Solvent exchange induced in situ forming gel(ISG) is the promising drug delivery system for periodontitis treatment owing to the prospect of maintaining an effective high drug level in the gingival crevicular fluid. I...Solvent exchange induced in situ forming gel(ISG) is the promising drug delivery system for periodontitis treatment owing to the prospect of maintaining an effective high drug level in the gingival crevicular fluid. In the present study, the influence of clove oil(CO) on the characteristics of doxycycline hyclate(DH)-loaded ISG comprising Eudragit RS(ERS) was investigated including viscosity/rheology, syringeability, in vitro gel formation/drug release, matrix formation/solvent diffusion and antimicrobial activities. CO could dissolve ERS and increase the viscosity of ISG and its hydrophobicity could also retard the diffusion of solvent and hinder the drug diffusion; thus, the minimization of burst effect and sustained drug release were achieved effectively. All the prepared ISGs comprising CO could expel through the 27-gauge needle for administration by injection and transform into matrix depot after exposure to the simulated gingival crevicular fluid. The antimicrobial activities against Staphylococcus aureus, Escherichia coli, Streptococcus mutans and Porphyromonas gingivalis were increased when the ratio of CO and N-methyl pyrrolidone(NMP) was decreased from 1:1 to 1:10 owing to higher diffusion of DH except that for C. albicans was increased as CO amount was higher.Therefore, CO could minimize the burst while prolonging the drug release of DH-loaded ERS ISG for use as a local drug delivery system for periodontitis treatment.展开更多
Based on the geochemical characteristics of oil-cracking gas and kerogen-cracking gas revealed by simu-lation experiments and the chemical composition of natural gases in actual gas reservoirs, two kinds of natural ga...Based on the geochemical characteristics of oil-cracking gas and kerogen-cracking gas revealed by simu-lation experiments and the chemical composition of natural gases in actual gas reservoirs, two kinds of natural gases with different relationships between C2/C3 and C1/C2, C2/C3 and C1/C3, C2/C3 and 100×C1/(C1-C5) were identified in the Tarim Basin, and proposed further by the authors. The relationship charts of C2/C3 and C1/C2, C2/C3 and C1/C3, C2/C3 and 100×C1/(C1-C5) can be used to effectively distinguish oil-cracking gas from kerogen-cracking gas. Petro-leum geological analysis of the oil-cracking gas reservoirs showed that the distribution of oil-cracking gas is mostly related with deep-seated faults or faults with a large fault throw, and the burial depth of paleo-oil reservoir is rela-tively high; crude oil-cracking gas resources have been evaluated by using both forward and inversion methods. The plots of C2/C3 vs. C1/C2, C2/C3 vs. C1/C3, and C2/C3 vs. 100×C1/(C1-C5) were used to distinguish between oil-crack-ing gas and kerogen-cracking gas, and estimate the mixed ratios of the two kinds of natural gases in the main gas reservoirs of the platform area.展开更多
Based on summarizing of the effect of mantle-derived fluid on the formation of ores, especially on gold ore, and with the latest investigations, such as the formation of ore from the action of shallow-deep fluid, the ...Based on summarizing of the effect of mantle-derived fluid on the formation of ores, especially on gold ore, and with the latest investigations, such as the formation of ore from the action of shallow-deep fluid, the transportation effect of the thermal energy by mantle-derived fluid, this paper mainly aims at the effect of mantle-derived fluid on the generation of hydrocarbons. With the proof from geochemistry and fluid inclusion, it was suggested that the mantle-derived fluid not only supplied source materials for hydrocarbons, but also supplied essential energy and matter necessary for the generation of hydrocarbons. The mantle-derived fluid had a good effect, but at the same time it had an adverse effect under specific conditions, on the formation of reservoirs. This paper also discusses the future direction and significance of studying mantle-derived fluid.展开更多
By PVT fractionation experiments to model phase\|controlled and gas\|washing fractionations during the formation of petroleum reservoirs, the authors measured the physical and chemical properties of products formed in...By PVT fractionation experiments to model phase\|controlled and gas\|washing fractionations during the formation of petroleum reservoirs, the authors measured the physical and chemical properties of products formed in different fractionation stages and made a correlative analysis of the influence of depressurization and gas washing on oil/gas molecular composition and the rule of fractionation. The analytical results showed that gas washing is an important factor affecting the physical properties of crude oils, and also can be regarded as a good genetic interpretation of marine wax\|high oils in the Tarim region, Xinjiang, China. Phase\|controlled and gas\|washing fractionations can lead to the formation of condensates and their differences in chemical composition from crude oils are a direct reflection of evaporating fractionation. Phase\|controlled and gas\|washing fractionations have a great influence on the composition of molecular compounds and relevant parameters. So phase\|controlled and gas\|washing fractionations during the formation of petroleum reservoirs are not only favorable to identifying different processes of formation of petroleum reservoirs, but also to the scientific application of routine geochemical parameters.展开更多
The beach area of Shengli Oilfield lies 1n the east and north of Zhanhua sag which is located in the southern end of Bohai Bay Basin(Fig.1).Its geological situation is generally similar to that in Zhanhua sag.Several ...The beach area of Shengli Oilfield lies 1n the east and north of Zhanhua sag which is located in the southern end of Bohai Bay Basin(Fig.1).Its geological situation is generally similar to that in Zhanhua sag.Several decades of exploration shows that this area is the most enriched petroleum area in Bo-hai Bay Basin.Oil and gas distributed there in a same way as in Bohai Bay Basin,but also distributed in its own unique way.展开更多
基金the Research and Development Institute, Silpakorn University (Grant No. SURDI 58/01/38)facilitated by the Faculty of Pharmacy, Silpakorn University, Thailand
文摘Solvent exchange induced in situ forming gel(ISG) is the promising drug delivery system for periodontitis treatment owing to the prospect of maintaining an effective high drug level in the gingival crevicular fluid. In the present study, the influence of clove oil(CO) on the characteristics of doxycycline hyclate(DH)-loaded ISG comprising Eudragit RS(ERS) was investigated including viscosity/rheology, syringeability, in vitro gel formation/drug release, matrix formation/solvent diffusion and antimicrobial activities. CO could dissolve ERS and increase the viscosity of ISG and its hydrophobicity could also retard the diffusion of solvent and hinder the drug diffusion; thus, the minimization of burst effect and sustained drug release were achieved effectively. All the prepared ISGs comprising CO could expel through the 27-gauge needle for administration by injection and transform into matrix depot after exposure to the simulated gingival crevicular fluid. The antimicrobial activities against Staphylococcus aureus, Escherichia coli, Streptococcus mutans and Porphyromonas gingivalis were increased when the ratio of CO and N-methyl pyrrolidone(NMP) was decreased from 1:1 to 1:10 owing to higher diffusion of DH except that for C. albicans was increased as CO amount was higher.Therefore, CO could minimize the burst while prolonging the drug release of DH-loaded ERS ISG for use as a local drug delivery system for periodontitis treatment.
基金the National Natural Science Foundation of China (Grant No. 40973041)
文摘Based on the geochemical characteristics of oil-cracking gas and kerogen-cracking gas revealed by simu-lation experiments and the chemical composition of natural gases in actual gas reservoirs, two kinds of natural gases with different relationships between C2/C3 and C1/C2, C2/C3 and C1/C3, C2/C3 and 100×C1/(C1-C5) were identified in the Tarim Basin, and proposed further by the authors. The relationship charts of C2/C3 and C1/C2, C2/C3 and C1/C3, C2/C3 and 100×C1/(C1-C5) can be used to effectively distinguish oil-cracking gas from kerogen-cracking gas. Petro-leum geological analysis of the oil-cracking gas reservoirs showed that the distribution of oil-cracking gas is mostly related with deep-seated faults or faults with a large fault throw, and the burial depth of paleo-oil reservoir is rela-tively high; crude oil-cracking gas resources have been evaluated by using both forward and inversion methods. The plots of C2/C3 vs. C1/C2, C2/C3 vs. C1/C3, and C2/C3 vs. 100×C1/(C1-C5) were used to distinguish between oil-crack-ing gas and kerogen-cracking gas, and estimate the mixed ratios of the two kinds of natural gases in the main gas reservoirs of the platform area.
文摘Based on summarizing of the effect of mantle-derived fluid on the formation of ores, especially on gold ore, and with the latest investigations, such as the formation of ore from the action of shallow-deep fluid, the transportation effect of the thermal energy by mantle-derived fluid, this paper mainly aims at the effect of mantle-derived fluid on the generation of hydrocarbons. With the proof from geochemistry and fluid inclusion, it was suggested that the mantle-derived fluid not only supplied source materials for hydrocarbons, but also supplied essential energy and matter necessary for the generation of hydrocarbons. The mantle-derived fluid had a good effect, but at the same time it had an adverse effect under specific conditions, on the formation of reservoirs. This paper also discusses the future direction and significance of studying mantle-derived fluid.
文摘By PVT fractionation experiments to model phase\|controlled and gas\|washing fractionations during the formation of petroleum reservoirs, the authors measured the physical and chemical properties of products formed in different fractionation stages and made a correlative analysis of the influence of depressurization and gas washing on oil/gas molecular composition and the rule of fractionation. The analytical results showed that gas washing is an important factor affecting the physical properties of crude oils, and also can be regarded as a good genetic interpretation of marine wax\|high oils in the Tarim region, Xinjiang, China. Phase\|controlled and gas\|washing fractionations can lead to the formation of condensates and their differences in chemical composition from crude oils are a direct reflection of evaporating fractionation. Phase\|controlled and gas\|washing fractionations have a great influence on the composition of molecular compounds and relevant parameters. So phase\|controlled and gas\|washing fractionations during the formation of petroleum reservoirs are not only favorable to identifying different processes of formation of petroleum reservoirs, but also to the scientific application of routine geochemical parameters.
文摘The beach area of Shengli Oilfield lies 1n the east and north of Zhanhua sag which is located in the southern end of Bohai Bay Basin(Fig.1).Its geological situation is generally similar to that in Zhanhua sag.Several decades of exploration shows that this area is the most enriched petroleum area in Bo-hai Bay Basin.Oil and gas distributed there in a same way as in Bohai Bay Basin,but also distributed in its own unique way.
