Automated operation and artificial intelligence technology have become essential for ensuring the safety, efficiency, and punctuality of railways, with applications such as ATO (Automatic Train Operation). In this stu...Automated operation and artificial intelligence technology have become essential for ensuring the safety, efficiency, and punctuality of railways, with applications such as ATO (Automatic Train Operation). In this study, the authors propose a method to efficiently simulate the kinematic characteristics of railroad vehicles depending on their speed zone. They utilized the function overloading function supported by a programming language and applied the fourth-order Lunge-Kutta method for dynamic simulation. By constructing an object model, the authors calculated vehicle characteristics and TPS and compared them with actual values, verifying that the developed model represents the real-life vehicle characteristics accurately. The study highlights potential improvements in automated driving and energy consumption optimization in the railway industry.展开更多
Virtual assembly is a Virtual Reality (VR) based engineering application which allows engineers to evaluate, analyze, and plan the assembly of mechanical systems. To model the virtual assembly process, new methodology...Virtual assembly is a Virtual Reality (VR) based engineering application which allows engineers to evaluate, analyze, and plan the assembly of mechanical systems. To model the virtual assembly process, new methodology must be applied. Based on the idea that the virtual assembly system is an event driven system, the interactive behavior and information model is proposed to describe the dynamic process of virtual assembly. Definition of the object-oriented model of virtual assembly is put forward.展开更多
To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these me...To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly age-related.In this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed laser.We observed the molding process in mice of different ages and presented age-dependent vascular embolism differentiation.Moreover,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a stroke.Our imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.展开更多
Object-oriented Petri nets (OPNs) is extended into stochastic object-oriented Petri nets (SOPNs) by associating the OPN of an object with stochastic transitions and introducing stochastic places. The stochastic transi...Object-oriented Petri nets (OPNs) is extended into stochastic object-oriented Petri nets (SOPNs) by associating the OPN of an object with stochastic transitions and introducing stochastic places. The stochastic transition of the SOPNs of a production resources can be used to model its reliability, while the SOPN of a production resource can describe its performance with reliability considered. The SOPN model of a case production system is built to illustrate the relationship between the system's performances and the failures of individual production resources.展开更多
Recently automotive nets are adopted to solve increasing problems in automotive electronic systems.Technologies of automotive local area network from CAN and LIN can solve the problems of the increasing of wire bunch ...Recently automotive nets are adopted to solve increasing problems in automotive electronic systems.Technologies of automotive local area network from CAN and LIN can solve the problems of the increasing of wire bunch weight and lack in module installation space.However,the multilayer automotive nets software becomes more and more complex,and the development expense is difficult to predict and to keep in check.In this paper,the modeling method of hierarchical automotive nets and the substitution operation based on object-oriented colored Petri net(OOCPN) are proposed.The OOCPN model which analyzes the software structure and validates the collision mechanism of CAN/LIN bus can speed the automobile system development.First,the subsystems are divided and modeled by object-oriented Petri net(OOPN).According to the sets of message sharing relations,the message ports among them are set and the communication gate transitions are defined.Second,the OOPN model is substituted step by step until the inner objects in the automotive body control modules(BCM) are indivisible and colored by colored Petri net(CPN).And the color subsets mark the node messages for the collision mechanism.Third,the OOCPN model of the automotive body CAN/LIN nets is assembled,which keeps the message sets and the system can be expanded.The proposed model is used to analyze features of information sharing among the objects,and it is also used to describe each subsystem real-time behavior of processing messages and implemental device controllers operating,and puts forward a reasonable software framework for the automotive body control subsystem.The research can help to design the communication model in the automotive body system effectively and provide a convenient and rapid way for developing the logical hierarchy software.展开更多
Multi-energy systems(MES)involving networks of different energy carriers can support the balancing of fluctuating renewable generation by co-ordinated joint operation.In this paper,an object-oriented modeling methodol...Multi-energy systems(MES)involving networks of different energy carriers can support the balancing of fluctuating renewable generation by co-ordinated joint operation.In this paper,an object-oriented modeling methodology for planning and operations control of MES based on nodal analysis is proposed.The framework provides the modularity to simulate scenarios with varying network configurations.Based on object-oriented programming,classes are formed with regard to common attributes of the network elements.The instances of classes represent physical network elements,such as buses,lines,and power conversion units.The models of the individual network elements involve adjustable and flexible parameters.This is especially advantageous for scenarios with operatingpoint-dependent efficiencies.The overall framework makes use of a uniform description of the model parameters across the diverse energy carriers.Thus,the methodology is particularly suited for the analysis of MES.The applicability of the modeling framework is demonstrated by two use cases involving a technology campus in Berlin.展开更多
In the developing course of the information system, the modeling method of information system and model expressing problem are very important. This paper through discussing the facing object of Petri network, expatiat...In the developing course of the information system, the modeling method of information system and model expressing problem are very important. This paper through discussing the facing object of Petri network, expatiates the basic problem of how to set up the business procedure model on the basis of Petri network, and shows the expressing and storing methods of the model in computer way.展开更多
Modelica-based object-orient method is proved to be rapid, accurate and easy to modify, which is suitable for prototype modeling and simulation of rotor system, whose parameters need to be modified frequently. Classic...Modelica-based object-orient method is proved to be rapid, accurate and easy to modify, which is suitable for prototype modeling and simulation of rotor system, whose parameters need to be modified frequently. Classical non-object-orient method appears to be inefficient because the code is difficult to modify and reuse. An adequate library for object-orient modeling of rotor system with multi-faults is established, a comparison with non-object-orient method on Jeffcott rotor system and a case study on turbo expander with multi-faults are implemented. The relative tolerance between object-orient method and non-object-orient is less than 0.03%, which proves that these two methods are as accurate as each other. Object-orient modeling and simulation is implemented on turbo expander with crack, rub-impact, pedestal looseness and multi-faults simultaneously. It can be conclude from the case study that when acting on compress side of turbo expander separately, expand wheel is not influenced greatly by crack fault, the existence of rub-impact fault forces expand wheel into quasi-periodic motion and the orbit of expand wheel is deformed and enhanced almost 1.5 times due to pedestal looseness. When acting simultaneously, multi-faults cannot be totally decomposed but can be diagnosed from the feature of vibration. Object-orient method can enhance the efficiency of modeling and simulation of rotor system with multi-faults, which provides an efficient method on prototype modeling and simulation.展开更多
BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical management.AIM To develop a synthetic minority oversampling techn...BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical management.AIM To develop a synthetic minority oversampling technique(SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer patients.METHODS In this retrospective cohort study,we analyzed data from 611 elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October 2022.The incidence of postoperative delirium was recorded for 7 d post-surgery.Patients were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not.A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative delirium.The SMOTE technique was applied to enhance the model by oversampling the delirium cases.The model’s predictive accuracy was then validated.RESULTS In our study involving 611 elderly patients with abdominal malignant tumors,multivariate logistic regression analysis identified significant risk factors for postoperative delirium.These included the Charlson comorbidity index,American Society of Anesthesiologists classification,history of cerebrovascular disease,surgical duration,perioperative blood transfusion,and postoperative pain score.The incidence rate of postoperative delirium in our study was 22.91%.The original predictive model(P1)exhibited an area under the receiver operating characteristic curve of 0.862.In comparison,the SMOTE-based logistic early warning model(P2),which utilized the SMOTE oversampling algorithm,showed a slightly lower but comparable area under the curve of 0.856,suggesting no significant difference in performance between the two predictive approaches.CONCLUSION This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of traditional methods,effectively addressing data imbalance.展开更多
Macrosegregation is a critical factor that limits the mechanical properties of materials.The impact of equiaxed crystal sedimentation on macrosegregation has been extensively studied,as it plays a significant role in ...Macrosegregation is a critical factor that limits the mechanical properties of materials.The impact of equiaxed crystal sedimentation on macrosegregation has been extensively studied,as it plays a significant role in determining the distribution of alloying elements and impurities within a material.To improve macrosegregation in steel connecting shafts,a multiphase solidification model that couples melt flow,heat transfer,microstructure evolution,and solute transport was established based on the volume-averaged Eulerian-Eulerian approach.In this model,the effects of liquid phase,equiaxed crystals,columnar dendrites,and columnar-to-equiaxed transition(CET)during solidification and evolution of microstructure can be considered simultaneously.The sedimentation of equiaxed crystals contributes to negative macrosegregation,where regions between columnar dendrites and equiaxed crystals undergo significant A-type positive macrosegregation due to the CET.Additionally,noticeable positive macrosegregation occurs in the area of final solidification in the ingot.The improvement in macrosegregation is beneficial for enhancing the mechanical properties of connecting shafts.To mitigate the thermal convection of molten steel resulting from excessive superheating,reducing the superheating during casting without employing external fields or altering the design of the ingot mold is indeed an effective approach to control macrosegregation.展开更多
The exploration of Mars would heavily rely on Martian rocks mechanics and engineering technology.As the mechanical property of Martian rocks is uncertain,it is of utmost importance to predict the probability distribut...The exploration of Mars would heavily rely on Martian rocks mechanics and engineering technology.As the mechanical property of Martian rocks is uncertain,it is of utmost importance to predict the probability distribution of Martian rocks mechanical property for the success of Mars exploration.In this paper,a fast and accurate probability distribution method for predicting the macroscale elastic modulus of Martian rocks was proposed by integrating the microscale rock mechanical experiments(micro-RME),accurate grain-based modeling(AGBM)and upscaling methods based on reliability principles.Firstly,the microstructure of NWA12564 Martian sample and elastic modulus of each mineral were obtained by micro-RME with TESCAN integrated mineral analyzer(TIMA)and nanoindentation.The best probability distribution function of the minerals was determined by Kolmogorov-Smirnov(K-S)test.Secondly,based on best distribution function of each mineral,the Monte Carlo simulations(MCS)and upscaling methods were implemented to obtain the probability distribution of upscaled elastic modulus.Thirdly,the correlation between the upscaled elastic modulus and macroscale elastic modulus obtained by AGBM was established.The accurate probability distribution of the macroscale elastic modulus was obtained by this correlation relationship.The proposed method can predict the probability distribution of Martian rocks mechanical property with any size and shape samples.展开更多
Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth environment.However,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but...Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth environment.However,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by sunlight.Nightglow emissions and scattered sunlight can contribute to the background signal.To fully utilize such images in space science,background contamination must be removed to isolate the auroral signal.Here we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical harmonics.The approach is robust,flexible,and iteratively deselects outliers,such as auroral emissions.The final model is smooth across the terminator and accounts for slow temporal variations and large-scale asymmetries in the dayglow.We demonstrate the model by using the three far ultraviolet cameras on the Imager for Magnetopause-to-Aurora Global Exploration(IMAGE)mission.The method can be applied to historical missions and is relevant for upcoming missions,such as the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.展开更多
Object-oriented programming divides the crop production into subsystems and simulates their behaviors. Many classes were designed to simulate the behaviors of different parts or different physiological processes in cr...Object-oriented programming divides the crop production into subsystems and simulates their behaviors. Many classes were designed to simulate the behaviors of different parts or different physiological processes in crop production system. At the same time, many classes have to be employed for bettering user's interface. But how to manage these classes on a higher level to cooperate them into a perfect system is another problem to study. The Rice Growth Models (RGM) system represents an effort to define and implement a framework to manage these classes. In RGM system, the classes were organized into the model-document-view architecture to separate the domain models, data management and user interface. A single document with multiple views interface frame window was adopted in RGM. In the architectures, the simulation models only exchange data with documents while documents act as intermediacies between simulation models and interfaces. Views get data from documents and show the results to users. The classes for the different functions can be grouped into different architectures. Different architectures communicate with each other through documents. The classes for the different functions can be grouped into different architectures. By using the architecture, communication between classes is more efficient. Modeler can add classes in architectures or other architectures to extend the system without having to change system structure, which is useful for construction and maintenance of agricultural system models.展开更多
Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated soils.Traditional pure data-driven methods(e.g.deep neural network,DNN)can provide rapid predictions,but t...Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated soils.Traditional pure data-driven methods(e.g.deep neural network,DNN)can provide rapid predictions,but they do require sufficient on-site data for accurate training,and lack interpretability to the physical processes within the data.In this paper,we provide a physics and equalityconstrained artificial neural network(PECANN),to derive unsaturated infiltration solutions with a small amount of initial and boundary data.PECANN takes the physics-informed neural network(PINN)as a foundation,encodes the unsaturated infiltration physical laws(i.e.Richards equation,RE)into the loss function,and uses the augmented Lagrangian method to constrain the learning process of the solutions of RE by adding stronger penalty for the initial and boundary conditions.Four unsaturated infiltration cases are designed to test the training performance of PECANN,i.e.one-dimensional(1D)steady-state unsaturated infiltration,1D transient-state infiltration,two-dimensional(2D)transient-state infiltration,and 1D coupled unsaturated infiltration and deformation.The predicted results of PECANN are compared with the finite difference solutions or analytical solutions.The results indicate that PECANN can accurately capture the variations of pressure head during the unsaturated infiltration,and present higher precision and robustness than DNN and PINN.It is also revealed that PECANN can achieve the same accuracy as the finite difference method with fewer initial and boundary training data.Additionally,we investigate the effect of the hyperparameters of PECANN on solving RE problem.PECANN provides an effective tool for simulating unsaturated infiltration.展开更多
We have proposed a methodology to assess the robustness of underground tunnels against potential failure.This involves developing vulnerability functions for various qualities of rock mass and static loading intensiti...We have proposed a methodology to assess the robustness of underground tunnels against potential failure.This involves developing vulnerability functions for various qualities of rock mass and static loading intensities.To account for these variations,we utilized a Monte Carlo Simulation(MCS)technique coupled with the finite difference code FLAC^(3D),to conduct two thousand seven hundred numerical simulations of a horseshoe tunnel located within a rock mass with different geological strength index system(GSIs)and subjected to different states of static loading.To quantify the severity of damage within the rock mass,we selected one stress-based(brittle shear ratio(BSR))and one strain-based failure criterion(plastic damage index(PDI)).Based on these criteria,we then developed fragility curves.Additionally,we used mathematical approximation techniques to produce vulnerability functions that relate the probabilities of various damage states to loading intensities for different quality classes of blocky rock mass.The results indicated that the fragility curves we obtained could accurately depict the evolution of the inner and outer shell damage around the tunnel.Therefore,we have provided engineers with a tool that can predict levels of damages associated with different failure mechanisms based on variations in rock mass quality and in situ stress state.Our method is a numerically developed,multi-variate approach that can aid engineers in making informed decisions about the robustness of underground tunnels.展开更多
Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of...Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of clinicians.Moreover,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical practice.In contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical endpoints.Studies have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized medicine.However,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical modeling.In this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with cancer.We focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical modeling.Furthermore,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of models.Finally,we offer possible solutions to current challenges in radiomics research.展开更多
To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main compon...To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main components:a 3D viscoplastic isotropic constitutive relation that considers excavation damage and complex stress state,a quantitative relationship between critical irreversible deformation and complex stress state,and evolution characteristics of strength parameters.The proposed model is implemented in a self-developed numerical code,i.e.CASRock.The reliability of the model is validated through experiments.It is indicated that the time-dependent fracturing potential index(xTFPI)at a given time during the attenuation creep stage shows a negative correlation with the extent of excavationinduced damage.The time-dependent fracturing process of rock demonstrates a distinct interval effect of the intermediate principal stress,thereby highlighting the 3D stress-dependent characteristic of the model.Finally,the influence of excavation-induced damage and intermediate principal stress on the time-dependent fracturing characteristics of the surrounding rocks around the tunnel is discussed.展开更多
Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive...Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive disintegration and kinematics of multi-deformable rock blocks during rockslides.The present study proposes a discrete-continuous numerical model,based on a cohesive zone model,to explicitly incorporate the progressive fragmentation and intricate interparticle interactions inherent in rockslides.Breakable rock granular assemblies are released along an inclined plane and flow onto a horizontal plane.The numerical scenarios are established to incorporate variations in slope angle,initial height,friction coefficient,and particle number.The evolutions of fragmentation,kinematic,runout and depositional characteristics are quantitatively analyzed and compared with experimental and field data.A positive linear relationship between the equivalent friction coefficient and the apparent friction coefficient is identified.In general,the granular mass predominantly exhibits characteristics of a dense granular flow,with the Savage number exhibiting a decreasing trend as the volume of mass increases.The process of particle breakage gradually occurs in a bottom-up manner,leading to a significant increase in the angular velocities of the rock blocks with increasing depth.The simulation results reproduce the field observations of inverse grading and source stratigraphy preservation in the deposit.We propose a disintegration index that incorporates factors such as drop height,rock mass volume,and rock strength.Our findings demonstrate a consistent linear relationship between this index and the fragmentation degree in all tested scenarios.展开更多
Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and rockfalls.This st...Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and rockfalls.This study presents a systematic outcrop research of fracture pattern variations in a complicated rock slope,and the qualitative and quantitative study of the complex phenomena impact on threedimensional(3D)discrete fracture network(DFN)modeling.As the studies of the outcrop fracture pattern have been so far focused on local variations,thus,we put forward a statistical analysis of global variations.The entire outcrop is partitioned into several subzones,and the subzone-scale variability of fracture geometric properties is analyzed(including the orientation,the density,and the trace length).The results reveal significant variations in fracture characteristics(such as the concentrative degree,the average orientation,the density,and the trace length)among different subzones.Moreover,the density of fracture sets,which is approximately parallel to the slope surface,exhibits a notably higher value compared to other fracture sets across all subzones.To improve the accuracy of the DFN modeling,the effects of three common phenomena resulting from vegetation and rockfalls are qualitatively analyzed and the corresponding quantitative data processing solutions are proposed.Subsequently,the 3D fracture geometric parameters are determined for different areas of the high-steep rock slope in terms of the subzone dimensions.The results show significant variations in the same set of 3D fracture parameters across different regions with density differing by up to tenfold and mean trace length exhibiting differences of 3e4 times.The study results present precise geological structural information,improve modeling accuracy,and provide practical solutions for addressing complex outcrop issues.展开更多
Deterministic compartment models(CMs)and stochastic models,including stochastic CMs and agent-based models,are widely utilized in epidemic modeling.However,the relationship between CMs and their corresponding stochast...Deterministic compartment models(CMs)and stochastic models,including stochastic CMs and agent-based models,are widely utilized in epidemic modeling.However,the relationship between CMs and their corresponding stochastic models is not well understood.The present study aimed to address this gap by conducting a comparative study using the susceptible,exposed,infectious,and recovered(SEIR)model and its extended CMs from the coronavirus disease 2019 modeling literature.We demonstrated the equivalence of the numerical solution of CMs using the Euler scheme and their stochastic counterparts through theoretical analysis and simulations.Based on this equivalence,we proposed an efficient model calibration method that could replicate the exact solution of CMs in the corresponding stochastic models through parameter adjustment.The advancement in calibration techniques enhanced the accuracy of stochastic modeling in capturing the dynamics of epidemics.However,it should be noted that discrete-time stochastic models cannot perfectly reproduce the exact solution of continuous-time CMs.Additionally,we proposed a new stochastic compartment and agent mixed model as an alternative to agent-based models for large-scale population simulations with a limited number of agents.This model offered a balance between computational efficiency and accuracy.The results of this research contributed to the comparison and unification of deterministic CMs and stochastic models in epidemic modeling.Furthermore,the results had implications for the development of hybrid models that integrated the strengths of both frameworks.Overall,the present study has provided valuable epidemic modeling techniques and their practical applications for understanding and controlling the spread of infectious diseases.展开更多
文摘Automated operation and artificial intelligence technology have become essential for ensuring the safety, efficiency, and punctuality of railways, with applications such as ATO (Automatic Train Operation). In this study, the authors propose a method to efficiently simulate the kinematic characteristics of railroad vehicles depending on their speed zone. They utilized the function overloading function supported by a programming language and applied the fourth-order Lunge-Kutta method for dynamic simulation. By constructing an object model, the authors calculated vehicle characteristics and TPS and compared them with actual values, verifying that the developed model represents the real-life vehicle characteristics accurately. The study highlights potential improvements in automated driving and energy consumption optimization in the railway industry.
文摘Virtual assembly is a Virtual Reality (VR) based engineering application which allows engineers to evaluate, analyze, and plan the assembly of mechanical systems. To model the virtual assembly process, new methodology must be applied. Based on the idea that the virtual assembly system is an event driven system, the interactive behavior and information model is proposed to describe the dynamic process of virtual assembly. Definition of the object-oriented model of virtual assembly is put forward.
基金supported by University of Macao,China,Nos.MYRG2022-00054-FHS and MYRG-GRG2023-00038-FHS-UMDF(to ZY)the Macao Science and Technology Development Fund,China,Nos.FDCT0048/2021/AGJ and FDCT0020/2019/AMJ and FDCT 0011/2018/A1(to ZY)Natural Science Foundation of Guangdong Province of China,No.EF017/FHS-YZ/2021/GDSTC(to ZY)。
文摘To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly age-related.In this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed laser.We observed the molding process in mice of different ages and presented age-dependent vascular embolism differentiation.Moreover,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a stroke.Our imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.
基金This project is supported by National Natural Science Foundation of China (No.50085003).
文摘Object-oriented Petri nets (OPNs) is extended into stochastic object-oriented Petri nets (SOPNs) by associating the OPN of an object with stochastic transitions and introducing stochastic places. The stochastic transition of the SOPNs of a production resources can be used to model its reliability, while the SOPN of a production resource can describe its performance with reliability considered. The SOPN model of a case production system is built to illustrate the relationship between the system's performances and the failures of individual production resources.
基金supported by National Natural Science Foundation of China (Grant No. 60873003)
文摘Recently automotive nets are adopted to solve increasing problems in automotive electronic systems.Technologies of automotive local area network from CAN and LIN can solve the problems of the increasing of wire bunch weight and lack in module installation space.However,the multilayer automotive nets software becomes more and more complex,and the development expense is difficult to predict and to keep in check.In this paper,the modeling method of hierarchical automotive nets and the substitution operation based on object-oriented colored Petri net(OOCPN) are proposed.The OOCPN model which analyzes the software structure and validates the collision mechanism of CAN/LIN bus can speed the automobile system development.First,the subsystems are divided and modeled by object-oriented Petri net(OOPN).According to the sets of message sharing relations,the message ports among them are set and the communication gate transitions are defined.Second,the OOPN model is substituted step by step until the inner objects in the automotive body control modules(BCM) are indivisible and colored by colored Petri net(CPN).And the color subsets mark the node messages for the collision mechanism.Third,the OOCPN model of the automotive body CAN/LIN nets is assembled,which keeps the message sets and the system can be expanded.The proposed model is used to analyze features of information sharing among the objects,and it is also used to describe each subsystem real-time behavior of processing messages and implemental device controllers operating,and puts forward a reasonable software framework for the automotive body control subsystem.The research can help to design the communication model in the automotive body system effectively and provide a convenient and rapid way for developing the logical hierarchy software.
基金This work was supported by the project“Energienetz Berlin Adlershof”(no.03ET1038G)funded by the German Federal Ministry of Economic Affairs and Energy(BMWi).
文摘Multi-energy systems(MES)involving networks of different energy carriers can support the balancing of fluctuating renewable generation by co-ordinated joint operation.In this paper,an object-oriented modeling methodology for planning and operations control of MES based on nodal analysis is proposed.The framework provides the modularity to simulate scenarios with varying network configurations.Based on object-oriented programming,classes are formed with regard to common attributes of the network elements.The instances of classes represent physical network elements,such as buses,lines,and power conversion units.The models of the individual network elements involve adjustable and flexible parameters.This is especially advantageous for scenarios with operatingpoint-dependent efficiencies.The overall framework makes use of a uniform description of the model parameters across the diverse energy carriers.Thus,the methodology is particularly suited for the analysis of MES.The applicability of the modeling framework is demonstrated by two use cases involving a technology campus in Berlin.
文摘In the developing course of the information system, the modeling method of information system and model expressing problem are very important. This paper through discussing the facing object of Petri network, expatiates the basic problem of how to set up the business procedure model on the basis of Petri network, and shows the expressing and storing methods of the model in computer way.
基金supported by National Basic Research Program of China(973 Program,Grant No.2011CB706502)
文摘Modelica-based object-orient method is proved to be rapid, accurate and easy to modify, which is suitable for prototype modeling and simulation of rotor system, whose parameters need to be modified frequently. Classical non-object-orient method appears to be inefficient because the code is difficult to modify and reuse. An adequate library for object-orient modeling of rotor system with multi-faults is established, a comparison with non-object-orient method on Jeffcott rotor system and a case study on turbo expander with multi-faults are implemented. The relative tolerance between object-orient method and non-object-orient is less than 0.03%, which proves that these two methods are as accurate as each other. Object-orient modeling and simulation is implemented on turbo expander with crack, rub-impact, pedestal looseness and multi-faults simultaneously. It can be conclude from the case study that when acting on compress side of turbo expander separately, expand wheel is not influenced greatly by crack fault, the existence of rub-impact fault forces expand wheel into quasi-periodic motion and the orbit of expand wheel is deformed and enhanced almost 1.5 times due to pedestal looseness. When acting simultaneously, multi-faults cannot be totally decomposed but can be diagnosed from the feature of vibration. Object-orient method can enhance the efficiency of modeling and simulation of rotor system with multi-faults, which provides an efficient method on prototype modeling and simulation.
基金Supported by Discipline Advancement Program of Shanghai Fourth People’s Hospital,No.SY-XKZT-2020-2013.
文摘BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical management.AIM To develop a synthetic minority oversampling technique(SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer patients.METHODS In this retrospective cohort study,we analyzed data from 611 elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October 2022.The incidence of postoperative delirium was recorded for 7 d post-surgery.Patients were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not.A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative delirium.The SMOTE technique was applied to enhance the model by oversampling the delirium cases.The model’s predictive accuracy was then validated.RESULTS In our study involving 611 elderly patients with abdominal malignant tumors,multivariate logistic regression analysis identified significant risk factors for postoperative delirium.These included the Charlson comorbidity index,American Society of Anesthesiologists classification,history of cerebrovascular disease,surgical duration,perioperative blood transfusion,and postoperative pain score.The incidence rate of postoperative delirium in our study was 22.91%.The original predictive model(P1)exhibited an area under the receiver operating characteristic curve of 0.862.In comparison,the SMOTE-based logistic early warning model(P2),which utilized the SMOTE oversampling algorithm,showed a slightly lower but comparable area under the curve of 0.856,suggesting no significant difference in performance between the two predictive approaches.CONCLUSION This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of traditional methods,effectively addressing data imbalance.
基金supported by the National Key Research and Development Program of China(2021YFB3702005)the National Natural Science Foundation of China(52304352)+3 种基金the Central Government Guides Local Science and Technology Development Fund Projects(2023JH6/100100046)2022"Chunhui Program"Collaborative Scientific Research Project(202200042)the Doctoral Start-up Foundation of Liaoning Province(2023-BS-182)the Technology Development Project of State Key Laboratory of Metal Material for Marine Equipment and Application[HGSKL-USTLN(2022)01].
文摘Macrosegregation is a critical factor that limits the mechanical properties of materials.The impact of equiaxed crystal sedimentation on macrosegregation has been extensively studied,as it plays a significant role in determining the distribution of alloying elements and impurities within a material.To improve macrosegregation in steel connecting shafts,a multiphase solidification model that couples melt flow,heat transfer,microstructure evolution,and solute transport was established based on the volume-averaged Eulerian-Eulerian approach.In this model,the effects of liquid phase,equiaxed crystals,columnar dendrites,and columnar-to-equiaxed transition(CET)during solidification and evolution of microstructure can be considered simultaneously.The sedimentation of equiaxed crystals contributes to negative macrosegregation,where regions between columnar dendrites and equiaxed crystals undergo significant A-type positive macrosegregation due to the CET.Additionally,noticeable positive macrosegregation occurs in the area of final solidification in the ingot.The improvement in macrosegregation is beneficial for enhancing the mechanical properties of connecting shafts.To mitigate the thermal convection of molten steel resulting from excessive superheating,reducing the superheating during casting without employing external fields or altering the design of the ingot mold is indeed an effective approach to control macrosegregation.
文摘The exploration of Mars would heavily rely on Martian rocks mechanics and engineering technology.As the mechanical property of Martian rocks is uncertain,it is of utmost importance to predict the probability distribution of Martian rocks mechanical property for the success of Mars exploration.In this paper,a fast and accurate probability distribution method for predicting the macroscale elastic modulus of Martian rocks was proposed by integrating the microscale rock mechanical experiments(micro-RME),accurate grain-based modeling(AGBM)and upscaling methods based on reliability principles.Firstly,the microstructure of NWA12564 Martian sample and elastic modulus of each mineral were obtained by micro-RME with TESCAN integrated mineral analyzer(TIMA)and nanoindentation.The best probability distribution function of the minerals was determined by Kolmogorov-Smirnov(K-S)test.Secondly,based on best distribution function of each mineral,the Monte Carlo simulations(MCS)and upscaling methods were implemented to obtain the probability distribution of upscaled elastic modulus.Thirdly,the correlation between the upscaled elastic modulus and macroscale elastic modulus obtained by AGBM was established.The accurate probability distribution of the macroscale elastic modulus was obtained by this correlation relationship.The proposed method can predict the probability distribution of Martian rocks mechanical property with any size and shape samples.
基金supported by the Research Council of Norway under contracts 223252/F50 and 300844/F50the Trond Mohn Foundation。
文摘Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth environment.However,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by sunlight.Nightglow emissions and scattered sunlight can contribute to the background signal.To fully utilize such images in space science,background contamination must be removed to isolate the auroral signal.Here we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical harmonics.The approach is robust,flexible,and iteratively deselects outliers,such as auroral emissions.The final model is smooth across the terminator and accounts for slow temporal variations and large-scale asymmetries in the dayglow.We demonstrate the model by using the three far ultraviolet cameras on the Imager for Magnetopause-to-Aurora Global Exploration(IMAGE)mission.The method can be applied to historical missions and is relevant for upcoming missions,such as the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.
文摘Object-oriented programming divides the crop production into subsystems and simulates their behaviors. Many classes were designed to simulate the behaviors of different parts or different physiological processes in crop production system. At the same time, many classes have to be employed for bettering user's interface. But how to manage these classes on a higher level to cooperate them into a perfect system is another problem to study. The Rice Growth Models (RGM) system represents an effort to define and implement a framework to manage these classes. In RGM system, the classes were organized into the model-document-view architecture to separate the domain models, data management and user interface. A single document with multiple views interface frame window was adopted in RGM. In the architectures, the simulation models only exchange data with documents while documents act as intermediacies between simulation models and interfaces. Views get data from documents and show the results to users. The classes for the different functions can be grouped into different architectures. Different architectures communicate with each other through documents. The classes for the different functions can be grouped into different architectures. By using the architecture, communication between classes is more efficient. Modeler can add classes in architectures or other architectures to extend the system without having to change system structure, which is useful for construction and maintenance of agricultural system models.
基金funding support from the science and technology innovation Program of Hunan Province(Grant No.2023RC1017)Hunan Provincial Postgraduate Research and Innovation Project(Grant No.CX20220109)National Natural Science Foundation of China Youth Fund(Grant No.52208378).
文摘Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated soils.Traditional pure data-driven methods(e.g.deep neural network,DNN)can provide rapid predictions,but they do require sufficient on-site data for accurate training,and lack interpretability to the physical processes within the data.In this paper,we provide a physics and equalityconstrained artificial neural network(PECANN),to derive unsaturated infiltration solutions with a small amount of initial and boundary data.PECANN takes the physics-informed neural network(PINN)as a foundation,encodes the unsaturated infiltration physical laws(i.e.Richards equation,RE)into the loss function,and uses the augmented Lagrangian method to constrain the learning process of the solutions of RE by adding stronger penalty for the initial and boundary conditions.Four unsaturated infiltration cases are designed to test the training performance of PECANN,i.e.one-dimensional(1D)steady-state unsaturated infiltration,1D transient-state infiltration,two-dimensional(2D)transient-state infiltration,and 1D coupled unsaturated infiltration and deformation.The predicted results of PECANN are compared with the finite difference solutions or analytical solutions.The results indicate that PECANN can accurately capture the variations of pressure head during the unsaturated infiltration,and present higher precision and robustness than DNN and PINN.It is also revealed that PECANN can achieve the same accuracy as the finite difference method with fewer initial and boundary training data.Additionally,we investigate the effect of the hyperparameters of PECANN on solving RE problem.PECANN provides an effective tool for simulating unsaturated infiltration.
基金funding received by a grant from the Natural Sciences and Engineering Research Council of Canada(NSERC)(Grant No.CRDPJ 469057e14).
文摘We have proposed a methodology to assess the robustness of underground tunnels against potential failure.This involves developing vulnerability functions for various qualities of rock mass and static loading intensities.To account for these variations,we utilized a Monte Carlo Simulation(MCS)technique coupled with the finite difference code FLAC^(3D),to conduct two thousand seven hundred numerical simulations of a horseshoe tunnel located within a rock mass with different geological strength index system(GSIs)and subjected to different states of static loading.To quantify the severity of damage within the rock mass,we selected one stress-based(brittle shear ratio(BSR))and one strain-based failure criterion(plastic damage index(PDI)).Based on these criteria,we then developed fragility curves.Additionally,we used mathematical approximation techniques to produce vulnerability functions that relate the probabilities of various damage states to loading intensities for different quality classes of blocky rock mass.The results indicated that the fragility curves we obtained could accurately depict the evolution of the inner and outer shell damage around the tunnel.Therefore,we have provided engineers with a tool that can predict levels of damages associated with different failure mechanisms based on variations in rock mass quality and in situ stress state.Our method is a numerically developed,multi-variate approach that can aid engineers in making informed decisions about the robustness of underground tunnels.
基金supported in part by the National Natural Science Foundation of China(82072019)the Shenzhen Basic Research Program(JCYJ20210324130209023)+5 种基金the Shenzhen-Hong Kong-Macao S&T Program(Category C)(SGDX20201103095002019)the Mainland-Hong Kong Joint Funding Scheme(MHKJFS)(MHP/005/20),the Project of Strategic Importance Fund(P0035421)the Projects of RISA(P0043001)from the Hong Kong Polytechnic University,the Natural Science Foundation of Jiangsu Province(BK20201441)the Provincial and Ministry Co-constructed Project of Henan Province Medical Science and Technology Research(SBGJ202103038,SBGJ202102056)the Henan Province Key R&D and Promotion Project(Science and Technology Research)(222102310015)the Natural Science Foundation of Henan Province(222300420575),and the Henan Province Science and Technology Research(222102310322).
文摘Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of clinicians.Moreover,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical practice.In contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical endpoints.Studies have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized medicine.However,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical modeling.In this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with cancer.We focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical modeling.Furthermore,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of models.Finally,we offer possible solutions to current challenges in radiomics research.
基金supported by the National Natural Science Foundation of China(Grant No.52125903)the China Postdoctoral Science Foundation(Grant No.2023M730367)the Fundamental Research Funds for Central Public Welfare Research Institutes of China(Grant No.CKSF2023323/YT).
文摘To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main components:a 3D viscoplastic isotropic constitutive relation that considers excavation damage and complex stress state,a quantitative relationship between critical irreversible deformation and complex stress state,and evolution characteristics of strength parameters.The proposed model is implemented in a self-developed numerical code,i.e.CASRock.The reliability of the model is validated through experiments.It is indicated that the time-dependent fracturing potential index(xTFPI)at a given time during the attenuation creep stage shows a negative correlation with the extent of excavationinduced damage.The time-dependent fracturing process of rock demonstrates a distinct interval effect of the intermediate principal stress,thereby highlighting the 3D stress-dependent characteristic of the model.Finally,the influence of excavation-induced damage and intermediate principal stress on the time-dependent fracturing characteristics of the surrounding rocks around the tunnel is discussed.
基金support from the National Key R&D plan(Grant No.2022YFC3004303)the National Natural Science Foundation of China(Grant No.42107161)+3 种基金the State Key Laboratory of Hydroscience and Hydraulic Engineering(Grant No.2021-KY-04)the Open Research Fund Program of State Key Laboratory of Hydroscience and Engineering(sklhse-2023-C-01)the Open Research Fund Program of Key Laboratory of the Hydrosphere of the Ministry of Water Resources(mklhs-2023-04)the China Three Gorges Corporation(XLD/2117).
文摘Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive disintegration and kinematics of multi-deformable rock blocks during rockslides.The present study proposes a discrete-continuous numerical model,based on a cohesive zone model,to explicitly incorporate the progressive fragmentation and intricate interparticle interactions inherent in rockslides.Breakable rock granular assemblies are released along an inclined plane and flow onto a horizontal plane.The numerical scenarios are established to incorporate variations in slope angle,initial height,friction coefficient,and particle number.The evolutions of fragmentation,kinematic,runout and depositional characteristics are quantitatively analyzed and compared with experimental and field data.A positive linear relationship between the equivalent friction coefficient and the apparent friction coefficient is identified.In general,the granular mass predominantly exhibits characteristics of a dense granular flow,with the Savage number exhibiting a decreasing trend as the volume of mass increases.The process of particle breakage gradually occurs in a bottom-up manner,leading to a significant increase in the angular velocities of the rock blocks with increasing depth.The simulation results reproduce the field observations of inverse grading and source stratigraphy preservation in the deposit.We propose a disintegration index that incorporates factors such as drop height,rock mass volume,and rock strength.Our findings demonstrate a consistent linear relationship between this index and the fragmentation degree in all tested scenarios.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3080200)the National Natural Science Foundation of China(Grant No.42022053)the China Postdoctoral Science Foundation(Grant No.2023M731264).
文摘Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and rockfalls.This study presents a systematic outcrop research of fracture pattern variations in a complicated rock slope,and the qualitative and quantitative study of the complex phenomena impact on threedimensional(3D)discrete fracture network(DFN)modeling.As the studies of the outcrop fracture pattern have been so far focused on local variations,thus,we put forward a statistical analysis of global variations.The entire outcrop is partitioned into several subzones,and the subzone-scale variability of fracture geometric properties is analyzed(including the orientation,the density,and the trace length).The results reveal significant variations in fracture characteristics(such as the concentrative degree,the average orientation,the density,and the trace length)among different subzones.Moreover,the density of fracture sets,which is approximately parallel to the slope surface,exhibits a notably higher value compared to other fracture sets across all subzones.To improve the accuracy of the DFN modeling,the effects of three common phenomena resulting from vegetation and rockfalls are qualitatively analyzed and the corresponding quantitative data processing solutions are proposed.Subsequently,the 3D fracture geometric parameters are determined for different areas of the high-steep rock slope in terms of the subzone dimensions.The results show significant variations in the same set of 3D fracture parameters across different regions with density differing by up to tenfold and mean trace length exhibiting differences of 3e4 times.The study results present precise geological structural information,improve modeling accuracy,and provide practical solutions for addressing complex outcrop issues.
基金supported by the National Natural Science Foundation of China(Grant Nos.82173620 to Yang Zhao and 82041024 to Feng Chen)partially supported by the Bill&Melinda Gates Foundation(Grant No.INV-006371 to Feng Chen)Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Deterministic compartment models(CMs)and stochastic models,including stochastic CMs and agent-based models,are widely utilized in epidemic modeling.However,the relationship between CMs and their corresponding stochastic models is not well understood.The present study aimed to address this gap by conducting a comparative study using the susceptible,exposed,infectious,and recovered(SEIR)model and its extended CMs from the coronavirus disease 2019 modeling literature.We demonstrated the equivalence of the numerical solution of CMs using the Euler scheme and their stochastic counterparts through theoretical analysis and simulations.Based on this equivalence,we proposed an efficient model calibration method that could replicate the exact solution of CMs in the corresponding stochastic models through parameter adjustment.The advancement in calibration techniques enhanced the accuracy of stochastic modeling in capturing the dynamics of epidemics.However,it should be noted that discrete-time stochastic models cannot perfectly reproduce the exact solution of continuous-time CMs.Additionally,we proposed a new stochastic compartment and agent mixed model as an alternative to agent-based models for large-scale population simulations with a limited number of agents.This model offered a balance between computational efficiency and accuracy.The results of this research contributed to the comparison and unification of deterministic CMs and stochastic models in epidemic modeling.Furthermore,the results had implications for the development of hybrid models that integrated the strengths of both frameworks.Overall,the present study has provided valuable epidemic modeling techniques and their practical applications for understanding and controlling the spread of infectious diseases.