeted agents. 展开更多
关键词 non-SMALL cell lung cancer Molecular targeted therapy Vascular endothelial GROWTH FACTOR Epidermal GROWTH FACTOR receptor TYROSINE KINASE inhibitors BRAF ANAPLASTIC lymphoma KINASE
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Review of the current targeted therapies for non-small-cell lung cancer 被引量:13
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作者 Kim-Son H Nguyen Joel W Neal Heather Wakelee 《World Journal of Clinical Oncology》 CAS 2014年第4期576-587,共12页
The last decade has witnessed the development of oncogene-directed targeted therapies that have significantly changed the treatment of non-small-cell lung cancer(NSCLC). In this paper we review the data demonstrating ... The last decade has witnessed the development of oncogene-directed targeted therapies that have significantly changed the treatment of non-small-cell lung cancer(NSCLC). In this paper we review the data demonstrating efficacy of gefitinib, erlotinib, and afatinib, which target the epidermal growth factor receptor(EGFR), and crizotinib which targets anaplastic lymphoma kinase(ALK). We discuss the challenge of acquired resistance to these small-molecular tyrosine kinase inhibitors and review promising agents which may overcome resistance, including the EGFR T790 Mtargeted agents CO-1686 and AZD9291, and the ALKtargeted agents ceritinib(LDK378), AP26113, alectinib(CH/RO5424802), and others. Emerging therapies directed against other driver oncogenes in NSCLC including ROS1, HER2, and BRAF are covered as well. The identification of specific molecular targets in a significant fraction of NSCLC has led to the personalized deployment of many effective targeted therapies, with more to come. 展开更多
关键词 LUNG cancer non-small cell LUNG cancer targeted therapies EPIDERMAL growth factor RECEPTOR EPIDERMAL growth factor RECEPTOR ANAPLASTIC LYMPHOMA KINASE ANAPLASTIC LYMPHOMA KINASE Acquired resistance
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Treatment of non-small cell lung cancer in the era of targeted therapy
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作者 James Chung-Man Ho 《Advances in Lung Cancer》 2012年第1期1-4,共4页
Lung cancer, mostly non-small cell carcinoma (NSCLC), is still a major global problem with devastating outcomes. The majority presents at late stages, in which the chance of cure is minimal. With the better understand... Lung cancer, mostly non-small cell carcinoma (NSCLC), is still a major global problem with devastating outcomes. The majority presents at late stages, in which the chance of cure is minimal. With the better understanding of lung cancer biology, there have been several novel targeted approaches against NSCLC. Anti-angiogenesis has been proven to be an important approach in combination with systemic chemotherapy treatment in NSCLC at the first-line setting. The prototypic monoclonal antibody against vascular endothelial growth factor (VEGF), be- vacizumab, is now approved for clinical use in combination with platinum-based chemotherapy in first-line treatment of advanced non-squamous NSCLC, associated with improved response and survival compared with chemotherapy alone. The most notable example of targeted therapy for lung cancer is epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKI). There have been extensive evidences supporting the superiority of EGFR TKI (like gefitinib or erlotinib) over standard platinum-based doublet chemotherapy in first-line treatment of advanced NSCLC carrying EGFR activating mutations. Almost following the same path as EGFR TKI, a novel target (anaplastic lymphoma kinase, ALK) has been identified recently with a very promising targeted agent (crizotinib) that has already been approved for clinical use in NSCLC carrying ALK rearrangements. Over the past decade, there have been undoubtedly growing armamentaria in the treatment of NSCLC, focusing on personalized and targeted approach. 展开更多
关键词 targetED Therapy non-SMALL Cell Lung Cancer BEVACIZUMAB ERLOTINIB GEFITINIB CRIZOTINIB
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Non-Detection Probability of a Diffusing Target by a Stationary Searcher in a Large Region
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作者 Hongyun Wang Hong Zhou 《Applied Mathematics》 2016年第3期250-266,共17页
We revisit one of the classical search problems in which a diffusing target encounters a stationary searcher. Under the condition that the searcher’s detection region is much smaller than the search region in which t... We revisit one of the classical search problems in which a diffusing target encounters a stationary searcher. Under the condition that the searcher’s detection region is much smaller than the search region in which the target roams diffusively, we carry out an asymptotic analysis to derive the decay rate of the non-detection probability. We consider two different geometries of the search region: a disk and a square, respectively. We construct a unified asymptotic expression valid for both of these two cases. The unified asymptotic expression shows that the decay rate of the non-detection probability, to the leading order, is proportional to the diffusion constant, is inversely proportional to the search region, and is inversely proportional to the logarithm of the ratio of the search region to the searcher’s detection region. Furthermore, the second term in the unified asymptotic expansion indicates that the decay rate of the non-detection probability for a square region is slightly smaller than that for a disk region of the same area. We also demonstrate that the asymptotic results are in good agreement with numerical solutions. 展开更多
关键词 Detection of a Random target Asymptotic Solutions Decay of the non-Detection Probability
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Thrips-mediated impacts from transgenic rice expressing Cry1Ab on ecological fitness of non-target predator Orius tantilus(Hemiptera:Anthocoridae)
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作者 Akhtar Zunnu Raen DANG Cong +2 位作者 WANG Fang PENG Yu-fa YE Gong-yin 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2016年第9期2059-2069,共11页
Various rice lines have been genetically modified with genes from Bacillus thuringiensis(Bt) to continuously produce Bt insecticidal proteins against lepidopteran larvae. The Bt insecticidal protein constantly expre... Various rice lines have been genetically modified with genes from Bacillus thuringiensis(Bt) to continuously produce Bt insecticidal proteins against lepidopteran larvae. The Bt insecticidal protein constantly expresses in the plants to create an opportunity for non-target herbivores to acquire and convey the protein to their predators or parasitoids across trophic levels. This paper evaluates the effects of Bt rice(namely, Kemindao 1(KMD1) and Kemindao 2(KMD2)) expressing Cry1 Ab as compared to its non-Bt control line, Xiushui 11 on non-target predator Orius tantilus(a generalist predatory anthocorid of thrips) under laboratory and field conditions. To measure several biological parameters such as total nymphal duration and fecundity of this bug, it was reared on thrips and pollens of KMD1 and KMD2 as compared to their control under laboratory conditions. By comparison with the control, Bt rice did not significantly affect main life-history characteristics(total nymphal duration, female adult longevity, oviposition period and fecundity) of this anthocorid preying on Bt rice-fed thrips along with Bt rice pollens, except that the fecundity of this predator for KMD1 was distinctly lower as compared with KMD2 or the control. Enzyme-linked immunosorbent assay(ELISA) results showed that no Cry1 Ab protein was detected in this predator fed on thrips or rice pollen from Bt rice but was in Bt rice pollens. With the beat plate, plastic bag and color trap sampling methods, two-year field monitoring of O. tantilus abundance demonstrated that Bt rice had no significant detrimental effects on the population dynamics and seasonal average densities of this predatory anthocorid as compared with the control. Thus, it is suggested that growing our tested Bt rice(KMD1 and KMD2) producing Cry1 Ab will pose a negligible risk to the anthocorid, O. tantilus. 展开更多
关键词 Orius tantilus Btrice Cry1Ab risk assessment non-target effects
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ISAR target recognition based on non-negative sparse coding
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作者 Ning Tang Xunzhang Gao Xiang Li 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第6期849-857,共9页
Aiming at technical difficulties in feature extraction for the inverse synthetic aperture radar (ISAR) target recognition, this paper imports the concept of visual perception and presents a novel method, which is ba... Aiming at technical difficulties in feature extraction for the inverse synthetic aperture radar (ISAR) target recognition, this paper imports the concept of visual perception and presents a novel method, which is based on the combination of non-negative sparse coding (NNSC) and linear discrimination optimization, to recognize targets in ISAR images. This method implements NNSC on the matrix constituted by the intensities of pixels in ISAR images for training, to obtain non-negative sparse bases which characterize sparse distribution of strong scattering centers. Then this paper chooses sparse bases via optimization criteria and calculates the corresponding non-negative sparse codes of both training and test images as the feature vectors, which are input into k neighbors classifier to realize recognition finally. The feasibility and robustness of the proposed method are proved by comparing with the template matching, principle component analysis (PCA) and non-negative matrix factorization (NMF) via simulations. 展开更多
关键词 inverse synthetic aperture radar (ISAR) PRE-PROCESSING non-negative sparse coding (NNSC) visual percep-tion target recognition.
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