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Therapeutic Communication Methods Targeting Families and Family Members: A Literature Review
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作者 Taketo Watsuji Naohiro Hohashi 《Open Journal of Nursing》 2024年第1期11-26,共16页
Background and Purpose: Therapeutic communication is a new term in family health care nursing, defined by Hohashi (2019) as a method of family intervention, and characterized by inclusion of not only verbal conversati... Background and Purpose: Therapeutic communication is a new term in family health care nursing, defined by Hohashi (2019) as a method of family intervention, and characterized by inclusion of not only verbal conversation but also nonverbal interaction. However, specific therapeutic communication methods have not been systematized. The purpose of this study was to clarify therapeutic communication methods for families/family members from the perspectives of verbal communication and non-verbal communication through a review of existing literature. Methods: We conducted a search using the medical literature databases PubMed and Ichushi-Web using the keywords “therapeutic communication”. Analysis was performed on seven articles from PubMed and 14 articles from Ichushi-Web that described therapeutic communication methods performed by healthcare professionals for families/family members. Through directed content analysis, therapeutic communication methods were subcategorized, and classified into three categories: verbal communication, non-verbal communication, and verbal/non-verbal communication. Results: A total of 23 subcategories were extracted. Verbal communication included 11 subcategories, such as “asking questions using the communicatee’s words as they are”. Non-verbal communication included five subcategories, such as “noticing changes in the content of the communicatee’s story”. And verbal/non-verbal communication featured seven subcategories, such as “making the communicatee aware of one’s own beliefs”. Conclusion: Therapeutic communication methods included basic care/caring in family interviews/meetings, as well as verbal communication and non-verbal communication that act on family/family members’ beliefs. It is believed that changes in family/family members’ beliefs can be used to eliminate, reduce, or improve problematic conditions in the family. . 展开更多
关键词 Therapeutic Communication Family Nursing Family Interview/Meeting Family Belief Systems Theory Literature Review
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Intergenerational Trauma and Resilience among Im/Migrant Families: Child Mental Health Outcomes and Psychosocial Mechanisms of Transmission
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作者 Maggie Gillen Annekathryn Goodman +3 位作者 Fiona Danaher Rahel Bosson Mary Greenwald Rashmi Jasrasaria 《Health》 2024年第10期888-920,共33页
Research Background: Psychological stressors leading to poor mental health outcomes accumulate throughout the migration process. The impact of a parent or caregiver’s posttraumatic stress on non-traumatized children ... Research Background: Psychological stressors leading to poor mental health outcomes accumulate throughout the migration process. The impact of a parent or caregiver’s posttraumatic stress on non-traumatized children is significant and may lead to adverse development and mental health outcomes. Research Objectives: The objective of this review is to explore both the consequences of parental trauma transmission on descendants’ psychological adjustment and well-being, and the mechanisms through which trauma has been transmitted among im/migrant populations. Methods: Criteria outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guided this systemic review. The questions guiding this review are: (a) What are the consequences of parental trauma transmission on the psychological adjustment and well-being of im/migrant offspring? And (b) What are the psychosocial mechanisms of trauma and resilience transmission among im/migrant populations? Each potential study was assessed based on relevance to the review question(s). Results: Parental trauma can lead to adverse mental health outcomes among descendants including increased internalizing and externalizing problems, the adoption of coping behaviors and worldviews, and worsening school performance. Mechanisms that influence trauma transmission include parental trauma symptom severity, the parent-child dyad, social learning, and family stressors. Pathways of resilience exist across socioecological levels to include individual resilience such as coping skills and meaning making, family resilience, structural protective factors, and social and cultural protective factors. Conclusions: Despite the prevalence of traumatic events throughout the migration process, im/migrant families display strong levels of resilience. Mental health services and providers should incorporate a strength-based approach in designing interventions that are culturally responsive and take into accounts the broader ecological contexts in which im/migrant families live. 展开更多
关键词 Intergenerational Trauma Im/Migrants families RESILIENCE Mental Health
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Familial Forms of Spondyloarthritis Study of 100 Senegalese Multiplex Families
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作者 Adama Bah Chiekh Ahamadou Bamba Diaw +10 位作者 Dieynaba Sala Tamara Kane Adama Doucouré Siddiki Charifah Ramadhane Bouchrane Harine Abdel Aziz Garba Aissatou N’diaye Mondukpe Joane Immanuelle Houansou Laurine Marlyse Adogle Yaye Aminata Gueye Moustapha Niasse Saidou Diallo 《Open Journal of Rheumatology and Autoimmune Diseases》 2024年第3期132-143,共12页
Introduction: Spondyloarthritis (SpA) comprises a group of chronic inflammatory rheumatic diseases characterized by predominant axial involvement. These include ankylosing spondylitis (AS), reactive arthritis (ReA), p... Introduction: Spondyloarthritis (SpA) comprises a group of chronic inflammatory rheumatic diseases characterized by predominant axial involvement. These include ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel diseases (IBD), SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis), juvenile spondyloarthritis (JSPA), and undifferentiated SpA. Their exact cause is unknown but is believed to stem from a combination of factors. The first familial forms were described by de Blécourt et al. in 1961. The objective was to evaluate the epidemiological, clinical, therapeutic and evolutionary aspects of familial forms of SpA and in particular, to prove the severity of the disease in family members compared to index cases in the rheumatology department of the Aristide Le Dantec University Hospital in Dakar. Methodology: This was a prospective, cross-sectional and descriptive study with an analytical aim on patients with the familial form of spondyloarthritis defined by the existence of at least one other family member with SpA outside the propositus, collected within the Aristide Le Dantec rheumatology department in Dakar over a period of 10 years between January 2012 and December 2021. There were two phases of study, the first of which consisted of collecting index cases with miserly SpA and the second of which consisted of family screening after consent. The data analysed were epidemiological, clinical, paraclinical, therapeutic and evolving. Results: Out of 100 families of 1905 members, 667 SpA patients included, i.e. a prevalence of 35%, including 225 (33.73%) men and 412 women (61.17%), i.e. a ratio of 1.8. The mean age at diagnosis among relatives was 26.3 years (range 13 and 80 years), 47.14 years among the propositus, in whom the mean age at onset was 36.26 years and that of relatives 49.9 years in the first degree, 15 years in the second degree and 1 year in the third degree. The time to diagnosis was 11.20 years in the first degree, 2.5 years in the second degree, 1 year in the third degree and 10.88 years in the case of the proposes. The number of marriages in families was 420 of which 116 were consanguineous (consanguinity rate 27.62%), 19% among the propositus. HLA-B27 positive in 92% of the proposers and 33.43% in the families;70% of the propositus had an inflammatory syndrome and 17.54% in the families;87% of sacroilliitis in the propositus and 5.54% in the families. Clinical forms were dominated by undifferentiated SpA (338 cases) and APS (295 cases). The average BASFI was 3.23 on D0;2.59 in the 3rd month and 1 in the 6th month for the propositus versus 2.55 at D0;1.86 at the 3rd month and 1.55 in the 6th month in the families. Average BASDAI was 3.92 at D0;3.12 at the 3rd month and 2.07 at the 6th month in the propositus and 3 at D0;2.21 at the 3rd month and 1 at the 6th month in the families. Autoimmune associated conditions were 18 cases, degenerative 24 cases, autoinflammatory 2 metabolic cases 18 cases. They all received: NSAIDs, methotrexate, salazopyrine (11 cases) and anti-TNF-α (1 case). The evolution was generally favourable. Conclusion: SpA is on the rise in Senegalese hospitals, frequent in young people, SPA and undifferentiated SpA are the most frequent, management is essentially based on conventional care, and the disease is less severe in family members than index cases. 展开更多
关键词 familial Forms of Spondyloarthritis Propositus Senegal
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Literature Review on Support for Children and Families Experiencing Parental Bereavement
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作者 Rurie Namiki Keita Sasaki +1 位作者 Iku Taniguchi Rie Wakimizu 《Open Journal of Nursing》 2024年第4期139-163,共25页
Purpose: This study aimed to understand the actual nursing support in a wide perspective by reviewing overseas literature on support for children who have experienced parental bereavement and their families. The goal ... Purpose: This study aimed to understand the actual nursing support in a wide perspective by reviewing overseas literature on support for children who have experienced parental bereavement and their families. The goal was to identify future challenges in nursing support in clinical practice in Japan. Method: Literature searchable as of May 2023 was retrieved using PubMed, resulting in 11 relevant articles. Result: The results revealed the following: 1) For support provided to children, 13 codes were condensed into 5 subcategories and 4 categories. 2) For support provided to families, 36 codes were condensed into 11 subcategories and 4 categories. Conclusion: Open communication was found to be essential for supporting children and their families who have experienced parental bereavement. Moreover, involvement of multiple professions facilitated the provision of specialized support to address diverse needs of children and families, playing a crucial role in overcoming grief. Additionally, the effectiveness of support systems for bereaved families highlighted the need for nursing professionals in Japan to gain knowledge through learning opportunities and to establish a multi-disciplinary approach to support, thus indicating future challenges in nursing support. 展开更多
关键词 Terminal Care Family Support CHILD Parental Death Palliative Care
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Relations Between School and Immigrant Families in Albertan Francophone School: Perspectives of Settlement Workers in Schools - A Secondary Publication
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作者 Marianne Jacquet Gwenaëlle André 《Journal of Contemporary Educational Research》 2024年第3期136-147,共12页
In recent years,Francophone schools in Alberta,a province in western Canada,have seen significant ethnocultural diversification of their school population,thus reflecting recent migratory changes in Canada.The populat... In recent years,Francophone schools in Alberta,a province in western Canada,have seen significant ethnocultural diversification of their school population,thus reflecting recent migratory changes in Canada.The population of a Francophone school board located in an agglomeration of Alberta reflects these new migratory trends.A partial ethnodemographic portrait carried out in 2003 in six of its schools indicates that 50%of the pupils come from an immigrant background and come from 23 different countries;mostly from sub-Saharan African countries.This demographic reality,confirmed more than a decade later,represents a major structural change for Francophone schools.In Alberta,as in other Canadian provinces,inclusion is at the heart of discourse and educational practices.With a transformative aim,it intends to promote ethnocultural diversity in the classroom and equal opportunities through school equity practices.This article focuses on the settlement workers in schools responsible for bridging family,community,and school cultures.The analysis of the interviews of the four workers sheds light on and questions both the institutional practices and the personal strategies put in place to face the challenges encountered in this tripartite collaboration. 展开更多
关键词 Educational inclusion and exclusion Immigration and ethnicity Interculturality and multiculturalism Family and education Help for pupils and students Actors in education Canada
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Study on the variation in and selection of Fraxinus mandshurica provenances and families in northeast China
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作者 Junfei Hao Na Chen +3 位作者 Pingyu Yan Kaiyuan Xu Lei Zhang Hanguo Zhang 《Journal of Forestry Research》 SCIE CAS CSCD 2023年第2期519-529,共11页
Fraxinus mandshurica Rupr.is one of the main afforestation species in northeast China,and there is great demand for improved F.mandshurica varieties.The results of an investigation into and analysis of the growth trai... Fraxinus mandshurica Rupr.is one of the main afforestation species in northeast China,and there is great demand for improved F.mandshurica varieties.The results of an investigation into and analysis of the growth traits of F.mandshurica provenances and families showed that there were significant differences in different periods.However,variations in growth traits decreased year by year.There was a significant negative correlation between tree heights of the provenances and sunshine hours in their areas of origin.The provenances of Xinglong,Hailin and Wuchang were selected based on the volume of 18-year-old trees.The average genetic gain from the selection of fast-growing provenances was 19.4%.Ten superior fast-growing families were selected.The average volume of the selected families was22.6%,higher than that of all families.The correlation coefficient between heights at 6-year-old and at 18a was 0.838for provenances,and between heights at 4-year-old and at 18-year-old was 0.303 for families.These results indicate that early selection for height in provenances or families could be performed at 6 years or 4 years,respectively.Early selection for DBH and volume in families could start at 8 years. 展开更多
关键词 Fraxinus mandshurica PROVENANCE Family selection Early-late correlation
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Minimal Doubly Resolving Sets of Certain Families of Toeplitz Graph
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作者 Muhammad Ahmad Fahd Jarad +1 位作者 Zohaib Zahid Imran Siddique 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第6期2681-2696,共16页
The doubly resolving sets are a natural tool to identify where diffusion occurs in a complicated network.Many realworld phenomena,such as rumour spreading on social networks,the spread of infectious diseases,and the s... The doubly resolving sets are a natural tool to identify where diffusion occurs in a complicated network.Many realworld phenomena,such as rumour spreading on social networks,the spread of infectious diseases,and the spread of the virus on the internet,may be modelled using information diffusion in networks.It is obviously impractical to monitor every node due to cost and overhead limits because there are too many nodes in the network,some of which may be unable or unwilling to send information about their state.As a result,the source localization problem is to find the number of nodes in the network that best explains the observed diffusion.This problem can be successfully solved by using its relationship with the well-studied related minimal doubly resolving set problem,which minimizes the number of observers required for accurate detection.This paper aims to investigate the minimal doubly resolving set for certain families of Toeplitz graph Tn(1,t),for t≥2 and n≥t+2.We come to the conclusion that for Tn(1,2),the metric and double metric dimensions are equal and for Tn(1,4),the double metric dimension is exactly one more than the metric dimension.Also,the double metric dimension for Tn(1,3)is equal to the metric dimension for n=5,6,7 and one greater than the metric dimension for n≥8. 展开更多
关键词 Family of Toeplitz graph resolving sets metric dimension doubly resolving sets double metric dimension
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PML nuclear bodies:new players in familial amyotrophic lateral sclerosis-frontotemporal dementia?
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作者 Anand Goswami Serena Carra 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1875-1876,共2页
Amyotrophi c lateral s c lerosis(ALS)and frontotemporal dementia(FTD)are two closely related disorders with overlapping clinical,genetic,and neuropathological features,forming a continuous disease spectrum(Ling et al.... Amyotrophi c lateral s c lerosis(ALS)and frontotemporal dementia(FTD)are two closely related disorders with overlapping clinical,genetic,and neuropathological features,forming a continuous disease spectrum(Ling et al.,2013).The major pathological hallmark of ALS and FTD are the depletion from the nucleus of the RNA-binding proteins TAR DNA‐binding protein 43(TDP-43)and FUsed in Sarcoma(FUS)and their abnormal accumulation in ubiquitin-positive cytoplasmic inclusions(Ling et al.,2013). 展开更多
关键词 CLINICAL familiAL
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Novel subtype of obesity influencing the outcomes of sleeve gastrectomy:Familial aggregation of obesity
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作者 Ze-Yu Wang Yun-Fei Qu +4 位作者 Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu 《World Journal of Gastroenterology》 SCIE CAS 2024年第13期1887-1898,共12页
BACKGROUND Differences in the preoperative characteristics and weight loss outcomes after sleeve gastrectomy(SG)between patients with familial aggregation of obesity(FAO)and patients with sporadic obesity(SO)have not ... BACKGROUND Differences in the preoperative characteristics and weight loss outcomes after sleeve gastrectomy(SG)between patients with familial aggregation of obesity(FAO)and patients with sporadic obesity(SO)have not been elucidated.AIM To explore the impact of SG on weight loss and the alleviation of obesity-related comorbidities in individuals with FAO.METHODS A total of 193 patients with obesity who underwent SG were selected.Patients with FAO/SO were matched 1:1 by propensity score matching and were categorized into 4 groups based on the number of first-degree relatives with obesity(1 SO vs 1FAO,2SO vs 2FAO).The baseline characteristics,weight loss outcomes,prevalence of obesity-related comorbidities and incidence of major surgeryrelated complications were compared between groups.RESULTS We defined FAO as the presence of two or more first-degree relatives with obesity.Patients with FAO did not initially show significant differences in baseline data,short-term postoperative weight loss,or obesity-related comorbidities when compared to patients with SO preoperatively.However,distinctions between the two groups became evident at the two-year mark,with statistically significant differences in both percentage of total weight loss(P=0.006)and percentage of excess weight loss(P<0.001).The FAO group exhibited weaker remission of type 2 diabetes mellitus(T2DM)(P=0.031),hyperlipidemia(P=0.012),and non-alcoholic fatty liver disease(NAFLD)(P=0.003)as well as a lower incidence of acid reflux(P=0.038).CONCLUSION FAO patients is associated with decreased mid-to-long-term weight loss outcomes;the alleviation of T2DM,hyperlipidemia and NAFLD;and decreased incidence of acid reflux postoperatively. 展开更多
关键词 OBESITY Bariatric surgery Sleeve gastrectomy Family history Weight loss
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Development of immature ovarian teratoma after mature teratoma in a girl with familial ovarian teratoma:A case report
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作者 U Chul Ju Woo Dae Kang Seok Mo Kim 《World Journal of Clinical Cases》 SCIE 2024年第8期1442-1447,共6页
BACKGROUND Immature ovarian teratoma is a rare and aggressive neoplasm that affects young women.This report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of... BACKGROUND Immature ovarian teratoma is a rare and aggressive neoplasm that affects young women.This report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of the ovary in an adolescent female with a family history of ovarian teratoma.CASE SUMMARY A 16-year-old girl who had undergone bilateral ovarian cystectomy for mature teratomas 3 years ago showed bilateral adnexal tumors during her regular ultrasonography follow-up every 6 months.She received laparoscopic bilateral ovarian cystectomy,and final histopathology showed grade-1 immature teratoma of the left ovary and mature teratoma of the right ovary.Laparoscopic left salpingo-oophorectomy and staging procedures were performed again.Her mother,maternal aunt,and maternal grandmother had also received surgeries for mature ovarian teratomas.CONCLUSION It is important to have guidance on management of patient and family members with familial ovarian teratomas. 展开更多
关键词 familial ovarian teratomas Adolescent female Immature ovarian teratoma Management Case report
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Familial hypercholesterolemia:Current limitations and future breakthroughs
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作者 Ze Xiang Jia-Rui Li +2 位作者 Wei-Min Wan Shu-Hui Li Jian Wu 《World Journal of Experimental Medicine》 2024年第4期174-177,共4页
Familial hypercholesterolemia(FH)is characterized by elevated low-density lipoprotein cholesterol levels due to genetic mutations,presenting with xanthomas,corneal arch,and severe cardiovascular diseases.Early identif... Familial hypercholesterolemia(FH)is characterized by elevated low-density lipoprotein cholesterol levels due to genetic mutations,presenting with xanthomas,corneal arch,and severe cardiovascular diseases.Early identification,diagnosis,and treatment are crucial to prevent severe complications like acute myocardial infarction.Statins are the primary treatment,supplemented by Ezetimibe and proprotein convertase subtilisin/kexin type 9 inhibitors,though their effectiveness can be limited in severe cases.Over 90%of FH cases remain undiagnosed,and current treatments are often inadequate,underscoring the need for improved diagnostic and management systems.Future strategies include advancements in gene testing,precision medicine,and novel drugs,along with gene therapy approaches like AAV-mediated gene therapy and clustered regularly interspaced short palindromic repeats.Lifestyle modifications,including health education,dietary control,and regular exercise,are essential for managing FH and preventing related diseases.Research into FH-related gene mutations,especially LDLR,is critical for accurate diagnosis and effective treatment. 展开更多
关键词 familial hypercholesterolemia Genetic mutations TREATMENT LIMITATIONS Breakthroughs
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Two different mutational types of familial gastrointestinal stromal tumors:Two case reports
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作者 Xiao-Ke Wang Lu-Fan Shen +7 位作者 Xin Yang He Su Tao Wu Peng-Xian Tao Hong-Ying Lv Tong-Han Yao Lin Yi Yuan-Hui Gu 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第9期4028-4036,共9页
BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases... BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each year.The rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and treatment.Familial GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type GISTs.However,whether the same genetic family has different phenotypes has not been reported.CASE SUMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing surgery.The favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial disease.CONCLUSION Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs. 展开更多
关键词 Gastrointestinal stromal tumor familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA IMATINIB Treatment Case report
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Empirical Bayes Absolute Error Loss Estimation for Parameter of One-Side Truncation Distribution Families
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作者 李金平 《Chinese Quarterly Journal of Mathematics》 CSCD 1992年第2期20-22,共3页
In this paper we propose an absolute error loss EB estimator for parameter of one-side truncation distribution families. Under some conditions we have proved that the convergence rates of its Bayes risk is o, where 0&... In this paper we propose an absolute error loss EB estimator for parameter of one-side truncation distribution families. Under some conditions we have proved that the convergence rates of its Bayes risk is o, where 0<λ,r≤1,Mn≤lnln n (for large n),Mn→∞ as n→∞. 展开更多
关键词 one-side truncation distribution families absolute error loss function empirical Bayes estimator convergence rates
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Selection of superior families of Pinus massoniana in southern China for large-diameter construction timber 被引量:4
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作者 Zhangqi Yang Hui Xia +2 位作者 Jianhui Tan Yuanheng Feng Yongli Huang 《Journal of Forestry Research》 SCIE CAS CSCD 2020年第2期475-484,共10页
This study addresses the increasing demand for large-diameter production timber,and considers the time and space variability of half-sib families of Pinus massoniana.Height,diameter at breast height(DBH)and timber vol... This study addresses the increasing demand for large-diameter production timber,and considers the time and space variability of half-sib families of Pinus massoniana.Height,diameter at breast height(DBH)and timber volume of 440 open-pollinated half-sib progeny families were investigated in 14 progeny trials in different years and production regions.An evaluation of the genetic variation of all half-sib families was carried out during the sustainable rapid growth period and individual volumes were characterized as a major index.ANOVA analysis showed that there was considerable variance in the growth traits of most families in different years and on different sites.The variations caused by temporal and spatial changes of the mating system required three selection methods for analysis.The results show that there were differences among the heritabilities of different growth traits by different halfsib progenies.Average heritability values of height,DBH and volume were 0.33,0.34 and 0.36,respectively.Fortyfive superior families were selected in every progeny test,12 were selected in progeny trials by different years and five in different habitat progeny trials.Three superior families(Gui GC553A,Gui GC414A and Gui GC431A)were selected,although in different years and production regions.The genetic gains of timber volume of these selected r families ranged from 1.20 to 47.00%,which could provide a foundation for superior wood property selection and serve as material for seed improvement and extension in surrounding areas. 展开更多
关键词 Pinus massoniana open-pollinated progeny Large-diameter timber Superior family selection Mating system
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Polymorphism of Methionine Synthase Gene in Nuclear Families of Congenital Heart Disease 被引量:11
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作者 WEN-LIZHU JUNCHENG +4 位作者 JING-JINGDAO RU-BINGZHAO LI-YINGYAN SHU-QINGLI YONGLI 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2004年第1期57-64,共8页
Objective To investigate the relation of methionine synthase (MS) gene variation with congenital heart disease (CHD) phenotype. Methods One hundred and ninety three CHD patients (94 males and 99 females) and their bio... Objective To investigate the relation of methionine synthase (MS) gene variation with congenital heart disease (CHD) phenotype. Methods One hundred and ninety three CHD patients (94 males and 99 females) and their biological parents (nuclear families) in Liaoning Province were selected as the case group, and another 104 normal persons (60 males and 44 females) and their parents without family history of birth defects as the control group. For all subjects the polymorphism of MS gene A2756G locus was examined by PCR-RFLP method. Results In offspring of the control group the frequencies of MS genotype (+/ -) and allele (+) were 10.7% and 5.3%, without existence of homozygote. The MS genotype distribution and allele frequencies of CHD patients and their mothers were not significantly different from the control (P > 0.05). The frequency of allele (+) in case fathers (5.0 %) was apparently lower than that in the control (9.1%, P=0.060), and the odds ratio (OR) was 0.53 (95% CI: 0.25-1.09). There was no difference in parents' genotype combination between the two groups, and in genotype distribution among different types of CHD. Analysis of genetic transmission indicated that mutation allele (+) existed transmission disequilibrium in CHD nuclear families. The percentage of allele (+) transmitted from parents was lower than that allele (-) with OR 0.26 (95% CI: 0.11-0.60). Conclusion MS gene variation in parents is associated with occurrence of CHD in offspring, and mutation allele (+) in parents may be related with the decrease of CHD risk in offspring. 展开更多
关键词 Methionine synthase Gene polymorphism Congenital heart disease Nuclear family
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NORMAL FAMILIES AND SHARED VALUES OF HOLOMORPHIC FUNCTIONS 被引量:10
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作者 Li Jiangtao Yi Hongxun 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2006年第3期335-342,共8页
Let F be a family of holomorphic functions in a domain D, k be a positive integer, a, b(≠0), c(≠0) and d be finite complex numbers. If, for each f∈F, all zeros of f-d have multiplicity at least k, f^(k) = a w... Let F be a family of holomorphic functions in a domain D, k be a positive integer, a, b(≠0), c(≠0) and d be finite complex numbers. If, for each f∈F, all zeros of f-d have multiplicity at least k, f^(k) = a whenever f=0, and f=c whenever f^(k) = b, then F is normal in D. This result extends the well-known normality criterion of Miranda and improves some results due to Chen-Fang, Pang and Xu. Some examples are provided to show that our result is sharp. 展开更多
关键词 holomorphic function normal family shared value.
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A CHARACTERIZATION OF ORTHONORMAL WAVELET FAMILIES IN SOBOLEV SPACES 被引量:6
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作者 鲁大勇 李登峰 《Acta Mathematica Scientia》 SCIE CSCD 2011年第4期1475-1488,共14页
In this paper, a characterization of orthonormal wavelet families in Sobolev spaces H s (R) is established.
关键词 WAVELETS orthonormal wavelet families Sobolev spaces
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NORMAL FAMILIES OF MEROMORPHIC FUNCTIONS SHARING A HOLOMORPHIC FUNCTION AND THE CONVERSE OF THE BLOCH PRINCIPLE 被引量:7
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作者 姜云波 高宗升 《Acta Mathematica Scientia》 SCIE CSCD 2012年第4期1503-1512,共10页
In this paper, we investigate normal families of meromorphic functions, prove some theorems of normal families sharing a holomorphic function, and give a counterex- ample to the converse of the Bloch principle based o... In this paper, we investigate normal families of meromorphic functions, prove some theorems of normal families sharing a holomorphic function, and give a counterex- ample to the converse of the Bloch principle based on the theorems. 展开更多
关键词 meromorphic function holomorphic function shared function normal family Bloch principle
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NORMAL FAMILIES OF MEROMORPHIC FUNCTIONS WITH SHARED VALUES 被引量:5
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作者 陈玮 田宏根 扈培础 《Acta Mathematica Scientia》 SCIE CSCD 2016年第1期87-93,共7页
We obtain some normality criteria of families of meromorphic functions sharing values related to Hayman conjecture, which improves some earlier related results.
关键词 meromorphic function shared value normal family
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Relationship Between Polymorphism of Cystathionine beta Synthase Gene and Congenital Heart Disease in Chinese Nuclear Families 被引量:7
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作者 XIAO-MING SONG XIAO-YING ZHENG +2 位作者 WEN-LI ZHU LEI HUANG YONG LI 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2006年第6期452-456,共5页
Objective To study the relationship between polymorphism of cystathionine beta synthase (CBS) gene and development of congenital heart disease (CHD). Methods One hundred and twenty-seven CHD case-parent triads wer... Objective To study the relationship between polymorphism of cystathionine beta synthase (CBS) gene and development of congenital heart disease (CHD). Methods One hundred and twenty-seven CHD case-parent triads were recruited from Liaoning Province as patient group, and 129 healthy subjects without family history of birth defect were simultaneously recruited as control group together with their biological parents. For all subjects the polymorphism of CBS gene G919A locus was examined by PCR-ARMS method, Results The frequencies of three genotypes (w/w, w/m, and m/m) in control group were 27.2%, 58,4%, and 14.4%, respectively, with no significant difference in gender. A significant difference in the allele frequency was found between CHD patients and controls, the wild allele frequency was 67,9% in patients and 55.7% in controls CHD parents' genotype distribution was significantly different from that in controls. Further comparison of each type of CHD showed that genotype frequencies in several CHD subtypes were significantly different from those in their corresponding controls. The results of TDT analysis showed that no allele transmission disequilibrium existed in CHD nuclear families. Conclusions CBS gene G919A mutation is associated with the development of CHD, and the mutated allele may decrease the risk of CHD. 展开更多
关键词 Congenital heart disease Gene polymorphism Cystathionine beta synthase Case-control family study
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