Optical diagnosis of colorectal polyps using convolutional neural networks

Colonoscopy remains the gold standard investigation for colorectal cancer screening as it offers the opportunity to both detect and resect pre-malignant and neoplastic polyps.Although technologies for image-enhanced endoscopy are widely available,optical diagnosis has not been incorporated into routine clinical practice,mainly due to significant inter-operator variability.In recent years,there has been a growing number of studies demonstrating the potential of convolutional neural networks(CNN)to enhance optical diagnosis of polyps.Data suggest that the use of CNNs might mitigate the inter-operator variability amongst endoscopists,potentially enabling a“resect and discard”or“leave in”strategy to be adopted in real-time.This would have significant financial benefits for healthcare systems,avoid unnecessary polypectomies of non-neoplastic polyps and improve the efficiency of colonoscopy.Here,we review advances in CNN for the optical diagnosis of colorectal polyps,current limitations and future directions.

The Optical Diagnosis of Underwater Positive Sparks and Corona Discharges

In this paper, two types of underwater discharges, spark discharge and corona discharge, are investigated by optical diagnosis using a high speed framing camera （HSFC） with the framing time within nanoseconds under the same experimental conditions. In order to capture the photographs of streamer propagation, the influence of the randomicity of the prebreakdown duration is taken into consideration. By increasing the conductivity of water, the randomicity reduces effectively. Experimental results show that, for a spark discharge, the process can be separated into three stages： the generation and propagation of a streamer, the generation and expansion of the discharge channel, and the development and annihilation of the plasma. The streamers do not directly move to the opposite electrode, but form a bush-like figure. With the increase of the number of branches, the velocity of streamer propagation slows down. The trajectory of the initial channel between electrodes is not straight. However, with the channel expanding, its shape transforms into a straight column. For a corona discharge, there are two stages： the generation and propagation of a streamer, and the stagnation and annihilation of the streamer. The initial streamer in a corona discharge is generated later than in a spark discharge. The forms of streamers for both kinds of discharge are similar; however, streamers generated by a corona discharge propagate with a slower velocity and the number of branches is less compared with a spark discharge. When the energy injection stops, the luminescence of plasma inside the discharge channel （spark discharge） or streamers （corona discharge） becomes weaker and weaker, and finally disappears.

Optical Fibre Communication Feature Analysis and Small Sample Fault Diagnosis Based on VMD-FE and Fuzzy Clustering

To solve the problems of a few optical fibre line fault samples and the inefficiency of manual communication optical fibre fault diagnosis,this paper proposes a communication optical fibre fault diagnosis model based on variational modal decomposition(VMD),fuzzy entropy(FE)and fuzzy clustering(FC).Firstly,based on the OTDR curve data collected in the field,VMD is used to extract the different modal components(IMF)of the original signal and calculate the fuzzy entropy(FE)values of different components to characterize the subtle differences between them.The fuzzy entropy of each curve is used as the feature vector,which in turn constructs the communication optical fibre feature vector matrix,and the fuzzy clustering algorithm is used to achieve fault diagnosis of faulty optical fibre.The VMD-FE combination can extract subtle differences in features,and the fuzzy clustering algorithm does not require sample training.The experimental results show that the model in this paper has high accuracy and is relevant to the maintenance of communication optical fibre when compared with existing feature extraction models and traditional machine learning models.

Photographic Analysis and Optical Diagnosis of Kilowatt Microwave Plasma Torch with Air Carrier Gas

The spatiotemporal motion characteristics of the kilowatt argon microwave plasma torch with the air carrier gas(kW-AC-ArMPT)and the behavior of the plasma filaments are investigated with a digital single-lens reflex(SLR)camera and a high-speed camera.Along with the introduction of the air,both the volume of the central channel and the rotational frequency of the plasma filament are increased.Besides,the excitation temperature(Texc),rotational temperature(Trot),and density of electron number(ne)of the kW-AC-ArMPT are measured with optical diagnosis.It is clearly shown that the introduction of air contributed to the rise of Trot and ne of the plasma,which is beneficial to improving the analytical performance of the plasma.Then the detection limits of some heavy metal elements are measured by kW-AC-ArMPT,which are in the ppb range.The experimental results show that the kW-ArMPT has a high tolerance to air injection at least 1.0 L/min,which allows the direct extraction of air from the environment for analysis and therefore has the potential for online and in-situ detection of ambient air quality and industrial exhaust gases.

Artificial intelligence for characterization of diminutive colorectal polyps:A feasibility study comparing two computer-aided diagnosis systems

BACKGROUND Artificial intelligence(AI)has potential in the optical diagnosis of colorectal polyps.AIM To evaluate the feasibility of the real-time use of the computer-aided diagnosis system(CADx)AI for ColoRectal Polyps(AI4CRP)for the optical diagnosis of diminutive colorectal polyps and to compare the performance with CAD EYE^(TM)(Fujifilm,Tokyo,Japan).CADx influence on the optical diagnosis of an expert endoscopist was also investigated.METHODS AI4CRP was developed in-house and CAD EYE was proprietary software provided by Fujifilm.Both CADxsystems exploit convolutional neural networks.Colorectal polyps were characterized as benign or premalignant and histopathology was used as gold standard.AI4CRP provided an objective assessment of its characterization by presenting a calibrated confidence characterization value(range 0.0-1.0).A predefined cut-off value of 0.6 was set with values<0.6 indicating benign and values≥0.6 indicating premalignant colorectal polyps.Low confidence characterizations were defined as values 40%around the cut-off value of 0.6(<0.36 and>0.76).Self-critical AI4CRP’s diagnostic performances excluded low confidence characterizations.RESULTS AI4CRP use was feasible and performed on 30 patients with 51 colorectal polyps.Self-critical AI4CRP,excluding 14 low confidence characterizations[27.5%(14/51)],had a diagnostic accuracy of 89.2%,sensitivity of 89.7%,and specificity of 87.5%,which was higher compared to AI4CRP.CAD EYE had a 83.7%diagnostic accuracy,74.2%sensitivity,and 100.0%specificity.Diagnostic performances of the endoscopist alone(before AI)increased nonsignificantly after reviewing the CADx characterizations of both AI4CRP and CAD EYE(AI-assisted endoscopist).Diagnostic performances of the AI-assisted endoscopist were higher compared to both CADx-systems,except for specificity for which CAD EYE performed best.CONCLUSION Real-time use of AI4CRP was feasible.Objective confidence values provided by a CADx is novel and self-critical AI4CRP showed higher diagnostic performances compared to AI4CRP.

Axial uniformity diagnosis of coaxial surface wave linear plasma by optical emission spectroscopy

The coaxial surface wave linear plasma with preeminent axial uniformity is developed with the 2.45 GHz microwave generator.By optical emission spectroscopy,parameters of the argon linear plasma with a length over 600 mm are diagnosed under gas pressure of 30 and 50 Pa and different microwave powers.The spectral lines of argon and Hβ(486.1 nm)atoms in excited state are observed for estimating electron excitation temperature and electron density.Spectrum bands in305–310 nm of diatomic OH(Σ-Π+A X22 i)radicals are used to determine the molecule rotational temperature.Finally,the axial uniformity of electron density and electron excitation temperature are analyzed emphatically under various conditions.The results prove the distinct optimization of compensation from dual powers input,which can narrow the uniform coefficient of electron density and electron excitation temperature by around 40%and 22%respectively.With the microwave power increasing,the axial uniformity of both electron density and electron excitation temperature performs better.Nevertheless,the fluctuation of electron density along the axial direction appeared with higher gas pressure.The axial uniformity of coaxial surface wave linear plasma could be controlled by pressure and power for a better utilization in material processing.

Non-optical polyp-based resect and discard strategy:A prospective clinical study

BACKGROUND Post-polypectomy surveillance intervals are currently determined based on pathology results.AIM To evaluate a polyp-based resect and discard model that assigns surveillance intervals based solely on polyp number and size.METHODS Patients undergoing elective colonoscopies at the Montreal University Medical Center were enrolled prospectively.The polyp-based strategy was used to assign the next surveillance interval using polyp size and number.Surveillance intervals were also assigned using optical diagnosis for small polyps(<10 mm).The primary outcome was surveillance interval agreement between the polyp-based model,optical diagnosis,and the pathology-based reference standard using the 2020 United States Multi-Society Task Force guidelines.Secondary outcomes included the proportion of reduction in required histopathology evaluations and proportion of immediate post-colonoscopy recommendations provided to patients.RESULTS Of 944 patients(mean age 62.6 years,49.3%male,933 polyps)were enrolled.The surveillance interval agreement for the polyp-based strategy was 98.0%[95%confidence interval(CI):0.97-0.99]compared with pathology-based assignment.Optical diagnosis-based intervals achieved 95.8%(95%CI:0.94-0.97)agreement with pathology.When using the polyp-based strategy and optical diagnosis,the need for pathology assessment was reduced by 87.8%and 70.6%,respectively.The polyp-based strategy provided 93.7%of patients with immediate surveillance interval recommendations vs 76.1%for optical diagnosis.CONCLUSION The polyp-based strategy achieved almost perfect surveillance interval agreement compared with pathology-based assignments,significantly reduced the number of required pathology evaluations,and provided most patients with immediate surveillance interval recommendations.

Brillouin optical time-domain analysis for geotechnical monitoring

In this paper, we show some recent experimental applications of Brillouin optical time-domain analysis （BOTDA） based sensors for geotechnical monitoring. In particular, how these sensors can be applied to detecting early movements of soil slopes by the direct embedding of suitable fiber cables in the ground is presented. Furthermore, the same technology can be used to realize innovative inclinometers, as well as smart foundation anchors.

Optic diagnosis of neutral beam injection on HL-1M

During the operation of a high-power neutral beam injection (NBI) system on theHL-1M tokamak, an optical diagnostic means using CCD camera was developed to characterize theNBI performance. The vacuum valve opening process and NBI period in the HL-1M experimentwere displayed by a lot of photos taken with this means. Thus, the Hα emission profiles of theneutral beam (NB) and its interaction with plasma were given. Finally, the reason possible forplasma breakdown during NBI mode Ⅱ discharge was investigated. Therefore, this in-situ diagnosiscan provide more information of the NBI.

定容弹内柴油/丁醇混合燃料燃烧特性研究

In this paper,the spray and combustion characteristics of diesel/butanol-blended fuels were studied within a high-temperature and high-pressure constant volume chamber equipped with a single-hole injector.Two blends with 80%diesel/20%butanol and 60%diesel/40%butanol mixed by volume were tested in this study.The pure diesel B0 was also tested here as a reference.The spray penetration,flame lift-off length,and soot optical thickness were obtained through high-speed schlieren imaging,OH*chemiluminescence,and diffused back-illumination extinction imaging technique,respectively.The thermogravimetric curves of different fuels were obtained through a thermogravimetric analyzer.The results showed that butanol/diesel blends presented a longer ignition delay(ID)and flame lift-off length compared with pure diesel,and such finding was mainly caused by the lower cetane number and higher latent heat of vaporization of n-butanol.With the increase in the n-butanol ratio,soot production in the combustion process decreased significantly.Given the shorter ID period,the soot distribution of pure diesel reached a steady state earlier than the blends.

This research was supported by E.U.FP6 Integrated Project“Molecular Imaging”LSHG-CT-2003-503259 and E.U.FP7 Collaborative Project“FMT-XCT”.R.F.acknowledges support from the Marie Curie Program EST-MolecImag Early Stage Training MEST-CT-2004-007643.

We have imaged mitochondrial oxidation-reduction states by taking a ratio of mitochondrial fluorophores:NADH(reduced nicotinamide adenine dinucleotide)to Fp(oxidized flavoprotein).Although NADH has been investigated for tissue metabolic state in cancer and in oxygen deprived tissues,it alone is not an adequate measure of mitochondrial metabolic state since the NADH signal is altered by dependence on the number of mitochondria and by blood absorption.The redox ratio,NADH/(Fp+NADH),gives a more accurate measure of steady-state tissue metabolism since it is less dependent on mitochondrial number and it compensates effectively for hemodynamic changes.This ratio provides important diagnostic information in living tissues.In this study,the emitted fluorescence of mouse colon in situ is passed through an emission filter wheel and imaged on a CCD camera.Redox ratio images of the healthy and hypoxic mouse intestines clearly showed significant differences.Furthermore,the corrected redox ratio indicated an increase from an average value of 0.51±0.10 in the healthy state to 0.92±0.03 in dead tissue due to severe ischemia(N=5).We show that the CCD imaging system is capable of displaying the metabolic differences in normal and ischemic tissues as well as quantifying the redox ratio in vivo as a marker of these changes.

Shock wave velocity measurement in the Al_2O_3 under ultrahigh pressure

in indirect-drive experiment, the blank effect caused by X-rays from Hohlraum will show the dark area in time scale of optical streak camera （OSC）. This blank effect, which was a serious problem in indirect-drive shock wave experiments, has been explained by the semiconductor model. The X-rays cause the band to band transition and the probe laser is absorbed by the intraband transition, which leads to a dark region in time scale of the OSC image. In the experiment, the reflectivity of shock wave front was measured to be about 50% at shock wave velocity 32 km/s and was compared to the theoretical calculations with the Drude free electron model. From the experimental data, it is found that the blank effect can be avoided at radiation temperature of 170 eV if the Al layer is thicker than 60μm.

Comparative study of pulsed breakdown processes and mechanisms in self-triggered four-electrode pre-ionized switches

This work investigates the pulsed breakdown processes and mechanisms of self-triggered preionized switches with a four-electrode structure in nitrogen through intensified charge coupled device photographs.The diameter of the trigger plane hole mainly determines the switch’s electric field distribution.Two configurations with minimum and maximum trigger plane holes are adopted for comparison.In the switch with a minimum trigger plane hole,the maximum electric field distributes at the surfaces of the main electrodes.Although charged particles in the triggering spark channel cannot drift out,homogeneous discharges can be stimulated from both the cathode and anode surfaces through ultraviolet illumination.Two sub-gaps are likely to break down simultaneously.In the switch with a maximum trigger plane hole,the maximum electric field locates near the trigger electrodes.Discharges in both sub-gaps initiate from the trigger electrodes in the form of a positive or negative streamer.Due to the lower breakdown voltage and electric field threshold for discharge initiation,the cathode side sub-gap breaks down first.The analysis of two extreme examples can be referenced in the future design and improvement of self-triggered four-electrode switches with different trigger electrode structures.

Small invasive colon cancer with adenoma observed by endocytoscopy: A case report

Endocytoscopy is a next-generation endoscopic system that facilitates real-time histopathologic endoscopic diagnosis of colorectal lesions by virtue of its 520×maximum magnification.CASE SUMMARY We present the case of a 63-year-old man with sigmoid colon cancer who was regularly referred for follow-up colonoscopy after endoscopic resection of T1 rectal cancer.Colonoscopy revealed a 12 mm reddish polyp,including a depression and a flat area in the sigmoid colon.Endocytoscopic observation showed unclear gland formation and agglomeration of distorted nuclei(depression),suggesting a submucosal invasive(T1)cancer.In the flat area,slitlike smooth lumens and regular pattern of fusiform nuclei were found,suggesting an adenoma.On the basis of these endocytoscopic findings,we predicted this lesion as T1 cancer(depression)with adenoma(flat area)and performed endoscopic resection corresponding to the final histopathological diagnosis.CONCLUSION We could perform an optical diagnosis of T1 sigmoid cancer with adenoma by using endocytoscopy before treatment.

Effect of multiple parameters on the supersonic gas-jet target characteristics for laser wakefield acceleration

The supersonic gas-jet target is an important experimental target for laser wakefield acceleration(LWFA),which has great potential for driving novel radiation sources such as betatron radiation and Compton scattering gamma rays.According to different electron acceleration requirements,it is necessary to provide specific supersonic gas jets with different density profiles to generate electron beams with high quality and high repetition rates.In this study,the interference images and density profiles of different gas-jet targets were obtained through a modified Nomarski interference diagnosis system.The relationships between the gas density and back pressure,nozzle structure,and other key parameters were studied.Targets with different characteristics are conducive to meeting the various requirements of LWFA.

Understanding hydrogen plasma processes based on the diagnostic results of 2.45 GHz ECRIS at Peking University

Optical emission spectroscopy（OES）, as a simple in situ method without disturbing the plasma, has been performed for the plasma diagnosis of a 2.45 GHz permanent magnet electron cyclotron resonance（PMECR） ion source at Peking University（PKU）. A spectrum measurement platform has been set up with the quartz-chamber electron cyclotron resonance（ECR） ion source [Patent Number： ZL 201110026605.4] and experiments were carried out recently. The electron temperature and electron density inside the ECR plasma chamber have been measured with the method of line intensity ratio of noble gas. Hydrogen plasma processes inside the discharge chamber are discussed based on the diagnostic results. What is more, the superiority of the method of line intensity ratio of noble gas is indicated with a comparison to line intensity ratio of hydrogen. Details will be presented in this paper.

Effects of dimethyl ether and ethanol additions on soot transition in ethylene counterflow diffusion flames

This paper investigates the effect of blending dimethyl ether(DME)and ethanol on the soot transition periods in ethylene counterflow diffusion flames by using a novel optical diagnostic method.The soot critical transition point in different conditions is identified experimentally and numerically.Two kinds of flames are carried out to gain the soot critical transition point in counterflow diffusion flames by changing oxygen fraction(Xo)and changing volume flow rates of fuel and oxidizer(Qv).The red-green-blue(RGB)ratio method is used to precisely identify the soot critical transition point,and chemical kinetic simulations are performed to analyze the detailed reaction paths.The results show that compared to the ethylene flame,the soot critical transition point occurs at a higher Xoand a lower Qvwhen DME or ethanol is blended.The addition of DME and ethanol can inhibit soot formation,due to the degree of soot formation reaction being lower than the degree of the oxidation reaction in the blending flames.