Laparoscopic cholecystectomy for a left-sided gallbladder

Cholecystectomy is a common procedure.Abnormalities in the anatomy of the biliary system are common but an abnormal location of the gallbladder is much rarer.Despite frequent pre-operative imaging,the aberrant location of the gallbladder is commonly discovered at surgery.This article presents a case of a patient with the gallbladder located to the left of the falciform ligament in the absence of situs inversus totalis that presented with right upper quadrant pain.A laparoscopic cholecystectomy was performed and it was noted that the cystic duct originated from the right side.The presence of a left sided gall bladder is often associated with various biliary,portal venous and other anomalies that might lead to intra-operative injuries.The spectrum of unusual positions and anatomical gallbladder abnormalities is reviewed in order to facilitate elective and emergent cholecystectomy as well as other hepatobiliary procedures.With proper identification of the anatomy,minimally invasive approaches are still considered safe.

Preparation of Large Area Double Sided YBCO Thin Films by DC Magneton Sputtering

Tc, Jc and Rs properties of large area double sided YBCO thin films deposited on LaAlO3 substrates by direct current sputtering were reported.Film thickness of the obtained thin films is over 300 nm, Tc > 90 K; Rs can be as low as less than 1.0 mΩ(77 K, 10 GHz).Homogenousity of the properties around the plane was studied.Under the measnous distributions.Influences of substrate temperature and Ar and O2 pressures on properties of the double-sided thin films were discussed.

THE ONE-SIDED HANDAMARD PRINCIPAL VALUE FOR SINGULAR-INTEGRALS OF HIGH ORDER AND ITS APPLICATIONS

0 IntroductionLet L = ab be a non-closed smooth arc oriented from a to b, t∈ L, t≠a,b, be the fixed point, andf(t) ∈H. (L) . The usual Hadamard principal value is defined asAbout properties and applications of singular integals of high order were investigated by many authors([1],[2],[3] etc. ) In 1987, the concepts of Hadamard principal value at one-side for singular integralsof high order and the rules of their differentiation are introduced [4]. In this paper we established the rulesof substitution of variable for one-sided Hadamard principal value of singular integrals of high order, andthen, we gave some applications in evaluation of real definite integrals.

Left sided Amyand's hernia

The presence of the appendix in an inguinal hernia sac has been referred to as Amyand’s hernia.Vermiform appendix located in an external hernia sac is not an uncommon condition,and the incidence of these cases is approximately 1%.In Amyand’s hernias,appendices are frequently found in the hernia sac;but an incarceration particularly on the left side is a very unusual sight.In this report we present 32-year-old male with Amyand’s hernia on the left side.

Considering FOLFOXIRI plus bevacizumab for metastatic colorectal cancer with left-sided tumors

A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS or BRAF status. Our subanalysis of a phase Ⅱ trial of the FOLFOXIRI triplet regimen plus bevacizumab in patients with mCRC who had RAS mutant tumors showed that tumor shrinkage was better and the duration of treatment was longer in patients with leftsided tumors than in those with right-sided tumors, leading to a higher rate of conversion to surgery in mCRC patients with left-sided tumors. The early and deep responses to the triplet-regimen in patients with left-sided tumors might facilitate conversion treatment resulting in favorable survival. Our data suggest that the FOLFOXIRI plus bevacizumab might be a promising treatment for left-sided mCRC involving RAS mutant tumors.

Left-sided gallbladder:A rare biliary tree anomaly

To the Editor:Hepatobiliary anatomical variations may increase the complexity of surgery with a relevant risk of iatrogenic lesions.Left-sided gallbladder(LSG)is a rare and little known condition whereby the viscus is located on the visceral surface of the left lobe of the liver and is often discovered unexpectedly during surgery.The position of the gallbladder over the liver pedicle and the simultaneous presence of variations in the liver vascularization are potentially associated to a challenging surgical dissection and consequently to an increased risk of morbidity.Despite open approach remains an option in more complex procedures,cholecystectomy is usually performed with a minimally invasive technique,which is generally safe even in the rare case of an LSG,as long as a high level of awereness of anatomical variations and a careful surgical dissection are pursued.

Applications of the CE/SE Scheme to Incompressible Viscous Flows in Two-Sided Lid-Driven Square Cavities

The spacetime conservation element-solution element(CE/SE)method is extended to two-dimensional incompressible viscous flow in a two-sided lid-driven square cavity.Based on the SIMPLE method concept,the preconditioned dual-time scheme is introduced for unsteady computations.The CE/SE-based code is validated by simulating one-sided lid-driven cavity flows.The two-sided lid-driven square cavity problem involves several interesting characteristics being successfully predicted,including development of a pair of off-corner vortices and a free shear layer in the case of parallel wall motion,as well as the appearance of corner vortices for lower Reynolds numbers in the case of anti-parallel motion of the walls.It is found that both the Reynolds number and the direction of the moving walls affect the fluid flow in the cavity.

Maintaining sidedness and fluidity in cell membrane coatings supported on nano-particulate and planar surfaces

Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials,provided sidedness and fluidity of the natural membrane are maintained upon coating.However,the properties of a support-surface responsible for maintaining correct sidedness and fluidity are unknown.Here,we briefly review the properties of natural membranes and membrane-isolation methods,with focus on the asymmetric distribution of functional groups in natural membranes(sidedness)and the ability of molecules to float across a membrane to form functional domains(fluidity).This review concludes that hydrophilic sugar-residues of glycoproteins in the outer-leaflet of cell membranes direct the more hydrophobic inner-leaflet towards a support-surface to create a correctly-sided membrane coating,regardless of electrostatic double-layer interactions.On positively-charged support-surfaces however,strong,electrostatic double-layer attraction of negatively-charged membranes can impede homogeneous coating.In correctly-sided membrane coatings,fluidity is maintained regardless of whether the surface carries a positive or negative charge.However,membranes are frozen on positively-charged,highly-curved,small nanoparticles and localized nanoscopic structures on a support-surface.This leaves an unsupported membrane coating in between nanostructures on planar support-surfaces that is in dual-sided contact with its aqueous environment,yielding enhanced fluidity in membrane coatings on nanostructured,planar support-surfaces as compared with smooth ones.

Double-sided Plasmonic Metasurface for Simultaneous Biomolecular Separation and SERS Detection

Biomolecular separation is an important technique for biological applications such as medical diagnosis where molecular selectivity and ux control are key technical concerns^([1]).Nanoporous membranes have been considered as a powerful platform to ltrate and separate biomolecules^([2]).Among diverse membranes,the ion-track-etched membranes with uniform yet tunable pore size,density and shapes have been widely recognized due to their excellent selectivity and high permlability.

张载与此岸性认定

张载率先改变儒释道三教并用格局,告别宗教时代,推进中国哲学史进程,揭开宋明理学新篇章。他站在儒家立场上回应佛教,创立气本体论,证明此岸世界的唯一性和真实性,重申一元世界观,迈出了宋明理学思潮的第一步。他提出的太虚即气说和天人合一说有新意也有局限。由于气在价值上中立,限制张载的视野,难以对儒家伦理提供本体论担保,不得不让位于天理本体论。

Exploring Shaking for Cancer Treatment

1.Double-sided role of vibration and shaking Removing vibration and shaking is a pivotal engineering task,which is showcased,for instance,in spacecraft attitude control systems that ensure a precise three-dimensional orientation.Vibration or shaking,such as precession caused by external torque,nutation stemming from off-axis angular momentum,and wobbling due to geometric misalignment,necessitate active and passive damping mechanisms.This principle extends beyond spacecraft to centrifugation techniques,pivotal not only in washing machines but also in a spectrum of biomedical apparatuses used for isolating cells and organelles and separating DNA and proteins.

SAC/SWG 38 on general agricultural standards set up

The founding ceremony and the first plenary meeting of SAC/SWG 38, Basic and general standards in agriculture, were held on October 29 in Beijing. Xu Changxing, First-class Inspector of the Standards Technical Management Department of SAMR, Xu Minggang, Academician of the Chinese Academy of Engineering and Chair of SAC/SWG 38, and 59 members of SAC/SWG 38 attended the meeting. Li Zhiping, Vice President of China National Institute of Standardization(CNIS), which holds the secretariat of the working group, presided over the meeting.

National technical committee on rock and soil mechanics set up in Liaoning

The founding ceremony and the first plenary meeting of SAC/TC 605,Rock and soil mechanics,was held on February 26 at the Northeastern University (NEU) in Liaoning province.The meeting was presided over by Feng Xiating, President of Northeastern University and Academician of Chinese Academy of Engineering (CAE), and addressed by Gao Tao.

Bolstering Ties China-Cambodia Dialogue on Cultural and Economic Exchanges in Phnom Penh

On the afternoon of September7,the ChinaCambodia Dialogue on Cultural and Economic Exchanges,themed"building a China-Cambodia community with a shared future in the new era,"took place in Phnom Penh,capital of Cambodia.Du Zhanyuan,president of China International Communications Group (CICG),and Kha Leng,Secretary of State of the Ministry of Commerce of Cambodia,delivered speeches at the conference.Neth Pheaktra,Minister of Information of Cambodia,delivered an address via video.Chen Cong,Minister Counselor of the Embassy of China in Cambodia,and Chhean Leang,Secretary of State of the Ministry of Information of Cambodia,also attended.Chen Wenge,president of the CICG Center for Asia-Pacific,presided over the opening ceremony.

BRIEFING

CCPIT BRICS Women’s Leadership Forum Was Held On June 11,the 2024 BRICS Women’s Leadership Forum was held in Beijing.Ren Hongbin,Chairman of the China Council for the Promotion of International Trade(CCPIT)and the China Chamber of International Commerce(CCOIC),Huang Xiaowei,Vice-President and First Member of the Secretariat of the All-China Women’s Federation(ACWF),and Vice-Chairperson of the National Working Committee on Children and Women under the State Council,Siyabonga Cyprian Cwele,Ambassador of South Africa to China,Assem Hanafi,Ambassador of Egypt to China,Zhao Haiying,Chairperson of the Chinese Chapter of the BRICS Women’s Business Alliance(WBA),and Anna Nesterova,Rotating Chairperson of the BRICS WBA in 2024,attended the opening ceremony and delivered speeches.Yu Jianlong,Vice Chairman of the CCPIT and the CCOIC,presided over the opening ceremony.

标准对话:国外标准化组织2024年工作规划

To bolster mutual understanding,better understand major tasks of overseas standards organizations and facilitate in-depth cooperation in standardization field,China Standardization Press organized a high-end dialogue on standards in March.Presided over by Ms.Yu Xinli,President of China Association for Standardization,Dr.Yuan Yu,Ms.Hu Yanan,Dr.Betty Xu and Mr.Xu Fang,as representatives of IEEE SA,ASTM International,SESEC and ANSI respectively,were invited to brief on the current development trend of standardization,the work plan and priorities of each organization in 2024,and their suggestions for China’s standardization work.

标准引领 推动高质量发展——第二届中国标准化大会在浙江衢州召开

The Second China Standardization Conference was held in Quzhou city,Zhejiang province,on May 22-23,2024,which was hosted by China Association for Standardization(CAS).The conference was presided over by Zhang Xiuchun,Secretary General of CAS,and addressed by Xu Zhangyan,Mayor of Quzhou,and Li Yaowu,Deputy Secretary-General of Zhejiang Provincial People’s Government,and Yu Xinli,President of CAS.The conference was attended by more than 1,300 participants on site including renowned experts and scholars on standardization,leaders of research institutes,heads of standards technical management,and representatives of enterprises at home and abroad,and watched by over 20,000 audiences on line.

Clinical and molecular heterogeneity associated with tumor sidedness in colorectal liver metastasis: a multicenter propensity cohort study

Background:Colorectal liver metastasis(CRLM)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their prognosis.The aim of this study is to explore whether left-sided tumors is clinically and gnomically distinct from right-sided tumors in CRLM.Methods:This retrospective study included 1,307 patients who underwent primary tumor and metastases resection at three academic centers in China from January 1,2012,to December 31,2020.Propensity score matching with 1:1 ratio matching was performed.The prognostic impact of tumor sidedness was determined after stratifying by the KRAS mutational status.Moreover,whole-exome sequencing(WES)of 200 liver tumor tissues were performed to describe the heterogeneity across the analysis of somatic and germline profiles.Results:The median follow-up was 68 months.Matching yielded 481 pairs of patients.Compared to right-sided CRLM,left-sided patients experienced with better 5-year overall survival(OS)in surgery responsiveness,with a 14.6 lower risk of death[hazard ratio(HR),1.36,95%confidence interval(CI),1.10-1.69,P=0.004].Interaction between tumor sidedness and KRAS status was statistically significant:left-sidedness was associated with better prognosis among KRAS wild-type patients(HR 1.71;95%CI:1.20-2.45;P=0.003),but not among KRAS mutated-type patients.Integrated molecular analyses showed that right-sided tumors more frequently harbored TP53,APC,KRAS,and BRAF alterations,and identified a critical role of KRAS mutation in correlation with their survival differences.Higher pathogenic germline variants were identified in the right-sided tumors compared with left-sided tumors(29.3%vs.15.5%,P=0.03).Conclusions:We demonstrated that the prognostic impacts of tumor sidedness in CRLM is restricted patients with KRAS wild-type tumors.Tumor sidedness displays considerable clinical and molecular heterogeneity that may associate with their therapy benefits and prognosis.

Parallel session on robot standardization

The session on robot standardization,hosted by CAS and organized by Robot Sub-committee of CAS,IAM Science and Technology Company,China Jiliang University and Jinyi Holding Group,was held on May 23,which was presided over by Ma Dejun,Vice President of CAS.The meeting invited 9 experts from well-known research institutes,universities and companies to deliver keynote speeches,sharing their latest research results and profound insights on robots and standards.Here,the main contents of two speeches are presented.

Review and update on the management of triangular fibrocartilage complex injuries in professional athletes

Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in association with rotations or radial/ulnar deviations.In order to treat professional athletes,a detailed specific knowledge of the pathology is needed.Moreover,the clinician should fully understand the specific and unique environment and needs of the athletes,their priorities and goals,the type of sport,the time of the season,and the position played.An early diagnosis and appropriate management with the quickest possible recovery time are the uppermost goals for both the athlete and the surgeon.A compromise between conservative vs surgical indications,athletes’needs and expectations,and financial implications should be achieved.Arthroscopic procedures should be timely planned when indicated as they could allow early diagnosis and treatment at the same time.Conservative measures are often used as first line treatment when possible.Peripheral lesions are treated by arthroscopic repair,whilst central lesions are treated by arthroscopic debridement.Further procedures(such as the Wafer procedure,ulnar osteotomies,etc.)have specific indications and great implications with regard to rehabilitation.