This article introduces a new normalized nonlocal hybrid level set method for image segmentation.Due to intensity overlapping,blurred edges with complex backgrounds,simple intensity and texture information,such kind o...This article introduces a new normalized nonlocal hybrid level set method for image segmentation.Due to intensity overlapping,blurred edges with complex backgrounds,simple intensity and texture information,such kind of image segmentation is still a challenging task.The proposed method uses both the region and boundary information to achieve accurate segmentation results.The region information can help to identify rough region of interest and prevent the boundary leakage problem.It makes use of normalized nonlocal comparisons between pairs of patches in each region,and a heuristic intensity model is proposed to suppress irrelevant strong edges and constrain the segmentation.The boundary information can help to detect the precise location of the target object,it makes use of the geodesic active contour model to obtain the target boundary.The corresponding variational segmentation problem is implemented by a level set formulation.We use an internal energy term for geometric active contours to penalize the deviation of the level set function from a signed distance function.At last,experimental results on synthetic images and real images are shown in the paper with promising results.展开更多
This is an experimental study conducted on two groups of control and experimental using pretestposttest design, applying psychological intervention on the study sample. The present study aimed to determine the effecti...This is an experimental study conducted on two groups of control and experimental using pretestposttest design, applying psychological intervention on the study sample. The present study aimed to determine the effectiveness of collective education life skills on mental health and resilience of teachers in Zahedan. The population of the study included all teachers at schools with normal students and teachers at schools with exceptional students in Zahedan, among which 60 teachers at normal schools and 20 teachers at exceptional schools were selected and placed in two groups of experimental and control, respectively. Initially, members of the experimental group were taught 10 basic life skills in 10 2-hour sessions. Mental health and resilience questionnaires were distributed and gathered before and after the training sessions. Results indicated the positive effect of life skills training on mental health of teachers at schools with normal students and teachers at schools with exceptional students, which meant that the more the life skills training to teachers at schools with normal students and teachers at schools with exceptional students, the lower their mental health scores would be. Results also indicated the positive effect of life skills training on resilience of teachers at schools with normal students and teachers at schools with exceptional students, which meant that the more the life skills training to teachers at schools with normal students and teachers at schools with exceptional students, the higher their resilience scores would be.展开更多
AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compare...AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compared the treatment response of HCV-infected patients with PNALT to that of patients with non-PNALT.Between February 2010 and April2013,278 patients infected with HCV were enrolled in this study.All of the patients were treated with peginterferon-alpha 2a or 2b plus ribavirin.In addition,180μg of peginterferon alpha-2a or 1.5μg/kg peginterferon alpha-2b per week plus weight-based ribavirin(600-1000 mg/d)were typically administered for 24 wk to HCV genotype 2-infected patients or for 48-72 wk to HCV genotype 1-infected patients.In all of the patients,the IL-28B rs8099917 genotype was determined using a TaqMan single-nucleotide polymorphism assay.HCV RNA was measured using the COBAS TaqMan HCV test.RESULTS:Female patients were dominant in the PNALT group(P【0.0001).Among 72 HCV genotype 1-infected patients with PNALT,the early virologic response(EVR)rates(P【0.01)and the sustained virologic response(SVR)rates(P【0.01)were higher in patients with the IL-28B TT genotype than in those with the IL-28B TG/GG genotype.In HCV genotype 1-infected patients with PNALT,multivariate logistic-regression analysis showed that SVR was independently predicted by the IL-28B rs8099917 TT type(P【0.05)and having an EVR(P【0.01).The IL-28B rs8099917 TT genotype strongly correlated with treatment response in HCV genotype 1-infected Asian patients with PNALT.CONCLUSION:The IL-28B genotype may be useful for selecting HCV genotype 1-infected patients with PNALT who should receive interferon-based treatment.展开更多
The PLIC/SN method that combines the second-order volume tracking method (PLIC-VOF) with the equation of surface normal (SN) vector was recently proposed (M. Sun, “Volume Tracking of Subgrid Particles,” Internationa...The PLIC/SN method that combines the second-order volume tracking method (PLIC-VOF) with the equation of surface normal (SN) vector was recently proposed (M. Sun, “Volume Tracking of Subgrid Particles,” International Journal for Numerical Methods in Fluids, Vol. 66, No. 12, 2011, pp. 1530-1554). The method is able to track the motion of a subgrid particle, but the accuracy is not as good as expected on high resolution grids for vortical flows. In this paper, a simple unsplit multidimensional advection algorithm is coupled with the equation of SN vector. The advection algorithm is formulated as the finite volume method, so that it can be used readily for both structured and unstructured grids while maintaining the exact mass conservation. The new method improves the accuracy significantly for high resolution grids. In the well-known test of the time-resolved vortex problem of T = 2, the circular interface is resolved with an accuracy better than ever using the equation of SN vector.展开更多
基金supported in part by the National Natural Science Foundation of China(11626214,11571309)the General Research Project of Zhejiang Provincial Department of Education(Y201635378)+3 种基金the Zhejiang Provincial Natural Science Foundation of China(LY17F020011)J.Peng is supported by the National Natural Science Foundation of China(11771160)the Research Promotion Program of Huaqiao University(ZQN-PY411)Natural Science Foundation of Fujian Province(2015J01254)
文摘This article introduces a new normalized nonlocal hybrid level set method for image segmentation.Due to intensity overlapping,blurred edges with complex backgrounds,simple intensity and texture information,such kind of image segmentation is still a challenging task.The proposed method uses both the region and boundary information to achieve accurate segmentation results.The region information can help to identify rough region of interest and prevent the boundary leakage problem.It makes use of normalized nonlocal comparisons between pairs of patches in each region,and a heuristic intensity model is proposed to suppress irrelevant strong edges and constrain the segmentation.The boundary information can help to detect the precise location of the target object,it makes use of the geodesic active contour model to obtain the target boundary.The corresponding variational segmentation problem is implemented by a level set formulation.We use an internal energy term for geometric active contours to penalize the deviation of the level set function from a signed distance function.At last,experimental results on synthetic images and real images are shown in the paper with promising results.
文摘This is an experimental study conducted on two groups of control and experimental using pretestposttest design, applying psychological intervention on the study sample. The present study aimed to determine the effectiveness of collective education life skills on mental health and resilience of teachers in Zahedan. The population of the study included all teachers at schools with normal students and teachers at schools with exceptional students in Zahedan, among which 60 teachers at normal schools and 20 teachers at exceptional schools were selected and placed in two groups of experimental and control, respectively. Initially, members of the experimental group were taught 10 basic life skills in 10 2-hour sessions. Mental health and resilience questionnaires were distributed and gathered before and after the training sessions. Results indicated the positive effect of life skills training on mental health of teachers at schools with normal students and teachers at schools with exceptional students, which meant that the more the life skills training to teachers at schools with normal students and teachers at schools with exceptional students, the lower their mental health scores would be. Results also indicated the positive effect of life skills training on resilience of teachers at schools with normal students and teachers at schools with exceptional students, which meant that the more the life skills training to teachers at schools with normal students and teachers at schools with exceptional students, the higher their resilience scores would be.
基金Supported by Grants for Scientific Research from the Ministry of Education,Culture,Sports,Science,and Technology,JapanGrants from the Ministry of Health,Labour and Welfare of Japan
文摘AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compared the treatment response of HCV-infected patients with PNALT to that of patients with non-PNALT.Between February 2010 and April2013,278 patients infected with HCV were enrolled in this study.All of the patients were treated with peginterferon-alpha 2a or 2b plus ribavirin.In addition,180μg of peginterferon alpha-2a or 1.5μg/kg peginterferon alpha-2b per week plus weight-based ribavirin(600-1000 mg/d)were typically administered for 24 wk to HCV genotype 2-infected patients or for 48-72 wk to HCV genotype 1-infected patients.In all of the patients,the IL-28B rs8099917 genotype was determined using a TaqMan single-nucleotide polymorphism assay.HCV RNA was measured using the COBAS TaqMan HCV test.RESULTS:Female patients were dominant in the PNALT group(P【0.0001).Among 72 HCV genotype 1-infected patients with PNALT,the early virologic response(EVR)rates(P【0.01)and the sustained virologic response(SVR)rates(P【0.01)were higher in patients with the IL-28B TT genotype than in those with the IL-28B TG/GG genotype.In HCV genotype 1-infected patients with PNALT,multivariate logistic-regression analysis showed that SVR was independently predicted by the IL-28B rs8099917 TT type(P【0.05)and having an EVR(P【0.01).The IL-28B rs8099917 TT genotype strongly correlated with treatment response in HCV genotype 1-infected Asian patients with PNALT.CONCLUSION:The IL-28B genotype may be useful for selecting HCV genotype 1-infected patients with PNALT who should receive interferon-based treatment.
文摘The PLIC/SN method that combines the second-order volume tracking method (PLIC-VOF) with the equation of surface normal (SN) vector was recently proposed (M. Sun, “Volume Tracking of Subgrid Particles,” International Journal for Numerical Methods in Fluids, Vol. 66, No. 12, 2011, pp. 1530-1554). The method is able to track the motion of a subgrid particle, but the accuracy is not as good as expected on high resolution grids for vortical flows. In this paper, a simple unsplit multidimensional advection algorithm is coupled with the equation of SN vector. The advection algorithm is formulated as the finite volume method, so that it can be used readily for both structured and unstructured grids while maintaining the exact mass conservation. The new method improves the accuracy significantly for high resolution grids. In the well-known test of the time-resolved vortex problem of T = 2, the circular interface is resolved with an accuracy better than ever using the equation of SN vector.