Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in mortality.Liver cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ab...Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in mortality.Liver cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ablation,transarterial chemoembolization,radiotherapy,chemotherapy,targeted therapy,immuno-therapy,and traditional Chinese medicine(TCM).A multidisciplinary team(MDT)is essential to customize treatment plans based on tumor staging,liver function,and performance status(PS),ensuring individualized patient care.Treatment decisions require a MDT to tailor strategies based on tumor staging,liver function,and PS,ensuring personalized care.The approval of new first-line and second-line drugs and the establishment of standard treatments based on immune checkpoint inhibitors have significantly expanded treatment options for advanced liver cancer,improving overall prognosis.However,many patients do not respond effectively to these treatments and ultimately succumb to the disease.Modern oncology treatments,while extending patient survival,often come with severe side effects,resistance,and damage to the body,negatively impacting quality of life.Huang et al's study published at World Journal of Gastroenterology rigorously validates the anticancer properties of Calculus bovis,enhancing our understanding of TCM and contributing to new liver cancer treatment strategies.For over 5000 years,TCM has been used in East Asian countries like China to treat various diseases,including liver conditions.Analysis of real-world clinical data suggests that for patients with advanced-stage tumors lacking effective treatments,integrated TCM therapies could provide significant breakthroughs.展开更多
Einstein Probe,an astronomical satellite designed for X-ray observation on astronomical events drastically evolving over time,was successfully sent into preset orbit by a Long March 2C rocket from China’s Xichang Sat...Einstein Probe,an astronomical satellite designed for X-ray observation on astronomical events drastically evolving over time,was successfully sent into preset orbit by a Long March 2C rocket from China’s Xichang Satellite Launch Center located in Sichuan Province at 15:03 GMT+8 on January 9,2024.展开更多
Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases(Alzheimer’s disease,multiple sclerosis,Parkinson’s disease,Huntington’s disease),cerebr...Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases(Alzheimer’s disease,multiple sclerosis,Parkinson’s disease,Huntington’s disease),cerebrovascular conditions(stroke),and neurodevelopmental disorders(autism spectrum disorder).Although they affect millions of individuals around the world,only a limited number of effective treatment options are available today.Since most neurological disorders express mitochondria-related metabolic perturbations,metformin,a biguanide type II antidiabetic drug,has attracted a lot of attention to be repurposed to treat neurological disorders by correcting their perturbed energy metabolism.However,controversial research emerges regarding the beneficial/detrimental effects of metformin on these neurological disorders.Given that most neurological disorders have complex etiology in their pathophysiology and are influenced by various risk factors such as aging,lifestyle,genetics,and environment,it is important to identify perturbed molecular functions that can be targeted by metformin in these neurological disorders.These molecules can then be used as biomarkers to stratify subpopulations of patients who show distinct molecular/pathological properties and can respond to metformin treatment,ultimately developing targeted therapy.In this review,we will discuss mitochondria-related metabolic perturbations and impaired molecular pathways in these neurological disorders and how these can be used as biomarkers to guide metformin-responsive treatment for the targeted therapy to treat neurological disorders.展开更多
Recent studies have demonstrated that neuroplasticity,such as synaptic plasticity and neurogenesis,exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheime...Recent studies have demonstrated that neuroplasticity,such as synaptic plasticity and neurogenesis,exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer’s disease.Hence,promoting neuroplasticity may represent an effective strategy with which Alzheimer’s disease can be alleviated.Due to their significant ability to self-renew,differentiate,and migrate,neural stem cells play an essential role in reversing synaptic and neuronal damage,reducing the pathology of Alzheimer’s disease,including amyloid-β,tau protein,and neuroinflammation,and secreting neurotrophic factors and growth factors that are related to plasticity.These events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the mammalian brain.Consequently,neural stem cells are considered to represent a potential regenerative therapy with which to improve Alzheimer’s disease and other neurodegenerative diseases.In this review,we discuss how neural stem cells regulate neuroplasticity and optimize their effects to enhance their potential for treating Alzheimer’s disease in the clinic.展开更多
In recent years, a large number of approaches to constrained multi-objective optimization problems(CMOPs) have been proposed, focusing on developing tweaked strategies and techniques for handling constraints. However,...In recent years, a large number of approaches to constrained multi-objective optimization problems(CMOPs) have been proposed, focusing on developing tweaked strategies and techniques for handling constraints. However, an overly finetuned strategy or technique might overfit some problem types,resulting in a lack of versatility. In this article, we propose a generic search strategy that performs an even search in a promising region. The promising region, determined by obtained feasible non-dominated solutions, possesses two general properties.First, the constrained Pareto front(CPF) is included in the promising region. Second, as the number of feasible solutions increases or the convergence performance(i.e., approximation to the CPF) of these solutions improves, the promising region shrinks. Then we develop a new strategy named even search,which utilizes the non-dominated solutions to accelerate convergence and escape from local optima, and the feasible solutions under a constraint relaxation condition to exploit and detect feasible regions. Finally, a diversity measure is adopted to make sure that the individuals in the population evenly cover the valuable areas in the promising region. Experimental results on 45 instances from four benchmark test suites and 14 real-world CMOPs have demonstrated that searching evenly in the promising region can achieve competitive performance and excellent versatility compared to 11 most state-of-the-art methods tailored for CMOPs.展开更多
The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The ...The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The technology would also allow surgeons to perform operations remotely on patients thousands of kilometers away,permit communications between driverless cars,and offer other life-changing benefits[2,3].展开更多
Corchorus olitorius (Jew’s mallow), is one of the African indigenous leafy vegetables increasingly getting attention as a possible contributor of both micronutrients and bioactive compounds including proteins, lipids...Corchorus olitorius (Jew’s mallow), is one of the African indigenous leafy vegetables increasingly getting attention as a possible contributor of both micronutrients and bioactive compounds including proteins, lipids, fiber and vitamin C to human nutrition. Leaves of Corchorus olitorius have been found to have high level of phytochemicals: flavonoids, polyphenols, tannins, and saponins that possess strong radical scavenging activity and antioxidant power. In the arid and semi-arid areas of the world, drought is the main limiting factor affecting plant productivity and influences almost all aspects of plant biology. Water stress deficit is known to cause oxidative stress condition that has generally been reported to elevate phenolic antioxidants in various crops including Jew’s mallow. On the other hand, fertilization is crucial for crop management and high yield, it also affects nutritional value of the food plants. Nitrogen (N) fertilization affects health and nutritional value, including mineral content, fatty acid profile, anti-oxidative capacity and polyphenol levels and composition. The possible effects of fertilization should be considered when deciding on fertilization regime, to optimize both plant physiology, productivity and food-related effects. Nitrogen is an important element for Jew’s mallow production since it responds well to it. However, appropriate amounts of nutrients need to be provided to crops at the right time to favor both crop growth, yield and quality. Different reports confirmed that addition or increase of N, negatively affects the total phenolics and total flavonoids, and reduces accumulation of defense-related secondary metabolites resulting in lower oxidative capacity. Increased secondary metabolite production during water deficit and low nitrogen in the soil has been reported as a stress mechanism by most plants. However, further research is required to explore the biochemical response of Jew’s mallow to water deficit and nitrogen fertilization.展开更多
President Xi Jinping’s inspection tour of Hebei to promote coordinated Beijing-Tianjin-Hebei development underlines the region’s pursuit of Chinese modernization.
[目的]本文旨在解决在自然环境下不同成熟度苹果目标检测精度较低的问题。[方法]提出了一种改进的YOLOv5s模型SODSTR-YOLOv5s(YOLOv5s with small detection layer and omni-dimensional dynamic convolution and swin transformer bloc...[目的]本文旨在解决在自然环境下不同成熟度苹果目标检测精度较低的问题。[方法]提出了一种改进的YOLOv5s模型SODSTR-YOLOv5s(YOLOv5s with small detection layer and omni-dimensional dynamic convolution and swin transformer block),用于不同成熟度苹果检测。首先改进YOLOv5s的多尺度目标检测层,在Prediction中构建检测160×160特征图的检测头,提高小尺寸的不同成熟度苹果的检测精度;其次在Backbone结构中融合Swin Transformer Block,加强同级成熟度的苹果纹理特征融合,弱化纹理特征分布差异带来的消极影响,提高模型泛化能力;最后将Neck结构的Conv模块替换为动态卷积模块ODConv,细化局部特征映射,实现局部苹果细粒度特征的充分提取。基于不同成熟度苹果数据集进行试验,验证改进模型的性能。[结果]改进模型SODSTR-YOLOv5s检测的精确率、召回率、平均精度均值分别为89.1%、95.5%、93.6%,高、中、低成熟度苹果平均精度均值分别为94.1%、93.1%、93.7%,平均检测时间为16 ms,参数量为7.34 M。相比于YOLOv5s模型,改进模型SODSTR-YOLOv5s精确率、召回率、平均精度均值分别提高了3.8%、5.0%、2.9%,参数量和平均检测时间分别增加了0.32 M和5 ms。[结论]改进模型SODSTR-YOLOv5s提升了在自然环境下对不同成熟度苹果的检测能力,能较好地满足实际采摘苹果的检测要求。展开更多
文摘Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in mortality.Liver cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ablation,transarterial chemoembolization,radiotherapy,chemotherapy,targeted therapy,immuno-therapy,and traditional Chinese medicine(TCM).A multidisciplinary team(MDT)is essential to customize treatment plans based on tumor staging,liver function,and performance status(PS),ensuring individualized patient care.Treatment decisions require a MDT to tailor strategies based on tumor staging,liver function,and PS,ensuring personalized care.The approval of new first-line and second-line drugs and the establishment of standard treatments based on immune checkpoint inhibitors have significantly expanded treatment options for advanced liver cancer,improving overall prognosis.However,many patients do not respond effectively to these treatments and ultimately succumb to the disease.Modern oncology treatments,while extending patient survival,often come with severe side effects,resistance,and damage to the body,negatively impacting quality of life.Huang et al's study published at World Journal of Gastroenterology rigorously validates the anticancer properties of Calculus bovis,enhancing our understanding of TCM and contributing to new liver cancer treatment strategies.For over 5000 years,TCM has been used in East Asian countries like China to treat various diseases,including liver conditions.Analysis of real-world clinical data suggests that for patients with advanced-stage tumors lacking effective treatments,integrated TCM therapies could provide significant breakthroughs.
文摘Einstein Probe,an astronomical satellite designed for X-ray observation on astronomical events drastically evolving over time,was successfully sent into preset orbit by a Long March 2C rocket from China’s Xichang Satellite Launch Center located in Sichuan Province at 15:03 GMT+8 on January 9,2024.
文摘Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases(Alzheimer’s disease,multiple sclerosis,Parkinson’s disease,Huntington’s disease),cerebrovascular conditions(stroke),and neurodevelopmental disorders(autism spectrum disorder).Although they affect millions of individuals around the world,only a limited number of effective treatment options are available today.Since most neurological disorders express mitochondria-related metabolic perturbations,metformin,a biguanide type II antidiabetic drug,has attracted a lot of attention to be repurposed to treat neurological disorders by correcting their perturbed energy metabolism.However,controversial research emerges regarding the beneficial/detrimental effects of metformin on these neurological disorders.Given that most neurological disorders have complex etiology in their pathophysiology and are influenced by various risk factors such as aging,lifestyle,genetics,and environment,it is important to identify perturbed molecular functions that can be targeted by metformin in these neurological disorders.These molecules can then be used as biomarkers to stratify subpopulations of patients who show distinct molecular/pathological properties and can respond to metformin treatment,ultimately developing targeted therapy.In this review,we will discuss mitochondria-related metabolic perturbations and impaired molecular pathways in these neurological disorders and how these can be used as biomarkers to guide metformin-responsive treatment for the targeted therapy to treat neurological disorders.
基金supported by the National Natural Science Foundation of China,No.82074533(to LZ).
文摘Recent studies have demonstrated that neuroplasticity,such as synaptic plasticity and neurogenesis,exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer’s disease.Hence,promoting neuroplasticity may represent an effective strategy with which Alzheimer’s disease can be alleviated.Due to their significant ability to self-renew,differentiate,and migrate,neural stem cells play an essential role in reversing synaptic and neuronal damage,reducing the pathology of Alzheimer’s disease,including amyloid-β,tau protein,and neuroinflammation,and secreting neurotrophic factors and growth factors that are related to plasticity.These events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the mammalian brain.Consequently,neural stem cells are considered to represent a potential regenerative therapy with which to improve Alzheimer’s disease and other neurodegenerative diseases.In this review,we discuss how neural stem cells regulate neuroplasticity and optimize their effects to enhance their potential for treating Alzheimer’s disease in the clinic.
基金partly supported by the National Natural Science Foundation of China(62076225)。
文摘In recent years, a large number of approaches to constrained multi-objective optimization problems(CMOPs) have been proposed, focusing on developing tweaked strategies and techniques for handling constraints. However, an overly finetuned strategy or technique might overfit some problem types,resulting in a lack of versatility. In this article, we propose a generic search strategy that performs an even search in a promising region. The promising region, determined by obtained feasible non-dominated solutions, possesses two general properties.First, the constrained Pareto front(CPF) is included in the promising region. Second, as the number of feasible solutions increases or the convergence performance(i.e., approximation to the CPF) of these solutions improves, the promising region shrinks. Then we develop a new strategy named even search,which utilizes the non-dominated solutions to accelerate convergence and escape from local optima, and the feasible solutions under a constraint relaxation condition to exploit and detect feasible regions. Finally, a diversity measure is adopted to make sure that the individuals in the population evenly cover the valuable areas in the promising region. Experimental results on 45 instances from four benchmark test suites and 14 real-world CMOPs have demonstrated that searching evenly in the promising region can achieve competitive performance and excellent versatility compared to 11 most state-of-the-art methods tailored for CMOPs.
文摘The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The technology would also allow surgeons to perform operations remotely on patients thousands of kilometers away,permit communications between driverless cars,and offer other life-changing benefits[2,3].
文摘Corchorus olitorius (Jew’s mallow), is one of the African indigenous leafy vegetables increasingly getting attention as a possible contributor of both micronutrients and bioactive compounds including proteins, lipids, fiber and vitamin C to human nutrition. Leaves of Corchorus olitorius have been found to have high level of phytochemicals: flavonoids, polyphenols, tannins, and saponins that possess strong radical scavenging activity and antioxidant power. In the arid and semi-arid areas of the world, drought is the main limiting factor affecting plant productivity and influences almost all aspects of plant biology. Water stress deficit is known to cause oxidative stress condition that has generally been reported to elevate phenolic antioxidants in various crops including Jew’s mallow. On the other hand, fertilization is crucial for crop management and high yield, it also affects nutritional value of the food plants. Nitrogen (N) fertilization affects health and nutritional value, including mineral content, fatty acid profile, anti-oxidative capacity and polyphenol levels and composition. The possible effects of fertilization should be considered when deciding on fertilization regime, to optimize both plant physiology, productivity and food-related effects. Nitrogen is an important element for Jew’s mallow production since it responds well to it. However, appropriate amounts of nutrients need to be provided to crops at the right time to favor both crop growth, yield and quality. Different reports confirmed that addition or increase of N, negatively affects the total phenolics and total flavonoids, and reduces accumulation of defense-related secondary metabolites resulting in lower oxidative capacity. Increased secondary metabolite production during water deficit and low nitrogen in the soil has been reported as a stress mechanism by most plants. However, further research is required to explore the biochemical response of Jew’s mallow to water deficit and nitrogen fertilization.
文摘President Xi Jinping’s inspection tour of Hebei to promote coordinated Beijing-Tianjin-Hebei development underlines the region’s pursuit of Chinese modernization.
文摘[目的]本文旨在解决在自然环境下不同成熟度苹果目标检测精度较低的问题。[方法]提出了一种改进的YOLOv5s模型SODSTR-YOLOv5s(YOLOv5s with small detection layer and omni-dimensional dynamic convolution and swin transformer block),用于不同成熟度苹果检测。首先改进YOLOv5s的多尺度目标检测层,在Prediction中构建检测160×160特征图的检测头,提高小尺寸的不同成熟度苹果的检测精度;其次在Backbone结构中融合Swin Transformer Block,加强同级成熟度的苹果纹理特征融合,弱化纹理特征分布差异带来的消极影响,提高模型泛化能力;最后将Neck结构的Conv模块替换为动态卷积模块ODConv,细化局部特征映射,实现局部苹果细粒度特征的充分提取。基于不同成熟度苹果数据集进行试验,验证改进模型的性能。[结果]改进模型SODSTR-YOLOv5s检测的精确率、召回率、平均精度均值分别为89.1%、95.5%、93.6%,高、中、低成熟度苹果平均精度均值分别为94.1%、93.1%、93.7%,平均检测时间为16 ms,参数量为7.34 M。相比于YOLOv5s模型,改进模型SODSTR-YOLOv5s精确率、召回率、平均精度均值分别提高了3.8%、5.0%、2.9%,参数量和平均检测时间分别增加了0.32 M和5 ms。[结论]改进模型SODSTR-YOLOv5s提升了在自然环境下对不同成熟度苹果的检测能力,能较好地满足实际采摘苹果的检测要求。
