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A study on the feasibility of CET oral test based on automatic essay marking
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作者 刘健刚 郑玉琪 +2 位作者 陈美华 姜浩 赵力 《Journal of Southeast University(English Edition)》 EI CAS 2012年第4期410-414,共5页
This paper discusses the approach to the CET (college English test) oral test based on automatic essay marking (AEM). The reliability and validity arouses a dispute on Internet-based CET (iB-CET) oral test in Ch... This paper discusses the approach to the CET (college English test) oral test based on automatic essay marking (AEM). The reliability and validity arouses a dispute on Internet-based CET (iB-CET) oral test in China, leading to the penetration into oral test contents in dialogue, description or comment, and question answering. Then, a probe into transformation from a spoken document into a textual document is touched on a conversion ratio of 72% adopted at the present time, AEM to be carried forward being a necessary hypothesis for Afterwards, this paper focuses on the pipeline in AEM with the content features and the language itself, which is established in two different models in marking for extraction and detection. Through experiments, this paper reveals the fact that an iB-CET oral test can be performed perfectly in the pipeline of spoken documents transformed into textual documents which can be automatically marked. Hence the design of the iB-CET oral test reaches its reliability and validity. 展开更多
关键词 reliability and validity spoken document and textual document automatic essay marking
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应用Beach marking方法检测钢结构疲劳裂纹扩展 被引量:2
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作者 董亮 童乐为 +1 位作者 彭洋 赵晓林 《结构工程师》 2011年第B01期179-183,共5页
掌握裂纹扩展规律是钢结构疲劳性能研究的一个基本问题。本文介绍了一种检测钢结构疲劳裂纹扩展的新型方法,即Beach marking方法。论文首先简述了这种方法测试疲劳裂纹扩展的基本原理,然后通过一个试验案例,展示了这种方法的具体应用和... 掌握裂纹扩展规律是钢结构疲劳性能研究的一个基本问题。本文介绍了一种检测钢结构疲劳裂纹扩展的新型方法,即Beach marking方法。论文首先简述了这种方法测试疲劳裂纹扩展的基本原理,然后通过一个试验案例,展示了这种方法的具体应用和要点试验表明这种方法简单实用,通过运用合适的疲劳荷载序列,可在疲劳断口留下疲劳弧线,从而间接有效地记录了疲劳裂纹的扩展全过程。 展开更多
关键词 BEACH marking 疲劳断口 裂纹扩展行为 疲劳试验
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The Marking Technology in Motion Capture for the Complex Locomotor Behavior of Flexible Small Animals(Gekko gecko) 被引量:1
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作者 Zhouyi WANG Weijia ZONG +3 位作者 Bingcheng WANG Junjie ZHU Kai QIN Zhendong DAI 《Asian Herpetological Research》 SCIE CSCD 2019年第3期197-210,共14页
Animals have evolved a variety of behavior patterns to adapt to the environment. Motion-capture technology is utilized to quantify and characterize locomotor behaviors to reveal the mechanisms of animal motion. In the... Animals have evolved a variety of behavior patterns to adapt to the environment. Motion-capture technology is utilized to quantify and characterize locomotor behaviors to reveal the mechanisms of animal motion. In the capture of flexible, small animals with complex locomotor behaviors, the markers interfere with each other easily, and the motion forms(bending, twisting) of the moving parts are obviously different;thus, it is a great challenge to realize accurate quantitative characterization of complex locomotor behaviors. The correlation between the marker properties, including the size and space length, and the precision of the system are revealed in this paper, and the effects of diverse marker shapes on the capturing accuracy of the captured objects in different motion forms were tested. Results showed that the precision of system is significantly improved when the ratio of the space length to the diameter of the markers is larger than four;for the capture of the spatial twisting motion of the flexible object, the hexagon markers had the lowest spatial lost-marker rate relative to the circle, triangle, and square. Customized markers were used to capture the locomotor behavior of the gecko-inspired robot(rigid connection) and the gecko(flexible connection). The results showed that this marking technology can achieve high accuracy of motion capture for geckos(the average deviation was approximately 0.32 mm, and the average deviation’s variation rate was approximately 0.96%). In this paper, the marking technology for the motion capture of flexible, small animals with complex motion is proposed;it can effectively improve the system precision as well as the capture accuracy, and realize the quantitative characterization of the complex motion of flexible, small objects. It provides a reliable technical means to deeply study the evolution of the motion function of small animals and advance systematic research of motion-capture technology. 展开更多
关键词 small FLEXIBLE animals marking TECHNOLOGY motion capture quantification of LOCOMOTOR behavior GECKO
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A Novel Packet Marking Algorithm in Context-aware Autonomic QoS Framework 被引量:2
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作者 Gong Xiangyang Wang Wendong Li Yan 《China Communications》 SCIE CSCD 2009年第4期98-107,共10页
Autonomic networking is one of the hot research topics in the research area of future network architectures.In this paper, we introduce context-aware and autonomic attributes into DiffServ QoS framework, and propose a... Autonomic networking is one of the hot research topics in the research area of future network architectures.In this paper, we introduce context-aware and autonomic attributes into DiffServ QoS framework, and propose a novel autonomic packet marking(APM) algorithm.In the proposed autonomic QoS framework, APM is capable of collecting various QoS related contexts, and adaptively adjusting its behavior to provide better QoS guarantee according to users' requirements and network conditions.Simulation results show that APM provides better performance than traditional packet marker, and significantly improves user's quality of experience. 展开更多
关键词 autonomic QoS framework DIFFSERV CONTEXT-AWARE packet marking
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A Lane-Level Road Marking Map Using a Monocular Camera 被引量:1
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作者 Wonje Jang Junhyuk Hyun +2 位作者 Jhonghyun An Minho Cho Euntai Kim 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2022年第1期187-204,共18页
The essential requirement for precise localization of a self-driving car is a lane-level map which includes road markings(RMs).Obviously,we can build the lane-level map by running a mobile mapping system(MMS)which is ... The essential requirement for precise localization of a self-driving car is a lane-level map which includes road markings(RMs).Obviously,we can build the lane-level map by running a mobile mapping system(MMS)which is equipped with a high-end 3D LiDAR and a number of high-cost sensors.This approach,however,is highly expensive and ineffective since a single high-end MMS must visit every place for mapping.In this paper,a lane-level RM mapping system using a monocular camera is developed.The developed system can be considered as an alternative to expensive high-end MMS.The developed RM map includes the information of road lanes(RLs)and symbolic road markings(SRMs).First,to build a lane-level RM map,the RMs are segmented at pixel level through the deep learning network.The network is named RMNet.The segmented RMs are then gathered to build a lane-level RM map.Second,the lane-level map is improved through loop-closure detection and graph optimization.To train the RMNet and build a lane-level RM map,a new dataset named SeRM set is developed.The set is a large dataset for lane-level RM mapping and it includes a total of 25157 pixel-wise annotated images and 21000 position labeled images.Finally,the proposed lane-level map building method is applied to SeRM set and its validity is demonstrated through experimentation. 展开更多
关键词 Autonomous driving lane-level map road lane road marking map symbolic road marking weighted loss
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沉默MARK4通过NF-κB信号通路抑制溃疡性结肠炎细胞焦亡和炎症因子表达 被引量:1
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作者 叶璐 廖盛涛 +5 位作者 李传飞 苏建淋 余兴涟 王彦辉 宋亚 吕琳 《免疫学杂志》 CAS CSCD 2024年第2期131-137,共7页
目的探讨MARK4(microtubule-affinity regulating kinase 4,MARK4)在脂多糖(lipopolysaccharide,LPS)诱导的FHC细胞溃疡性结肠炎(ulcerative colitis,UC)模型中对FHC细胞焦亡、炎症因子释放和肠道屏障相关蛋白表达的影响及其可能分子机... 目的探讨MARK4(microtubule-affinity regulating kinase 4,MARK4)在脂多糖(lipopolysaccharide,LPS)诱导的FHC细胞溃疡性结肠炎(ulcerative colitis,UC)模型中对FHC细胞焦亡、炎症因子释放和肠道屏障相关蛋白表达的影响及其可能分子机制。方法采用Western blot检测UC患者、健康人群结肠组织和LPS诱导的FHC细胞炎症模型中MARK4和细胞焦亡相关的因子Caspase-1、NLRP3和GSDMD的表达水平;通过质粒转染shRNA沉默FHC细胞中MARK4,在正常对照组、LPS组和沉默MARK4+LPS组中采用Western blot分别检测Caspase-1、NLRP3、GSDMD、肠道屏障相关蛋白和NF-κB信号通路相关蛋白的表达水平;ELISA和RT-qPCR检测炎症因子IL-1β、IL-6和TNF-α表达水平;流式细胞术检测细胞凋亡情况。结果在UC患者结肠组织和LPS诱导FHC细胞体外UC炎症模型中MARK4和焦亡相关蛋白包括NLRP3、Caspase-1和GSDMD的表达水平显著升高。沉默MARK4能够抑制LPS诱导FHC细胞中焦亡相关蛋白NLRP3、Caspase-1、GSDMD表达水平,下调炎症相关细胞因子IL-1β、IL-6和TNF-α的表达水平,抑制FHC细胞凋亡,上调肠道屏障相关蛋白ZO-1、Occludin表达和上调Claudin2的表达水平。GSEA富集分析显示,MARK4与NF-κB信号通路呈正相关。沉默MARK4能够抑制NF-κB信号通路中p-P65、p-IKKα的表达水平。结论MARK4在UC组织和细胞中显著高表达,沉默MARK4能够通过阻滞NF-κB信号通路激活,进而抑制UC细胞焦亡和炎症因子表达。MARK4可能成为UC患者治疗的一个潜在靶点。 展开更多
关键词 溃疡性结肠炎 mark4 焦亡 炎症 NF-ΚB信号通路
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Simple Fabrication of Hierarchical Micro/Nanostructure Superhydrophobic Surface with Stable and Superior Anticorrosion Silicon Steel via Laser Marking Treatment 被引量:3
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作者 FU Jing TANG Mingkai ZHANG Qiaoxin 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2020年第2期411-417,共7页
To improve the weak corrosion resistance of silicon steel to acid solution and alkaline solution with high temperature,a stable hierarchical micro/nanostructure superhydrophobic surface with myriad irregular micro-sca... To improve the weak corrosion resistance of silicon steel to acid solution and alkaline solution with high temperature,a stable hierarchical micro/nanostructure superhydrophobic surface with myriad irregular micro-scale hump and sheet-like nanostructure was successfully prepared on silicon steel by a simple,efficient and facile operation in large-area laser marking treatment.The morphology,composition,wettability of the as-prepared surface were studied.The superhydrophobic performance of the surface was investigated as well.Additionally,the corrosion resistance of the superhydrophobic surface to acidic solutions at room temperature and alkaline solutions at high temperature (80 ℃) was carefully explored.The corrosion resistance mechanism was clarified.Moreover,considering the practical application of the surface in the future,the hardness of the hierarchical micro/nanostructure superhydrophobic surface was studied.The experimental results indicate that the hierarchical micro/nanostructure surface with texture spacing of 100 μm treated at laser scanning speed of 100 mms/ presents superior superhydrophobicity after decreasing surface energy.The contact angle can be as high as 156.6°.Additionally,the superhydrophobic surface provide superior and stable anticorrosive protection for silicon steel in various corrosive environments.More importantly,the prepared structure of the surface shows high hardness,which ensures that the surface of the superhydrophobic surface cannot be destroyed easily.The surface is able to maintain great superhydrophobic performance when it suffers from slight impacting and abrasion. 展开更多
关键词 silicon steel laser marking hierarchical micro/nanostructure superhydrophobic surface corrosion resistance
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Evidence of return of chum salmon released from Tangwang River by strontium marking method 被引量:1
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作者 Jilong Wang Wei Liu +4 位作者 Peilun Li Fujiang Tang Wanqiao Lu Jian Yang Tao Jiang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2021年第8期182-186,共5页
In order to assess the effect of enhancement release of chum salmon(Oncorhynchus keta),otolith strontium(Sr)marking method was used to tag chum salmon released in Tangwang River in 2016.The homing chum salmon were det... In order to assess the effect of enhancement release of chum salmon(Oncorhynchus keta),otolith strontium(Sr)marking method was used to tag chum salmon released in Tangwang River in 2016.The homing chum salmon were detected and the samples were collected in Tangwang River,Ussuri River and Suifen River in the autumn of2018.The samples were analyzed by examining Sr and calcium(Ca)fingerprints in the otolith using electron probe microanalysis.The results suggested that two samples collected in Tangwang River had the marking ring near the core of otolith where the Sr concentration and Sr/Ca ratio were significantly higher than comparative samples.Proving that the two fish belonged to the released population in Tangwang River in 2016.This article indicated the success of the enhancement release of chum salmon from the Tangwang River for the first time and also confirmed the validity of Sr marking in enhancement release of fishes. 展开更多
关键词 chum salmon(Oncorhynchus keta) OTOLITH strontium(Sr)marking enhancement release
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Fragile Watermarking of 3D Models Using Genetic Algorithms
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作者 Mukesh Motwani Rakhi Motwani Frederick Harris 《Journal of Electronic Science and Technology》 CAS 2010年第3期244-250,共7页
This paper describes a novel algorithm for fragile watermarking of 3D models. Fragile watermarking requires detection of even minute intentional changes to the 3D model along with the location of the change. This pose... This paper describes a novel algorithm for fragile watermarking of 3D models. Fragile watermarking requires detection of even minute intentional changes to the 3D model along with the location of the change. This poses a challenge since inserting random amount of watermark in all the vertices of the model would generally introduce perceptible distortion. The proposed algorithm overcomes this challenge by using genetic algorithm to modify every vertex location in the model so that there is no perceptible distortion. Various experimental results are used to justify the choice of the genetic algorithm design parameters. Experimental results also indicate that the proposed algorithm can accurately detect location of any mesh modification. 展开更多
关键词 3D mesh models fragile water- marking genetic algorithms SNR.
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Reasons and countermeasures for “marking problem” during the production of double-walled copper-brazed steel tubes
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作者 YAN Yuanyuan LIANG Gaofei +1 位作者 WANG Guodong LIAN Fuliang 《Baosteel Technical Research》 CAS 2015年第2期55-60,共6页
This study explores the reasons underlying the frequent appearance of "marking problem" during the production of double-walled copper-brazed steel tubes. To this end, we compared two types of copper-coated steel str... This study explores the reasons underlying the frequent appearance of "marking problem" during the production of double-walled copper-brazed steel tubes. To this end, we compared two types of copper-coated steel strips, of which one has almost no problem during production, whereas the other has higher number of incidences of "marking problem". We analyzed the chemical composition,mechanical properties,the cross-sectional metallographs, and surface quality of the trimmed edge in both types of specimen. After the roll forming process, the bonding condition between the steel layers of the tubes before and after brazing process has also been examined. Results indicate that the chemical composition and mechanical properties of the two kinds of strips are similar; however, the edge quality of the trimmed strips is significantly different. It is believed that the irregular shape of the edge portions in the strips will be more pronounced during the bevel treatment. Consequently, smooth and tight seams cannot be guaranteed by such uneven beveled edges,which lead to higher number of incidences of "marking problem" during production. 展开更多
关键词 double-walled copper-brazed marking problem trimmed edge
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基于三圆轨迹规划的MARKⅢ型LNG薄膜舱波纹板机器人焊接
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作者 商泽坤 何建萍 +1 位作者 华学明 李芳 《材料科学与工艺》 CAS CSCD 北大核心 2024年第5期34-41,共8页
MARKⅢ型LNG薄膜舱波纹板的焊接质量是LNG船建造成功与否的关键之一。为了实现MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板的机器人焊接,研究了基于“三圆”连接构思的波纹板机器人焊接的轨迹规划模型,通过模型计算了沿波纹板轨迹焊接过... MARKⅢ型LNG薄膜舱波纹板的焊接质量是LNG船建造成功与否的关键之一。为了实现MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板的机器人焊接,研究了基于“三圆”连接构思的波纹板机器人焊接的轨迹规划模型,通过模型计算了沿波纹板轨迹焊接过程中的焊枪位置和焊枪姿态坐标,并对模型和计算的结果进行了仿真验证;在此基础上,进行了不锈钢波纹板机器人搭接焊的脉冲等离子弧焊的工艺优化研究。结果表明:本文建立的波纹板机器人焊接的“三圆”轨迹规划模型以及基于该模型计算的焊枪位姿坐标准确;基于模型和计算,结合优化后的脉冲等离子弧焊工艺参数,实现了焊缝成形良好的MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板搭接的机器人焊接,焊缝成形达到了法国GTT公司标准文件中提供的成形尺寸标准。 展开更多
关键词 轨迹规划 markⅢ型LNG薄膜舱 304L不锈钢 波纹板 焊接
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Glass Marking with CO<sub>2</sub>Laser: Experimental Study of the Interaction Laser - Material
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作者 Pascal Deprez Ciprian-Florin Melian +1 位作者 Florin Breaban Jean-Francois Coutouly 《Journal of Surface Engineered Materials and Advanced Technology》 2012年第1期32-39,共8页
Laser marking is a laser processing technology used in many fields of industry like automotive [1], aerospace [2], microelectronic [3] and medecine [4]. CO2 laser is an appropriate source for marking glasses [5]. Comp... Laser marking is a laser processing technology used in many fields of industry like automotive [1], aerospace [2], microelectronic [3] and medecine [4]. CO2 laser is an appropriate source for marking glasses [5]. Compared to the other techniques of marking, the principal advantages of the use of the laser are: made inalterable, high degree of accuracy and the smoothness of the features, the possibility of marking at difficult to reach places, and the fact of being able to mark fragile materials like ceramic and glass [6]. In this experimental work, the influence of marking parameters like interaction time laser-glass, laser power, shooting time etc. on the micromarking precision are reported. A “melt” depth prediction model has been established. 展开更多
关键词 LASER GLASS marking Experimental Design
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Optimization Model of Oil-Volume Marking with Tilted Oil Tank
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作者 Wei Xie Xiaojing Wang +1 位作者 Huizhe Cui Jun Chen 《Open Journal of Optimization》 2012年第2期20-24,共5页
In this paper, the relationship model between the oil volume and the vertically tilting parameter (α), the horizontally tilting parameter (β) and the displayed height of oil (h*) is first constructed with the tilted... In this paper, the relationship model between the oil volume and the vertically tilting parameter (α), the horizontally tilting parameter (β) and the displayed height of oil (h*) is first constructed with the tilted oil tank. Then, based on the data of the oil output volume at different time of day, an optimization model of oil-volume marking with tilted oil tank is established. Finally, parameters α = 2.2° and β = 3.05° are estimated by using nonlinear least squares method and the marking number of the tank-volume meter is given. 展开更多
关键词 OPTIMIZATION Model OIL Tank TILT Oil-Volume marking Problem Least SQUARES Method Parameter Estimation
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Degradation of Retro-Reflectivity of Thermoplastic Pavement Markings: A Review
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作者 Victor Owusu Yaw A. Tuffour +1 位作者 Daniel A. Obeng Mohammed Salifu 《Open Journal of Civil Engineering》 2018年第3期301-311,共11页
For an effective thermoplastic pavement marking replacement strategy, the rate at which the marking’s retro-reflectivity deteriorates in service must be well established in order to avoid re-stripping that is too soo... For an effective thermoplastic pavement marking replacement strategy, the rate at which the marking’s retro-reflectivity deteriorates in service must be well established in order to avoid re-stripping that is too soon or too late. Against this background, this paper undertook a review of models that deal with degradation of thermoplastic pavement markings under different traffic and environmental conditions in order to establish service life and the terminal retro-reflectivity levels that have informed re-striping. Service life in the context of this paper is the time taken for a newly-installed marking to degrade to some minimum retro-reflectivity level below which motorists would find it difficult to navigate on the carriageway under night-time and poor visibility conditions. It was established that the minimum retro-reflectivity requiring re-stripping intervention reported varied, although commonly-adopted values tended to range from 50 mcd/m2/lx to 150 mcd/m2/lx. A number of empirical models, based on site specific conditions, have been developed by researchers using field data, to estimate marking retro-reflectivity at any time since placement. Whereas some of the models used time as the only independent variable, others used a combination of time, traffic level and a few other parameters to estimate retro-reflectivity. Even though degradation of marking retro-reflectivity is a reflection, among other things of material degeneration impacted by environmental and service conditions, almost all the models reviewed failed to consider environmental factors. Additionally, for some of the models, non-inclusion of the initial retro-reflectivity level and their generally low coefficient of determination statistic erode the confidence in their reliability. 展开更多
关键词 DEGRADATION Re-Striping Retro-Reflectivity Service Life THERMOPLASTIC PAVEMENT marking
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Movement of Autonomous Vehicles in Work Zone Using New Pavement Marking: A New Approach
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作者 Prashant Singh Md Ahsanul Islam 《Journal of Transportation Technologies》 2020年第3期183-197,共15页
The autonomous vehicles are the future of mobility across the globe and are expected to touch the lives of every person of all ages. But this comes with certain challenges regarding safety, reliability, cost, legal fr... The autonomous vehicles are the future of mobility across the globe and are expected to touch the lives of every person of all ages. But this comes with certain challenges regarding safety, reliability, cost, legal framework, regulations, etc. however, of all the concern safety and reliability are of utmost importance for researchers and engineers. The current research is focused on the movement of the autonomous vehicle in the work zone. The work zone is one of the most challenging areas for the autonomous vehicle to drive from. This is because the work zones are very dynamic, and all the construction activities are specific to the site condition and cannot always be predefined. The study provides a concept of how pavement marking can be used for smooth <span style="font-family:Verdana;">movement through the complicated work zone. In this study, various pav</span><span style="font-family:Verdana;">ement marking signs have been designed as a concept considering the standard colors and striping width being used in the Manual of Uniform Traffic control device (MUTCD). The study assumes that the movement of the autonomous vehicle will not be exclusive and that it will move with the driver driven vehicle. It is expected that autonomous vehicles will require special pavement marking and signage for smooth movement through the work zone. These pavement marking and signage will eventually become part of standard Traffic Control Plans (TCP) and Maintenance of Traffic Plans (MOT). The research aims to study the current research being done in this area and technology being used for detecting various pavement markings and signages.</span> 展开更多
关键词 Autonomous Vehicle Movement in Work Zone Pavement markings MUTCD Traffic Control Plans Maintenance of Traffic Plans Work Zone Safety
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Shaped Refractory Products-Packing, Marking,Transportation and Storage
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《China's Refractories》 CAS 2007年第4期39-41,共3页
1 Scope This standard specifies the technical requirement of the packing, marking, transportation and storage of shaped refractory products.
关键词 Shaped Refractory Products-Packing marking Transportation and Storage GB THAN
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The Inspirations of LIFT on Marking of EFL Writing in Chinese Secondary Classrooms
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作者 于璐梅 《海外英语》 2017年第18期232-233,共2页
What constitutes the most effective marking of EFL learners' writing in secondary schools is still the focus of EFL teachers. Traditional feedback is not as successful as it is expected to be because students have... What constitutes the most effective marking of EFL learners' writing in secondary schools is still the focus of EFL teachers. Traditional feedback is not as successful as it is expected to be because students haven't concerned themselves with the teacher's comments too much.LIFT(Learner Initiated Feedback Technique), as a creative means of enhancing marking, has been tested and adopted in foreign language teaching. Through the introduction of current conditions of marking of EFL writing, selfcorrection, peer-marking and feedback workshop in EFL secondary classrooms are proposed in light of the theory of LIFT. 展开更多
关键词 LIFT marking of EFL writing self-correction peer-marking feedback workshop Chinese secondary classrooms
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运动对孤独症谱系障碍大鼠内侧前额叶皮层树突棘重塑的影响及MARK1/MAP1A/PSD-95通路的作用
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作者 凃耿红 封纪伟 廖八根 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第6期1008-1016,共9页
目的:探讨游泳结合转轮跑步运动干预对丙戊酸(valproic acid,VPA)诱导的孤独症谱系障碍(autism spectrum disorder,ASD)大鼠内侧前额叶皮层树突棘结构重塑的影响,以及微管亲和力调节激酶1(microtubule affinity regulating kinase 1,MAR... 目的:探讨游泳结合转轮跑步运动干预对丙戊酸(valproic acid,VPA)诱导的孤独症谱系障碍(autism spectrum disorder,ASD)大鼠内侧前额叶皮层树突棘结构重塑的影响,以及微管亲和力调节激酶1(microtubule affinity regulating kinase 1,MARK1)、微管相关蛋白1A(microtubule-associated protein 1A,MAP1A)和突触后致密蛋白95(postsynaptic density protein-95,PSD-95)的作用。方法:通过妊娠期VPA或生理盐水暴露的方法收集雄性子代制备ASD模型大鼠及对照大鼠,随机分为运动组和静置组,每组9~11只。采用三箱社交实验评价运动对ASD大鼠社交行为的影响,荧光示踪病毒局部感染观察内侧前额叶皮层亚区边缘前皮层(prelimbic cortex,PrL)和边缘下皮层(infralimbic cortex,IL)树突棘密度和形态,Western blot检测PSD-95和突触小泡蛋白(synaptophysin,Syn)蛋白表达,RNA原位杂交检测MARK1、MAP1A和PSD-95阳性颗粒数及共定位情况。结果:与对照组相比,ASD模型组大鼠社交行为存在缺陷,表现为在陌生大鼠箱体的活动时间、嗅探陌生大鼠的时间和频率均显著减少(P<0.05);经过运动干预后ASD大鼠的社交行为显著改善。树突棘形态观察发现ASD大鼠PrL区而不是IL区总树突棘密度显著增加,主要表现为蘑菇型和短粗型树突棘密度增加(P<0.05);运动干预能有效改善树突棘异常重塑。Western blot发现运动干预能有效逆转ASD大鼠PrL区的PSD-95蛋白表达上升的趋势;而PrL区的Syn及IL区的PSD-95和Syn蛋白表达在各组均无统计学差异。RNA原位杂交发现运动干预能有效降低ASD大鼠PrL区异常增多的MARK1、MAP1A和PSD-95的RNA阳性颗粒数,降低MARK1+MAP1A、MARK1+PSD-95和MAP1A+PSD-95的共定位。结论:运动干预可能通过PrL区MARK1/MAP1A/PSD-95分子通路改善ASD大鼠树突棘结构重塑,从而改善社交相关行为障碍。 展开更多
关键词 孤独症谱系障碍 树突棘 结构重塑 mark1/MAP1A/PSD-95信号通路
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Color Digital Watermarking Based on Amplitude Modulation and SVR 被引量:1
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作者 Yilin Bei Shengju Sang 《通讯和计算机(中英文版)》 2010年第2期37-42,共6页
关键词 彩色数字水印 振幅调制 SVR 支持向量回归 彩色图像水印 人类视觉系统 回归模型 预测技术
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Tourism Invigorates Economy—Notes on Activities Marking '93 Tourism Day
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《China's Foreign Trade》 1994年第1期33-33,共1页
On September 27 this year, in the golden autumn, more than 1,000 overseas travel agents and tourists and over 100 Chinese and foreign reporters converged in Zhengzhou City of China’s Henan Province, and joined thousa... On September 27 this year, in the golden autumn, more than 1,000 overseas travel agents and tourists and over 100 Chinese and foreign reporters converged in Zhengzhou City of China’s Henan Province, and joined thousands of local people in celebrating the ’93 World Tourism Day. World Tourism Day, which was set by the World Tourism Organization in September 1979, is a festival of 展开更多
关键词 World Notes on Activities marking Tourism Day Tourism Invigorates Economy
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