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Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey 被引量:5
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作者 Kyle B Jones Ophir D Klein 《International Journal of Oral Science》 SCIE CAS CSCD 2013年第3期121-129,共9页
The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine.The advent of genetic inducible fate mapping techniques has made it possible to precisely label... The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine.The advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny over time.When combined with advanced mathematical and statistical methods,stem cell division dynamics can be studied in new and exciting ways.Despite advances in a number of tissues,relatively little attention has been paid to stem cells in the oral epithelium.This review will focus on current knowledge about adult oral epithelial stem cells,paradigms in other epithelial stem cell systems that could facilitate new discoveries in this area and the potential roles of epithelial stem cells in oral disease. 展开更多
关键词 cancer stem cell invariant asymmetry neutral drift oral epithelial stem cell population asymmetry
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