World Health Organization(WHO)reported that the integration of some traditional medicine practices with national main stream health system was started since the 1970s[1].WHO developed and published two strategies rega...World Health Organization(WHO)reported that the integration of some traditional medicine practices with national main stream health system was started since the 1970s[1].WHO developed and published two strategies regarding traditional and complementary medicine,which were WHO strategy for traditional medicine 2002–2005 and WHO strategy for traditional medicine 2014–2023[2,3].展开更多
Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have ...Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.展开更多
Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role...Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of patients.Precision medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic factors.It is a recent and rapidly developing medicine.The widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with IBD.Though precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing research.There is discordance in study conduct,and data collection,utilization,interpretation,and analysis.This review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.展开更多
Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.Transplantation of midbrain dopaminergic progenitor cells is a p...Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.Transplantation of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson’s disease.However,transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation niche.Here,we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells.These beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion,effectively maintaining axonal integrity in vitro.Importantly,midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts.Overall,our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation.展开更多
In this article, we use the Hausdorf distance to treat triple Simpson’s rule of the Henstock triple integral of a fuzzy valued function as well as the error bound of the method. We also introduce δ-fine subdivisions...In this article, we use the Hausdorf distance to treat triple Simpson’s rule of the Henstock triple integral of a fuzzy valued function as well as the error bound of the method. We also introduce δ-fine subdivisions for a Henstock triple integral and numerical example is presented in order to show the application and the consequence of the method.展开更多
The Owen’s T function is presented in four new ways, one of them as a series similar to the Euler’s arctangent series divided by 2π, which is its majorant series. All possibilities enable numerically stable ...The Owen’s T function is presented in four new ways, one of them as a series similar to the Euler’s arctangent series divided by 2π, which is its majorant series. All possibilities enable numerically stable and fast convergent computation of the bivariate normal integral with simple recursion. When tested computation on a random sample of one million parameter triplets with uniformly distributed components and using double precision arithmetic, the maximum absolute error was 3.45 × 10<sup>-</sup><sup>16</sup>. In additional testing, focusing on cases with correlation coefficients close to one in absolute value, when the computation may be very sensitive to small rounding errors, the accuracy was retained. In rare potentially critical cases, a simple adjustment to the computation procedure was performed—one potentially critical computation was replaced with two equivalent non-critical ones. All new series are suitable for vector and high-precision computation, assuming they are supplemented with appropriate efficient and accurate computation of the arctangent and standard normal cumulative distribution functions. They are implemented by the R package Phi2rho, available on CRAN. Its functions allow vector arguments and are ready to work with the Rmpfr package, which enables the use of arbitrary precision instead of double precision numbers. A special test with up to 1024-bit precision computation is also presented.展开更多
Having argued the importance of China's sustainable development in global sustainability, the authors review the achievements of China in sustainable development, especially its institutional construction. Environ...Having argued the importance of China's sustainable development in global sustainability, the authors review the achievements of China in sustainable development, especially its institutional construction. Environment to be counted in official's political performance rating system is thought of as a new institutional mechanism in China facilitating its sustainable development and then global sustainability. Then its significance is narrated and visions in future are envisioned. In the end, certain concrete suggestions for the rating system are given in a practical way.展开更多
Malaysia has long been involved in the initiative of becoming a high income country by the year 2020. In this essence, fighting and eliminating any means of corruption in the public and private companies have been one...Malaysia has long been involved in the initiative of becoming a high income country by the year 2020. In this essence, fighting and eliminating any means of corruption in the public and private companies have been one of the key challenges in the long run. The globalization of businesses has somehow led to an increase in the number of unethical conduct and hazardous corruption. In the urge to enliven ethics and integrity in a company and among employees, the whole business processes and stakeholders should position code of ethics and integrity at its highest standard. However, can ethics and integrity really increase the company's reputation, strengthening its business operations and sustainability, and deliver trust amongst employees and employers? The objective of this study is to analyze the perceptions of employees on issues pertaining ethics and integrity. The study has been conducted in one of the giant telecommunication companies in Malaysia where a sample of 7,056 employees were the participants involved in the survey. The study has used questionnaires to collect data. The data have then been analysed using the SPSS data analysis software. The findings explained that employees view the company as an ethical place to work where the finance department is deemed to have the highest level of integrity. While in matters of corruption risk areas, there are still practices of bribery. It is also founded that a majority of respondents about 93% agree that the company's initiatives are effective in building business integrity and that the level of business ethics and integrity has improved over the last two years. Running a business with ethics and integrity while selecting the fight business partners will create a corporation of ethics, integrity, and anti-corruption.展开更多
China's reform and opening-up policy, which started in 1978, has become more effective. The success of reform and opening-up has transformed China from a low-income country to one of the world's largest econo- mies ...China's reform and opening-up policy, which started in 1978, has become more effective. The success of reform and opening-up has transformed China from a low-income country to one of the world's largest econo- mies today. In my view, the success of China's develop- ment lies in the country greatly reducing the number of people living in poverty. According to the World Bank, hundreds of millions of Chinese people have been lifted out of extreme poverty.展开更多
Customs statistics show the foreign tradevolume of eastern China’s Zhejiang Provincein 1998 amounted to US$14.85 billion,anannual increase of 4.3 percent.The exportswas US$10.8 billion,up 7.7 percent from1997;the imp...Customs statistics show the foreign tradevolume of eastern China’s Zhejiang Provincein 1998 amounted to US$14.85 billion,anannual increase of 4.3 percent.The exportswas US$10.8 billion,up 7.7 percent from1997;the imports ranked the fourth in thenation.This was hard won in the difficultiescaused by the Asian financial crisis.展开更多
Dear Readers, Recently I had the great honor to meet Under Secretary of State for Public Diplomacy Ms.Karen Hughes,and Public Di- plomacy Envoy Ms.Michelle Kwan(关颖姗)during their visit to Guangzhou in late January...Dear Readers, Recently I had the great honor to meet Under Secretary of State for Public Diplomacy Ms.Karen Hughes,and Public Di- plomacy Envoy Ms.Michelle Kwan(关颖姗)during their visit to Guangzhou in late January this year.I was even more thrilled to show our Crazy English Teens magazine to such distin- guished guests.Ms.Hughes and Ms.Kwan were visibly im- pressed by the cover and the enjoyable entertainment展开更多
The SubBytes (S-box) transformation is the most crucial operation in the AES algorithm, significantly impacting the implementation performance of AES chips. To design a high-performance S-box, a segmented optimization...The SubBytes (S-box) transformation is the most crucial operation in the AES algorithm, significantly impacting the implementation performance of AES chips. To design a high-performance S-box, a segmented optimization implementation of the S-box is proposed based on the composite field inverse operation in this paper. This proposed S-box implementation is modeled using Verilog language and synthesized using Design Complier software under the premise of ensuring the correctness of the simulation result. The synthesis results show that, compared to several current S-box implementation schemes, the proposed implementation of the S-box significantly reduces the area overhead and critical path delay, then gets higher hardware efficiency. This provides strong support for realizing efficient and compact S-box ASIC designs.展开更多
Algorithm for Laplace ′s integral is given when the inverse image function has high order discontinui ty. The multi-node technique of B-spline is used to describe the interruption point, cusp and non-smooth point of...Algorithm for Laplace ′s integral is given when the inverse image function has high order discontinui ty. The multi-node technique of B-spline is used to describe the interruption point, cusp and non-smooth point of the inverse image function. The difference quotient and de Boor algorithm are used to derive the image function of the Lapl ace′s integral under non-uniform partition. And a set of practical formula is got when the partition is quasi-uniform. The scheme enables the image function to be approximated within any prescribed tolerance. Experiments also show that g ood result is achieved. It is much faster than that of Simpsons rule, and much s impler than that of Berge method, the traditional efficient method. It is no lon ger to find the zero points and coefficients of Gauss-Laguerre or Gauss-Legend re polynomials. The image function of Laplace′s integral can also be computed while the inverse image function is hyper-function with high order discontinuity.展开更多
文摘World Health Organization(WHO)reported that the integration of some traditional medicine practices with national main stream health system was started since the 1970s[1].WHO developed and published two strategies regarding traditional and complementary medicine,which were WHO strategy for traditional medicine 2002–2005 and WHO strategy for traditional medicine 2014–2023[2,3].
文摘Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.
文摘Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of patients.Precision medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic factors.It is a recent and rapidly developing medicine.The widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with IBD.Though precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing research.There is discordance in study conduct,and data collection,utilization,interpretation,and analysis.This review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.
基金supported by the National Key Research and Development Program of China,Nos.2017YFE0122900(to BH),2019YFA0110800(to WL),2019YFA0903802(to YW),2021YFA1101604(to LW),2018YFA0108502(to LF),and 2020YFA0804003(to JW)the National Natural Science Foundation of China,Nos.31621004(to WL,BH)and 31970821(to YW)+1 种基金CAS Project for Young Scientists in Basic Research,No.YSBR-041(to YW)Joint Funds of the National Natural Science Foundation of China,No.U21A20396(to BH)。
文摘Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.Transplantation of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson’s disease.However,transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation niche.Here,we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells.These beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion,effectively maintaining axonal integrity in vitro.Importantly,midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts.Overall,our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation.
文摘In this article, we use the Hausdorf distance to treat triple Simpson’s rule of the Henstock triple integral of a fuzzy valued function as well as the error bound of the method. We also introduce δ-fine subdivisions for a Henstock triple integral and numerical example is presented in order to show the application and the consequence of the method.
文摘The Owen’s T function is presented in four new ways, one of them as a series similar to the Euler’s arctangent series divided by 2π, which is its majorant series. All possibilities enable numerically stable and fast convergent computation of the bivariate normal integral with simple recursion. When tested computation on a random sample of one million parameter triplets with uniformly distributed components and using double precision arithmetic, the maximum absolute error was 3.45 × 10<sup>-</sup><sup>16</sup>. In additional testing, focusing on cases with correlation coefficients close to one in absolute value, when the computation may be very sensitive to small rounding errors, the accuracy was retained. In rare potentially critical cases, a simple adjustment to the computation procedure was performed—one potentially critical computation was replaced with two equivalent non-critical ones. All new series are suitable for vector and high-precision computation, assuming they are supplemented with appropriate efficient and accurate computation of the arctangent and standard normal cumulative distribution functions. They are implemented by the R package Phi2rho, available on CRAN. Its functions allow vector arguments and are ready to work with the Rmpfr package, which enables the use of arbitrary precision instead of double precision numbers. A special test with up to 1024-bit precision computation is also presented.
文摘Having argued the importance of China's sustainable development in global sustainability, the authors review the achievements of China in sustainable development, especially its institutional construction. Environment to be counted in official's political performance rating system is thought of as a new institutional mechanism in China facilitating its sustainable development and then global sustainability. Then its significance is narrated and visions in future are envisioned. In the end, certain concrete suggestions for the rating system are given in a practical way.
文摘Malaysia has long been involved in the initiative of becoming a high income country by the year 2020. In this essence, fighting and eliminating any means of corruption in the public and private companies have been one of the key challenges in the long run. The globalization of businesses has somehow led to an increase in the number of unethical conduct and hazardous corruption. In the urge to enliven ethics and integrity in a company and among employees, the whole business processes and stakeholders should position code of ethics and integrity at its highest standard. However, can ethics and integrity really increase the company's reputation, strengthening its business operations and sustainability, and deliver trust amongst employees and employers? The objective of this study is to analyze the perceptions of employees on issues pertaining ethics and integrity. The study has been conducted in one of the giant telecommunication companies in Malaysia where a sample of 7,056 employees were the participants involved in the survey. The study has used questionnaires to collect data. The data have then been analysed using the SPSS data analysis software. The findings explained that employees view the company as an ethical place to work where the finance department is deemed to have the highest level of integrity. While in matters of corruption risk areas, there are still practices of bribery. It is also founded that a majority of respondents about 93% agree that the company's initiatives are effective in building business integrity and that the level of business ethics and integrity has improved over the last two years. Running a business with ethics and integrity while selecting the fight business partners will create a corporation of ethics, integrity, and anti-corruption.
文摘China's reform and opening-up policy, which started in 1978, has become more effective. The success of reform and opening-up has transformed China from a low-income country to one of the world's largest econo- mies today. In my view, the success of China's develop- ment lies in the country greatly reducing the number of people living in poverty. According to the World Bank, hundreds of millions of Chinese people have been lifted out of extreme poverty.
文摘Customs statistics show the foreign tradevolume of eastern China’s Zhejiang Provincein 1998 amounted to US$14.85 billion,anannual increase of 4.3 percent.The exportswas US$10.8 billion,up 7.7 percent from1997;the imports ranked the fourth in thenation.This was hard won in the difficultiescaused by the Asian financial crisis.
文摘Dear Readers, Recently I had the great honor to meet Under Secretary of State for Public Diplomacy Ms.Karen Hughes,and Public Di- plomacy Envoy Ms.Michelle Kwan(关颖姗)during their visit to Guangzhou in late January this year.I was even more thrilled to show our Crazy English Teens magazine to such distin- guished guests.Ms.Hughes and Ms.Kwan were visibly im- pressed by the cover and the enjoyable entertainment
文摘The SubBytes (S-box) transformation is the most crucial operation in the AES algorithm, significantly impacting the implementation performance of AES chips. To design a high-performance S-box, a segmented optimization implementation of the S-box is proposed based on the composite field inverse operation in this paper. This proposed S-box implementation is modeled using Verilog language and synthesized using Design Complier software under the premise of ensuring the correctness of the simulation result. The synthesis results show that, compared to several current S-box implementation schemes, the proposed implementation of the S-box significantly reduces the area overhead and critical path delay, then gets higher hardware efficiency. This provides strong support for realizing efficient and compact S-box ASIC designs.
文摘Algorithm for Laplace ′s integral is given when the inverse image function has high order discontinui ty. The multi-node technique of B-spline is used to describe the interruption point, cusp and non-smooth point of the inverse image function. The difference quotient and de Boor algorithm are used to derive the image function of the Lapl ace′s integral under non-uniform partition. And a set of practical formula is got when the partition is quasi-uniform. The scheme enables the image function to be approximated within any prescribed tolerance. Experiments also show that g ood result is achieved. It is much faster than that of Simpsons rule, and much s impler than that of Berge method, the traditional efficient method. It is no lon ger to find the zero points and coefficients of Gauss-Laguerre or Gauss-Legend re polynomials. The image function of Laplace′s integral can also be computed while the inverse image function is hyper-function with high order discontinuity.