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Exploring the novel role of oligodendrocyte precursor cells in phagocytosis:beyond myelinogenesis
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作者 Gen Hamanaka Ken Arai 《Neural Regeneration Research》 SCIE CAS 2025年第2期473-474,共2页
Roles of oligodendrocyte precursor cells in the central nervous system:Oligodendrocyte precursor cells(OPCs)have long been recognized for their critical role as precursors to oligodendrocytes,the primary myelin-produc... Roles of oligodendrocyte precursor cells in the central nervous system:Oligodendrocyte precursor cells(OPCs)have long been recognized for their critical role as precursors to oligodendrocytes,the primary myelin-producing cells.As precursors,OPCs mature and differentiate into oligodendrocytes,which contribute significantly to the formation of myelin sheaths around axons.This myelination,which is critical for the conduction of salutatory nerve impulses in the cerebral white matter,underscores the classical role of oligodendrocytes in central nervous system(CNS)functionality.Importantly,because oligodendrocytes are differentiated cells that cannot proliferate. 展开更多
关键词 CRITICAL system conduction
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Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma
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作者 Yan Li William Lee +3 位作者 Zhen-Gang Zhao Yi Liu Hao Cui Hao-Yu Wang 《World Journal of Clinical Oncology》 2024年第1期130-144,共15页
BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide.Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell... BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide.Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival,growth,and evolution.Emerging evidence suggests the importance of fatty acid binding proteins(FABPs)in contribution to cancer progression and metastasis;however,how these FABPs are dysregulated in cancer cells,especially in HCC,and the roles of FABPs in cancer progression have not been well defined.AIM To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.METHODS We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma(LIHC)as well as patient cohorts with other cancer types in this study.We investigated genetic alterations of FABPs in various cancer types.mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome,enriched cancer hallmarks and oncogenes previously reported for patients with HCC.We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.RESULTS We discovered that a gene cluster including five FABP family members(FABP4,FABP5,FABP8,FABP9 and FABP12)is frequently co-amplified in cancer.Amplification,in fact,is the most common genetic alteration for FABPs,leading to overexpression of FABPs.FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues.High FABP5 expression correlates well with worse patient outcomes(P<0.05).FABP5 expression highly correlates with enrichment of G2M checkpoint(r=0.33,P=1.1e-10),TP53 signaling pathway(r=0.22,P=1.7e-5)and many genes in the gene sets such as CDK1(r=0.56,P=0),CDK4(r=0.49,P=0),and TP53(r=0.22,P=1.6e-5).Furthermore,FABP5 also correlates well with two co-expressed oncogenes PLK1 and BIRC5 in pan cancer especially in LIHC patients(r=0.58,P=0;r=0.58,P=0;respectively).FABP5high Huh7 cells also expressed higher protein levels of p53,BIRC5,CDK1,CDK2,and CDK4 than FABP5low HepG2 cells.FABP5 inhibition more potently inhibited the tumor cell growth in Huh7 cells than in HepG2 cells.CONCLUSION We discovered that FABP5 gene is frequently amplified in cancer,especially in HCC,leading to its significant elevated expression in HCC.Its high expression correlates well with worse patient outcome,enriched cancer hallmarks and oncogenes in HCC.FABP5 inhibition impaired the cell viability of FABP5high Huh7 cells.All these support that FABP5 is a novel therapeutic target for treating FABP5high HCC. 展开更多
关键词 Hepatocellular carcinoma Fatty acid binding protein novel target AMPLIFICATION Correlated expression
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Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen:Novel viral biomarkers for chronic hepatitis B management
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作者 Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana 《World Journal of Hepatology》 2024年第4期550-565,共16页
The management of hepatitis B virus(HBV)infection now involves regular and appropriate monitoring of viral activity,disease progression,and treatment response.Traditional HBV infection biomarkers are limited in their ... The management of hepatitis B virus(HBV)infection now involves regular and appropriate monitoring of viral activity,disease progression,and treatment response.Traditional HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic effectiveness.Quantitation of HBV core antibodies(qAnti-HBc)is a novel non-invasive biomarker that may help with a variety of diagnostic issues.It was shown to correlate strongly with infection stages,hepatic inflammation and fibrosis,chronic infection exacerbations,and the presence of occult infection.Furthermore,qAnti-HBc levels were shown to be predictive of spontaneous or treatment-induced HBeAg and HBsAg seroclearance,relapse after medication termination,re-infection following liver transplantation,and viral reactivation in the presence of immunosuppression.qAnti-HBc,on the other hand,cannot be relied on as a single diagnostic test to address all problems,and its diagnostic and prognostic potential may be greatly increased when paired with qHBsAg.Commercial qAnti-HBc diagnostic kits are currently not widely available.Because many methodologies are only semi-quantitative,comparing data from various studies and defining universal cut-off values remains difficult.This review focuses on the clinical utility of qAnti-HBc and qHBsAg in chronic hepatitis B management. 展开更多
关键词 Quantitative hepatitis B core antibody Quantitative hepatitis B surface antigen Chronic hepatitis B management novels viral biomarkers
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On Ethical Literary Criticism and Game Theory--An Interview with Professor Nie Zhenzhao
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作者 HUANG Kai-hong NIE Zhen-zhao HE Qiong(Translator) 《Journal of Literature and Art Studies》 2024年第3期207-214,共8页
In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic vi... In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic visiting to Central China Normal University.As early as in 2005,Huang Kaihong conducted an interview with Professor Nie Zhenzhao on the topic of the general introduction of ethical literary criticism.So around 11 years later,the second interview mainly covers not only the ethical literary criticism theory,but the game theory and the relationship between them as well.Professor Nie thinks whether the game theory can be applied to literature research is still under discussion.The theory of ethical literary criticism is a kind of methodology based on science and it can get the attention of literary critics at home and abroad,which is because it fits the practical needs of literary criticism,draws the literary criticism away from only emphasizing criticism genres and the research of criticism terms,and pays attention to the true nature of the literary text in literature research.After consulting Professor Nie Zhenzhao about some related questions from the perspective of game theory.Huang Kaihong gets some significant information concerning literature research and understands the latest core terms and the concrete application method of ethical literary criticism,especially the relationship between the instructing and aesthetic functions of literature. 展开更多
关键词 ethical literary criticism game theory relationship methodology application
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Criticism on the Critical Approaches in J. Hillis Miller's Fiction and Repetition:Seven English Novels
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作者 汤梦颖 《海外英语》 2014年第23期206-209,共4页
Fiction and Repetition is and will remain a distinguished deconstructionist guide of literary criticism. However, after detailed and systematic research, I also find some shortcomings in this important academic work: ... Fiction and Repetition is and will remain a distinguished deconstructionist guide of literary criticism. However, after detailed and systematic research, I also find some shortcomings in this important academic work: Firstly, written in the metaphysical language, Fiction and Repetition can never succeed in escaping the logocentrism and binary opposition inherent in this language.Secondly, based on Saussure's argument on langue, the monograph's view of indeterminacy of literary work's meaning is theoretically correct but practically inadequate. Last but not the least, Miller's proposal on repetition also has some limitations. By taking into account both the work's merits and demerits, we can gain a more comprehensive outlook on Miller's idea of repetition as well as the deconstruction theory of literary criticism in general. 展开更多
关键词 FICTION and REPETITION J.Hillis MILLER criticism d
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An Experimental Method to Read Novels Without Literary Criticism
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作者 周天宇 《海外英语》 2012年第13期202-202,209,共2页
Though novel reading is a common experience to everybody,little has been researched to help average readers to understand a novel.In practice,there are two ways for them to understand a novel:one is to use literary cr... Though novel reading is a common experience to everybody,little has been researched to help average readers to understand a novel.In practice,there are two ways for them to understand a novel:one is to use literary criticism theories and the other is to refer to professional critics'criticism directly.However,the trouble is that the two methods are either time-consuming or far from convincing.In this paper,an experimental reading method is discussed to help average readers enhance reading experience.It aims at reaching the goal of reading without criticism,which,through making clear the aim of reading,putting main focus on the story only,will help readers to have a better understanding of reading. 展开更多
关键词 EXPERIMENTAL method READ novelS LITERARY criticism
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AI绘画软件的创作特征研究——以绘画软件Novel AI生成的动漫人物形象为例 被引量:9
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作者 余青龙 《信阳师范学院学报(哲学社会科学版)》 2023年第3期127-132,共6页
近年来,随着扩散模型、Lora模型、Controlnet等技术应用于绘画领域,现今的AI绘画软件已经能够生成完整的动漫人物,具备了较高的可控性和精确性。文章通过分析AI绘画软件“Novel AI”生成的动漫人物形象,总结了这一AI软件表现出的绘画创... 近年来,随着扩散模型、Lora模型、Controlnet等技术应用于绘画领域,现今的AI绘画软件已经能够生成完整的动漫人物,具备了较高的可控性和精确性。文章通过分析AI绘画软件“Novel AI”生成的动漫人物形象,总结了这一AI软件表现出的绘画创作特征,并在此基础上评估了现今人工智能技术对于动漫创作产生的影响。 展开更多
关键词 AI绘画 novel AI 动漫人物
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Clinical and genetic characteristics of retinoblastoma patients in a single center with four novel RB1 variants 被引量:1
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作者 Özge Vural Hatice Tuba Atalay +5 位作者 Gulsum Kayhan Bercin Tarlan Merve Oral Arzu Okur Faruk GüçlüPınarlı Ceyda Karadeniz 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第8期1274-1279,共6页
AIM:To assess the clinical and genetic characteristics of children diagnosed with retinoblastoma(RB)at Gazi University Faculty of Medicine’s Department of Pediatric Oncology.METHODS:All cases diagnosed with RB and re... AIM:To assess the clinical and genetic characteristics of children diagnosed with retinoblastoma(RB)at Gazi University Faculty of Medicine’s Department of Pediatric Oncology.METHODS:All cases diagnosed with RB and received treatment and follow-up in the Ophthalmology and Pediatric Oncology Department,October 2016 to May 2021 were evaluated retrospectively.The RB1 gene was analyzed by next-generation sequencing(NGS)technique in DNAs obtained from peripheral blood samples of the patients.RESULTS:This study included 53 cases with 67 RBaffected eyes during the study period.The mean age was 24.6(median:18.5,range:3–151)mo.There were 15(22.3%)Group D eyes and 39(58.2%)Group E eyes.The RB1 gene was sequenced by the NGS method in 19 patients.Heterozygous RB1:NM_000321.3:c.54_76del(p.Glu19AlafsTer4)variant was detected in a 15-month-old female with bilateral RB.Heterozygous RB1:NM_000321.3:c.1814+3A>T variant was detected in a 5.5-month-old male with bilateral RB.The intronic RB1:NM_000321.3:c.1332+4A>G variant was detected in patient 14,a 13-month-old male with unilateral RB.The RB1:NM_000321.3:c.575_576del(p.Lys192SerfsTer10)variant was found in an 18-month-old female with an allele frequency of 37%.These variants have not been reported in the literature and mutation databases.CONCLUSION:Four novel variants are described and one of them is found in two different patients.This data is crucial for assessing prognosis.It serves as a guide for estimating the long-term risk of secondary malignancy as well as the short-term risk of developing additional malignancies in the same eye and the other eye. 展开更多
关键词 RETINOBLASTOMA RB1 novel mutations next generation sequencing
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Identification and functional analyses of a novel FOXL2 pathogenic variant causing blepharophimosis, ptosis, and epicanthus inversus syndrome 被引量:1
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作者 Yu-Cheng Yan Lu Zhou Jin-Cai Fan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第5期680-686,共7页
AIM: To discover the molecular pathogenic basis of the blepharophimosis, ptosis, and epicanthus inversus syndrome(BPES), and to predict the clinical subtype according to in vitro experiments, which is significant to t... AIM: To discover the molecular pathogenic basis of the blepharophimosis, ptosis, and epicanthus inversus syndrome(BPES), and to predict the clinical subtype according to in vitro experiments, which is significant to the prognosis.METHODS: A 3-year-old sporadic female patient with typical clinical manifestations of BPES was enrolled. The coding region of forkhead box L2(FOXL2) gene was sequenced, and the functional assays were performed in vitro by Western blotting, subcellular localization experiment, luciferase reporter assay, and quantitative realtime polymerase chain reaction.RESULTS: A novel FOXL2 point pathogenic variant(c.274G>T) was detected, resulting in a truncated protein(p.E92*). Functional studies demonstrated that the FOXL2 pathogenic variant induced the subcellular mislocalization and the abnormal transcriptional activity on promoters of the steroidogenic acute regulatory protein(StAR or STARD1) gene and the odd-skipped related 2 transcription factor(OSR2) gene.CONCLUSION: A novel pathogenic variant is identified to expand the spectrum of the known FOXL2 mutations. The in vitro experiments provide reference data and more insights to the molecular pathogenesis of BPES. The predicted high risk of ovarian insufficiency makes it significant for the patient enrolled to have further follow-up and therapy concerning female endocrinology. 展开更多
关键词 novel mutation pathogenic variant blepharophimosis-ptosis-epicanthus inversus syndrome FOXL2
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Novel combined endoscopic and laparoscopic surgery for advanced T2 gastric cancer:Two case reports 被引量:1
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作者 Jian-Hua Dai Feng Qian +7 位作者 Lei Chen Sen-Lin Xu Xiao-Feng Feng Hong-Bo Wu Yao Chen Zhi-Hong Peng Pei-Wu Yu Gui-Yong Peng 《World Journal of Clinical Cases》 SCIE 2023年第9期2029-2035,共7页
BACKGROUND The standard treatment for advanced T2 gastric cancer(GC)is laparoscopic or surgical gastrectomy(either partial or total)and D2 lymphadenectomy.A novel combined endoscopic and laparoscopic surgery(NCELS)has... BACKGROUND The standard treatment for advanced T2 gastric cancer(GC)is laparoscopic or surgical gastrectomy(either partial or total)and D2 lymphadenectomy.A novel combined endoscopic and laparoscopic surgery(NCELS)has recently been proposed as a better option for T2 GC.Here we describe two case studies demonstrating the efficacy and safety of NCELS.CASE SUMMARY Two T2 GC cases were both resected by endoscopic submucosal dissection and full-thickness resection and laparoscopic lymph nodes dissection.This method has the advantage of being more precise and minimally invasive compared to current methods.The treatment of these 2 patients was safe and effective with no complications.These cases were followed up for nearly 4 years without recurrence or metastasis.CONCLUSION This novel method provides a minimally invasive treatment option for T2 GC,and its potential indications,effectiveness and safety needs to be further evaluated in controlled studies. 展开更多
关键词 novel combined endoscopic and laparoscopic surgery T2 gastric cancer Endoscopic submucosal dissection and full-thickness resection Laparoscopic lymph nodes
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Novel Deletion in Exon 7 of Betaine Aldehyde Dehydrogenase 2(BADH2)
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作者 VAN Quoc Giang HUYNH Ky +5 位作者 NGUYEN Chau Thanh Tung NGUYEN Loc Hien NGUYEN van Manh NGUYEN Nhut Thanh VO Cong Thanh SWEE Keong Yeap 《Rice science》 SCIE CSCD 2023年第2期104-112,I0020-I0030,共20页
The fragrance of rice is one of the premium characteristics that breeders want to include in rice varieties due to the higher market value. Nucleotide deletions in exons 2(7 bp) and 7(8 bp) of Betaine Aldehyde Dehydro... The fragrance of rice is one of the premium characteristics that breeders want to include in rice varieties due to the higher market value. Nucleotide deletions in exons 2(7 bp) and 7(8 bp) of Betaine Aldehyde Dehydrogenase 2(BADH2) are associated with fragrance in rice. In this study, a new 13 bp deletion in exon 7 of the BADH2 gene was discovered in the Nang Thom Cho Dao(NTCD) variety, and the mutation has been closely related to the genetic background of indica subspecies through the Bayesian phylogenetic approach and haplotype network analysis of the 3 000 Rice Genomes Project. In addition, a set of functional markers(EX07-13F, EX07-13RN, and EX07-13RM) identified the 13 bp deletion only within NTCD(no amplified band) compared with both non-aromatic and other aromatic rice varieties(110 bp band). The deletion of 13 bases instead of 8 bases in exon 7 of BADH2 caused a premature stop codon, which down-regulated the expression of the BADH2 transcript while associated with up-regulation of OsP5CS and the high amount of 2-acetyl-1-pyrroline. It is potential to use the deletion in exon 7 of the BADH2 gene as a novel marker for adulteration and breeding of fragrant rice varieties, particularly for NTCD. 展开更多
关键词 novel deletion BADH2 fragrant rice functional marker
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盾构施工诱发临近桥梁安全风险评价 被引量:1
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作者 樊燕燕 王瑞 李子奇 《铁道科学与工程学报》 EI CAS CSCD 北大核心 2024年第1期375-385,共11页
针对地铁盾构施工诱发临近桥梁安全风险评估结果不完善、存在失真等问题,提出一种基于变权可拓云模型的盾构施工诱发临近桥梁安全风险评价方法。首先,结合以往研究基础和实际工程经验,建立盾构施工诱发临近桥梁安全事故机理模型,进而确... 针对地铁盾构施工诱发临近桥梁安全风险评估结果不完善、存在失真等问题,提出一种基于变权可拓云模型的盾构施工诱发临近桥梁安全风险评价方法。首先,结合以往研究基础和实际工程经验,建立盾构施工诱发临近桥梁安全事故机理模型,进而确定孕险环境、致险因子和承险体3个1级指标,其中包括有岩土层物理性能参数、隧道工程条件、盾构施工条件、盾构施工参数、施工管理风险、桥梁现状及桥梁自身条件7个2级指标和内摩擦角、弹性模量等27个3级指标为依据建立盾构施工诱发临近桥梁安全风险评价指标体系。其次,通过改进CRITIC客观赋权法获取评价指标权重,并采用变权可拓云模型构建盾构施工诱发临近桥梁安全风险评价模型,其中引入变权理论得到使评价结果更加科学合理的变化权重。最后,对某市轨道交通1号线一期工程Ⅱ标段沿线桥梁进行实例分析。研究结果表明,4座盾构施工临近桥梁安全风险等级分别为Ⅲ、Ⅱ、Ⅱ、Ⅰ级。其中,该施工场地各项土体指标、隧道覆跨比、隧道埋深、隧道直径及桥桩与隧道的相对位置等指标风险较大,即该段隧道盾构施工时对于桥梁自身情况及其施工场地环境需要重点监测,并严格做好周围土体加固等各项技术措施。研究结果可为盾构施工诱发临近桥梁安全风险防控提供科学有效的参考依据。 展开更多
关键词 盾构施工 临近桥梁 改进CRITIC客观赋权法 变权可拓云模型 风险评价
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Chinese Sources for AfterWards:From Premodern Poetry,Paintings,and Medical Texts to Modern Novels,Film,and Documentaries
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作者 Marta Hanson 《Chinese Medicine and Culture》 2023年第2期127-138,共12页
This paper focuses on Chinese sources suggested for a narrative medicine(NM)program,called AfterWards.Dr Lauren Small established AfterWards in 2014 and has been coordinating it since out of the Pediatrics Department ... This paper focuses on Chinese sources suggested for a narrative medicine(NM)program,called AfterWards.Dr Lauren Small established AfterWards in 2014 and has been coordinating it since out of the Pediatrics Department at Johns Hopkins Medicine.In early 2019,she started giving a series of lectures and workshops about AfterWards to Chinese medical educators and clinicians in Beijing and Shanghai.She created an AfterWards Facilitator’s Guide based on Western-language sources for workshop participants.She also started to organize with Jiang Yuhong(Peking Union Medical College)a workshop for Chinese colleagues to be held at Johns Hopkins Medicine in October 2019.They invited the author to participate.The idea was hatched then to develop Chinese source materials following the AfterWards structure for an updated Facilitator’s Guide that Dr Small had initially written.A typical one-hour AfterWards session consists of a specific five-part structure:a literary text or artwork,an associated theme,discussion topics,a writing exercise,and shared reflection.While the content of the program always changes from session to session,the basic structure remains the same.This paper summarizes the types of Chinese sources and their related narrative-medicine themes that were originally selected for inclusion in the updated AfterWards Facilitator’s Guide intended for Chinese colleagues.These sources about coping with sick family members,aging,and illness ranged from the textual(classical Chinese poems on aging and diagnostic forms for training students)and visual(premodern Chinese paintings and murals of medical encounters)to the fictive(novels)and performative(contemporary Asian-American film in English and Chinese-language film and documentaries). 展开更多
关键词 Documentaries Films MURALS Narrative medicine novelS PAINTINGS POETRY
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Characterization and distribution of novel alleles of the vernalization gene Vrn-A1 in Chinese wheat(Triticum aestivum L.) cultivars
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作者 Bo Zhang Yangyang Guo +3 位作者 Qiru Fan Ruibo Li Dongsheng Chen Xiaoke Zhang 《The Crop Journal》 SCIE CSCD 2023年第3期852-862,共11页
The ability of wheat to adapt to a wide range of environmental conditions is determined mostly by allelic diversity among genes regulating vernalization requirement.Vrn-1 is a major regulator of this requirement.In th... The ability of wheat to adapt to a wide range of environmental conditions is determined mostly by allelic diversity among genes regulating vernalization requirement.Vrn-1 is a major regulator of this requirement.In this study,two novel alleles of Vrn-A1 were discovered in Chinese cultivars:vrn-A1n was identified in two landraces,Jiunong 2 and Ganchun 16,and Vrn-A1o was detected in Duanhongmangmai.Both novel alleles showed a linked duplication in the promoter region.The common copy of these two alleles was identical to the recessive allele vrn-A1.Compared with the recessive allele vrn-A1,the other copy of vrn-A1n contained a 54-bp deletion in the promoter region and the distinct copy of Vrn-A1o contained an11-bp deletion in the promoter region.In segregating populations in the greenhouse under nonvernalizing(20–25°C)and long-day(16 h light)conditions,plants with the novel vrn-A1n allele did not head earlier than those with the recessive vrn-A1 allele.However,plants that were either homozygous or heterozygous for the novel Vrn-A1o allele headed earlier than those with the recessive vrn-A1 allele.To identify the novel allele with the small-sized product and facilitate screening,a DNA marker for the novel dominant allele Vrn-A1o was designed.Analysis of the novel-allele distribution showed that two cultivars carrying the vrn-A1n allele were dispersed in the northwestern spring wheat zone,and 12 cultivars carrying the dominant Vrn-A1o allele were widely distributed in the northwestern spring wheat zone,Xinjiang winter and spring wheat zone,Yellow and Huai River valley winter wheat zone,and QinghaiTibetan Plateau spring and winter wheat zone.Our study identifies useful germplasm and a DNA marker for wheat breeding. 展开更多
关键词 Common wheat Vernalization genes novel alleles DNA marker Heading time
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Exploring Splicing Variants and Novel Genes in Sacred Lotus Based on RNA-seq Data
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作者 Xinyi Zhang Zimeng Yu Pingfang Yang 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第6期1665-1679,共15页
Sacred lotus(Nelumbo nucifera)is a typical aquatic plant,belonging to basal eudicot plant,which is ideal for genome and genetic evolutionary study.Understanding lotus gene diversity is important for the study of molec... Sacred lotus(Nelumbo nucifera)is a typical aquatic plant,belonging to basal eudicot plant,which is ideal for genome and genetic evolutionary study.Understanding lotus gene diversity is important for the study of molecular genetics and breeding.In this research,public RNA-seq data and the annotated reference genome were used to identify the genes in lotus.A total of 26,819 consensus and 1,081 novel genes were identified.Meanwhile,a comprehensive analysis of gene alternative splicing events was conducted,and a total of 19,983“internal”alternative splicing(AS)events and 14,070“complete”AS events were detected in 5,878 and 5,881 multi-exon expression genes,respectively.Observations made from the AS events show the predominance of intron retention(IR)subtype of AS events representing 33%.IR is followed by alternative acceptor(AltA),alternative donor(AltD)and exon skipping(ES),highlighting the universality of the intron definition model in plants.In addition,functional annotations of the gene with AS indicated its relationship to a number of biological processes such as cellular process and metabolic process,showing the key role for alternative splicing in influencing the growth and development of lotus.The results contribute to a better understanding of the current gene diversity in lotus,and provide an abundant resource for future functional genome analysis in lotus. 展开更多
关键词 novel genes alternative splicing intron retention ONTOLOGY
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The Influence of Integrated Chinese and Western Medicine Treatment on the Quality of Life and Laboratory Indicators of Patients with Novel Coronavirus Pneumonia
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作者 Zhenxu Lan Zeduan Liu +2 位作者 Xiaolu Luo Shaoyong Xi Lida Mo 《Journal of Biosciences and Medicines》 2023年第8期18-34,共17页
Objective: To investigate the influence of integrated Chinese and Western medicine treatment on the quality of life and laboratory indicators of patients with novel coronavirus pneumonia (COVID-19). Methods: A prospec... Objective: To investigate the influence of integrated Chinese and Western medicine treatment on the quality of life and laboratory indicators of patients with novel coronavirus pneumonia (COVID-19). Methods: A prospective, self-controlled study was conducted to analyze the changes in corresponding laboratory indicators and quality of life in 75 confirmed COVID-19 patients treated with integrated Chinese and Western medicine in our hospital during the early stage, middle stage, recovery period, and two weeks after discharge. The effectiveness and safety of the treatment regimen were evaluated in conjunction with the time for 2019-nCoV nucleic acid conversion, disease progression, and adverse reactions. Results: The PLT levels in the initial stage were significantly lower than those in the recovery period in 75 patients. The CRP levels in the initial stage were significantly lower than those after discharge for 2 weeks. The TBIL, IBTL, and DHIL levels in the initial stage were significantly lower than those in the middle stage. The K+ levels in the initial stage were significantly lower than those in the recovery period and after discharge for 2 weeks. The LYMGH levels in the initial stage were significantly lower than those in the recovery period and after discharge for 2 weeks. The TP and ALB levels in the initial stage were higher than those in the middle stage and the recovery period. The LDH levels, scores of daily activity limitation, scores of respiratory distress symptoms, scores of psychological emotions, CT imaging scores, and positive rate of nucleic acid were significantly lower than those in the recovery period and after discharge for 2 weeks. The AG, CK, CK-MB, and α-HBDH levels in the initial stage were significantly higher than those in the recovery period. However, the AMY level in the initial stage was significantly lower than that in the recovery period and after discharge for 2 weeks (p Conclusion: Integrated Chinese and Western medicine treatment has a significant impact on laboratory indicators such as PLT, LYMGH, CRP, TBIL, IBTL, DHIL, TP, ALB, K+, AG, LDH, CK, CK-MB, α-HBDH, AMY, CT imaging, and 2019-nCoV nucleic acid in COVID-19 patients. It has good clinical efficacy and safety, and can improve the quality of life of patients. 展开更多
关键词 Western Medicine Treatment Traditional Chinese Medicine Treatment novel Coronavirus Pneumonia Laboratory Indicators Quality of Life
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新质人才培养:数智时代教育的新使命 被引量:16
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作者 祝智庭 戴岭 +1 位作者 赵晓伟 沈书生 《电化教育研究》 北大核心 2024年第1期52-60,共9页
大力培养新质人才是深入实施人才强国战略、加快建设世界重要人才中心和创新高地的行动要义。新质人才所具有的创变思维使其具有了创新恒常性,复合思维使其具有了生态营造性,技术思维使其具有了技术具身性,这就使得他们符合新质生产力... 大力培养新质人才是深入实施人才强国战略、加快建设世界重要人才中心和创新高地的行动要义。新质人才所具有的创变思维使其具有了创新恒常性,复合思维使其具有了生态营造性,技术思维使其具有了技术具身性,这就使得他们符合新质生产力的需要,助力中国式现代化不断开拓发展新赛道。新质人才具有成长心态与高意识学习特质、人机共生思维与AI渗透技能、开拓精神与“破界”能力、创想能力与实践智慧、人文精神与科技合伦行动力、人类共同体思维与跨文化行动力等特质。新质人才的培育需要建构一体化的培养范式,包括:细化融通培养机制,以素养导向的AI教育培育新质后备人才的基础教育;依托智能学科平台,以“AI+X”微专业塑造新质中坚人才的高等教育;建立数字孪生平台,以产教融合认证发展新质技能人才的职业教育。未来的新质人才应当是具有创新潜质的AI原民,新质人才培养思路应推广到新生代(AI原民)人才的培养,致力培植好人才成长的沃土,让新质人才不断涌现。 展开更多
关键词 新质生产力 新质人才 新质学习力 创新能力 AI渗透技能
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Study on Load Bearing Characteristics of Novel Expandable Deepwater Drilling Conductor Based on Laboratory Experiment and Field Test
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作者 ZHANG Ming-he YANG Jin +2 位作者 YANG Yu-xiang XU Dong-sheng ZHOU Yi-su 《China Ocean Engineering》 SCIE EI CSCD 2023年第1期16-28,共13页
A novel expandable conductor was designed and applied in deep-water drilling to improve the vertical and lateral bearing capacity with a significant reduction of conductor jetting depth and soaking time. The vertical ... A novel expandable conductor was designed and applied in deep-water drilling to improve the vertical and lateral bearing capacity with a significant reduction of conductor jetting depth and soaking time. The vertical and lateral bearing capability of expandable conductors was depicted based on the ultimate subgrade reaction method and pile foundation bearing theory. The load-bearing characteristics of a laboratory-scale expandable conductor were analyzed through laboratory experiments. The serial simulation experiments are accomplished to study the bearing characteristics(vertical ultimate bearing capacity, lateral soil pressure, and lateral displacement) during the conductor soaking process. The laboratory experimental results show that the larger the length and thickness of expandable materials are,the higher the bearing capacity of the wellhead will be. During the conductor soaking process, the soil pressure around the three expandable conductors increases faster, strings representing a stronger squeezing effect and resulting in higher vertical bearing capacity. Furthermore, the lateral displacement of novel expandable conductor is smaller than that of the conventional conductor. All the advantages mentioned above contributed to the reduction of conductor’s jetting depth and soaking time. Lastly, the application workflow of a novel expandable deep-water drilling conductor was established and the autonomous expandable conductor was successfully applied in the South China Sea with a significant reduction of conductor’s jetting depth and soaking time. According to the soil properties and designed installation depth of the surface conductor, the arrangement of expandable materials should be designed reasonably to meet the safety condition and reduce the construction cost of the subsea wellhead. 展开更多
关键词 novel expandable surface conductor deep water subsea wellhead laboratory experiment field test
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A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy designed using cluster-plus-glue-atom model for laser additive manufacturing
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作者 Tian-yu Liu Yan-chun Lou +5 位作者 Shuang Zhang Zhi-hao Zhu Jun Zhao Shi-bing Liu Kun Shi Ning Zhao 《China Foundry》 SCIE CAS CSCD 2023年第5期414-422,共9页
A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy was designed using the cluster formula approach(cluster-plus-glue-atom model)and prepared by laser melting deposition(LMD).Its composition formula 12[Al-Ti_(12... A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy was designed using the cluster formula approach(cluster-plus-glue-atom model)and prepared by laser melting deposition(LMD).Its composition formula 12[Al-Ti_(12)](AlTi_(2))+5[Al_(0.8)Si_(0.2)-Ti_(12)Zr_(2)](V_(0.8)Mo_(0.2)Nb_(1)Ti)features an enhancedβ-Ti via co-alloying of Zr,V,Mo,Nb and Si.The experimental results show that the cluster formula ofαandβphases in the novel alloy are respectivelyα-[Al-Ti_(11.5)Zr_(0.5)](Al_(1)Ti_(2))andβ-[Al_(0.8)Si_(0.2)-Ti_(13.2)Zr_(0.8)](V_(1)Mo_(0.4)Nb_(1.6)),both containing Zr elements.The fitted composition via the α andβphase cluster formulas has little difference with the actual alloy composition,suggesting that the validity of cluster-plus-glue-atom model in the alloy composition design.After hot isostatic pressing(HIP),both the Ti-6Al-4V and the novel alloy by LMD are characterized by prior-βcolumnar grains,while the typical<100>texture disappears.Compared with Ti-6Al-4V,Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy exhibits a combination of higher strength(1,056 MPa)and higher ductility(14%)at room temperature and higher strength(580 MPa)at 550℃ after HIP,and can potentially serves as LMD materials. 展开更多
关键词 additive manufacturing laser melting deposition novel titanium alloy composition design cluster-plus-glue-atom model
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A Novel Approach for Optimum Conjunctive Use Management of Groundwater and Surface Water Resources under Uncertainty
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作者 Gislar Edgar Kifanyi 《Open Journal of Modern Hydrology》 CAS 2023年第1期52-75,共24页
Uncertainty in determining optimum conjunctive water use lies not only on variability of hydrological cycle and climate but also on lack of adequate data and perfect knowledge about groundwater-surface water system in... Uncertainty in determining optimum conjunctive water use lies not only on variability of hydrological cycle and climate but also on lack of adequate data and perfect knowledge about groundwater-surface water system interactions, errors in historic data and inherent variability of system parameters both in space and time. Simulation-optimization models are used for conjunctive water use management under uncertain conditions. However, direct application of such approach whereby all realizations are considered at every-iteration of the optimization process leads to a highly computational time-consuming optimization problem as the number of realizations increases. Hence, this study proposes a novel approach—a Retrospective Optimization Approximation (ROA) approach. In this approach, a simulation model was used to determine aquifer system responses (draw-downs) which were assembled as response matrices and incorporated in the optimization model (procedure) as coefficients in the constraints. The sample optimization sub-problems generated, were solved and analyzed through ROA-Active-Set procedure implemented under MATLAB code. The ROA-Active Set procedure solves and evaluates a sequence of sample path optimization sub-problems in an increasing number of realizations. The methodology was applied to a real-world conjunctive water use management problem found in Great Letaba River basin, South Africa. In the River basin, surface water source contributes 87% of the existing un-optimized total conjunctive water use withdrawal rate (6512.04 m<sup>3</sup>/day) and the remaining 13% is contributed by groundwater source. Through ROA approach, results indicate that the optimum percentages contribution of the surface and subsurface sources to the total water demand are 58% and 42% respectively. This implies that the existing percentage contribution can be increased or reduced by ±29% that is groundwater source can be increased by 29% while the surface water source contribution can be reduced by 29%. This reveals that the existing conjunctive water use practice is unsustainable wherein surface water system is overstressed while groundwater system is under-utilized. Through k-means sampling technique ROA-Active Set procedure was able to attain a converged maximum expected total optimum conjunctive water use withdrawal rate of 4.35 × 10<sup>4</sup> m<sup>3</sup>/day within a relatively few numbers of iterations (6 to 8 iterations) in about 2.30 Hrs. In conclusion, results demonstrated that ROA approach is capable of managing real-world regional aquifers sustainable conjunctive water use practice under hydro-geological uncertainty conditions. 展开更多
关键词 A novel Approach Conjunctive Use Management Retrospective Optimization Approximation (ROA) UNCERTAINTY
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