公共数据授权运营数据要素流通监管的理念、模式与发展策略

[目的/意义]加强授权运营公共数据要素流通全生命周期的监管是其安全、高质量、平等和包容创新利用的重要保障。[方法/过程]文章采用了文献研究法和案例分析法,阐述了公共数据授权运营数据要素流通监管的含义、相关研究以及监管理念,重点构建和分析了其监管模式和发展策略。[结果/结论]提出公共数据授权运营需要建立全生命周期的数据质量管控机制,构建可用不可见与全程可追溯的科技监管模式,促进授权运营公共数据多元共享、严格规制算法垄断行为以及以监管沙盒优化与促进“包容审慎”监管模式的发展策略。

金黄色葡萄球菌和表皮葡萄球菌对奶牛中性粒细胞炎性因子分泌的影响

[目的]探究金黄色葡萄球菌和表皮葡萄球菌对奶牛外周血中性粒细胞(PMNs)活力以及炎性因子分泌的影响。[方法]以体外培养的奶牛外周血PMNs为研究对象,用姬姆萨和台盼蓝染色对分离培养的奶牛PMNs进行形态鉴定和细胞活率检测,确定奶牛外周血PMNs的最佳作用时间。构建金黄色葡萄球菌、表皮葡萄球菌诱导的奶牛外周血PMNs感染模型,测定奶牛外周血PMNs对两种细菌的杀伤能力;利用CCK-8法测定奶牛PMNs活力,用ELISA法检测细胞中炎性因子肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-8和IL-10含量。[结果]体外分离培养的奶牛外周血PMNs纯度达99%,其存活率随培养时间延长逐渐降低,24 h内存活率达85%以上。金黄色葡萄球菌和表皮葡萄球菌对数生长期分别为4~7和4~8 h,二者感染奶牛PMNs后,当MOI为10时,2、4、6 h时金黄色葡萄球菌存活率极显著高于表皮葡萄球菌(P<0.01)。与对照组相比,金黄色葡萄球菌和表皮葡萄球菌感染PMNs不同时间点细胞中TNF-α、IL-8含量均极显著或显著升高(P<0.01;P<0.05);感染3、6、12、24 h时细胞中IL-10含量极显著或显著升高(P<0.01;P<0.05);感染6、9、12、24 h时细胞中IL-1β含量极显著或显著升高(P<0.01;P<0.05)。与金黄色葡萄球菌组相比,感染3 h时表皮葡萄球菌组细胞中TNF-α含量极显著降低(P<0.01),IL-10、IL-8含量极显著或显著升高(P<0.01;P<0.05);感染6 h时表皮葡萄球菌组细胞中TNF-α、IL-1β含量极显著降低(P<0.01);感染9 h时细胞中TNF-α、IL-8含量极显著或显著升高(P<0.01;P<0.05)。[结论]金黄色葡萄球菌和表皮葡萄球菌均能逃避奶牛外周血PMNs的吞噬和杀伤作用,二者感染后细胞活力显著降低,能通过调控PMNs中炎性因子的分泌介导先天免疫应答反应,试验结果为靶向PMNs筛选金黄色葡萄球菌性的奶牛乳房炎抗性相关的候选因子研究奠定基础。

Quantitative analysis of geological ore-controlling factors and stereoscopic quantitative prediction of concealed ore bodies

To address the issues for assessing and prospecting the replaceable resource of crisis mines, a geological ore-controlling field model and a mineralization distribution field model were proposed from the viewpoint of field analysis. By dint of solving the field models through transferring the continuous models into the discrete ones, the relationship between the geological ore-controlling effect field and the mineralization distribution field was analyzed, and the quantitative and located parameters were extracted for describing the geological factors controlling mineralization enrichment. The method was applied to the 3-dimensional localization and quantitative prediction for concealed ore bodies in the depths and margins of the Daehang mine in Guangxi, China, and the 3-dimensional distribution models of mineralization indexes and ore-controlling factors such as magmatic rocks, strata, faults, lithology and folds were built. With the methods of statistical analysis and the non-linear programming, the quantitative index set of the geological ore-controlling factors was obtained. In addition, the stereoscopic located and quantitative prediction models were set up by exploring the relationship between the mineralization indexes and the geological ore-controlling factors. So far, some concealed ore bodies with the resource volume of a medium-sized mineral deposit are found in the deep parts of the Dachang Mine by means of the deep prospecting drills following the prediction results, from which the effectiveness of the predication models and results is proved.

Geological Characteristics and Ore-controlling Factors of the Beiya Gold–Polymetallic Ore Deposit, Northwestern Yunnan Province

Based on comprehensive petrological, geochronological, and geochemical studies, this study analyzed the relationships between the Beiya gold-polymetallic skarn deposit and quartz syenite porphyries, and discussed the source（s） and evolution of magmas. Our results suggest that syenite porphyries（i.e. the Wandongshan, the Dashadi, and the Hongnitang porphyries）, which formed between the Eocene and the early Oligocene epochs, are the sources for the gold-polymetallic ores at the Beiya deposit. Carbonate rocks（T2 b） of the Triassic Beiya Formation in the ore district provide favorable host space for deposit formation. Fold and fault structures collectively play an important role in ore formation. The contact zone between the porphyries and carbonates, the structurally fractured zone of carbonate and clastic rocks, and the zone with well-developed fractures are the ideal locations for ore bodies. Four types of mineralization have been recognized： 1） porphyry-style stockwork gold–iron（copper） ore, 2） skarn-style gold-iron（copper and lead） ore in the near contact zone, 3） strata-bound, lense-type lead–silver–gold ore in the outer contact zone, and 4） distal vein-type gold–lead–silver ore. Supergene processes led to the formation of oxide ore, such as the weathered and accumulated gold–iron ore, the strata-bound fracture oxide ore, and the structure-controlled vein-type ore. Most of these ore deposits are distributed along the axis of the depressed basin, with the hypogene ore controlling the shape and characteristics of the oxide ore. This study provides critical geology understanding for mineral prospecting scenarios.

The Characteristics of Ore-Controlling Structure in Baoshan Cu-Pb-Zn Polymetallic Deposit,Hunan Province

The Baoshan Cu-Pb-Zn polymetallic deposit is lied in the central Nanling mineralization zone,and belongs to the junction area of the Chenzhou-Linwu fault zone and the Leiyang-Linwu fault zone.It is a significant part of Nanling polymetallic deposit belt.The outcropping stratas consist of upper Devonian Shetianqiao,Xikuangshan Formation,Lower Carboniferous Menggong’ao,Shidengzi,Ceshui,and Zimenqiao Formation.Igneous rocks in the Baoshan ore area mainly comprise granodiorite porphyry.Furthermore,the radio isotopic age ranges from 123 Ma to 183 Ma,belonging to the early to middle Yanshanian.

Mineralization and Ore-controlling Implications of Low-angle Faults

Abstract Low-angle faults include those occurring in thrust-nappe structures in a compressive setting and the detachment of metamorphic core complexes in an extensional setting. All low-angle faults have their own particularities. The low-angle fault plays an important role in controlling over some endogenetic metallic ore deposits. Based on studies of the Xiaoban gold deposit, Xinzhou gold deposit, and Longfengchang polymetallic ore deposit, and comparisons with other mines, the authors conclude the ore-controlling implications of low-angle faults as follows. (1) Because of high temperature and high pressure, as well as strong ductile deformation, the internal energy of the elements rises in the large-scale deep ductile low-angle faults, which causes the elements to activate and differentiate from the source rocks, forming ore-bearing hydrothermal solution, and bring mineralization to happen. (2) When rising from depths and flowing along the low-angle faults, the ore-bearing hydrothermal solution will alter and replace the tectonites in the fault zone. The rocks of the hanging side and the heading side differ in lithology, texture and structure, which results in changes or dissimilarities of the physical-chemical conditions. This destroys the balance of the hydrothermal solution system and causes the dissolved ore-forming elements to precipitate; as a result, a deposit is formed. Therefore, the meso-shallow ductile-brittle low-angle faults play the role of a geochemical interface in the process of mineralization. (3) Low-angle faults are often one of the important host structures.

Analysis of Ore-controlling Structure in the Qifengcha-Detiangou Gold Deposit,Huairou County,Beijing

The Qifengcha-Detiangou gold deposit is a medium-sized deposit recently found in Huairou County, Beijing. It belongs to the altered mylonite type with superimposed quartz vein type and is related to the early Yanshanian magmatic activity. Characterized by multiperiodic activity, the NE-trending Qifengcha fault is a regional ore-controlling structure in the area, and gold mineralization develops only in its southeastern part. Meanwhile, gold mineralization is controlled by the Yunmengshan metamorphic core complex. The nearly N-S- and E-W-trending low-angle detachment faults, reformed by the Qifengcha fault in the northwestern part of the core complex, are the main ore-bearing faults. All discovered gold deposits are located within an area 1.5–4.0 km away from the boundary of the upwelling centre. The N-S- (NNE-) and E-W-trending ore-bearing faults are ductile-brittle structural zones developing in shallow positions and subjected mainly to compressive deformation. The structural ore-controlling effects are as follows. (1) The attitude, shape, and distribution of gold orebodies are controlled by faults. (2) There is a negative correlation between the gold abundance and the magnetic anisotropy (P) of the altered mylonite samples from the deposit, which shows that the gold mineralization is later than the structural deformation. (3) Quartz vein type mineralization is superimposed on altered mylonite type mineralization. (4) In mineralized mylonite, the stronger the ductile shear deformation, the easier the late-stage gold mineralization to occur and the higher the gold abundance. The richest gold mineralization occurs only around the centre of the fault subjected to the strongest deformation.

Geophysical Features of the Ore-Controlling Fault in the Chang'an Gold Deposit, Southern Yunnan Province

The Ailao Mountain is one of the most important metallogenic belts ofpolymetallic deposits in the Sanjiang region, southwestern China. Located in the southern segment of this metallogenic belt, the newly-discovered Chang＇an gold deposit is large in scale （Fig. 1A）, and has attracted much attention among geologists. The ore-hosted rocks in the district include the Late Ordovician Xiangyang Fm. sandstone and clastic rocks and the Early Silurian Kanglang Fm. dolomite. Affected by the multistage tectonic activities, stocks and dykes of lamprophyre, dolerite, syenite porphyry and orthoclasite are widely exposed, and the orebodies are in symbiosis with or crosscut the dyke rocks.

Analysis of Ore-Controlling Structures of the Xincheng-Hexi Gold Deposit,Shandong Province,China

Based on quantitative and semi-quantitative mathematical and mechanical analysis of the shape, motion, structural factors, stress field and deformation field of the ore-hosting faults in the Xincheng-Hexi gold deposit, the ore-controlling features of faults and mineralization mechanism are discussed. It is concluded that the mineralization is controlled by the main faults, subsidiary fractures, joint density, mechanical features and deformation of the faults. The ore bodies are mainly located in the lower part of the convex crest and upper part of the concave trough of the main undulating fault surface. Mineralization is positively correlated to the development of subsidiary fractures and joints, which correspond to zones of low internal stress and high body strain and shear strain. They are favourable positions for mineralization and alteration.

Ore-controlling Regularitiesof Structureinthe Lehong Lead-zinc Deposit, Northeastern Yunnan

1 Introduction The Lehonglead-zincdeposit is a large-sized Pb-Zn depositnewly found in recent years in the Sichuan-Yunnan-Guizhou Lead-zinc Poly-metallic Mineralization Area,which occurrenceis strictly

Ore-controlling Characteristics of Synchronous Faults of Dongshengmiao Polymetallic Sulfide Deposits in Inner Mongolia

1 Introduction The Dongshengmiao deposit is a super-large Zn-Pb polymetallic sulfide deposit which occurring in the Langshan-Zhaertaaishan metallogenic belt,and located in the western margin of the North China Platform.The ore-bodies of Dongshengmiao deposits are mainly hosted in the second Formation of Langshan Group.There are some studies on the geological characteristics(Peng et al.,2004),geological and

Ore-controlling Regularities of Thrust-fold structures and features of Tectono-geochemical Anomalies at the Xiaozhuqing Exploration Area in the Huize Zn-Pb District

1 Introduction The huize Zn-Pb ore district in Yunnan province is locatedinthecentralsouthernofthe Sichuan—Yunnan—GuizhouPb-ZnPoly-metallic Mineralization Area in the southwestern margin of the Yangtze Block,and is strictly controlled by fault structures.It has developed to one of the famous production bases of lead&zinc and germanium in China.

GEOCHEMICAL REASERCH ON ORE-CONTROLLING STRUCTURE IN LIAODONG LUOQUANBEI-BAIYUN GOLD MINERAL BELT

In recent2 0 years,because of the finding ofmany large- superlargegold deposits,we re- new the theories for prospecting and gain many things and conceptions.The current geo- chemical and gold- forming theories underline the importance of the early submarine volcano- sedimentation,metamorphic differention,sedimentation of terrigenous clastics,thermal spring and it’s sedimentation,syngenesis process and other hypergene supplying the source for metallogenic materials.According to the study for source bed(rock) and depsitional for- mation of gold,we find that gold will be gradually enriched and mineralized in source bed (rock) ,because of variousgeologicprocesses,such as regional metamorphism ormigmatiza- tion,geothermal bittern,volcanism. The ore- control of deep and giant fault and ductile shear beltand tectono- flash space is emphasized,especially,we should notice the long- term, succession and multistage of the

重症患者医院获得性血小板减少的预后因素分析

目的 探讨重症患者医院获得性血小板减少的预后影响因素。方法 回顾性分析2020年1月至2021年12月杭州师范大学附属医院的急诊重症监护室(emergency intensive care unit,EICU)入院时血小板计数正常,入院后复查血小板计数低于正常值的患者的临床资料。分析患者的一般资料、实验室指标、是否有机械通气、住院时间及28d病死率的差异;采用多因素Logistic回归分析评价血小板减少的影响因素。结果 共纳入141例医院获得性血小板减少患者。血小板减少在EICU中的发病率为21.04%(141/670),病死率为33.33%(45/135)。住院天数为15(9,22)d。单因素分析结果显示,脓毒症(P=0.017)、血小板减少的程度(P<0.001)、白细胞计数(P=0.029)、中性粒细胞比例(P=0.029)、乳酸水平(P<0.001)、总胆红素水平(P=0.025)、降钙素原(P=0.012)、急性生理学和慢性健康状况评价Ⅱ(acute physiology and chronic health evaluation Ⅱ,APACHE Ⅱ)评分(P=0.004)、血小板减少的天数(P=0.006)、住院天数(P=0.001)、机械通气(P=0.001)是影响预后的相关因素。将上述因素纳入多因素Logistic回归分析结果显示,血小板轻度减少(P=0.007,OR=4.932)、中性粒细胞比例(P=0.044,OR=0.923)、血小板减少的天数(P=0.031,OR=0.883)、住院天数(P<0.001,OR=1.221)、机械通气(P<0.001,OR=0.077)是影响血小板减少重症患者预后的独立因素。结论 血小板轻度减少、中性粒细胞比例、血小板减少天数、住院天数、机械通气是影响血小板减少重症患者预后的独立因素。

生长分化因子15与子痫前期的关联Meta分析

目的:分析子痫前期(PE)患者各组织中生长分化因子15(GDF-15)的表达水平,为子痫前期发病机制和生物标志物的研究提供依据。方法:从基因表达综合(GEO)数据库下载子痫前期患者和正常对照孕妇胎盘组织的GDF15mRNA表达数据,同时通过检索PubMed、Google Scholar、Embase、Web of Science等数据库纳入子痫前期和GDF-15的相关英文文献,检索日期均截止到2022年8月10日。使用STATA软件对搜集到的数据进行Meta分析。结果:从GEO数据库中共检索出23个数据集,共包含269例子痫前期患者和392名正常孕妇;另有6篇符合标准的文献被纳入,包含331例子痫前期患者和2245名健康对照者。Meta分析结果显示,GDF-15 mRNA和GDF-15蛋白在子痫前期患者和正常孕妇中的表达水平与正常孕妇比较,差异无统计学意义(P>0.05),其标准化均数差(SMD)和95%置信区间(CI)分别为0.25(-0.12,0.63)和0.23(-0.18,0.64)。通过对样本采集时间进行亚组分析后发现,子痫前期患者孕中期GDF-15蛋白的表达水平较高[SMD(95%CI)为0.40(0.16,0.63)],而孕晚期的GDF-15 mRNA的升高与子痫前期发病风险呈正相关[SMD(95%CI)为0.56(0.09,1.03)]。结论:该研究结果表明GDF-15或不能成为子痫前期的预测或诊断标志物,仍需要其他的研究来进一步探究GDF-15与子痫前期的关联。

生长分化因子15和细胞因子对老年冠心病合并衰弱病人的诊断价值

目的探讨生长分化因子15(GDF15)和细胞因子对老年CHD合并衰弱病人的诊断价值。方法选取徐州医科大学附属医院在2022年7~9月间收治的88例老年CHD病人为研究对象,根据Frail衰弱量表分为衰弱组(27例)和非衰弱组(61例)。比较2组间一般资料、血清GDF15水平、细胞因子水平;绘制ROC曲线,分析GDF15及细胞因子对老年CHD合并衰弱的诊断价值。结果衰弱组年龄、年龄修正查尔森共病指数(age-adjusted Charlson comorbidity index,ACCI)、IL-1β、IL-5、IL-6、IL-10、IFN-α、IFN-γ、TNF-α和GDF15水平均明显高于非衰弱组(P<0.05)。ROC曲线分析显示,IFN-α、IFN-γ、GDF15联合诊断老年CHD病人合并衰弱的敏感度和特异度分别为85.19%和78.69%(AUC=0.868,95%CI:0.798~0.942),优于单项指标的诊断价值(P<0.05)。结论IFN-α、IFN-γ、GDF15单独或联合均可作为老年CHD病人合并衰弱的诊断指标,且联合诊断的效能更高。

南方典型区域水稻镉富集系数差异影响因素探析

该研究通过自采样分析及综合其他人员研究结果分析了我国南方典型稻米产区水稻吸收镉差异性。方差分析结果表明我国南方稻米产区稻米镉富集系数差异显著且可划分为高吸收(富集系数平均值及标准差为(0.96±0.73)、中高吸收(0.64±0.59)、中低吸收(0.29±0.22)及低吸收(0.26±0.30)4种类型,在19个研究区内中及中低吸收型(富集系数介于0.2~0.3)是4种类型中最常见的。对土壤p H、有机质含量、质地、土壤类型、土壤镉含量、土壤Zn/Cd等影响稻米镉富集系数的因素进行了探讨,结果表明,土壤p H对稻米镉富集系数影响最大且符合韦布尔非线性方程模型。土壤有机质影响明显较p H低,土壤质地在土壤酸性条件下对稻米镉富集系数的影响要大于碱性条件,土壤Zn/Cd比对稻米镉富集系数影响也比较突出,在高Zn/Cd比的土壤中稻米镉富集系数一般较低,而土壤类型、土壤镉含量对稻米镉富集系数的影响存在较大的地域差异性。

种群外部及内部因子对东方田鼠巢区大小的效应

在野外围栏条件下, 采用重复的2×2×2析因实验, 测定外部和内部因子对东方田鼠(Microtus fortis)巢区大小的作用模式。研究结果表明, 雄体巢区大小显著大于雌体巢区大小。雄体巢区大小与体重存在显著的正相关, 而雌体巢区大小与体重的相关不显著; 雄体和雌体巢区大小与种群数量均呈显著的线性负相关。外部因子对东方田鼠雄体和雌体巢区大小的作用不一致。在排除内部因子种群数量及体重对雄体巢区大小作用的条件下, 食物对雄体巢区大小的作用显著; 而捕食及种间竞争的独立作用及其交互作用, 以及3 种外部因子的交互作用均不显著; 在排除种群数量对巢区大小作用的条件下, 食物与捕食的独立作用及3 种外部因子的交互作用对雌体巢区大小的效应均达到显著水平, 食物与种间竞争的交互作用接近显著, 而种间竞争的独立作用、食物和捕食的交互作用, 以及捕食与种间竞争的交互作用对雌体巢区大小的效应均不显著。本文结果验证了种群外部因子食物、捕食及种间竞争、种群内部因子种群数量及个体体重对田鼠种群巢区大小具有独立和交互作用的假设。