Finite Mixture Normal Models, with Application to Dose-Response Studies

In this paper, we consider the risk assessment problem under multi-levels and multiple mixture subpopulations. Our result is the generalization of the results of [1-5].1 Finite Mixture Normal ModelsIn dose-response studies, a class of phenomena that frequently occur are that experimental subjects (e.g., mice) may have different responses like ’none, mild, severe’ after a toxicant experiment, or ’getting worse, no change, getting better’ after a medical treatment, etc. These phenomena have attracted the attention of many researchers in recent years. Finite

The influence of lipid-extraction on theδ^(13)C of mesopelagic and demersal fish in the South China Sea:modification and application of lipid normalization models

Mesopelagic fish,the most important daily vertically migrating community in the oceans,are characterized by high lipid content which may obscure the interpretation of stable isotopes analysis.Demersal fish,which are important consumers in the food web dominated by mesopelagic fish,also have a high lipid content.Here we collected 127 fish samples from the South China Sea and evaluated the effect of lipid contents on△δ^(13)C of mesopelagic and demersal fish.In lipid-extracted mesopelagic fish,the C/N content ratio(<5.5)shows a clear correlation withΔδ^(13)C(the offset of bulk and lipid-extractedδ^(13)C values),especially in non-migratory and semi-migratory species;these values were less correlation in demersal fish.Based on our results,we suggest that mesopelagic and demersal fish in different regions of the South China Sea should be studied separately using appropriate correction models and less fit for the traditional model.Moreover,the C/N content ratio should be used cautiously for establishing the lipid normalization model,especially for the fish in migratory mesopelagic fish and demersal fish.Our results also reveal that mesopelagic fish across nearby regions could be analyzed together.The new models described here can be applied in future studies of mesopelagic and demersal fish in the South China Sea.

Mixture Normal Models in which the Proportions of Susceptibility are Related to Dose Levels

A problem that frequently occurs in biological experiments with laboratory animals is that some subjects are less susceptible to the treatment group than others. Finite mixture models have traditionally been used to describe the distribution of responses in treated subjects for such studies. In this paper, we first study the mixture normal model with multi-levels and multiple mixture sub-populations under each level, with particular attention being given to the model in which the proportions of susceptibility are related to dose levels, then we use EM-algorithm to find the maximum likelihood estimators of model parameters. Our results are generalizations of the existing results. Finally, we illustrate realistic significance of the above extension based on a set of real dose-response data.

Imprecise Probability Method with the Power-Normal Model for Accelerated Life Testing

We present a new nonparametric predictive inference(NPI)method using a power-normal model for accelerated life testing(ALT).Combined with the accelerating link function and imprecise probability theory,the proposed method is a feasible way to predict the life of the product using ALT failure data.To validate the method,we run a series of simulations and conduct accelerated life tests with real products.The NPI lower and upper survival functions show the robustness of our method for life prediction.This is a continuous research,and some progresses have been made by updating the link function between different stress levels.We also explain how to renew and apply our model.Moreover,discussions have been made about the performance.

三参数Normal-Ogive模型参数估计的SAEM算法

Normal-Ogive模型是项目反应理论的代表性模型之一,其参数估计主要是基于MCMC抽样实现的,但MCMC抽样的不足是计算效率较低。针对这一问题,本文以混合模型(mixture model)的视角,通过变量扩充,提出三参数normalogive(3PNO)模型题目参数估计的随机逼近EM(stochastic approximation EM,简称SAEM)算法,并通过Monte Carlo模拟对SAEM算法的主要影响因素、计算效率、估计的返真性进行验证。模拟研究的结果表明:SAEM算法能够准确实现3PNO模型题目参数估计的计算,并且具有较高的计算效率,表现出优良的计算性质。

EQUIVALENT NORMAL CURVATURE APPROACH MILLING MODEL OF MACHINING FREEFORM SURFACES

A new milling methodology with the equivalent normal curvature milling model machining freeform surfaces is proposed based on the normal curvature theorems on differential geometry. Moreover, a specialized whirlwind milling tool and a 5-axis CNC horizontal milling machine are introduced. This new milling model can efficiently enlarge the material removal volume at the tip of the whirlwind milling tool and improve the producing capacity. The machining strategy of this model is to regulate the orientation of the whirlwind milling tool relatively to the principal directions of the workpiece surface at the point of contact, so as to create a full match with collision avoidance between the workpiece surface and the symmetric rotational surface of the milling tool. The practical results show that this new milling model is an effective method in machining complex three- dimensional surfaces. This model has a good improvement on finishing machining time and scallop height in machining the freeform surfaces over other milling processes. Some actual examples for manufacturing the freeform surfaces with this new model are given.

An improved model of partition curve based on accumulation normal distribution function

Extensive studies based on partition curve of gravity separation have been investigated. All created models are merely used to simulate density distribution at the same size fraction. However, they cannot be used to predictive distribution of materials depending on compound feature of density and size. According to this situation, an improved model of partition curve based on accumulation normal distribution, which was distinguished from conventional model of accumulation normal distribution for partition curve, was proposed in this paper. It could simulate density distribution at different size fractions by using the density-size compound index and conflating the partition curves at different size fractions as one partition curve. The feasibility of three compound indexes, including mass index, settlement index and transformation index, were investigated. Specific forms of the improved model were also proposed. It is found that transformation index leads to the best fitting results, while the fitting error is only 1.75 according to the fitting partition curve.

Joint modelling of location and scale parameters of the skew-normal distribution

Joint location and scale models of the skew-normal distribution provide useful ex- tension for joint mean and variance models of the normal distribution when the data set under consideration involves asymmetric outcomes. This paper focuses on the maximum likelihood estimation of joint location and scale models of the skew-normal distribution. The proposed procedure can simultaneously estimate parameters in the location model and the scale model. Simulation studies and a real example are used to illustrate the proposed methodologies.

Modeling of normal faulting in the subducting plates of the Tonga,Japan,Izu-Bonin and Mariana Trenches:implications for near-trench plate weakening

The plate flexure and normal faulting characteristics along the Tonga, Japan, Izu-Bonin and Mariana Trenches are investigated by combining observations and modeling of elastoplastic deformation of the subducting plate. The observed average trench relief is found to be the smallest at the Japan Trench(3 km) and the largest at the Mariana Trench(4.9 km), and the average fault throw is the smallest at the Japan Trench(113 m) and the largest at the Tonga Trench(284 m). A subducting plate is modeled to bend and generate normal faults subjected to three types of tectonic loading at the trench axis: vertical loading, bending moment, and horizontal tensional force. It is inverted for the solutions of tectonic loading that best fit the observed plate flexure and normal faulting characteristics of the four trenches. The results reveal that a horizontal tensional force(HTF) for the Japan Trench is 33%, 50% and 60% smaller than those of the Mariana, Tonga and Izu-Bonin Trenches, respectively. The normal faults are modeled to penetrate to a maximum depth of 29, 23, 32 and 32 km below the sea floor for the Tonga,Japan, Izu-Bonin and Mariana Trenches, respectively, which is consistent with the depths of relocated normal faulting earthquakes in the Japan and Izu-Bonin Trenches. Moreover, it is argued that the calculated horizontal tensional force is generally positively correlated with the observed mean fault throw, while the integrated area of the reduction in the effective elastic thickness is correlated with the trench relief. These results imply that the HTF plays a key role in controlling the normal faulting pattern and that plate weakening can lead to significant increase in the trench relief.

An Efficient Three-Dimensional Coupled Normal Mode Model and Its Application to Internal Solitary Wave Problems

We present an efficient three-dimensional coupled-mode model based on the Fourier synthesis technique. In principle, this model is a one-way model, and hence provides satisfactory accuracy for problems where the forward scattering dominates. At the same time, this model provides an efficiency gain of an order of magnitude or more over two-way coupled-mode models. This model can be applied to three-dimensional range-dependent problems with a slowly varying bathymetry or internal waves. A numerical example of the latter is demonstrated in this work. Comparisons of both accuracy and efficiency between the present model and a benchmark model are also provided.

ASYMPTOTIC NORMALITY OF PARAMETERSESTIMATION IN EV MODEL WITH REPLICATEDOBSERVATIONS

This paper based on the essay [1], studies in case that replicated observations are available in some experimental points., the parameters estimation of one dimensional linear errors-in-variables (EV) models. Asymptotic normality is established.

A Revision of <i>AIC</i>for Normal Error Models

Conventional Akaike’s Information Criterion (AIC) for normal error models uses the maximum-likelihood estimator of error variance. Other estimators of error variance, however, can be employed for defining AIC for normal error models. The maximization of the log-likelihood using an adjustable error variance in light of future data yields a revised version of AIC for normal error models. It also gives a new estimator of error variance, which will be called the “third variance”. If the model is described as a constant plus normal error, which is equivalent to fitting a normal distribution to one-dimensional data, the approximated value of the third variance is obtained by replacing (n-1) (n is the number of data) of the unbiased estimator of error variance with (n-4). The existence of the third variance is confirmed by a simple numerical simulation.

Study on the Universality of the Normal Cloud Model

The distribution function is an important tool in the study of the stochastic variances. The normal distribution is very popular in the nature and our society. The idea of membership functions is the foundation of the fuzzy sets theory. While the fuzzy theory is widely used, the completely certain membership function that has no any fuzziness at all has been the bottleneck of the applications of this theory. Cloud models are the effective tools in transforming between qualitative concepts and their quantitative expressions. It can represent the fuzziness and randomness and their relations of uncertain concepts. Also cloud models can show the concept granularity in multi-scale spaces by the digital characteristic Entropy (En). The normal cloud model not only broadens the form conditions of the normal distribution but also makes the normal membership function be the expectation of the random membership degree. In this paper, the universality of the normal cloud model is proved, which is more superior and easier, and can fit the fuzziness and gentleness of human cognitive processing. It would be more applicable and universal in the representation of uncertain notions.

Centrifuge modeling of buried continuous pipelines subjected to normal faulting

Seismic ground faulting is the greatest hazard for continuous buried pipelines.Over the years,researchers have attempted to understand pipeline behavior mostly via numerical modeling such as the finite element method.The lack of well-documented field case histories of pipeline failure from seismic ground faulting and the cost and complicated facilities needed for full-scale experimental simulation mean that a centrifuge-based method to determine the behavior of pipelines subjected to faulting is best to verify numerical approaches.This paper presents results from three centrifuge tests designed to investigate continuous buried steel pipeline behavior subjected to normal faulting.The experimental setup and procedure are described and the recorded axial and bending strains induced in a pipeline are presented and compared to those obtained via analytical methods.The influence of factors such as faulting offset,burial depth and pipe diameter on the axial and bending strains of pipes and on ground soil failure and pipeline deformation patterns are also investigated.Finally,the tensile rupture of a pipeline due to normal faulting is investigated.

A parametric bootstrap approach for one-way classification model with skew-normal random effects

In this paper,several properties of one-way classification model with skew-normal random effects are obtained,such as moment generating function,density function and noncentral skew chi-square distribution,etc.Based on the EM algorithm,we discuss the maximum likelihood(ML)estimation of unknown parameters.For testing problem of fixed effect,a parametric bootstrap(PB)approach is developed.Finally,some simulation results on the Type I error rates and powers of the PB approach are obtained,which show that the PB approach provides satisfactory performances on the Type I error rates and powers,even for small samples.For illustration,our main results are applied to a real data problem.

Basic mathematical model for the normal black smoker system and the hydrothermal megaplume formation

A tube model to simulate the normal black smoker system has been built, where the Darcy flow equation, the Ergun equation and the turbulent pipe flow equation are used respectively to describe the dynamic process of different key areas in the hydrothermal circulation system. At the same time, a convection - diffuse Equation for the temperature field is used for describe the exchange of thermal energy and the law of temperature variation. Combining the above facts and using efficient mathematical algorithms and programming with the MatLab programming language, the variation curves of temperature, pressure and mass flow rate are determined, while also the dynamic heat equilibrium and pressure equilibrium within the black smoker system are analyzed. On the basis of the model of the normal black smoker system, a megaplume formation model is further built. For instance, the hydrothermal venting plume on the Juan de Fuca Ridge has been simulated and the simulation results are fairly consistent with Baker＇ s imputed data in 1986. On the basis of the above productive simulation, a series of factors for megaplume formation and the effectiveness of the main parameters of the periodicity of the megaplume formation, temperature and the maximum mass flow rate are systematically discussed. Main conclusions are as follows： The normal black smoker system can evolve into a megaplum eruption. In fact, the passageway of the hydrothermal discharge is blocked by the hydrothermal sediments during the black smoker period, which leads to a hydrothermal fluid accumulation, rise of temperature and increase of buoyancy pressure under the seabed. After a period of 2 - 3 a, the megaplume hydrothermal eruption will occur when the increasing buoyancy pressure is high enough to crack the blockage （cap）. Meanwhile, the temperature of the heat source must exceed 500 ℃, while the highest temperature of the eruption fluid may be high up to 413 ℃, which is fairly consistent with the surveying data. If the temperature of the heat source were to be higher than 500 ℃, then the critical period for the megaplume formation could be obviously curtailed to be less than 1 a, while the critical temperature and the maximum mass flow rate are nearly invariable. As the permeability increases, the maximum mass flow rate increases gradually close to a steady value.

半连续Bernoulli-Normal两部回归模型及变量选择

对于半连续两部回归模型,考虑到每个回归部分都会遇到大量的候选变量,此时就会产生变量选择问题。文章主要研究Bernoulli-Normal两部回归模型的变量选择问题。先提出一种基于Lasso惩罚函数的变量选择方法,但考虑到Lasso估计量不具有Oracle性质,又提出一种基于自适应Lasso惩罚函数的变量选择方法。模拟结果表明:两种方法都能够对Bernoulli-Normal回归模型进行变量选择,且自适应Lasso方法的变量选择性能往往优于Lasso方法。

Modeling of softsphere normal collisions with characteristic of coefficient of restitution dependent on impact velocity

This letter presents a theoretical model of the normal （head-on） collisions between two soft spheres for predicting the experimental characteristic of the coefficient of restitution dependent on impact velocity. After the contact force law between the contacted spheres during a collision is phenomenologically formulated in terms of the compression or overlap displacement under considera- tion of an elastic-plastic loading and a plastic unloading subprocesses, the coefficient of restitution is gained by the dynamic equation of the contact process once an initial impact velocity is input. It is found that the theoretical predictions of the coefficient of restitution varying with the impact velocity are well in agreement with the existing experimental characteristics which are fitted by the explicit formula.

压裂复杂裂缝中支撑剂输送数值模拟研究

在非常规储层水力压裂施工过程中,水力裂缝容易与天然裂缝交汇形成复杂裂缝,支撑剂的运移和铺置形态直接决定了储层的增产效果。为了研究支撑剂在复杂裂缝中的铺置规律,基于欧拉-欧拉方法建立了支撑剂-压裂液两相流数学模型,并利用复杂裂缝室内实验装置与数值模拟的砂堤铺置形态对比的方式进行了模型验证,结果表明,选取的模型可用于研究滑溜水在复杂裂缝内的携带支撑剂的运移铺置规律。以相似准则为基础,建立了简化的复杂裂缝平板模型,并将砂堤形态参数、砂堤面积进行归一化处理,获得了压裂液排量、黏度、支撑剂粒径、裂缝宽度以及裂缝形态对支撑剂在复杂裂缝中铺置的影响规律。结果表明:增大排量、黏度和减小粒径均有利于支撑剂向裂缝深处运移,并且排量对支缝中的砂堤形态影响最明显,但增大排量不利于支撑剂填充近井地带。缝宽的影响体现在壁面效应,在注入时间相同的情况下,当压裂液黏度从1 mPa·s增加到5 mPa·s时,主缝砂堤的归一化长度平均增加了37.9%,归一化高度平均降低了61.4%。裂缝结构越复杂,所有支缝中的支撑剂铺置面积占比越高,分流作用越大。随着复杂裂缝的支缝数量、级数以及支缝延伸长度的增大,支缝中的砂堤高度与长度均有所降低;相对于T1型裂缝,T3和T5型裂缝中的砂堤长度、高度减小最多。