A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this condition.Psychoneuroimmunoendocrinology(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a whole.The initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and well-being.In the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are interconnected.Finally,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

Realm of hepatitis E:Challenges and opportunities

Hepatitis E virus(HEV),responsible for widespread viral hepatitis,infects approximately 2.3 billion individuals globally,with a significant mortality burden in Asia.The virus,primarily transmitted through contaminated water and undercooked meat,is often underdiagnosed,particularly in immunocompromised patients.Current HEV treatments,while effective,are limited by adverse effects,necessitating research into safer alternatives.Moreover,HEV’s extrahepatic manifestations,impacting the nervous and renal systems,remain poorly understood.This study underscores the imperative for enhanced HEV research,improved diagnostic methods,and more effective treatments,coupled with increased public health awareness and preventive strategies.

Developing Healthcare Infrastructure in Saudi Arabia Using Smart Technologies: Challenges and Opportunities

This study aims to explore the challenges and opportunities associated with developing healthcare infrastructure in Saudi Arabia through the implementation of smart technologies. The healthcare sector in Saudi Arabia is undergoing significant transformation, and the integration of smart technologies has the potential to revolutionize healthcare delivery, improve patient outcomes, and enhance the overall healthcare experience. However, several challenges need to be addressed in order to fully leverage the benefits of smart technologies in healthcare infrastructure development. This research identifies and analyzes these challenges while also highlighting the opportunities that arise from the adoption of smart technologies in the Saudi Arabian healthcare system. The findings contribute to the understanding of the current state of healthcare infrastructure in Saudi Arabia and provide insights into the strategies and policies required to overcome challenges and maximize the benefits of smart technologies in healthcare.

Opportunities and Challenges of College Mental Health Education from the Perspective of Big Data

This paper explores the opportunities and challenges of college mental health education from the perspective of big data.Firstly,through literature review,the importance of mental health education and the current issues are elucidated.Then,from the perspective of big data,the potential opportunities of big data in college mental health education are analyzed,including data-driven personalized education,real-time monitoring and warning systems,and interdisciplinary research and collaboration.At the same time,the challenges faced by college mental health education under the perspective of big data are also pointed out,such as data privacy and security issues,insufficient data analysis and interpretation capabilities,and inadequate technical facilities and talent support.Lastly,the research content of this paper is summarized,and directions and suggestions for future research are proposed.

The Opportunities,Dilemmas,and Paths for the Development of Adult Higher Education in the New Era

This paper comprehensively analyzes the development opportunities and realistic dilemmas faced by adult higher education in China in the new era,and puts forward corresponding strategies as solutions.With the construction of a learning society,the development of digital technology,and the popularization of the concept of lifelong learning,adult higher education has unprecedented development opportunities.At the same time,these forms of education are facing a series of dilemmas due to challenges such as unsound guarantee mechanisms and traditional enrollment competition.Through the establishment of perfect legal and policy guarantees,transformation of school running mode,meeting the diversified needs of learners,and other multi-faceted measures,the development of adult higher education can be effectively promoted to meet the needs of individual and social development.

Research on the Impact and Opportunities of the Digital Economy Promoting the Development of Real Economy

The digital economy has infused vitality into the transformation and development of the real economy,urging enterprises to break through core technological barriers,address bottleneck issues,and improve their core competitiveness.It fosters the comprehensive digital transformation of agriculture,manufacturing,and service sectors,improving the dynamism of the real economy and fostering more consumption hotspots.Efforts are underway to enhance industrial supply chains and innovation chains,optimize regional resource allocation,and promote a virtuous cycle within the real economy.Initiatives are being undertaken to standardize the development of digital economic platforms,promote the high-quality development of regional economies,and leverage the advantages of the socialist market economy with Chinese characteristics.

Opportunities, Challenges, and Countermeasures of China Myanmar Economic and Trade Cooperation under the Background of RCEP

China and Myanmar are geographically adjacent and have close economic and trade cooperation. China has been Myanmar’s largest trading partner and largest source of investment for many consecutive years. With the official entry into force of RCEP (Regional Comprehensive Economic Partnership) for Myanmar on May 1, 2022, the reduction of trade tariffs on goods and flexible rules of origin between China and Myanmar will undoubtedly bring more practical results to China Myanmar economic and trade cooperation. However, the implementation of RCEP in Myanmar may face a series of challenges such as poor business environment, weak human resource management, and outdated infrastructure construction. Finally, the article provides countermeasures for China Myanmar economic and trade cooperation from three aspects: optimizing the business environment to attract Chinese investment, increasing investment in education and training to improve labor quality, strengthening infrastructure construction to enhance economic support.

Strengths,weaknesses,opportunities,and threats(SWOT)analysis of supercapacitors:A review

The development of clean and sustainable energy sources has received widespread interest in the past few decades due to the rolling energy demands while extenuating the rising tiers of greenhouse gases and environmental pollution.Due to their intermittent nature,these green and sustainable sources require appropriate energy storage systems.Amongst different energy storage technologies,electrochemical energy storage devices,particularly supercapacitors(SCs),have fascinated global attention for their utilization in electric vehicles,power supports,portable electronics,and many others application requiring electric energy devices for their operation.Thus,the growth of SCs in the commercial market has squeezed requirements,and further developments are obligatory for their effective industrialization.In the meantime,SCs also face technical complications and contests for their introduction in industrial settings because of their low energy density and high Levelized cost.The present study combines core strengths,weaknesses,opportunities,and threats(SWOT)analysis of SCs with new perspectives and recent ideas.The challenges and the future progressive prospects of SCs are also presented in detail.This review will afford consistent direction and new superhighways for the further development of SCs as standalone and complementary energy storage systems.

Towards a business model for second-life batteries: Barriers,opportunities, uncertainties, and technologies

Electric vehicles(EVs) and the recent pandemic outbreak give cities a new trend to primarily private and shared mobility with low noise and less air pollution.Crucial factors for the widespread of EVs are the electrical charging infrastructure,driving range,and the reduction of the cost of battery packets.For this reason,there is a massive effort from manufacturers,governments,and the scientific community to reduce battery costs and boost sustainable electrical production and distribution.Battery reuse is an alternative to reduce batteries’ costs and environmental impacts.Second-life batteries can be used in a wide variety of secondary applications.Second-life batteries can be connected with off-grid or on-grid photovoltaic and wind systems,vehicle charging stations,forklifts,and frequency control.The present work aims to analyze the main challenges imposed on the reuse of batteries,the leading technologies for their reuse,and the different types of batteries in terms of their feasibility for second-life use.The main novelty of this work is the discussion about the barriers,opportunities,uncertainties,and technologies for the second life market.Here we summarize the present state of the art in reusing lithium-ion batteries discussing technical and economic feasibility,environmental impacts,and perspectives.The results show five business models that have been proposed in the literature,three types of markets for trading second-life batteries,and the main opportunities and barriers for each actor in the battery supply chain.

A review of challenges and opportunities in micropillar compression studies in Mg alloys

This review paper provides an overview of the micropillar compression technique as applied to magnesium(Mg) and its alloys. It explores the influence of various factors, such as pillar size, shape, temperature, and strain rate on the mechanical properties of Mg.Additionally, the impact of alloying elements, aging, and precipitates in Mg alloys has been extensively examined, revealing their significant influence on mechanical performance. The study highlights the strength and strain hardening improvements in Mg with decreasing pillar size in micropillar compression. Furthermore, the role of precipitates as strengthening agents, affecting deformation mechanisms and overall mechanical response, is explored. These valuable insights are crucial for designing Mg-based materials with enhanced mechanical properties for advanced engineering applications.

Time is Not Money!——It Is a Providence of Opportunities

The essay discusses the interrelations between Time and Money and the right ways for managing them.Additionally it discusses other aspects of life and time,such as:definition of time,smart use of time,use of time as distincting between men and animals,time,age and responsibility,time and the“meaning of life”,quality and quantity of lifetime,social aspects of time and science,technology and time.The author clearly expresses his opinion,that Time is a neutral abstract entity,exists in free democratic regimes and in less-liberatated autocracies.It is the explicit responsibility of every man and woman,anywhere,and everywhere,to prepare and train themselves for a smart use of the time awarded to them.On the other hand,Time is available for everyone and everything.The busy diligent hard-working person always seeks more challenging missions,while the less-energetic idle person,is always busy and tire of doing nothing.The author also claims that Time is an opportunity.It is available and inviting every active person,a thinker,a doer,and an entrepreneur to use and have it to achieve their goals.The author advises:Do not complain I have no time-dare to make the first step and“the other will come,tumbling after”.Active individuals have time for every challenging initiative;passive ones have no time for anything.

Assessment of the Implementation of Energy Conservation Opportunities Arising from Energy Audits;A Study of Four-Star and Five-Star Hotels in Nairobi Kenya

This study assesses the implementation of energy conservation opportunities in four-star and five-star hotels in Nairobi. The Covid-19 pandemic had a significant impact on the Hospitality Industry. Currently, there is a growing inclination to furnish guests with superior and sustainable services in an energy-efficient and eco-friendly way. Comprehensive research was conducted from energy audits gathered from the establishments and contracted auditing companies, on top of this, hotel staff were given digital questionnaires. To add to the data, the researcher surveyed the hotels with engineering managers. The Energy Audits found that all 10 hotels had adopted Energy Conservation Opportunities (ECOs). After further analysis, the mean adoption rate of Energy Conservation Opportunities (ECOs) during the past three years was 55.83%, which was below the aim of 100%. According to studies, hotel staff manages energy to cut costs. The researcher found that hotels use up a lot of energy. However, they have conservation potential, depending on government policies, costs, ease of implementation, and management commitment to sustainable practices. Essentially, Energy Conservation Opportunities (ECOs) reduce energy expenditures and boost reliable revenues, especially during high energy prices and uncertainty.

Missed Opportunities for Diagnosing Bacilliferous Pulmonary Tuberculosis by Optical Microscopy versus GeneXpert MTB/RIF in Endemic Areas

Objective: To assess the missed opportunities from the diagnosis of bacilliferous pulmonary tuberculosis by optical microscopy compared to GeneXpert MTB/RIF between 2015 and 2019. Methods: This is a retrospective analysis of the diagnostic results of bacilliferous pulmonary tuberculosis in patients suspected of pulmonary tuberculosis at their first episode during the period. GeneXpert MTB/RIF (GeneXpert) and optical microscopy (OM) after Ziehl-Neelsen stained smear were performed on each patient’s sputum or gastric tubing fluid sample. Results: Among 341 patients suspected of pulmonary tuberculosis, 229 patients were declared bacilliferous tuberculosis by the two tests (67%), 220 patients by GeneXpert and 95 patients by OM, i.e. 64.5% versus 28% (p i.e. 58.5% of the positive cases detected by the two tests (134/229 patients) and 39.3% of the patients suspected of tuberculosis (134/341 patients). On the other hand, among 95 patients declared positive by OM, the GeneXpert ignored 9 (9.5%), i.e. 4% of all the positive cases detected by the two diagnostic tests (9/229 patients) and 3% of the patients suspected of tuberculosis (9/341 patients). The differences observed between the results of the two tests were statistically significant at the 5% threshold (p Conclusion: This study reveals missed diagnostic opportunities for bacilliferous pulmonary mycobacteriosis, statistically significant with optical microscopy than GeneXpert. The GeneXpert/optical microscopy couple could be a good contribution to the strategies for the elimination of pulmonary tuberculosis in sub-Saharan Africa.

机器人使用与创业选择

以人工智能、机器人为代表的自动化技术进步,对劳动力市场结构影响持续深化,不仅表现在传统受雇工作形态,还表现在企业创业选择和决策方面。文章基于国家层面自动化程度不断加深的背景,使用2011—2017年全球创业观察(GEM)创业活动数据和国际机器人联合会(IFR)国家层面机器人数据,研究机器人使用对创业活动的影响及可能机制。研究结果表明,机器人使用对创业活动具有显著促进作用。按照创业动机划分机会型创业活动和生存型创业活动发现,机器人使用增加显著促进了机会型创业活动。该结论在控制内生性和考虑不同衡量指标下依然稳健。文章进一步从市场进入障碍、人力资本效应两个维度考察机器人使用对创业活动的影响机制。机制分析发现,机器人使用通过简化企业生产程序,降低企业市场进入障碍,提高人力资本水平进而促进企业创业活动实现。异质性分析表明,机器人使用对创业活动促进作用在OECD国家幅度更大,机器人使用显著增加了中年群体、女性群体以及中低受教育水平群体机会型创业活动概率,机器人使用有利于缩小不同群体间的创业差距。文章研究为促进我国机器人应用深化以及机会型创业活动实现提供了一定的参考意义。

数字化转型背景下中小制造企业如何编排资源利用数字机会——基于资源编排理论的fsQCA研究

利用数字机会是中小制造企业实现数字化转型的关键。资源编排理论指出,利用数字机会离不开企业资源和能力的支持,尤其要将各种资源和能力有效组合起来。但大量中小制造企业难以有效编排自身资源和能力来利用数字机会。为此,本文关注中小制造企业的五种传统资源和能力(实物资源、关系资源、制造能力、营销能力和创新能力)及两种数字资源和能力(大数据资源和数字平台能力),运用模糊集定性比较分析(fsQCA)方法对392份问卷数据进行分析,研究发现:五种传统资源和能力及两种数字资源和能力都不能单独作为中小制造企业数字机会利用的必要条件,但数字平台能力作为核心条件能发挥较为普适的作用。同时,中小制造企业的数字机会利用存在三种路径,可归纳为“内向型”“外向型”和“内外兼顾型”,通过进一步聚焦高技术制造业,发现其数字机会利用存在两种路径:“渐进型”和“突破型”。本文有助于发现如何在数字化背景下编排企业资源和能力,拓展了资源编排理论的研究情境(数字化背景)和研究范围(数字资源和能力),回应了识别“数据时代的资源编排规律”的呼吁。

机构投资者退出威胁能有效抑制高管机会主义减持吗?

本文以2007—2020年中国A股上市公司为研究样本,考察机构投资者退出威胁对高管机会主义减持行为的影响及作用机制。研究发现,机构投资者退出威胁能够有效抑制高管机会主义减持行为,具有显著的治理效应。机构投资者退出威胁有效降低了股价波动和股票错误定价,从而显著抑制了高管机会主义减持。环境不确定性和管理层自利性越强,则机构投资者退出威胁对高管机会主义减持的抑制效应越弱。进一步分析发现,上市公司机构投资者为交易型、发生股权质押以及产权性质为非国有企业时,机构投资者退出威胁对高管机会主义减持的影响更强;而且机构投资者退出威胁治理效应产生了积极的后果,显著抑制了高管减持寻租,提升了企业价值,降低了高管减持时的择机性。

如何辨识中国式现代化新征程上的战略新机遇

当前国际上出现一些“看淡中国发展前景”“唱衰中国经济”的论调,这反映了一些西方国家对世界发展大势和中国发展优势缺乏准确认知,无法辨识中国式现代化新征程上的战略新机遇。事实上,从历史维度看,国际体系转型蕴含着双重战略机遇。一是国际秩序整体上从殖民秩序、霸权秩序不断向更加公正合理的国际新秩序转型;二是中国式现代化顺应了世界多极化、经济全球化、发展模式多样化、国际关系民主化的潮流,体现了中国发展的历史主动性和不断上升的塑造能力。从空间维度看,随着技术和产业的深刻变革,中国在推动开放型经济发展过程中蕴含着重要的战略机遇,尤其是超大规模市场和生产性权力结构所形成的市场空间整合效应,铁路物流和数字贸易的发展,数字化转型和绿色化产业变革等,都为中国带来了战略新机遇。从关系维度看,中国以人类命运共同体理念为引领,超越西方国际关系理论的传统逻辑,推动构建新型国际关系范式,促进全球治理机制改革创新,合力应对全球性挑战,为大国关系总体稳定及巩固和拓展中国的全球伙伴关系提供了战略新机遇。

“双碳”目标下旅游业发展的新机遇与新思路

旅游业发展中的碳排放量多少,在助力实现“双碳”目标中有巨大的潜力和举足轻重的作用,旅游业应遵循多方面、多层次高质量发展理念,从供给侧、消费侧、政策支撑等方面促进降碳减排。在供给侧视角下,促进旅游业科技创新,提升旅游业节能减碳技术发展,推动数字化建设,促进旅游业能源结构清洁化转型,以实现供给侧的降碳减排;在消费端视角下,通过从提高游客的低碳意识、倡导低碳旅游消费方式、建立利益相关方参与机制等倡导公众参与减碳措施,从消费端减少旅游碳排放量;在政策保障视角下,通过完善顶层设计、行业管理、人才培养等建议,完善旅游业低碳发展的总体政策规定,以期为实现我国“双碳”目标提供可行路径。

三重战略逻辑视域下的德国国家安全战略

德国出台的首份《国家安全战略》报告引起了国际社会的广泛关注。以大战略、机会主义、风险管理三种制定战略的政治逻辑为视角,系统检视德国的首份《国家安全战略》报告,可以发现,德国国家安全战略目前仍属于一种较为模糊的原则性规划,其详细行动计划还有待观察。同时,从长期的历史角度看,德国国家安全战略还存在有限的机会主义特征。此外,德国的国家安全政策以防范风险为主,重点是对军事、经济和制度的风险管理。在这种混合性质的国家安全战略引导下,未来德国外交中克制文化的约束力将进一步弱化,跨大西洋伙伴关系会进一步巩固,欧洲战略自主也将在北约框架下艰难推进,但德国国家安全战略的实施将受到其失稳的内政和美国大战略变动等因素的多重影响。

人口老龄化与少子化趋势下税收政策的应对策略

人口老龄化和少子化是当前我国经济社会发展面临的基本国情,对我国社会经济发展既有挑战和冲击,也有机遇。一方面,老龄化、少子化会带来人口红利的消失,与养老相关的财政支出压力增大,并通过影响消费需求、劳动参与率、劳动力成本等因素对税基产生影响。另一方面,人口老龄化会也会带来新的发展机遇,如用工成本增加倒逼企业进行技术创新、老年人口增加助力银发经济崛起等,为税收征收开辟新的增长点。为此,我国税收政策要积极适应老龄化、少子化带来的新变化,积极应对挑战,抓住机遇,调整完善有利于促进生育、促进企业技术创新、助推银色经济发展、促进低龄老年人再就业的税收政策,以促进老龄化进程中的经济发展和社会稳定,为未来的可持续发展奠定基础。