Effects of Diabetes Mellitus upon Sperm Quality Insight into Molecular Level

Diabetes Mellitus is a chronic disease that affects important body organs in a very serious manner. The consequences of this disease turn out to be a significant problem for the patient, who tries to cope with the new condition his organism has been placed in. The most common effect of the disease, hyperglycaemia, leads over time to serious damage to various body systems, such as nerves and blood vessels. What is not widely known among the population is that diabetes may have harmful effects on the reproductive system of the men suffering from diabetes type 1 and 2 and that such a parameter could lead to or might be the reason for infertility problems for couples, for example, miscarriage or embryonic failure. AGEs is a number of products which are believed to play an important role, because their presence has been detected in increased level in diabetic men. This implies that those glycation products might play a key role in diabetic complications. Their receptor, RAGE, member of the immunoglobulin superfamily has been detected in the reproductive tract of diabetic men. Reactive oxygen species (ROS), a possible product of AGEs appear in high levels in seminal plasma and are believed to be the cause of DNA fragmentation. The objective of this review was to gather all the available material i.e. studies on diabetes mellitus in one article, to study the research which has already been conducted and the conclusions that have been drawn, in order to offer, if possible, new pathways and perspectives to the scientists, who focus on fertility problems, sometimes intractable.

Isospin effect in peripheral heavy-ion collisions at Fermi energies

The isospin effect in peripheral heavy-ion collisions was thoroughly investigated within the framework of the Lanzhou quantum molecular dynamics （LQMD） transport model. A coalescence approach was used to recognize the primary fragments formed in nucleus-nucleus collisions. described using the statistical code GEMINI. The production The secondary decay process of these fragments was mechanism and isospin effect of the projectile-like and target-like fragments were analyzed using the combined approach. It was found that the isospin migration from the high-isospin density to the low-density matter occurred in the neutron-rich nuclear reactions, i.e., ^48Ca＋^208Pb, ^86Kr＋^48SCa/^208Pb/^124Sn,^136Xe＋^208Pb, ^124Sn＋^124Sn, and ^136Xe＋^136Xe. A hard symmetry energy was available for creating the neutron-rich fragments, particularly in the medium-mass region. The isospin effect of the neutron-to- proton （n/p） ratio of the complex fragments was reduced when the secondary decay process was included. However, a soft symmetry energy enhanced the n/p ratio of the light particles, particularly at kinetic energies greater than 15 MeV/nucleon.

Azimuthal correlations of hadrons and fragments in nucleus-nucleus collisions

Two-particle （two-fragment） azimuthal correlation functions are studied by using a simple formula which describes uniformly azimuthal distributions of final-state charged particles and nuclear fragments. This formula is obtained in the framework of a multi-source thermal model （or multi-source ideal gas model）. The calculated results are compared and found to be in agreement with the experimental data of charged hadrons and nuclear fragments in nucleus-nucleus collisions at intermediate and high energies.

System size dependence in backward relativistic hadron production in pA and AA collisions

Abstract： In this comprehensive study the multiplicity characteristics of the backward emitted relativistic hadron （shower particle） through hadron-nucleus and nucleus-nucleus are overviewed in three dimensions. These dimensions are the projectile size, target size, and energy. To confirm the universality in this production system, wide ranges of system size and energy （Elab～2.1 A up to 200 A GeV） are used. The multiplicity characteristics of this hadron imply a limiting behavior with respect to the projectile size and energy. The target size is the main effective parameter in this production system. The exponential decay shapes is a characteristic feature of the backward shower particle multiplicity distributions. The decay constant changes with the target size to be nearly 2.02, 1.41, and 1.12 for the interactions with CNO, Era, and AgBr nuclei, respectively, irrespective of the projectile size and energy. While the backward production probability and average multiplicity are constants at different projectile sizes and energies, they can be correlated with the target size in power law relations.