One pot synthesis of bis-silicon-bridged stilbene derivatives

Bis-silicon-bridged stilbene derivatives were synthesized in a modified procedure that combined the preparation of bis[2- （silyl）phenyl]acetylene and its intramolecular reductive cyclization in one pot. The results indicated that the one pot approach produced target products in a comparable yield to that of the two-step method reported previously.

One Pot Reduction of Imines Generated in-situ from Aldehydes and Amines by the NaBH4-InCl3 System

A combination of sodium borohydride and a catalytic amount of indium（Ⅲ） chloride in acetonitrile reduces imines formed in-situ from aldehydes and amines to the corresponding functionalised secondary and tertiary amines in moderate to good yields. Noteworthy is that highly chemoselective reactions were achieved in the presence of other functional groups such as halogens, carbon-carbon double bonds and hydroxyl groups.

One pot synthesis, crystal structures and properties of two new MOFs with imidazole-containing tripodal ligand

Two new different Cu(Ⅱ) MOFs with the same 1,3,5-tris(1-imidazolyl) benzene(tib) ligand {[Cu(tib)2]·(H2O)2·Br2}n(1) and {[Cu2(tib)·Br·Cl]·2Br}n(2) were obtained by one pot synthesized of tib with CuBr in the presences of HCl and water. X-ray single crystal diffraction analyses indicate that both complexes 1 and 2 have two dimensional frameworks containing different building blocks. Each Cu(Ⅱ) atom in complex 1 is coordinated by four N atoms from different tib ligands. However, there are two different cryptographic Cu(Ⅱ) atoms in complex 2, one is four coordinated by two bromine atoms and two N atoms from different tib ligands, the other is six coordinated by two chloride atoms and four N atoms from different tib ligands. The thermal gravimetric analysis of complexes 1 and 2 are depicted in the paper.

Visible light induced tandem reactions:An efficient one pot strategy for constructing quinazolinones using in-situ formed aldehydes under photocatalyst-free and room-temperature conditions

A facile tandem route has been developed for constructing quinazolinones from various aminobenzamides and in-situ generated aldehydes.Visible light was found to play a dual role:first oxidizes the alcohol to the aldehyde and then facilitates its cyclization with o-substituted aniline.Furthermore,alcohols are perfe ct alternatives to aldehydes because they are greene r,more available,more economical,more stable,and less toxic tha n aldehydes.The first reaction step continuously provides material for the second step,which effectively reduces loss through volatilization,oxidation,and polymerization of the aldehyde,while avoiding its toxicity.A variety of quinazolinones can be prepared in the presence of visible light without any additional photocatalyst.The developed synthesis protocol proceeds with the merits of mild conditions,broad substrate scope,operational simplicity,a nd high atom efficiency,with an eco-energy source under metal-free,photocatalyst-free,and ambient conditions.

Novel and Efficient One Pot Condensation Reactions between Ketones and Aromatic Alcohols in the Presence of CrO3 Producing α,β-Unsaturated Carbonyl Compounds

We report a new, effective and simple method for preparing a,fl-unsaturated carbonyl compounds by reacting ketones and aromatic alcohols at 56 ℃ in the presence of CrO3 （CrO3 acts as an oxidant and also a catalyst） for around 10 h. The condensation reactions occurred effectively among a wide combination of ketones and alcohols. The procedure is simple and the yields can be high up to 98%. And a probable mechanism is proposed.

One pot synthesis of dibenzodiazepinones via CuI catalysis in ethylene glycol

A one pot protocol for the synthesis of dibenzodiazepinones was developed. The substituted ethyl 2- halobenzoates are cross-coupled with o-phenylenediamine utilizing a ligand-free, Cul catalyzed system, which spontaneously undergo an intramolecular N-acylation in ethylene glycol to give the corresponding products in high yields. This synthetic protocol provides a concise and efficient access to a wide variety of dibenzodiazepinone, including biologically active molecules.

Ope Pot Synthesis and Characterization of Safener R-28725

The title compound was synthesized by a one pot synthesis method with ethanolamine ,ketone and dichloroacetyl chloride. The product was characterization by IR, 1 HNMR,UV, and elementary analysis.

Synthesis of Arylsubstituted Imidazolin-2-one Analogues

Herein we reported a one-pot synthesis of arylsubstituted imidazolin-2-ones by the cyclization of α-aminoacetophenone hydrochloride analogues 2 with arylisocyanates 3. Compared with other known synthetic route, this method resulted in higher yield.

Highly efficient one-pot synthesis of dihydropyran heterocycles

Diammonium hydrogen phosphate and potassium carbonate-catalyzed one-pot synthesis of 1,4- phenylene-bis（2-amino-4H-pyran-3-carbonitrile and 2-amino-4-aryl-4H-pyran-3-carbonitrile deriva- tives has been achieved by a three-component cyclocondensation of aldehydes, malononitrile, and different nucleophiles in aqueous medium in high yields.

One-Pot Synthesis of Spiro[fluorene-9,9'-xanthene]Derivatives

As a novel class of spirofluorenes,spirobifluorene(SBF)and spiro[fluo-rene-9,9'-xanthene]derivatives(SFXs)have orthogonal geometric config-uration,spiro-conjugation effect,and rigid steric hindrance,which can be widely used in the fields of synthetic chemistry,materials chemistry and supramolecular chemistry.Due to their facile one-pot synthetic route,and to the variety of molecular designs,SFXs are expected to become new spiro functional materials that replace SBF.In this review,we present the history,development and expansion of SFXs synthesis in one-pot methods,and the advantages and limitations of one-pot synthesis are also dis-cussed.

An efficient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives

A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction ofacetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyI derivatives 3a-3c in the presence of potassium carbonate afforded the target compounds, namely ethyl 2-（4-acetyl-3-methyl-5-（phenylamino）thiophen-2-yl）-2-oxoacetate derivatives 4a-4e, ethyl 3-（4- acetyl-3-methyl-5-（phenylamino）thiophen-2-yl）-3-oxopropanoate derivatives 4f-4i, di（（4-acetyl-3- methyl-5-phenylamino）thiophen-2-yl）ketone derivatives 4j-4n in reasonable overall yields. The synthesized compounds were screened for antirnicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported.

Iron-Promoted Practical One-Pot Synthesis of 2,5-Disubstituted Oxazoles

A practical one-pot protocol for the synthesis of 2,5-disubstituted oxazoles from 1-aryl-2-nitroethanones was reported. In the presence of iron/AcOH in acetonitrile, the reaction of 1-aryl-2-nitroethanones with trimethyl orthoacetate or trimethyl orthobenzoate delivered the corresponding 2,5-disubstituted oxazoles in moderate to good yields.

Facile, Direct Reaction of Benzaldehydes to 3-Arylprop-2-Enoic Acids and 3-Arylprop-2-Ynoic Acids in Aqueous Medium

Wittig reactions of benzaldehydes, alkanals, and cycloalkanals as well as of acetophenones are carried out with alkoxycarbonyl methylidenetriphenylphosphoranes in 10 w% aqueous NaOH, where the cinnamates and alkenoates produced are hydrolysed in situ and the corresponding acids are obtained after mostly simple extractive work-up, often without employing organic solvents. Under the same conditions, benzaldehydes are reacted with alkoxycarbonyl bromomethy-lidenephosphorane to produce 3-arylprop-2-ynoic acids (arylpropiolic acids).

α-Fe_2O_3 nanoparticles:An efficient,inexpensive catalyst for the one-pot preparation of 3,4-dihydropyrano[c]chromenes

This paper describes the combustion synthesis ofα-Fe2O3 nanopowder at much lower temperature and its catalytic activity for the one-pot preparation of 3,4-dihydropyrano[c]chromenes.The combustion derivedα-Fe_2O_3 nanopowder was characterized by powder X-ray diffraction（PXRD）,Braunauer,Emmett and Teller（BET） surface area,scanning electron microscopy（SEM） and Fourier transform infrared spectroscopy（FTIR）.Highly efficient,three-component condensation of aromatic aldehyde,malanonitrile and 4- hydroxycoumarin catalyzed byα-Fe2O3 nanoparticles at room temperature is described.The method offers an excellent alternative to the synthesis of 3,4-dihydropyrano[c]chromenes.The reactions are rapid,clean,and the products with good yield and high purity.

A Novel One-pot Synthesis of Biaryl Derivatives by Sequential Strategies via Suzuki Coupling/Knoevenagel Condensation in Aqueous Medium at Room Temperature

A novel one-pot synthesis of biaryl derivatives has been developed starting from bromobenzaldehyde and phenylboronic acid in the presence of activated methylene compounds via sequential Suzuki coupling/Knoevenagel condensation in aqueous isopropanol medium at room temperature. Significantly, this strategy afforded a straightforward and efficient approach to construct original biaryls in which a new carbon double bond bound to activated moieties such as nitrile, ester and amide is formed from three simple substrates in a one-pot procedure. Moreover, a wide scope of substrates could effectively participate in the process affording the target products in moderate to excellent yields.

Approach to the Synthesis of Dimeric Salen-Co(Ⅲ):A Recoverable Catalyst for Rac-Eprichlorohydrin HKR

The synthesis of chiral dimeric Salen ligand 5, 5＇-methylene-di-[（R, R ）-｜ N-（3-tert-butylsalicylidine）-N＇- （ 3＇, 5＇-di- tert-butylsalicylidene） ｜ - 1, 2-cyclohexanediamine ] which using 2-tert-butylphenol as starting material is reported. This compound reacts with cobalt （Ⅱ） acetate and then oxidized by air to give dimeric Salen catalyst 5 in this paper, which catalyzes the hydrolytic kinetic resolution （HKR） of racemic epichlorohydrin to afford biologically important chiral epoxides and diols. Ee values of diol up to 97 % were obtained, and the catalyst was recovered with no apparent loss.

Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols

A series of 4-thioflavonols compounds were synthesized by treating flavonols with lawsons reagent with variable substituent groups at A, B, and AB rings. All the synthesized compounds were checked for antibacterial and antifungal activity. We report that many compounds were found active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, bacterial strains and, C. albicans, C. parapsilosisstrains and C. krusei fungal strains. Most of the synthesized 4-thioflavonols compounds were found to show enhanced antimicrobial activity than respective flavonol compounds.

Study on the Synthesis of 3,4,5-Trimethoxytoluene

The 3,4,5 trimethoxytoluene(TMT) was systhesized using p cresol by three steps including bromination, methoxylation, and methylation with an overall yield of 84%. The structure of TMT was identified by NMR, GC/MS and IR.“One pot”method was used in methoxylation and methylation for economical and convenient consideration. The mechanism for the methoxylation of 2,6 dibromo 4 methylphenol was discussed.

Synthesis of Substituted Pyrroles via Ultrasound Assisted Three-component Coupling Reaction of Amines, α,β-Unsaturated Aldehydes and Nitroalkanes

An efficient synthesis of substituted pyrroles via ultrasound assisted three component coupling reaction of amines with α,β unsaturated aldehydes and nitroalkanes is reported.

Synthesis of hexacyclic fused isocoumarin framework through selective domino multicyclizations under catalyst and solvent free conditions

A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200℃ under catalyst and solvent free reaction conditions. Six fused rings with two stereogenic centers were assembled in a convenient onepot operation in good yield. The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.