Comparison of ocular biometry in Chinese patients using two swept-source optical coherence tomography devices

Background:To compare two swept-source optical coherence tomography(SS-OCT)biometers,IOLMaster 700 and ANTERION.Methods:This is a retrospective study.Biometric measurements of cataract patients performed between March and July 2021 in the Department of Ophthalmology,United Christian Hospital,Hong Kong,were reviewed.Patients scheduled for cataract surgery were measured with both SS-OCT devices on the same day.The following biometry parameters were compared:keratometry(K),total keratometry(TK),axial length(AL),central corneal thickness(CCT),anterior chamber depth(ACD),lens thickness(LT),white-to-white(WTW)and the predicted intraocular lens(IOL)power to achieve emmetropia.To assess the agreement between the devices,Bland-Altman analysis with 95%limits of agreement(LoA)were used.Results:In total,92 eyes of 47 subjects were measured with both devices.There were statistically significant differences between the two biometers for most measurements(P<0.05)except for flat K,AL and IOL power when using the right eyes for analysis.For the left eyes,there were statistically significant differences in the measurements from the two biometers in all parameters except for flat and steep K.The ANTERION did not obtain ACD,AL and LT in 2(2.17%),1(1.09%)and 5 cases(5.43%)respectively.Conclusions:The two biometers showed a clinically acceptable agreement in most parameters.Comparisons showed significant differences in most parameters but not clinically relevant except for the TK and WTW,and these two parameters should not be used interchangeably between the devices.

Agreements’profile of Scheimpflug-based optical biometer with gold standard partial coherence interferometry

AIM:To determine the agreement of ocular biometric indices including axial length,keratometric readings,anterior chamber depth,and horizontal corneal diameter between the Pentacam AXL and IOL Master 500.METHODS:The study was a large cross-sectional population-based study(Tehran Geriatric Eye Study)conducted from Jan 2019 to Jan 2020.A total of 160 clusters were randomly selected proportional to size(each cluster contained 20 individuals)from 22 strata of Tehran city.All people aged 60y and above were invited to participate in the study.For all participants,preliminary ocular examinations were performed including the measurement of uncorrected and best-corrected visual acuity,objective and subjective refraction,anterior and posterior segment examinations.All participants underwent an ocular biometry using the Pentacam AXL and IOL Master 500.RESULTS:The 95%limits of agreement(LoA)between the two devices were-0.13 to 0.19,-0.15 to 0.17,and-0.13 to 0.19 in normal,pseudophakic,and cataractous eyes,respectively.With increasing the axial length,the difference between the two devices significantly increased in all three groups of normal,pseudophakic,and cataractous eyes(P<0.001).The 95% LoAs between the two devices regarding the mean keratometry shows that the best LoAs were seen in cataractous(-0.33 to 0.81)and followed by normal eyes(-0.36 to 0.86)and the pseudophakic eyes(-0.48 to 0.90)had the widest LoA.The 95% LoAs for horizontal corneal diameter measurements were-0.08 to 0.86,-0.03 to 0.83,and-0.07 to 0.87 in normal,pseudophakic,and cataractous eyes,respectively.The 95% LoAs of anterior chamber depth measurements between the two devices was-0.39 to 0.19 and-0.37 to 0.13 in normal eyes and cataractous,respectively.CONCLUSION:The Pentacam AXL has excellent agreement with the gold standard,IOL Master 500 in measuring axial length.In eyes with cataracts,the difference between the two devices is more scattered.With the increasing of axial length,the difference between the two devices increased,which should be considered when using Pentacam AXL.

Optical biometry intraocular lens power calculation using different formulas in patients with different axial lengths

AIM: To investigate the predictability of intraocular lens (IOL) power calculation using the IOLMaster and different IOL power calculation formulas in eyes with various axial length (AL). METHODS: Patients were included who underwent uneventful phacoemulsification with IOL implantation in the Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan, China from February 2007 to January 2009. Preoperative AL and keratometric values (Ks) were measured by IOLMaster optical biometry. Patients were divided into 3 groups based on AL less than 22mm (Group 1), 22-26mm (Group 2), and more than 26mm (Group 3). The power of the implanted IOL was used to calculate the predicted postoperative spherical equivalence (SE) by various formulas: the Haigis, Hoffer Q, Holladay 1, and SRK/T. The predictive accuracy of each formula was analyzed by comparing the difference between the actual and predicted postoperative SE (MedAE, median absolute error). All the patients had follow-up periods exceeding 3 months. RESULTS: Totally, there were 200 eyes (33 eyes in Group 1, 92 eyes in Group 2, 75 eyes in Group 3). In all patients, the Haigis had the significantly lower MedAE generated by the other formulas (P【0.05). In Group 1 to 3, the MedAE calculated by the Haigis was either significantly lower or comparable to those calculated by the other formulas.CONCLUSION: Compared with other formulas using IOLMaster biometric data, the Haigis formula yields superior refractive results in eyes with various AL.

Impact of ultrasound and optical biometry on refractive outcomes of cataract surgery after penetrating keratoplasty in keratoconus

AIM: To analyse the impact of ultrasound and optical intraocular lens(IOL) calculation methods on refractive outcomes of cataract phacoemulsification performed after penetrating keratoplasty(PK) in keratoconus. METHODS: Phacoemulsification cataract surgery was performed on 42 eyes of 34 patients with keratoconus who had previously undergone PK. The IOL power was determined by using both standard and corneal topography-derived keratometry using the SRK/T formula. We used two independent methods-ultrasound biometry(UB) and interferometry [optical biometry(OB)] for IOL calculation. The analysed data from medical records included demographics, medical history, best corrected visual acuity(BCVA) on Snellen charts, technique of IOL calculation and calculation formula and its impact on final refractive result.RESULTS: BCVA ranged from 0.01 to 0.4(mean 0.09±0.19) before surgery and ranged from 0.2 to 0.7(mean 0.38±0.14) at 1 mo and from 0.2 to 1.0(mean 0.56±0.16)(P<0.05) at 3 mo, postoperatively. The refractive aim differed significantly from the refractive outcome in both the UB and OB groups(P<0.05). There was no statistically significant difference in the accuracy of the two biometry methods.CONCLUSION: The refractive aim in keratoconus eyes post-PK is not achieved with either ultrasound or OB.

Anti-Spoof Reliable Biometry of Fingerprints Using <i>En-Face</i>Optical Coherence Tomography

Optical coherence tomography (OCT) is a relatively new imaging technology which can produce high resolution images of three-dimensional structures. OCT has been mainly used for medical applications such as for ophthalmology and dermatology. In this study we demonstrate its capability in providing much more reliable biometry identification of fingerprints than conventional methods. We prove that OCT can serve secure control of genuine fingerprints as it can detect if extra layers are placed above the finger. This can prevent with a high probability, intruders to a secure area trying to foul standard systems based on imaging the finger surface. En-Face OCT method is employed and recommended for its capability of providing not only the axial succession of layers in depth, but the en-face image that allows the traditional pattern identification. Another reason for using such OCT technology is that it is compatible with dynamic focus and therefore can provide enhanced transversal resolution and sensitivity. Two En-Face OCT systems are used to evaluate the need for high resolution and conclusions are drawn in terms of the most potential commercial route to ex- ploitation.

Refractive Outcomes Using the Lenstar Optical Low Coherence Reflectometry Biometer in Phacovitrectomy for Epiretrinal Membranes and Macular Holes

Objective: To compare refractive outcomes using the Lenstar optical low-coherence reflectometry (OLCR) biometer in the following cases: phacovitrectomy for epiretinal membranes and macular holes (phacovitrectomy group);sequential cataract surgery after prior vitrectomy (sequential-phaco group);routine cataract surgery (phaco-only group). Methods: This study was a retrospective, consecutive comparative series. Main outcomes were mean prediction error (ME) and mean absolute prediction error (MAE). Secondary out-come was the variance in prediction error. Results: ME was significantly more myopic in the phacovitrectomy group (-0.08 ± 0.77D, mean ± SD, p = 0.04) and the sequentialphaco group (-0.09 ± 0.51D, p = 0.01) compared to the phaco-only group (+0.24 ± 0.53D). MAEs were not statistically different across the 3 groups. The phacovitrectomy group had a wider variance in prediction errors compared to the phaco-only group (p = 0.03). Conclusions: There is a myopic shift of approximately -0.3D in both phacovitrectomy and sequential-phaco cases compared to phaco-only cases when using OLCR-based optical biometry. Phacovitrectomy outcomes are more variable compared to phaco-only eyes.

Lens thickness assessment : anterior segment optical coherence tomography versus A-scan ultrasonography

AIMTo assess lens thickness measurements with anterior segment-optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US).METHODSThere were 218 adult subjects (218 eyes) aged 59.2&#x000b1;9.2y enrolled in this prospective cross-sectional study. Forty-three eyes had open angles and 175 eyes had narrow angles. Routine ophthalmic exam was performed and nuclear opacity was graded using the Lens Opacities Classification System III (LOCS III). Lens thickness was measured by AS-OCT (Visante OCT, Carl Zeiss Meditec, Dublin, CA, USA). The highest quality image was selected for each eye and lens thickness was calculated using ImageJ software. Lens thickness was also measured by A-scan US.RESULTSInterclass correlations showed a value of 99.7% for intra-visit measurements and 95.3% for inter-visit measurements. The mean lens thickness measured by AS-OCT was not significantly different from that of A-scan US (4.861&#x000b1;0.404 vs 4.866&#x000b1;0.351 mm, P=0.74). Lens thickness values obtained from the two instruments were highly correlated overall (Pearson correlation coefficient=0.81, P&#x0003c;0.001), and in all LOCS III specific subgroups except in grade 5 of nuclear opacity. Bland-Altman analysis revealed a 95% limit of agreement from -0.45 to 0.46 mm. Lens thickness difference between the two instruments became smaller as the lens thickness increased and AS-OCT yielded smaller values than A-scan US in thicker lens (&#x003b2;=-0.29, P&#x0003c;0.001)CONCLUSIONAS-OCT-derived lens thickness measurement is valid and comparable to the results obtained by A-scan US. It can be used as a reliable noncontact method for measuring lens thickness in adults with or without significant cataract.

基于扫频源OCT技术光学生物测量仪对IOL倾斜测量的可行性评价及倾斜特征分析

目的分析基于扫频源光学相干断层扫描(OCT)技术光学生物测量仪IOLMaster 700评估人工晶状体(IOL)倾斜测量的可行性、IOL倾斜特征及相关影响因素。方法采用横断面研究,纳入2018年7—9月于首都医科大学附属北京同仁医院行白内障超声乳化吸除联合IOL植入术术后患者185例242眼,其中右眼119眼,左眼123眼。采用IOLMaster 700扫描获取眼内IOL位置图像及κ角、α角、角膜曲率、前房深度(ACD)、瞳孔直径(PD)、眼轴长度(AL)等,计算IOL倾斜方向及幅度。采用合并组内相关标准差及组内相关系数计算法评估3次IOL倾斜测量的可重复性。采用Pearson线性相关分析或Spearman秩相关分析评估IOL倾斜的双眼对称性及IOL倾斜与不同影响因素之间的相关关系。IOL倾斜影响因素评估采用多元线性回归分析法。结果IOL倾斜测量具有较好的可重复性,合并组内相关标准差IOL倾斜方向为5.16°,IOL倾斜幅度为0.13°;双眼IOL倾斜具有镜像对称性,右眼IOL倾斜方向为-89.60~87.53°,平均(18.85±29.65)°,倾斜幅度为1.32~7.05°,平均(4.16±1.26)°。左眼IOL倾斜方向为-84.30~89.44°,平均(21.17±32.38)°,倾斜幅度为0.58~7.40°,平均(3.80±1.31)°。右眼和左眼IOL倾斜方向和倾斜幅度之间分别呈中等和弱正相关(r=0.473,P<0.001;r=0.335,P=0.011)。IOL倾斜幅度与α角、IOL屈光度均呈弱正相关(r s=0.272,P=0.003;r=0.285,P=0.002),与ACD、PD、AL呈弱负相关(r=-0.303,P=0.001;r=-0.233,P=0.011;r s=-0.331,P<0.001)。将IOL倾斜幅度与α角、ACD、PD、AL、IOL屈光度纳入多元线性回归分析,采用逐步后退法,建立回归方程为:IOL倾斜幅度=10.503+1.456×α角-0.532×ACD-0.196×AL(R 2=0.400;F=8.588,P<0.001)。结论基于扫频源OCT技术光学生物测量仪可作为IOL倾斜评估的有效方法。IOL倾斜双眼存在镜面对称。

Non-contact optical characterization of negative pressure in hydrogel voids and microchannels

Negative pressure in water under tension,as a thermodynamic non-equilibrium state,has facilitated the emergence of inno-vative technologies on microfluidics,desalination,and thermal management.However,the lack of a simple and accurate method to measure negative pressure hinders further in-depth understanding of the properties of water in such a state.In this work,we propose a non-contact optical method to quantify the negative pressure in micron-sized water voids of a hydrogel film based on the microscale mechanical deformation of the hydrogel itself.We tested three groups of hydrogel samples with different negative pressure inside,and the obtained results fit well with the theoretical prediction.Furthermore,we demonstrated that this method can characterize the distribution of negative pressure,and can thus provide the possibility of investigation of the flow behavior of water in negative pressure.These results prove this technique to be a promising approach to characterization of water under tension and for investigation of its properties under negative pressure.

眼前节成像与生物测量分析系统的最新进展

眼前节成像和生物测量分析系统广泛应用于眼前节疾病的诊断、白内障屈光手术的临床观察、眼前节结构生物参数的测量等。目前国内外许多仪器均能客观地对眼前节进行成像和生物测量,如裂隙灯生物显微镜、超声生物显微镜、光学相干断层扫描等。本次我们就各种最新的眼前节成像和生物测量仪器的原理、各自的特点及其在眼科领域的应用进行综述。

3D-OCT对早期原发性青光眼黄斑区视网膜神经节细胞复合体及神经纤维层结构变化的评估

背景 视网膜神经纤维层（RNFL）变薄被认为是能够检测到的青光眼最早期的改变,3D-OCT对黄斑区神经节细胞复合体（mGCC）厚度的检测使得检测黄斑区节细胞的改变成为可能,为更早发现和诊断青光眼提供思路. 目的 利用3D-OCT检查系统检测早期原发性青光眼mGCC厚度及视盘周围RNFL厚度的变化,评估早期原发性青光眼视神经损害的解剖基础. 方法 对2010年12月至2012年12月在中日友好医院眼科就诊的一眼为中晚期而对侧眼为早期的原发性青光眼的10例患者采集的3D-OCT扫描图像进行回顾性分析.所有患者均符合1987年中国青光眼学组推荐的诊断标准,临床检查资料完整.患者均接受常规眼科检查和眼底3D-OCT检查,分别采用3D-macular模式、3D-macular Wide模式和3D-disc模式对原发性青光眼黄斑区、后极部和视盘进行扫描,利用检查系统自带软件对黄斑6 mm×6 mm区域的扫描结果进行分析,由黄斑中心凹向外各方向等距离分成100个小格区,每个格区面积为0.6 mm×0.6 mm,按照mGCC的变薄程度由重到轻依次以红色、黄色和灰色标记,以每个小格中的数字与其正常值比较得到与颜色匹配的、mGCC变薄程度发生的概率值（依次为P＜1％、P＜5％、P≥5％）表示.然后分析视盘旁RNFL厚度和不同部位的厚度曲线改变,并评估视盘生理凹陷的改变. 结果 10例患者患早期青光眼的眼和对侧眼视细胞层和双极细胞层厚度均未发生改变,而患中晚期青光眼的一侧眼视盘周围RNFL厚度概率图呈红色,即视盘周围RNFL层厚度明显变薄,mGCC厚度概率和黄斑区RNFL厚度概率图呈红色,即mGCC和黄斑区RNFL层厚度明显变薄;而患早期青光眼的一侧眼视野均正常,mGCC厚度概率图和黄斑区RNFL区呈黄色,即mGCC和黄斑区RNFL厚度轻微变薄;视盘周围RNFL厚度概率图呈绿色或黄色,即视盘周围RNFL厚度正常或轻微变薄.结论 原发性青光眼mGCC层厚度变薄早于视盘周围RNFL的变薄,提示青光眼视神经结构的损害始于RGCs的细胞体并早于轴突的损伤或丢失.

光学相干生物测量仪Lenstar LS 900与IOLMaster对眼球生物学参数测量的一致性评价

目的探讨一种最新的光学低相干反射测量仪Lenstar LS900对于眼球生物测量的准确性，将其测量值与光学相干生物测量仪IOLMaster的测量结果进行比较。方法对照观察分别由Lenstar LS900和IOLMaster测量的正常人群眼球的眼轴长度（axial length，AL）、前房深度（anterior chamber depth，ACD）、角膜子午线上下的曲率半径（CR1、CR2）和白对白角膜直径（white—to—white distance，WTW）等眼球生物学参数。结果本研究纳入了206个健康的成年个体（206眼），年龄（26．9±15．6）岁。两种测量仪对于AL、ACD、CR1、CR2，和WTW等测量值的相关程度很高。Lenstar LS900与IOLMaster的测量结果比较，AL差值（0．014±0．090）mm（P=0．025），CR．差值（0．006±0．030）mm（P=0．005），CR，差值（0．020±0．040）mm（P〈0．001），均略长；WTW较短差值（-0．110±0．400）mm（P〈0．001），ACD的差异无统计学意义（P=0．554）。除WTW一致性界限为-0．89～0．67mm外，两种测量仪的测量数据具有良好的一致性。结论与IOLMaster相比较，LenstarLS900可提供同样准确、可靠的眼球生物测量数据（除wTw外），并且可提供中央角膜厚度和晶状体厚度数据，因此LenstarLS900在屈光手术和白内障手术领域有很好的应用前景，能满足未来高质量白内障手术的要求。

两种光学生物测量仪在中国学龄期儿童中应用的比较(英文)

目的：评估一种最新的光学低相干反射测量仪（ Lenstar LS900？ version 1.10）对学龄儿童的眼球生物测量结果的重复性,将其测量值与光学相干生物测量仪（ IOL Master？500 version 7.1）的测量结果进行比较。方法：前瞻性观察比较分别由Lenstar和IOLMaster测量的每个受检者右眼的眼球生物学参数。使用变异系数（coefficientofvariation，CV）评价Lenstar测量结果的重复性，应用Bland-Ahman图对Lenstar和IOLMaster的测量数据进行一致性评价。结果：本研究纳入了110个健康的学龄儿童，平均年龄10．9±2．0岁（年龄6～15岁），54．5％为女性。Lenstar测量结果的重复性很高，其中眼轴长度（axiallength，AL）的CV值最小（CV〈0．1％）。Lenstar与IOLMaster的测量结果比较，AL（23．90±1．28vs23．88±1．27mm，P〈0．001），前房深度（anteriorchamberdepth，ACD）（3．62±0．26vs3．58±0．25mm，P〈0．001）和最大屈光力主子午线上角膜曲率半径CR2（7．58±0．27vs7．56±0．27mm，P〈0．001）均略长。Lenstar和IOLMaster测量数据的95％的一致性界限（1imitsofagreement，LoA）从小到大依次为-0．025至0．053mm（AL），-0-047至0．057mm（最小屈光力主子午线上角膜曲率半径CRl），-0．057至0．102ram（CR2）和-0．083至0．152mm（ACD）。结论：对于学龄儿童，Lenstar可提供重复性很好的眼球生物测量数据（包括AL、ACD和角膜曲率测量值），这些数据与IOLMaster的测量结果之间具有很好的一致性。

原发性闭角型青光眼患者虹膜生物学结构特点

目的观察原发性闭角型青光眼(primary angle closure glaucoma,PACG)患者虹膜生物学结构特点。方法采用眼前段光学相干断层扫描仪(anterior segment optical coherence tomography,AS-OCT),获取PACG组与对照组眼前段图像,采用中山房角分析软件(Zhongshan angle analyze program,ZAAP)对图片进行分析,对比PACG组与对照组虹膜结构参数的差异。结果PACG组患者前房浅、眼轴短、晶状体厚、房角窄及前房宽度小,与对照组相比差异均有显著统计学意义(均为P<0.001)。PACG组虹膜厚度IT750为(0.48±0.15)mm,对照组为(0.43±0.18)mm,PACG大于对照组;PACG组虹膜厚度IT2000为(0.52±0.14)mm,对照组为(0.47±0.16)mm;PACG组虹膜面积为(1.56±0.28)mm2,对照组为(1.50±0.28)mm2;PACG组虹膜弯曲距离为(0.31±0.17)mm,对照组为(0.25±0.12)mm;PACG组瞳孔直径(4.09±1.71)mm,对照组为(4.48±1.71)mm;两组间虹膜厚度、虹膜面积、虹膜弯曲距离、瞳孔直径差异均有显著统计学意义(均为P<0.001)。结论与对照组相比,PACG患者虹膜厚、面积大、虹膜弯曲距离大,虹膜结构参数可能参与PACG发病。

两种光学生物测量仪和接触式A超对高度近视眼球生物学测量的一致性评价

【目的】评估两种光学眼球生物测量仪Lenstar和IOLMaster与超声生物测量对于高度近视眼的眼球生物测量的准确性和一致性。【方法】对照观察分别由Lenstar、IOLMaster和接触式A超测量的高度近视患者的眼球生物学参数。三种方法的比较采用Friedman检验或Wilcoxon符号秩和检验,测量结果的重复性使用变异系数进行评价,采用Bland-Altman分析进行一致性评价。【结果】纳入了66个高度近视患者(66只眼),平均年龄(31.2±12.4)岁。Lenstar、IOLMaster和接触式A超测量的眼轴长度(AL)的变异系数分别为0.05%,0.07%和0.2%。AL的95%一致性界限(Lo A)范围分别为0.12 mm(Lenstar vs.IOLMaster),1.06 mm(Lenstar vs.A-scan),和1.14 mm(IOLMaster vs.A-scan),前房深度(ACD)的95%Lo A分别为0.28 mm(Lenstar vs.IOLMaster),0.51 mm(Lenstar vs.A-scan)和0.52 mm(IOLMaster vs.A-scan)。在极高度近视(AL≥27.0 mm)和巩膜后葡萄肿患眼中也得到相近的重复性和一致性结果。【结论】高度近视眼中,光学测量方法的测量结果一致性很好,能提供比超声生物测量重复性和准确性更好的眼球生物测量数据。

儿童远视和近视眼睫状肌麻痹前后各屈光成分的变化

目的通过测量比较儿童远视和近视眼睫状肌麻痹前后各屈光成分的变化,探讨调节对其屈光成分的影响。方法对520例3～12岁儿童使用1%阿托品散瞳验光,睫状肌麻痹前后均采用光学相干生物测量仪(Zeiss IOL Master)测量眼轴长度、角膜屈光力(K1、K2)、前房深度。对其中远视646眼、近视221眼的睫状肌麻痹前后各屈光成分测量值进行统计对照分析。结果①儿童远视眼睫状肌麻痹后眼轴变短(P=0.01),角膜屈光力变小(K1P=0.01;K2P=0.04),前房深度加深(P=0.00)。②儿童近视眼睫状肌麻痹后前房深度加深(P=0.00),眼轴长度、角膜屈光力无变化。结论儿童远视眼睫状肌麻痹后眼轴变短,角膜屈光力变小,前房加深;儿童近视眼睫状肌麻痹后前房加深,而眼轴长度、角膜屈光力无变化。

光学相干生物测量仪测量人工晶体度数准确性的观察与护理

目的：探讨光学相干生物测量仪（IOL-Master）、A超法测量白内障患者拟植入人工晶体度数的准确性。方法：选取2013年9月-2014年3月我院接收的118例（120眼）老年白内障患者为研究对象,将其随机分为IOL-Master测量组60例（60眼）和A超测量组58例（60眼）。术前分别采用IOL-Master、超声波和自动验光仪测量眼部参数,使用SRK-T公式计算人工晶体度数,术后3个月检查两组患者的屈光状态。结果：术后3个月两组患者测得的平均绝对屈光误差值比较差异有统计学意义（P〈0.05）。结论：IOL-Master检测人工晶体度数具有高准确性、非接触性、操作简单、安全、患者易于接受等特点,临床效果较好,值得推广。

学龄儿童屈光状态检测与屈光参数光学相干生物测量的研究

目的探讨学龄儿童屈光度、性别、眼别、年龄与屈光参数中眼轴长度(axial length,AL)、角膜曲率(corneal curvature,CC)、前房深度(anterior chamber depth,ACD)的关系。方法6~11岁的学龄儿童151例(302眼),在眼科门诊使用复方托品卡胺滴眼液进行快速睫状肌麻痹后,进行医学检影验光确定屈光度;使用光学相干生物测量仪(IOLMaster,Zeiss)测量其眼轴长度、角膜曲率、前房深度,对测量值进行统计分析。结果①学龄儿童的屈光度值在不同性别之间差异无统计学意义(P>0.05),左右眼别之间差异无统计学意义(P>0.05);男性学龄儿童的眼轴明显长于女性(P<0.05),前房深度大于女性(P<0.05),角膜曲率小于女性(P<0.05);②学龄儿童屈光度与眼轴长度、角膜曲率呈负相关;③年龄与眼轴长度、前房深度呈正相关,与角膜曲率无相关性。结论学龄儿童在睫状肌麻痹状态下医学验光,屈光参数在左右眼别之间无差异;屈光度值在不同性别之间无差异,屈光参数在不同性别之间有差异;随着年龄增长,眼轴长度、前房深度增加,角膜曲率无明显变化;学龄儿童近视主要是眼轴长度过度增长所致。

晶星900光学生物测量仪测量近视患者眼轴及中央角膜厚度的准确性评价

目的评价晶星900光学生物测量仪测量近视患者眼轴长度(AL)及中央角膜厚度(CCT)的准确性。方法选取在广西视光中心就诊的近视患者48例(96眼),年龄18～45(26.38±6.03)岁,等效球镜-(1.0～6.75) D。采用晶星900和A超测量AL,用晶星900、A超和Pentacam测量CCT,应用配对t检验比较不同方法测量结果的差异,采用Pearson相关分析评估不同仪器测量结果的相关性,Bland-Altman分析评价不同方法测量结果的一致性。结果晶星900和A超测得的AL分别为(25.21±1.18) mm和(25.09±1.17) mm,差异有统计学意义(P<0.01),两者间呈正相关关系(r=0.982,P<0.01),95%一致性界限为(-0.31～0.10) mm。晶星900、A超和Pentacam测得的CCT分别为(532.55±24.09)μm、(530.03±23.39)μm和(537.64±23.75)μm,差异均有统计学意义(P均<0.01),Pearson相关分析显示晶星900测得的AL与A超(r=0.985,P<0.01)、Pentacam(r=0.956,P<0.01)的结果呈正相关关系,其三者测量CCT的95%界限:A超与晶星900为(-10.6～6.0)μm、晶星900与pentacam为(-14.7～8.4)μm、A超与Pentacam为(-14.8～5.2)μm。结论晶星900与A超所测AL相关性好;晶星900与A超、Pentacam所测量CCT均有明显相关性,其中晶星900与金标准的A超所测得的CCT一致性较好。晶星900可以作为近视患者AL和CCT的非接触式测量工具之一。

非接触式光学相干生物测量仪在高度近视白内障眼人工晶状体度数测量中的应用

目的通过比较非接触式光学相干生物测量仪(IOL-Master)与传统A超联合角膜曲率计测量法对高度近视白内障人工晶状体度数测量的准确性及特点,评价IOL-Master的临床应用价值。方法对78例(共90眼)高度近视且患有白内障的患者术前分别用IOL-Master、接触式A超联合角膜曲率计测量眼轴长度和角膜曲率,使用SRK/T公式计算人工晶状体度数。对患者施行白内障超声乳化吸除术,按A超联合角膜曲率计检查法得出的人工晶状体度数植入注入式人工晶状体。术后1个月随诊检查视力及眼屈光度。结果术前IOL-Master测得的眼轴长度与接触式A超相比差异有统计学意义(P=0.001),而测得的角膜曲率与角膜曲率计相比差异无统计学意义(P=0.067)。术后1个月IOL-Master测得的平均绝对屈光误差值(MAFE)与A超联合角膜曲率计相比差异有统计学意义(P=0.001),且IOL-Master测得的MAFE≤±0.50 D者及≤±1.00 D者均显著高于A超联合角膜曲率计(P<0.05)。结论 IOL-Master是一种操作简单、安全可靠的人工晶状体度数测量工具。与A超相比,IOL-Master对高度近视眼眼轴长度测量精确性较高,对高度近视白内障手术人工晶状体度数的选择有重要意义。