Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.

Objective:The fruit stalk of Schisandra chinensis(Turcz.)Baill.(S.chinensis)has been found to contain bioactive components similar to the fruit of S.chinensis.Here,we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity,which were isolated from the fruit stalk of S.chinensis.Methods:The chemical components of ethyl acetate extract from 70%ethanol extract from S.chinensis fruit stalk were separated,purified,and identified by liquid chromatography methods(silica gel,ODS,HPLC)and extensive spectroscopic analyses(NMR,IR,UV,MS,CD).Results:Two new nortriterpenoids,schilancitrilactone M and 25-hydroxyl schindilactone D(1 and 2),along with ten known nortriterpenoids(3-12)were isolated from the fruit stalk of S.chinensis.The isolated compounds were tested for their cytotoxic activities against MGC-803 cells,and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01,11.77,and 2.74μmol/L,respectively.Conclusion:Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of S.chinensis for the first time.Among them,compounds 6-8 showed significant anti-gastric cancer activities.We postulated that the fruit stalk of S.chinensis could be used as an anti-gastric cancer drug.

Three new nortriterpenoids from Schisandra wilsoniana and their anti-HIV-1 activities

Three new highly oxygenated nortriterpenoids,wilsonianadilactones D-F(1-3),were isolated from the leaves and stems of Schisandra wilsoniana.Their structures were established by means of spectroscopic analysis.Compounds 1-3 showed weak anti-HIV-1 activity with the therapeutic index(TI)values(CC50/EC50)greater than 8.16,14.7,and 17.5,respectively.

A Novel Hexanordammarane Glycoside from the Roots of Panax notoginseng

Notoginsenoside R-111, a novel hexanordammarane glycoside was isolated from the roots of Panax nototginseng, as a minor constituent. Its structure was determined as 6-O-(beta -D-glucopyranosyl)-3 beta ,6 alpha ,12 beta -trihydroxy-22,23,24,25,26,27-hexanordammaran-20-one(1), by means of spectroscopic methods.

A New Nortriterpenoid Glycoside from Sinofranchetia chinensis

A new 30-nortriterpenoid glycopside, 3-O-a-L-arabinopyranosyl-30-norhederagenin 28-O-a-L-rhamnopyranosyl(1-->4)-beta -D-glucopyranosyl (1-->6)-beta -D-glucopyranoside 1, named sinofoside A was isolated from Sinofranchetia chinensis. Its structure was elucidadated by spectra FAB-MS, 2D-NMR including H-1-H-1 COSY, H-1-C-13 COSY, TOSCY, HMBC and NOESY techniques.

A new cycloartane nortriterpenoid from Quercus variabilis Blume

The leaves and stems of Quercus variabilis Blume afforded a new cycloartane nortriterpenoid, 3α-acetyloxy-4α, 14α-dimethyl- 9β, 19-eycloergost-24-oic acid （1）, along with five known compounds （2-6）. The structure of 1 was elucidated by 1D and 2D NMR and mass spectroscopy. 2009 Qi Shi Sun. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

Limonoids from seeds of Azadirachta indica A.Juss. and their cytotoxic activity

Four new limonoid-type nortriterpenoids, 1-detigloyl-1-O-methacryloylsalannin(1), 28-deoxo-2,3-dihydronimbolide(2), 12-acetoxy-3-O-acetyl-7-O-tigloylvilasinin(3) and 12-acetoxy-3-Oacetyl-7-O-methacryloylvilasinin(4), along with five known ones, were isolated from seeds of Azadirachta indica A. Juss. Their structures were elucidated by various spectroscopic methods, including UV, IR, MS, NMR, X-ray crystallography, quantum chemical calculation, as well as by comparison of their spectroscopic data with those reported. In the in vitro cytotoxic assay, 2 showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_(50) value of 7.68±1.74 μmol/L, and 5 inhibited growth of human cervical cancer Hela cell line, melanoma A375 cell line and promyelocytic leukemia HL-60 cell line, with IC_(50) 12.00±2.08, 17.44±2.11, and 13.95±5.74 μmol/L, respectively.