AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compare...AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compared the treatment response of HCV-infected patients with PNALT to that of patients with non-PNALT.Between February 2010 and April2013,278 patients infected with HCV were enrolled in this study.All of the patients were treated with peginterferon-alpha 2a or 2b plus ribavirin.In addition,180μg of peginterferon alpha-2a or 1.5μg/kg peginterferon alpha-2b per week plus weight-based ribavirin(600-1000 mg/d)were typically administered for 24 wk to HCV genotype 2-infected patients or for 48-72 wk to HCV genotype 1-infected patients.In all of the patients,the IL-28B rs8099917 genotype was determined using a TaqMan single-nucleotide polymorphism assay.HCV RNA was measured using the COBAS TaqMan HCV test.RESULTS:Female patients were dominant in the PNALT group(P【0.0001).Among 72 HCV genotype 1-infected patients with PNALT,the early virologic response(EVR)rates(P【0.01)and the sustained virologic response(SVR)rates(P【0.01)were higher in patients with the IL-28B TT genotype than in those with the IL-28B TG/GG genotype.In HCV genotype 1-infected patients with PNALT,multivariate logistic-regression analysis showed that SVR was independently predicted by the IL-28B rs8099917 TT type(P【0.05)and having an EVR(P【0.01).The IL-28B rs8099917 TT genotype strongly correlated with treatment response in HCV genotype 1-infected Asian patients with PNALT.CONCLUSION:The IL-28B genotype may be useful for selecting HCV genotype 1-infected patients with PNALT who should receive interferon-based treatment.展开更多
目的:系统评价中医健康管理改善高血压前期人群健康结局的有效性。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Cochrane Library、PubMed、Web of Science、CINAHL中有关中医“治未病”理论的健康管理...目的:系统评价中医健康管理改善高血压前期人群健康结局的有效性。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Cochrane Library、PubMed、Web of Science、CINAHL中有关中医“治未病”理论的健康管理改善高血压前期人群健康结局的随机对照试验及类实验研究,检索时限为建库至2023年8月10日。由2名研究者进行文献筛选、质量评价及提取资料工作,采用RevMan 5.4及Stata 17软件进行分析。结果:共纳入9项随机对照试验、2项实验研究。干预组收缩压[MD=-5.08,95%CI(-6.44,-3.72),P<0.00001]、舒张压[MD=-3.78,95%CI(-5.13,-2.44),P<0.00001]、头痛发生率[OR=0.35,95%CI(0.25,0.49),P<0.00001]、眩晕发生率[OR=-0.15,95%CI(-0.21,-0.08),P<0.00001]、全血黏度[MD=-1.05,95%CI(-1.14,-0.96),P<0.00001]、甘油三酯[MD=-0.67,95%CI(-0.75,-0.59),P<0.00001]均低于对照组,差异均有统计学意义。结论:基于中医“治未病”理论的健康管理能有效改善高血压前期人群的健康结局,但其模式仍需进一步规范。展开更多
Antiepileptic drugs are the preferred treatment approach for epileptic patients. However, informal treatment is important for intractable epilepsy. In this study, 500 epileptic patients were recruited from the General...Antiepileptic drugs are the preferred treatment approach for epileptic patients. However, informal treatment is important for intractable epilepsy. In this study, 500 epileptic patients were recruited from the General Hospital of Beijing Military Area Command of Chinese PLA during the period of October 2009 to January 2012. These involved patients that had been medically treated for at least 1 year. Information on the initial treatment and changes to treatment regimens for each patient was collected through questionnaires. The survey results showed that 52.3% of the epileptic patients searched for treatment after the first seizure, and the mean numbers of seizures was 12.8; 59.8% of the epileptic patients were diagnosed at the first visit, and the mean onset time was 17 months after the first seizure. After diagnosis, patients were treated for an average of 20 days, and the median time was 1 day. Formal anti-epileptic drugs were selected as the first treatment regimen by 67.8% of patients, and 77.5% of these drugs were monotherapies. The mean and median numbers of seizure were respectively 36.9 and 3.0 times before the first regimen was changed. The regimen was changed within the first 6 months by 46.6% of patients, and after the first and second years of treatment, the proportions increased to 54.0% and 71.8%, respectively. In total, 78.5% of the regi- mens were changed to informal treatments. The informal treatment of epilepsy in China is common, being initiated by either patients or physicians. Enhancing epileptic treatment services in hospital, improving physicians＇ professional quality, and strengthening health propaganda may promote the normalization of drug treatment of epilepsy in China.展开更多
目的分析足月顺产产妇盆底康复治疗时机及治疗效果。方法88例足月顺产产妇,按照随机数字表法分为对照组及研究组,每组44例。两组产妇产后均接受盆底康复治疗,对照组产妇的治疗时间为产后12~20周,研究组产妇的治疗时间则为产后6~12周。...目的分析足月顺产产妇盆底康复治疗时机及治疗效果。方法88例足月顺产产妇,按照随机数字表法分为对照组及研究组,每组44例。两组产妇产后均接受盆底康复治疗,对照组产妇的治疗时间为产后12~20周,研究组产妇的治疗时间则为产后6~12周。比较两组产妇各项基础指标,满意度,治疗前后生活质量评分量表(QOL)评分。结果研究组产妇治疗后的Ⅰ类肌纤维持续收缩压(47.4±0.9)cm H_(2)O(1 cm H_(2)O=0.098 k Pa)、Ⅰ类肌纤维持续时间(18.2±1.1)s、Ⅱ类肌纤维收缩个数(13.9±0.6)个、Ⅱ类肌纤维持续收缩压(49.3±0.5)cm H_(2)O均优于对照组的(45.6±1.8)cm H_(2)O、(16.1±0.8)s、(12.3±0.4)个、(47.2±0.7)cm H_(2)O,差异具有统计学意义(P<0.05)。研究组产妇的治疗总满意度97.73%明显高于对照组的79.55%,差异具有统计学意义(P<0.05)。治疗前,两组产妇的QOL评分比较差异无统计学意义(P>0.05);治疗后,研究组产妇的QOL评分(87.2±1.3)分显著高于对照组的(67.1±2.9)分,差异具有统计学意义(P<0.05)。结论足月顺产产妇在产后6~12周接受盆底康复治疗的效果较好,产妇满意度高,值得推广。展开更多
基金Supported by Grants for Scientific Research from the Ministry of Education,Culture,Sports,Science,and Technology,JapanGrants from the Ministry of Health,Labour and Welfare of Japan
文摘AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compared the treatment response of HCV-infected patients with PNALT to that of patients with non-PNALT.Between February 2010 and April2013,278 patients infected with HCV were enrolled in this study.All of the patients were treated with peginterferon-alpha 2a or 2b plus ribavirin.In addition,180μg of peginterferon alpha-2a or 1.5μg/kg peginterferon alpha-2b per week plus weight-based ribavirin(600-1000 mg/d)were typically administered for 24 wk to HCV genotype 2-infected patients or for 48-72 wk to HCV genotype 1-infected patients.In all of the patients,the IL-28B rs8099917 genotype was determined using a TaqMan single-nucleotide polymorphism assay.HCV RNA was measured using the COBAS TaqMan HCV test.RESULTS:Female patients were dominant in the PNALT group(P【0.0001).Among 72 HCV genotype 1-infected patients with PNALT,the early virologic response(EVR)rates(P【0.01)and the sustained virologic response(SVR)rates(P【0.01)were higher in patients with the IL-28B TT genotype than in those with the IL-28B TG/GG genotype.In HCV genotype 1-infected patients with PNALT,multivariate logistic-regression analysis showed that SVR was independently predicted by the IL-28B rs8099917 TT type(P【0.05)and having an EVR(P【0.01).The IL-28B rs8099917 TT genotype strongly correlated with treatment response in HCV genotype 1-infected Asian patients with PNALT.CONCLUSION:The IL-28B genotype may be useful for selecting HCV genotype 1-infected patients with PNALT who should receive interferon-based treatment.
基金supported by Beijing Natural Science Foundation,No.4132017
文摘Antiepileptic drugs are the preferred treatment approach for epileptic patients. However, informal treatment is important for intractable epilepsy. In this study, 500 epileptic patients were recruited from the General Hospital of Beijing Military Area Command of Chinese PLA during the period of October 2009 to January 2012. These involved patients that had been medically treated for at least 1 year. Information on the initial treatment and changes to treatment regimens for each patient was collected through questionnaires. The survey results showed that 52.3% of the epileptic patients searched for treatment after the first seizure, and the mean numbers of seizures was 12.8; 59.8% of the epileptic patients were diagnosed at the first visit, and the mean onset time was 17 months after the first seizure. After diagnosis, patients were treated for an average of 20 days, and the median time was 1 day. Formal anti-epileptic drugs were selected as the first treatment regimen by 67.8% of patients, and 77.5% of these drugs were monotherapies. The mean and median numbers of seizure were respectively 36.9 and 3.0 times before the first regimen was changed. The regimen was changed within the first 6 months by 46.6% of patients, and after the first and second years of treatment, the proportions increased to 54.0% and 71.8%, respectively. In total, 78.5% of the regi- mens were changed to informal treatments. The informal treatment of epilepsy in China is common, being initiated by either patients or physicians. Enhancing epileptic treatment services in hospital, improving physicians＇ professional quality, and strengthening health propaganda may promote the normalization of drug treatment of epilepsy in China.
文摘目的分析足月顺产产妇盆底康复治疗时机及治疗效果。方法88例足月顺产产妇,按照随机数字表法分为对照组及研究组,每组44例。两组产妇产后均接受盆底康复治疗,对照组产妇的治疗时间为产后12~20周,研究组产妇的治疗时间则为产后6~12周。比较两组产妇各项基础指标,满意度,治疗前后生活质量评分量表(QOL)评分。结果研究组产妇治疗后的Ⅰ类肌纤维持续收缩压(47.4±0.9)cm H_(2)O(1 cm H_(2)O=0.098 k Pa)、Ⅰ类肌纤维持续时间(18.2±1.1)s、Ⅱ类肌纤维收缩个数(13.9±0.6)个、Ⅱ类肌纤维持续收缩压(49.3±0.5)cm H_(2)O均优于对照组的(45.6±1.8)cm H_(2)O、(16.1±0.8)s、(12.3±0.4)个、(47.2±0.7)cm H_(2)O,差异具有统计学意义(P<0.05)。研究组产妇的治疗总满意度97.73%明显高于对照组的79.55%,差异具有统计学意义(P<0.05)。治疗前,两组产妇的QOL评分比较差异无统计学意义(P>0.05);治疗后,研究组产妇的QOL评分(87.2±1.3)分显著高于对照组的(67.1±2.9)分,差异具有统计学意义(P<0.05)。结论足月顺产产妇在产后6~12周接受盆底康复治疗的效果较好,产妇满意度高,值得推广。
