In today’s information age,video data,as an important carrier of information,is growing explosively in terms of production volume.The quick and accurate extraction of useful information from massive video data has be...In today’s information age,video data,as an important carrier of information,is growing explosively in terms of production volume.The quick and accurate extraction of useful information from massive video data has become a focus of research in the field of computer vision.AI dynamic recognition technology has become one of the key technologies to address this issue due to its powerful data processing capabilities and intelligent recognition functions.Based on this,this paper first elaborates on the development of intelligent video AI dynamic recognition technology,then proposes several optimization strategies for intelligent video AI dynamic recognition technology,and finally analyzes the performance of intelligent video AI dynamic recognition technology for reference.展开更多
Structural optimization technologies are increasingly applied to lightweight automotive structural design.In a body-inwhite(BIW)development project,optimization technologies are applied in three steps that are seamles...Structural optimization technologies are increasingly applied to lightweight automotive structural design.In a body-inwhite(BIW)development project,optimization technologies are applied in three steps that are seamlessly integrated into engineering practice.By following a design-driven approach,an innovative design that was 50.65 kg lighter than the base design was achieved.First,topology optimization was used to investigate the optimal material distribution in a given design space,and helped in extracting the main load path,while considering crashworthiness,NVH,and static stiffness performance requirements.In the second step,the effective design of a beam cross-section and feasible joints was carried out based on optimization technology and expert knowledge.In this step,the deep involvement of manufacturing process experts on stamping and joint connection feasibility analysis increased the chance of success remarkably.The sensitivity analysis,topography optimization,and gauge optimization of the created draft 3D BIW frame comprised the last step before finalizing the initial design.The new design was validated by full load case simulations,including full vehicle crashworthiness analysis,mode frequency,and body mount point dynamic stiffness analysis,and BIW stiffness and component attachment stiffness analysis.The validation results indicate that the new BIW design achieves the performance goal,while being 13.3%lighter than the base design.展开更多
[ Objective ] This study aimed to optimize the extraction technology for rice bran oil. [ Method ] Using rice bran as raw material, effects of ultrasonicassisted extraction technology and different organic solvents, e...[ Objective ] This study aimed to optimize the extraction technology for rice bran oil. [ Method ] Using rice bran as raw material, effects of ultrasonicassisted extraction technology and different organic solvents, extraction durations, solid-liquid ratios and extraction temperatures on extraction results of rice bran oil were investigated. Based on the results of single-factor experiment, L9 (34 ) orthngonal experiment with three factors at three levels was conducted to optimize the extraction technological parameters, thus obtaining the optimal technological conditions for extracting rice bran oil. [ Result] Anhydrous ethanol led to the best extraction result; after ultrasonic treatment, the extraction rate of rice bran oil from raw material was not enhanced. The optimized technological parameters were : extraction temperature of 80 ℃, extraction duration of 20 rain and solid-liquid ratio of 1:24 ( g: ml). Under the optimized technological conditions, the extraction rate of rice bran oil reached 19.33%. [ Conclusion] This study laid solid foundation for further investigation and development of rice bran oil.展开更多
In order to solve the complex optimization problem dealing with uncertain phenomenon effectively, this paper presents a probability simulation optimization approach using orthogonal genetic algorithm. This approach sy...In order to solve the complex optimization problem dealing with uncertain phenomenon effectively, this paper presents a probability simulation optimization approach using orthogonal genetic algorithm. This approach synthesizes the computer simulation technology, orthogonal genetic algorithm and statistical test method faultlessly, which can solve complex optimization problem effectively. In this paper, the author gives the correlative conception of probability simulation optimization and describes the probability simulation optimization approach using orthogonal genetic algorithm in detail. Theoretically speaking, it has a strong rationality and maneuverability that can apply probability method in solving the complex optimization problems with uncertain phenomenon. In demonstration, the optimization performance of this method is better than other traditional methods. Simulation resuh suggests that the approach referred to this paper is feasible, correct and valid.展开更多
In order to reduce the production cost of imidacloprid, the preparation technology for the direct com-bination of 2-chloro-5-chloromethylpyridine and 2-nitryliminoglyoxaline has been optimized in a 10 L stirred tank r...In order to reduce the production cost of imidacloprid, the preparation technology for the direct com-bination of 2-chloro-5-chloromethylpyridine and 2-nitryliminoglyoxaline has been optimized in a 10 L stirred tank reactor with a new solvent, butanone, and a new catalyst, benzyl triethyl-ammonium chloride (BTEAC), which was proved to be more profitable for the production of imidacloprid. Three main affecting factors (the reaction temper-ature, the molar ratio of BTEAC to 2-nitryliminoglyoxaline and the concentration of 2-nitryuminoglyoxaline) for the production of imidacloprid were investigated and the optimum operating conditions were found. Based on the above technological optimization, an industrial process for imidacloprid with a production capacity of 50 tons per year was put in operation using a 2500 L stirred tank reactor under the same operating conditions. Good yield and purity of imidacloprid was also obtained in the industrial production.展开更多
In this paper, the spinning parameters are optimized by using the method of factor analysis. The yarns obtained from four different spinning parameters are evaluated by this method. Two common factors, fineness uneven...In this paper, the spinning parameters are optimized by using the method of factor analysis. The yarns obtained from four different spinning parameters are evaluated by this method. Two common factors, fineness unevenness and tenacity level, are extracted from the seven yarn-quality indexes. The accumulative contribution percentage of the two factors is up to 91.813%,and much information in the yarn-quality indexes is reflected by the two factors. Then the score of each factor is calculated to evaluate the quality of yarn. Based on that, the techniques are optimized. The result is well in line with spinning practices, so it is testified feasibly to use this method to optimize spinning parameter.展开更多
The relation between technology parameters and performance index of the wheat three-stage concurrent-flow drying technology is studied by use of quadratic orthogonial rotate combinative experiment design method.The op...The relation between technology parameters and performance index of the wheat three-stage concurrent-flow drying technology is studied by use of quadratic orthogonial rotate combinative experiment design method.The optimum parameters of drying technology are obtained by nonlinear optimize corresponding regression model and test.All experiment was finished in concurrent-flow grain drying experiment table.The results of this study will be significant for designing energy-saving grain drying machine.展开更多
Using artificial intelligence(AI) and machine learning(ML) techniques, we developed and validated the smart proxy models for history matching of reservoir simulation, sensitivity analysis, and uncertainty assessment b...Using artificial intelligence(AI) and machine learning(ML) techniques, we developed and validated the smart proxy models for history matching of reservoir simulation, sensitivity analysis, and uncertainty assessment by artificial neural network(ANN). The smart proxy models were applied on two cases, the first case study investigated the application of a proxy model for calibrating a reservoir simulation model based on historical data and predicting well production while the second case study investigated the application of an ANN-based proxy model for fast-track modeling of CO2 enhanced oil recovery, aiming at the prediction of the reservoir pressure and phase saturation distribution at injection stage and post-injection stage. The prediction effects for both cases are promising. While a single run of basic numerical simulation model takes hours to days, the smart proxy model runs in a matter of seconds, saving 98.9% of calculating time. The results of these case studies demonstrate the advantage of the proposed workflow for addressing the high run-time, computational time and computational cost of numerical simulation models. In addition, these proxy models predict the outputs of reservoir simulation models with high accuracy.展开更多
According to the status of the northern rural architecture analysis, the prevalence of high energy consumption, low comfort features, it is essential to design energy-efficient buildings in rural areas. Article resear...According to the status of the northern rural architecture analysis, the prevalence of high energy consumption, low comfort features, it is essential to design energy-efficient buildings in rural areas. Article research and analyze the layout of rural buildings, a variety of energy-saving technologies and building design measures development and utilization of new energy sources and other issues that can make rural buildings to save energy and improve the environmental quality of living of farmers. It also put forward some reasonable suggestions for carrying out residential building energy efficiency in cold areas.展开更多
The presented work will show the highest relevance of solving all the issues related to this problem and present the results of the analysis of the main expected potential problems,which may occur in the implementatio...The presented work will show the highest relevance of solving all the issues related to this problem and present the results of the analysis of the main expected potential problems,which may occur in the implementation of the INDUSTRY-4.0 reform.It is proved that the pace and level of development of this reform will be determined to a large extent by the effectiveness of the individual nodes used and the entire mechatronic system.It has also been established that as a result of systematic miniaturization of the nodes of radio-electronic equipment and microelectronic equipment and microelectronic technology,the main problem of these reforms and the implementation of complex technological processes is instrumental and technological support,especially with cutting micro-tools and equipment.Therefore,on the example of these investigations,methods for improving their performance are shown.展开更多
Two optimization technologies, namely, bypass and carry-control optimization, were demonstrated for enhancing the performance of a bit-slice Arithmetic Logic Unit (ALU) in 2n-bit Rapid Single-Flux-Quantum (RSFQ) micro...Two optimization technologies, namely, bypass and carry-control optimization, were demonstrated for enhancing the performance of a bit-slice Arithmetic Logic Unit (ALU) in 2n-bit Rapid Single-Flux-Quantum (RSFQ) microprocessors. These technologies can not only shorten the calculation time but also solve data hazards. Among them, the proposed bypass technology is applicable to any 2n-bit ALU, whether it is bit-serial, bit-slice or bit-parallel. The high performance bit-slice ALU was implemented using the 6 kA/cm^(2) Nb/AlOx/Nb junction fabrication process from Superconducting Electronics Facility of Shanghai Institute of Microsystem and Information Technology. It consists of 1693 Josephson junctions with an area of 2.46 0.81 mm^(2). All ALU operations of the MIPS32 instruction set are implemented, including two extended instructions, i.e., addition with carry (ADDC) and subtraction with borrow (SUBB). All the ALU operations were successfully obtained in SFQ testing based on OCTOPUX and the measured DC bias current margin can reach 86% - 104%. The ALU achieves a 100 utilization rate, regardless of carry/borrow read-after-write correlations between instructions.展开更多
In the face of harsh natural environment applications such as earth-orbiting and deep space satellites, underwater sea vehicles, strong electromagnetic interference and temperature stress,the circuits faults appear ea...In the face of harsh natural environment applications such as earth-orbiting and deep space satellites, underwater sea vehicles, strong electromagnetic interference and temperature stress,the circuits faults appear easily. Circuit faults will inevitably lead to serious losses of availability or impeded mission success without self-repair over the mission duration. Traditional fault-repair methods based on redundant fault-tolerant technique are straightforward to implement, yet their area, power and weight cost can be excessive. Moreover they utilize all plug-in or component level circuits to realize redundant backup, such that their applicability is limited. Hence, a novel selfrepair technology based on evolvable hardware(EHW) and reparation balance technology(RBT) is proposed. Its cost is low, and fault self-repair of various circuits and devices can be realized through dynamic configuration. Making full use of the fault signals, correcting circuit can be found through EHW technique to realize the balance and compensation of the fault output-signals. In this paper, the self-repair model was analyzed which based on EHW and RBT technique, the specific self-repair strategy was studied, the corresponding self-repair circuit fault system was designed, and the typical faults were simulated and analyzed which combined with the actual electronic devices. Simulation results demonstrated that the proposed fault self-repair strategy was feasible. Compared to traditional techniques, fault self-repair based on EHW consumes fewer hardware resources, and the scope of fault self-repair was expanded significantly.展开更多
Dear Editor,Despite tremendous effort devoted to the development of antiretroviral therapies to combat HIV over the past decades, AIDS remains one of the most important global infectious diseases. According to UNAIDS ...Dear Editor,Despite tremendous effort devoted to the development of antiretroviral therapies to combat HIV over the past decades, AIDS remains one of the most important global infectious diseases. According to UNAIDS report on the global AIDS epidemic in 2016, the estimated number of people living with HIV rose from 7.5 million in 2010 to 36.7 million in 2015. Furthermore, drug-resistance HIV strains have recently been reported (Wensing et al., 2017). Therefore, it is important to develop new therapies to eliminate HIV in the patients. Immortalized cell lines representing the major targets of HIV in human are important for HIV research and therapeutic development.展开更多
In this paper, we adopt the robust optimization method to consider linear complementarity problems in which the data is not specified exactly or is uncertain, and it is only known to belong to a prescribed uncertainty...In this paper, we adopt the robust optimization method to consider linear complementarity problems in which the data is not specified exactly or is uncertain, and it is only known to belong to a prescribed uncertainty set. We propose the notion of the p-robust counterpart and the p-robust solution of uncertain linear complementarity problems. We discuss uncertain linear complementarity problems with three different uncertainty sets, respectively, including an unknown-but-bounded uncertainty set, an ellipsoidal uncertainty set and an intersection-of-ellipsoids uncertainty set, and present some sufficient and necessary (or sufficient) conditions which p-robust solutions satisfy. Some special eases are investigated in this paper.展开更多
Today's emergence of nano-micro hybrid structures with almost biological complexity is of fundamental interest. Our ability to adapt intelligently to the challenges has ramifications all the way from fundamentally ch...Today's emergence of nano-micro hybrid structures with almost biological complexity is of fundamental interest. Our ability to adapt intelligently to the challenges has ramifications all the way from fundamentally changing research itself, over applications critical to future survival, to posing globally existential dangers. Touching on specific issues such as how complexity relates to the catalytic prowess of multi-metal compounds, we discuss the increasingly urgent issues in nanotechnology also very generally and guided by the motto 'Bio Is Nature's Nanotech'. Technology belongs to macro-evolution; for example integration with artificial intelligence (AI) is inevitable. Darwinian adaptation manifests as integration of complexity, and awareness of this helps in developing adaptable research methods that can find use across a wide range of research. The second half of this work reviews a diverse range of projects which all benefited from 'playful' programming aimed at dealing with complexity. The main purpose of reviewing them is to show how such projects benefit from and fit in with the general, philosophical approach, proving the relevance of the 'big picture' where it is usually disregarded.展开更多
文摘In today’s information age,video data,as an important carrier of information,is growing explosively in terms of production volume.The quick and accurate extraction of useful information from massive video data has become a focus of research in the field of computer vision.AI dynamic recognition technology has become one of the key technologies to address this issue due to its powerful data processing capabilities and intelligent recognition functions.Based on this,this paper first elaborates on the development of intelligent video AI dynamic recognition technology,then proposes several optimization strategies for intelligent video AI dynamic recognition technology,and finally analyzes the performance of intelligent video AI dynamic recognition technology for reference.
文摘Structural optimization technologies are increasingly applied to lightweight automotive structural design.In a body-inwhite(BIW)development project,optimization technologies are applied in three steps that are seamlessly integrated into engineering practice.By following a design-driven approach,an innovative design that was 50.65 kg lighter than the base design was achieved.First,topology optimization was used to investigate the optimal material distribution in a given design space,and helped in extracting the main load path,while considering crashworthiness,NVH,and static stiffness performance requirements.In the second step,the effective design of a beam cross-section and feasible joints was carried out based on optimization technology and expert knowledge.In this step,the deep involvement of manufacturing process experts on stamping and joint connection feasibility analysis increased the chance of success remarkably.The sensitivity analysis,topography optimization,and gauge optimization of the created draft 3D BIW frame comprised the last step before finalizing the initial design.The new design was validated by full load case simulations,including full vehicle crashworthiness analysis,mode frequency,and body mount point dynamic stiffness analysis,and BIW stiffness and component attachment stiffness analysis.The validation results indicate that the new BIW design achieves the performance goal,while being 13.3%lighter than the base design.
文摘[ Objective ] This study aimed to optimize the extraction technology for rice bran oil. [ Method ] Using rice bran as raw material, effects of ultrasonicassisted extraction technology and different organic solvents, extraction durations, solid-liquid ratios and extraction temperatures on extraction results of rice bran oil were investigated. Based on the results of single-factor experiment, L9 (34 ) orthngonal experiment with three factors at three levels was conducted to optimize the extraction technological parameters, thus obtaining the optimal technological conditions for extracting rice bran oil. [ Result] Anhydrous ethanol led to the best extraction result; after ultrasonic treatment, the extraction rate of rice bran oil from raw material was not enhanced. The optimized technological parameters were : extraction temperature of 80 ℃, extraction duration of 20 rain and solid-liquid ratio of 1:24 ( g: ml). Under the optimized technological conditions, the extraction rate of rice bran oil reached 19.33%. [ Conclusion] This study laid solid foundation for further investigation and development of rice bran oil.
基金Supported by the National Natural Science Foundation of China(70272002) .
文摘In order to solve the complex optimization problem dealing with uncertain phenomenon effectively, this paper presents a probability simulation optimization approach using orthogonal genetic algorithm. This approach synthesizes the computer simulation technology, orthogonal genetic algorithm and statistical test method faultlessly, which can solve complex optimization problem effectively. In this paper, the author gives the correlative conception of probability simulation optimization and describes the probability simulation optimization approach using orthogonal genetic algorithm in detail. Theoretically speaking, it has a strong rationality and maneuverability that can apply probability method in solving the complex optimization problems with uncertain phenomenon. In demonstration, the optimization performance of this method is better than other traditional methods. Simulation resuh suggests that the approach referred to this paper is feasible, correct and valid.
基金Natural Science Foundation of Tianjin(No.013605711)
文摘In order to reduce the production cost of imidacloprid, the preparation technology for the direct com-bination of 2-chloro-5-chloromethylpyridine and 2-nitryliminoglyoxaline has been optimized in a 10 L stirred tank reactor with a new solvent, butanone, and a new catalyst, benzyl triethyl-ammonium chloride (BTEAC), which was proved to be more profitable for the production of imidacloprid. Three main affecting factors (the reaction temper-ature, the molar ratio of BTEAC to 2-nitryliminoglyoxaline and the concentration of 2-nitryuminoglyoxaline) for the production of imidacloprid were investigated and the optimum operating conditions were found. Based on the above technological optimization, an industrial process for imidacloprid with a production capacity of 50 tons per year was put in operation using a 2500 L stirred tank reactor under the same operating conditions. Good yield and purity of imidacloprid was also obtained in the industrial production.
文摘In this paper, the spinning parameters are optimized by using the method of factor analysis. The yarns obtained from four different spinning parameters are evaluated by this method. Two common factors, fineness unevenness and tenacity level, are extracted from the seven yarn-quality indexes. The accumulative contribution percentage of the two factors is up to 91.813%,and much information in the yarn-quality indexes is reflected by the two factors. Then the score of each factor is calculated to evaluate the quality of yarn. Based on that, the techniques are optimized. The result is well in line with spinning practices, so it is testified feasibly to use this method to optimize spinning parameter.
文摘The relation between technology parameters and performance index of the wheat three-stage concurrent-flow drying technology is studied by use of quadratic orthogonial rotate combinative experiment design method.The optimum parameters of drying technology are obtained by nonlinear optimize corresponding regression model and test.All experiment was finished in concurrent-flow grain drying experiment table.The results of this study will be significant for designing energy-saving grain drying machine.
文摘Using artificial intelligence(AI) and machine learning(ML) techniques, we developed and validated the smart proxy models for history matching of reservoir simulation, sensitivity analysis, and uncertainty assessment by artificial neural network(ANN). The smart proxy models were applied on two cases, the first case study investigated the application of a proxy model for calibrating a reservoir simulation model based on historical data and predicting well production while the second case study investigated the application of an ANN-based proxy model for fast-track modeling of CO2 enhanced oil recovery, aiming at the prediction of the reservoir pressure and phase saturation distribution at injection stage and post-injection stage. The prediction effects for both cases are promising. While a single run of basic numerical simulation model takes hours to days, the smart proxy model runs in a matter of seconds, saving 98.9% of calculating time. The results of these case studies demonstrate the advantage of the proposed workflow for addressing the high run-time, computational time and computational cost of numerical simulation models. In addition, these proxy models predict the outputs of reservoir simulation models with high accuracy.
文摘According to the status of the northern rural architecture analysis, the prevalence of high energy consumption, low comfort features, it is essential to design energy-efficient buildings in rural areas. Article research and analyze the layout of rural buildings, a variety of energy-saving technologies and building design measures development and utilization of new energy sources and other issues that can make rural buildings to save energy and improve the environmental quality of living of farmers. It also put forward some reasonable suggestions for carrying out residential building energy efficiency in cold areas.
基金This work was supported by Shota Rustaveli National Science Foundation(SRNSF)[PHDF-19-2224,Improving the efficiency of mechatronic systems in order to ensure the reform of“Industry-4.0”].
文摘The presented work will show the highest relevance of solving all the issues related to this problem and present the results of the analysis of the main expected potential problems,which may occur in the implementation of the INDUSTRY-4.0 reform.It is proved that the pace and level of development of this reform will be determined to a large extent by the effectiveness of the individual nodes used and the entire mechatronic system.It has also been established that as a result of systematic miniaturization of the nodes of radio-electronic equipment and microelectronic equipment and microelectronic technology,the main problem of these reforms and the implementation of complex technological processes is instrumental and technological support,especially with cutting micro-tools and equipment.Therefore,on the example of these investigations,methods for improving their performance are shown.
基金Strategic Priority Research Program of Chinese Academy of Sciences,under Grant XDA18000000.
文摘Two optimization technologies, namely, bypass and carry-control optimization, were demonstrated for enhancing the performance of a bit-slice Arithmetic Logic Unit (ALU) in 2n-bit Rapid Single-Flux-Quantum (RSFQ) microprocessors. These technologies can not only shorten the calculation time but also solve data hazards. Among them, the proposed bypass technology is applicable to any 2n-bit ALU, whether it is bit-serial, bit-slice or bit-parallel. The high performance bit-slice ALU was implemented using the 6 kA/cm^(2) Nb/AlOx/Nb junction fabrication process from Superconducting Electronics Facility of Shanghai Institute of Microsystem and Information Technology. It consists of 1693 Josephson junctions with an area of 2.46 0.81 mm^(2). All ALU operations of the MIPS32 instruction set are implemented, including two extended instructions, i.e., addition with carry (ADDC) and subtraction with borrow (SUBB). All the ALU operations were successfully obtained in SFQ testing based on OCTOPUX and the measured DC bias current margin can reach 86% - 104%. The ALU achieves a 100 utilization rate, regardless of carry/borrow read-after-write correlations between instructions.
基金supported by the National Natural Science Foundation of China (Nos. 61271153, 61372039)
文摘In the face of harsh natural environment applications such as earth-orbiting and deep space satellites, underwater sea vehicles, strong electromagnetic interference and temperature stress,the circuits faults appear easily. Circuit faults will inevitably lead to serious losses of availability or impeded mission success without self-repair over the mission duration. Traditional fault-repair methods based on redundant fault-tolerant technique are straightforward to implement, yet their area, power and weight cost can be excessive. Moreover they utilize all plug-in or component level circuits to realize redundant backup, such that their applicability is limited. Hence, a novel selfrepair technology based on evolvable hardware(EHW) and reparation balance technology(RBT) is proposed. Its cost is low, and fault self-repair of various circuits and devices can be realized through dynamic configuration. Making full use of the fault signals, correcting circuit can be found through EHW technique to realize the balance and compensation of the fault output-signals. In this paper, the self-repair model was analyzed which based on EHW and RBT technique, the specific self-repair strategy was studied, the corresponding self-repair circuit fault system was designed, and the typical faults were simulated and analyzed which combined with the actual electronic devices. Simulation results demonstrated that the proposed fault self-repair strategy was feasible. Compared to traditional techniques, fault self-repair based on EHW consumes fewer hardware resources, and the scope of fault self-repair was expanded significantly.
文摘Dear Editor,Despite tremendous effort devoted to the development of antiretroviral therapies to combat HIV over the past decades, AIDS remains one of the most important global infectious diseases. According to UNAIDS report on the global AIDS epidemic in 2016, the estimated number of people living with HIV rose from 7.5 million in 2010 to 36.7 million in 2015. Furthermore, drug-resistance HIV strains have recently been reported (Wensing et al., 2017). Therefore, it is important to develop new therapies to eliminate HIV in the patients. Immortalized cell lines representing the major targets of HIV in human are important for HIV research and therapeutic development.
基金Supported by the National Natural Science Foundation of China(No.10671010,10871144 and 10671145)
文摘In this paper, we adopt the robust optimization method to consider linear complementarity problems in which the data is not specified exactly or is uncertain, and it is only known to belong to a prescribed uncertainty set. We propose the notion of the p-robust counterpart and the p-robust solution of uncertain linear complementarity problems. We discuss uncertain linear complementarity problems with three different uncertainty sets, respectively, including an unknown-but-bounded uncertainty set, an ellipsoidal uncertainty set and an intersection-of-ellipsoids uncertainty set, and present some sufficient and necessary (or sufficient) conditions which p-robust solutions satisfy. Some special eases are investigated in this paper.
基金jointly supported by the Natural Science Foundation of Jiangsu Province (No.2012729)the Innovation Fund of Jiangsu Province (No.BY2013072-06)the National Natural Science Foundation of China (No.51171078 and No.11374136)
文摘Today's emergence of nano-micro hybrid structures with almost biological complexity is of fundamental interest. Our ability to adapt intelligently to the challenges has ramifications all the way from fundamentally changing research itself, over applications critical to future survival, to posing globally existential dangers. Touching on specific issues such as how complexity relates to the catalytic prowess of multi-metal compounds, we discuss the increasingly urgent issues in nanotechnology also very generally and guided by the motto 'Bio Is Nature's Nanotech'. Technology belongs to macro-evolution; for example integration with artificial intelligence (AI) is inevitable. Darwinian adaptation manifests as integration of complexity, and awareness of this helps in developing adaptable research methods that can find use across a wide range of research. The second half of this work reviews a diverse range of projects which all benefited from 'playful' programming aimed at dealing with complexity. The main purpose of reviewing them is to show how such projects benefit from and fit in with the general, philosophical approach, proving the relevance of the 'big picture' where it is usually disregarded.