TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental effects.This highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained elusive.Here,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in NSCs.Conditional deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse phenotype.Notably,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate accumulation.Conversely,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this restoration.Furthermore,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO mice.Collectively,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

Explicit K-symplectic methods for nonseparable non-canonical Hamiltonian systems

We propose efficient numerical methods for nonseparable non-canonical Hamiltonian systems which are explicit,K-symplectic in the extended phase space with long time energy conservation properties. They are based on extending the original phase space to several copies of the phase space and imposing a mechanical restraint on the copies of the phase space. Explicit K-symplectic methods are constructed for two non-canonical Hamiltonian systems. Numerical tests show that the proposed methods exhibit good numerical performance in preserving the phase orbit and the energy of the system over long time, whereas higher order Runge–Kutta methods do not preserve these properties. Numerical tests also show that the K-symplectic methods exhibit better efficiency than that of the same order implicit symplectic, explicit and implicit symplectic methods for the original nonseparable non-canonical systems. On the other hand, the fourth order K-symplectic method is more efficient than the fourth order Yoshida’s method, the optimized partitioned Runge–Kutta and Runge–Kutta–Nystr ¨om explicit K-symplectic methods for the extended phase space Hamiltonians, but less efficient than the the optimized partitioned Runge–Kutta and Runge–Kutta–Nystr ¨om extended phase space symplectic-like methods with the midpoint permutation.

A Study of Non-Canonical Lagrangian

Non-canonical Lagrangian (Lagrangian with non-quadratic kinetic term) has been studied in the context of cosmology. In this work, the non-canonical Lagrangian with potential energy term has been discussed. We have obtained the periodic and solitary wave solutions for certain types of potential. The solutions obtained here may provide some new direction in the theory of phase transition, quantum field theory and related phenomena.

Oscillation of Systems of Parabolic Differential Equations with Deviating Arguments

To study a class of boundary value problems of parabolic differential equations with deviating arguments, averaging technique, Green’s formula and symbol function sign(·) are used. The multi dimensional problem was reduced to a one dimensional oscillation problem for ordinary differential equations or inequalities. Two oscillatory criteria of solutions for systems of parabolic differential equations with deviating arguments are obtained.

The Effects of Schema Instruction on Reading Comprehension of English Argumentation

Based on the perspective of the schema theory and modern education technology,In this paper,the method of ran dom experimnet is used to measure how two types of schema instruction‘video clip’and‘multimedia courseware’influence Chinese college students’reading comprehension of English argumentation.The results illustrate the schema instruction can not only develop the students’sensibility of English argumentation structure,but also activate the schema in students’memory.Mul timedia courseware instruction is superior to video clip instruction.The paper proposes its viewpoints concerned.

On a Class of Second Order Differential Inequality with Continuous Distributed Deviating Arguments

Aim To study properties of solutions to a class of second order differential inequality with continuous distributed deviating arguments. Methods A direct analysis technique was used. Results and Conclusion Some sufficient conditions that ensure a class of second order delay differential inequality having no eventually positive solutions were obtained, which generalized some given results. Using the results, some oscillatory criteria for solutions of the hyperbolic equation with distributed deviating arguments can be established.

The Efficacy of Explicit Instruction about Discourse Connectives in English Argumentative Writing on Second-Year Chinese University Students

This study investigated the effect of explicit instruction about DCs in argumentative writings by 15 Chinese learners of English. This study involved in a 4-week experiment. Pre-and post-writing tests were quantitatively analyzed to examine whether the explicit instruction about DCs had a significant effect on the students'argumentative writing. The findings revealed that the ex-plicit instruction of the target DCs facilitated the improvement of the participants in their argumentative writing .

ASP.NET按钮控件中CommandName和CommandArgument用法

在Web页面中,要判断用户单击了一组按钮中的哪个按钮,大多数情况下,可以利用命令按钮提供的CommandName和CommandArgument两个属性来完成。这两个属性是ASP.NET中创建命令按钮控件的两个重要属性,利用它们在程序中传递参数,通过引用参数值可,方便地在同一个事件过程确定哪个按钮被单击了。文章主要围绕CommandName和CommandArgument用法,介绍了如何在Click事件和Command事件中获取值的方法及正确使用它们应该注意的问题。

Periodic Solutions of Mixed Type p-Laplacian Equations with Deviating Arguments

Based on Mansevich-Mawhin continuation theorem and some analysis skill,some sufficient conditions for the existence of periodic solutions for mixed type p-Laplacian equation with deviating arguments are established,which are complement of previously known results.

A UNIFIED CLASS OF ANALYTIC FUNCTIONS WITH FIXED ARGUMENT OF COEFFICIENTS

In this paper we introduce new classes of analytic functions with fixed argument of coefficients defined by subordination. Coefficient estimates, distortion theorems, integral means inequalities, and the radii of convexity and starlikeness are investigated. Convolution properties are also pointed out.

The Existence and Uniqueness of Periodic Solutions for a Kind of Lienard Equation with a Deviating Argument

By means of Mawhin's continuation theorem,we study a kind of lie'nard functional differential equations:x"(t)+f(x(t))x'(t)+g(t,x(t-τ(t))) = e(t).Some new results on the existence and uniqueness of periodic solutions are obtained.

The Application of Thematic Progression in CET-4 Argumentative Writing Teaching

Based on the theoretical foundation of thematic progression construction, this paper introduces several common patterns of thematic progression and attempts to find applicability of patterns of thematic progression in the teaching of CET-4 argumentative writing from the perspective of discourse so as to show the implication of these patterns for the teaching of college English writing.

FLIP AND N-S BIFURCATION BEHAVIOR OF A PREDATOR-PREY MODEL WITH PIECEWISE CONSTANT ARGUMENTS AND TIME DELAY

In this paper, the stability and bifurcation behaviors of a predator-prey model with the piecewise constant arguments and time delay are investigated. Technical approach is fully based on Jury criterion and bifurcation theory. The interesting point is that the model will produce two different branches by limiting branch parameters of different intervals. Besides, image simulation is also given.

ASYMPTOTIC EQUIVALENCE OF ALTERNATELY ADVANCED AND DELAYED DIFFERENTIAL SYSTEMS WITH PIECEWISE CONSTANT GENERALIZED ARGUMENTS

In this paper, we investigate the existence, uniqueness and the asymptotic equiv- alence of a linear system and a perturbed system of differential equations with piecewise alternately advanced and retarded argument of generalized type （DEPCAG）. This is based in the study of an equivalent integral equation with Cauchy and Green matrices type and in a solution of a DEPCAG integral inequality of Gronwall type. Several examples are also given to show the feasibility of results.

New Criteria for Oscillation of Vector Parabolic Equations with Continuous Distribution Arguments

The oscillations of a class of vector parabolic partial differential equations with continuous distribution arguments are studied.By employing the concept of H-oscillation and the method of reducing dimension with inner product,the multi-dimensional oscillation problems are changed into the problems of which one-dimensional functional differential inequalities have not eventually positive solution.Some new sufficient conditions for the H-oscillation of all solutions of the equations are obtained under Dirichlet boundary condition,where H is a unit vector of RM.

Research on the Enhancement of the Argumentative Writing Ability of Medical School Learners through Email

This paper centers on the research on the enhancement of the argumentative writing ability of medical school learners through Email.And in recent years,the argumentative writing has been examined much more frequently that other writing styles in Band-4 Exams.As to how to enhance their argumentative writing ability,the author tries to use Email as a way of communication.Email as an instantaneous communication way,could be used to the utmost in this research.All the data collected for this research is true.The author made a careful analysis.And this paper will give us the result of this practice.

Generalized Central Factorial Numbers with Odd Arguments

In this paper, we consider r-generalization of the central factorial numbers with odd arguments of the first and second kind. Mainly, we obtain various identities and properties related to these numbers. Matrix representation and the relation between these numbers and Pascal matrix are given. Furthermore, the distributions of the signless r-central factorial numbers are derived. In addition, connections between these numbers and the Legendre-Stirling numbers are given.

Argument,Argumentation and Critical Thinking in Academic Writing

Academic writing has been emphasized for years among English major students,and PhD students who need to pub lish their work in English,but few of these people could produce essays academically. The key problem that they are faced with is argument,argumentation and critical thinking in academic writing. These three notions are reviewed and the followed teaching preliminary suggestions are presented in this essay.

Helping Student Develop Argumentative Writing Skills through Rich Feature Analysis

The primary concern of this paper is to address the issue of discrepancies between teachers intuitively defined stronger and weaker student argumentative writings.There exists a problem in Chinese university EFL writing classrooms that the teachers'remarks on student compositions are often found to be rather vague or even unhelpful.Remarks such as Needs further amendment and You wrote just like the way you speak cannot supply students with explicit reasons of what is really needed for their writing improvement.Affirming the dialectal view on text-context relationship held by Systemic Functional Grammar(SFG),the theoretical propositions of Rich Feature Analysis(Barton,2004) are contended to a sound solution to the problem proposed by this paper.To demonstrate its feasibility,the paper followed the gist of Rich Feature Analysis to analyze a corpus of four argumentative writings on same topics.The paper consolidates "the spoken-written continuum"(Barton,2004,p.64),and concludes stronger argumentative writings should own at least one of the following properties: product-like,condensed,recursive,coherent,distanced,and open to scrutiny.The absence of lexical density and nominalization constitutes the main reason for writing deficiencies by tertiary students.The implications for learning the register of schooling are discussed.

An Analysis of the Causal Reasoning Deficiencies in English Majors' Argumentative Writing

The Syllabus for English Majors at Universities and Colleges(2000) makes it clear to further strengthen the English majors' critical thinking and logical reasoning ability.But how to effectively incorporate the cultivation of critical thinking skills into English majors' core courses,such as the writing courses,remains one of the most important tasks of teaching reform for English majors.The present study is aimed at having a systematic analysis on the causal reasoning deficiencies in English majors' argumentative writing.Furthermore,the reasons resulting in the causal reasoning deficiencies and the implications for the teaching of second language writing are explored.