A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this condition.Psychoneuroimmunoendocrinology(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a whole.The initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and well-being.In the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are interconnected.Finally,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

Investigating and predicting the role of photovoltaic, wind, and hydrogen energies in sustainable global energy evolution

The global shift toward next-generation energy systems is propelled by the urgent need to combat climate change and the dwindling supply of fossil fuels.This review explores the intricate challenges and opportunities for transitioning to sustainable renewable energy sources such as solar,wind,and hydrogen.This transition economically challenges traditional energy sectors while fostering new industries,promoting job growth,and sustainable economic development.The transition to renewable energy demands social equity,ensuring universal access to affordable energy,and considering community impact.The environmental benefits include a significant reduction in greenhouse gas emissions and a lesser ecological footprint.This study highlights the rapid growth of the global wind power market,which is projected to increase from$112.23 billion in 2022 to$278.43 billion by 2030,with a compound annual growth rate of 13.67%.In addition,the demand for hydrogen is expected to increase,significantly impacting the market with potential cost reductions and making it a critical renewable energy source owing to its affordability and zero emissions.By 2028,renewables are predicted to account for 42%of global electricity generation,with significant contributions from wind and solar photovoltaic(PV)technology,particularly in China,the European Union,the United States,and India.These developments signify a global commitment to diversifying energy sources,reducing emissions,and moving toward cleaner and more sustainable energy solutions.This review offers stakeholders the insights required to smoothly transition to sustainable energy,setting the stage for a resilient future.

Flexner's legacy and the future of medical education:Embracing challenge and opportunity

This editorial comments on the article by Alzerwi.We focus on the development course,present challenges,and future perspectives of medical education.Modern medical education is gradually undergoing significant and profound changes worldwide.The emergence of new ideas,methodologies,and techniques has created opportunities for medical education developments and brought new concerns and challenges,ultimately promoting virtuous progress in medical education reform.The sustainable development of medical education needs joint efforts and support from governments,medical colleges,hospitals,researchers,administrators,and educators.

From Historical Landscapes to the Contemporary City: Interview with Professor Tim Bunnell

1.Chong Xu:It is my great honour to have this opportunity to interview you.You were trained as a geographer at the University of Nottingham in the UK.Can you talk to us about why you have chosen urban studies as your main research area?

Assessment of the Vaccination Status of Children Aged 6 to 30 Months in a Tertiary Level Health Care Center in Côte d’Ivoire

Introduction: Vaccination coverage in Côte d’Ivoire over the period 2011 to 2015 was below the target of 95% for all antigens. The objective of this study was to analyze the vaccination status of children aged 6 to 30 months with a view to improving vaccination coverage. Patients and Methods: This was a descriptive cross-sectional study which took place from June to September 2018 in a tertiary health center, focusing on children aged 6 to 30 months with a correctly completed health record. The parameters studied were sex, age, educational level of mothers, dates of vaccine administration and reason for missed vaccination opportunities. Results: We retained 212 children. The sex ratio was 1.21 and 93% had received the BCG vaccine before the age of 1 month. The average ages of combined and co-administered vaccines for the 1st and 2nd doses were 7.66 ± 3.81 and 12.88 ± 3.95 weeks, respectively. The median was 16.57 weeks for the 3rd dose. The proportion of vaccinated subjects was greater than 90% for the BCG vaccine and the 3 doses of combined vaccines, and 77% for the yellow fever and measles vaccines. The reasons for non-vaccination were attributable to the children’s parents and health facilities. Conclusion: Improving vaccination coverage requires regular supply of vaccines to centers, and the involvement of all health professionals, community and religious leaders in the vaccination awareness process.

The Opportunities,Dilemmas,and Paths for the Development of Adult Higher Education in the New Era

This paper comprehensively analyzes the development opportunities and realistic dilemmas faced by adult higher education in China in the new era,and puts forward corresponding strategies as solutions.With the construction of a learning society,the development of digital technology,and the popularization of the concept of lifelong learning,adult higher education has unprecedented development opportunities.At the same time,these forms of education are facing a series of dilemmas due to challenges such as unsound guarantee mechanisms and traditional enrollment competition.Through the establishment of perfect legal and policy guarantees,transformation of school running mode,meeting the diversified needs of learners,and other multi-faceted measures,the development of adult higher education can be effectively promoted to meet the needs of individual and social development.

Research on the Impact and Opportunities of the Digital Economy Promoting the Development of Real Economy

The digital economy has infused vitality into the transformation and development of the real economy,urging enterprises to break through core technological barriers,address bottleneck issues,and improve their core competitiveness.It fosters the comprehensive digital transformation of agriculture,manufacturing,and service sectors,improving the dynamism of the real economy and fostering more consumption hotspots.Efforts are underway to enhance industrial supply chains and innovation chains,optimize regional resource allocation,and promote a virtuous cycle within the real economy.Initiatives are being undertaken to standardize the development of digital economic platforms,promote the high-quality development of regional economies,and leverage the advantages of the socialist market economy with Chinese characteristics.

Challenges and Opportunities for the Development of Ideological and Political Education in Colleges and Universities in the New Media Era

The rapid advancement of new media technology has had a great impact on people’s lifestyles,and brought opportunities and challenges to the development of ideological and political education in colleges and universities.Ideological and political education in colleges and universities is faced with the challenge of how to grasp the opportunity,ride on the express train of science and technology,and implement the concepts of“all-round education”and“five ideologies and politics.”

Opportunities and Challenges of College Mental Health Education from the Perspective of Big Data

This paper explores the opportunities and challenges of college mental health education from the perspective of big data.Firstly,through literature review,the importance of mental health education and the current issues are elucidated.Then,from the perspective of big data,the potential opportunities of big data in college mental health education are analyzed,including data-driven personalized education,real-time monitoring and warning systems,and interdisciplinary research and collaboration.At the same time,the challenges faced by college mental health education under the perspective of big data are also pointed out,such as data privacy and security issues,insufficient data analysis and interpretation capabilities,and inadequate technical facilities and talent support.Lastly,the research content of this paper is summarized,and directions and suggestions for future research are proposed.

Analysis of Technical Intelligence of Tumor Cell Therapy Based on Patent Map

Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent data in the field of tumor cell therapy in China,the patent map method was used to construct a scientific technical information analysis model.Then,the technical status of new drug research and development in this field was explored to identify technical opportunities.Results and Conclusion Studies have found that China’s tumor immunotherapy is in the growth stage.The technical innovation regions are mainly distributed in the east and innovative entities are enterprises.Technology hotspots are concentrated in areas such as A61P35,C12N5,and the patented technical efficacy is high.Besides,the technical research and development opportunities identified are closely related to the background in this field.To better promote the development of the industry,enterprises and research institutions should strengthen cooperation in technological innovation Meanwhile,they should pay attention to technical efficacy analysis to identify more technical opportunities,thereby effectively guiding innovation strategic decisions.

Opportunities, Challenges, and Countermeasures of China Myanmar Economic and Trade Cooperation under the Background of RCEP

China and Myanmar are geographically adjacent and have close economic and trade cooperation. China has been Myanmar’s largest trading partner and largest source of investment for many consecutive years. With the official entry into force of RCEP (Regional Comprehensive Economic Partnership) for Myanmar on May 1, 2022, the reduction of trade tariffs on goods and flexible rules of origin between China and Myanmar will undoubtedly bring more practical results to China Myanmar economic and trade cooperation. However, the implementation of RCEP in Myanmar may face a series of challenges such as poor business environment, weak human resource management, and outdated infrastructure construction. Finally, the article provides countermeasures for China Myanmar economic and trade cooperation from three aspects: optimizing the business environment to attract Chinese investment, increasing investment in education and training to improve labor quality, strengthening infrastructure construction to enhance economic support.

Analysis of Young Girls’Eagerness to Spend for Disney Virtual Characters Based on Marketing Mix Theory

A virtual character is a design of a fictitious creature with distinctive characteristics created by people,and Disney virtual characters are those Intellectual Property(IP)images that appeared in Disneyland and Disney movies.This investigation aimed to explore why many younger females are keen to spend money on Disney virtual characters.This paper adopted the Marketing Mix Theory strategy(product,price,placement,and promotion(4P)),and the SWOT analysis method has been utilized.This paper investigated the relationship between the 4Ps and consumers’purchasing intentions,and it turned out that unique design and effective promotion in this Disney case would promote consumers’purchase intention,while the higher price and less accessible placements affected their purchase intentions.Thus,the high price and limited places somewhat inhibit customers’desire to buy;due to the attractiveness of the product itself and the promotion on the internet,the target consumers are still willing to consume.

Assessment of the Implementation of Energy Conservation Opportunities Arising from Energy Audits;A Study of Four-Star and Five-Star Hotels in Nairobi Kenya

This study assesses the implementation of energy conservation opportunities in four-star and five-star hotels in Nairobi. The Covid-19 pandemic had a significant impact on the Hospitality Industry. Currently, there is a growing inclination to furnish guests with superior and sustainable services in an energy-efficient and eco-friendly way. Comprehensive research was conducted from energy audits gathered from the establishments and contracted auditing companies, on top of this, hotel staff were given digital questionnaires. To add to the data, the researcher surveyed the hotels with engineering managers. The Energy Audits found that all 10 hotels had adopted Energy Conservation Opportunities (ECOs). After further analysis, the mean adoption rate of Energy Conservation Opportunities (ECOs) during the past three years was 55.83%, which was below the aim of 100%. According to studies, hotel staff manages energy to cut costs. The researcher found that hotels use up a lot of energy. However, they have conservation potential, depending on government policies, costs, ease of implementation, and management commitment to sustainable practices. Essentially, Energy Conservation Opportunities (ECOs) reduce energy expenditures and boost reliable revenues, especially during high energy prices and uncertainty.

Overview of the Third Global Forum

Computer science continues to grow at a rapid pace,raising the issue of how universities can best adapt to this trend.At the third Global Forum on the Development of Computer Science(GFDCS),five heads of departments of computer science from Asia,Europe,and North America came together to exchange ideas under the theme Challenges and Opportunities of Computer Science in the New Era.Through the discussions,a number of new challenges were explored,including how to meet the growing demand for computer science education,how to manage increased teaching loads,how to foster collaboration between computer science and other disciplines,how to raise ethical awareness,and how to support new“transdisciplinary”modes of education and research.At the same time,there was a consensus on the need to strengthen the role of computer science in other departments,the importance of industrial collaboration,and the need for more scalable approaches to teaching.The evolving role of computer science within the context of broader science was also discussed.

An Interpretation to the Modern American Dream in the Pursuit of Happyness

Focuses on the modern American Dream,with the movie the Pursuit of Happyness as the background,this paper analyzes every hero's American Dream in the movie and the hard process of pursuing the dreams so as to make people rethinking the American Dream expressed in the movie and understanding the distinct characteristics of the modern American Dream.

International Dissemination of TCM Culture under the "Belt and Road" Initiative: Opportunities and Challenges

The international dissemination of TCM culture, as a carrier of the implementation of the"Belt and Road"Initiative, is being endowed with greater importance. However, the spread of TCM culture into the world faces opportunities as well as challenges. To better serve the"Belt and Road"Initiative, measures should be taken to strengthen TCM communication and cooperation in different aspects and build a sound intellectual property protection system.

Analysis on Opportunities and Threats for Agricultural Sustainable Development of Yunnan Province in the Context of the 13th Five-year Plan

The research studied opportunities and potential threats confronted by agricultural sustainable development, laying foundation for optimization of agricultural structure, transformation of agricultural development mode, and accomplishment of agricultural modernization. On basis of development target, development theory and route of the 13^th Five-year Plan, the research analysis the opportunities and potential threats of Yunnan agriculture and proposed policy suggestions on sustainable development of agriculture from the perspectives of ecological and competitive advantage, as well as sustainable development division in order to provide references for scientific formulation and decision-making of relevant regional planning.

The Current Situation and Development of Chinese Animated Films:Taking Ne Zha as an Example

Taking Ne Zha as an example,this paper analyzes the strengths and weaknesses of Chinese animated films at the presentstage.Under the condition of both opportunities and challenges,some measures to develop Chinese animated films are proposed.

The American Way—A Brief Introduction to American Culture

The main values and believes of the Americansare:a.freedom(or individualism),the price paidfor it is self-reliance;b.equality of opportunity,the price paid for itis competition;c.inaterial wealth,the price paid for it is hardwork.These can be called the“theme”of life.Thesethemes cover different fields such as religion,family,life,education,business and politics.The followingare all embodied in American culture:

Tourism sectorization opportunity spectrum model and space partition of tourism urbanization area:a case of the Mayangxi ecotourism area,Fujian province,China

Nowadays, tourism has become an increasingly significant driving force of modern urbanization in China. However, it has caused varieties of problems, such as resource unreasonable utilization, society unfair play, and environment pollution, etc. Thus, the establishment of an efficient and sustainable space partition model for tourism urbanization, from the geographical perspective, is highly necessary and urgent. Herein, a new evaluation model of tourist town space, referred to as Tourism Sectorization Opportunity Spectrum(TSOS), is established on the relationships between productionliving-ecology spaces. TSOS is a kind of quantitative evaluation model involving such factors as urban living area, ecological conservation area and the tourism industry. Furthermore, the analysis of quantitative production-living-ecology spatial overlap has been utilized for space division in a tourism urbanization area. This paper, using both the TSOS model and GIS technology, analyzes the spatial restructure of the Mayangxi ecotourism area. Theresult demonstrates that tourism industrial space takes the Shanchong Village as a core which shows a pattern of local regional agglomeration and a fuzzy edge extending along the entire Mayangxi River. The urban living area should be consolidated in the Shili village with the supporting facilities and living space for tourism. In addition, Tianzhu Mountain forest park should be the key environmental protection area. The case study on the Mayangxi ecotourism area verifies that the TSOS model has strong operability. Therefore, TSOS model provides a scientific foundation for the space reconstruction of new urbanization area, and an effective tool for optimizing the space partition of a tourism urbanization area.