Interference with quorum sensing(QS)represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance.Over the past two deca...Interference with quorum sensing(QS)represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance.Over the past two decades,a novel series of studies have reported that quorum quenching approaches and the discovery of quorum sensing inhibitors(QSIs)have a strong impact on the discovery of anti-infective drugs against various types of bacteria.The discovery of QSI was demonstrated to be an appropriate strategy to expand the anti-infective therapeutic approaches to complement classical antibiotics and antimicrobial agents.For the discovery of QSIs,diverse approaches exist and develop in-step with the scale of screening as well as specific QS systems.This review highlights the latest findings in strategies and methodologies for QSI screening,involving activity-based screening with bioassays,chemical methods to seek bacterial QS pathways for QSI discovery,virtual screening for QSI screening,and other potential tools for interpreting QS signaling,which are innovative routes for future efforts to discover additional QSIs to combat bacterial infections.展开更多
Molybdenum-based materials have been intensively investigated for high-performance gas sensor applications.Particularly,molybdenum oxides and dichalcogenides nanostructures have been widely examined due to their tunab...Molybdenum-based materials have been intensively investigated for high-performance gas sensor applications.Particularly,molybdenum oxides and dichalcogenides nanostructures have been widely examined due to their tunable structural and physicochemical properties that meet sensor requirements.These materials have good durability,are naturally abundant,low cost,and have facile preparation,allowing scalable fabrication to fulfill the growing demand of susceptible sensor devices.Significant advances have been made in recent decades to design and fabricate various molybdenum oxides-and dichalcogenides-based sensing materials,though it is still challenging to achieve high performances.Therefore,many experimental and theoretical investigations have been devoted to exploring suitable approaches which can significantly enhance their gas sensing properties.This review comprehensively examines recent advanced strategies to improve the nanostructured molybdenum-based material performance for detecting harmful pollutants,dangerous gases,or even exhaled breath monitoring.The summary and future challenges to advance their gas sensing performances will also be presented.展开更多
With the ever-spreading of international globalization and much frequent communication among countries in politics, economics and culture. Interpretation which serves as communicative bridge between different language...With the ever-spreading of international globalization and much frequent communication among countries in politics, economics and culture. Interpretation which serves as communicative bridge between different languages, which has become an important inter-lingual communicative device. In order to meet the demand of the growing need for interpreting talents, more and more institutions of higher learning begin to set up translation and interpretation courses for undergraduate and graduate students. The thesis focuses on making a brief analysis on the present situation of interpreting courses of graduate students in Inner Mongolian Autonomous Region. The thesis is composed of three parts： the first part is a brief analysis of the interpreting features of graduate students in Inner Mongolia, the second part analyzes the principles of interpreting training from the perspective of interpretive theory. The third part is the suggestions for interpreting training so as to make a contribution to the teaching of interpreting in Inner Mongolia.展开更多
基金funded by the National Natural Science Foundation of China (Grant No.: 81803812)
文摘Interference with quorum sensing(QS)represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance.Over the past two decades,a novel series of studies have reported that quorum quenching approaches and the discovery of quorum sensing inhibitors(QSIs)have a strong impact on the discovery of anti-infective drugs against various types of bacteria.The discovery of QSI was demonstrated to be an appropriate strategy to expand the anti-infective therapeutic approaches to complement classical antibiotics and antimicrobial agents.For the discovery of QSIs,diverse approaches exist and develop in-step with the scale of screening as well as specific QS systems.This review highlights the latest findings in strategies and methodologies for QSI screening,involving activity-based screening with bioassays,chemical methods to seek bacterial QS pathways for QSI discovery,virtual screening for QSI screening,and other potential tools for interpreting QS signaling,which are innovative routes for future efforts to discover additional QSIs to combat bacterial infections.
基金partly supported by the JSPS Grant-in-Aid for Scientific Research(No.JP16H06439,No.20H00297)by the Dynamic Alliance for Open Innovation Bridging Human,Environment and Materials in Network Joint Research Center for Materialsfinancial grants provided by Indonesia Ministry of Education,Culture,Research,and Technology,under the scheme of Basic Research Program No.2/E1/KP.PTNBH/2021 managed by Institut Teknologi Bandung。
文摘Molybdenum-based materials have been intensively investigated for high-performance gas sensor applications.Particularly,molybdenum oxides and dichalcogenides nanostructures have been widely examined due to their tunable structural and physicochemical properties that meet sensor requirements.These materials have good durability,are naturally abundant,low cost,and have facile preparation,allowing scalable fabrication to fulfill the growing demand of susceptible sensor devices.Significant advances have been made in recent decades to design and fabricate various molybdenum oxides-and dichalcogenides-based sensing materials,though it is still challenging to achieve high performances.Therefore,many experimental and theoretical investigations have been devoted to exploring suitable approaches which can significantly enhance their gas sensing properties.This review comprehensively examines recent advanced strategies to improve the nanostructured molybdenum-based material performance for detecting harmful pollutants,dangerous gases,or even exhaled breath monitoring.The summary and future challenges to advance their gas sensing performances will also be presented.
文摘With the ever-spreading of international globalization and much frequent communication among countries in politics, economics and culture. Interpretation which serves as communicative bridge between different languages, which has become an important inter-lingual communicative device. In order to meet the demand of the growing need for interpreting talents, more and more institutions of higher learning begin to set up translation and interpretation courses for undergraduate and graduate students. The thesis focuses on making a brief analysis on the present situation of interpreting courses of graduate students in Inner Mongolian Autonomous Region. The thesis is composed of three parts： the first part is a brief analysis of the interpreting features of graduate students in Inner Mongolia, the second part analyzes the principles of interpreting training from the perspective of interpretive theory. The third part is the suggestions for interpreting training so as to make a contribution to the teaching of interpreting in Inner Mongolia.
