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Neoadjuvant treatment of rectal cancer: Where we are and where we are going
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作者 Elísabet González Del Portillo Felipe Couñago Fernando López-Campos 《World Journal of Clinical Oncology》 2024年第7期790-795,共6页
Locally advanced rectal cancer requires a multidisciplinary approach based on total neoadjuvant treatment with radiotherapy(RT)and chemotherapy(ChT),followed by deferred surgery.Currently,alternatives to the standard ... Locally advanced rectal cancer requires a multidisciplinary approach based on total neoadjuvant treatment with radiotherapy(RT)and chemotherapy(ChT),followed by deferred surgery.Currently,alternatives to the standard total neoadjuvant therapy(TNT)are being explored,such as new ChT regimens or the introduction of immunotherapy.With standard TNT,up to a third of patients may achieve a complete pathological response(CPR),potentially avoiding surgery.However,as of now,we lack predictive markers of response that would allow us to define criteria for a conservative organ strategy.The presence of muta-tions,genes,or new imaging tests is helping to define these criteria.An example of this is the diffusion coefficient in the diffusion-weighted sequence of magnetic resonance imaging and the integration of this imaging technique into RT treatment.This allows for the monitoring of the evolution of this coefficient over successive RT sessions,helping to determine which patients will achieve CPR or those who may require intensification of neoadjuvant therapy. 展开更多
关键词 Locally advanced rectal cancer Total neoadyuvant treatment Radiotherapy Biomarker Magnetic resonance imaging Conservative organ strategy Watch and wait
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Molecular uniting set identified characteristic(MUSIC): a promising strategy for purely organic RTP luminogens 被引量:1
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作者 Xiangfeng Shao 《Science China Chemistry》 SCIE EI CAS CSCD 2018年第8期975-976,共2页
The room temperature phosphorescences(RTP)are of growing interest owing to their promising applications in material science and bioimaging.To date,the lumiogens showing persistent RTP effect mainly contain the noble... The room temperature phosphorescences(RTP)are of growing interest owing to their promising applications in material science and bioimaging.To date,the lumiogens showing persistent RTP effect mainly contain the noble metals which have the shortcomings such as high cost,potential toxicity.The exploration of metal free luminogens,i.e.,purely organic RTP luminogens,is thus of great importance for the community. 展开更多
关键词 RTP Molecular uniting set identified characteristic a promising strategy for purely organic RTP luminogens MUSIC
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Ozone and secondary organic aerosol formation potential from anthropogenic volatile organic compounds emissions in China 被引量:42
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作者 WenJing Wu Bin Zhao +1 位作者 Shuxiao Wang Jiming Hao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2017年第3期224-237,共14页
Volatile organic compounds (VOCs) are major precursors for ozone and secondary organic aerosol (SOA), both of which greatly harm human health and significantly affect the Earth's climate. We simultaneously estima... Volatile organic compounds (VOCs) are major precursors for ozone and secondary organic aerosol (SOA), both of which greatly harm human health and significantly affect the Earth's climate. We simultaneously estimated ozone and SOA formation from anthropogenic VOCs emissions in China by employing photochemical ozone creation potential (POCP) values and SOA yields. We gave special attention to large molecular species and adopted the SOA yield curves from latest smog chamber experiments. The estimation shows that alkylbenzenes are greatest contributors to both ozone and SOA formation (36.0% and 51.6%, respectively), while toluene and xylenes are largest contributing individual VOCs. Industry solvent use, industry process and domestic combustion are three sectors with the largest contributions to both ozone (24.7%, 23.0% and 17.8%, respectively) and SOA (22.9%, 34.6% and 19.6%, respectively) formation. In terms of the formation potential per unit VOCs emission, ozone is sensitive to open biomass burning, transportation, and domestic solvent use, and SOA is sensitive to industry process, domestic solvent use, and domestic combustion. Biomass stoves, paint application in industrial protection and buildings, adhesives application are key individual sources to ozone and SOA formation, whether measured by total contribution or contribution per unit VOCs emission. The results imply that current VOCs control policies should be extended to cover most important industrial sources, and the control measures for biomass stoves should be tightened. Finally, discrepant VOCs control policies should be implemented in different regions based on their ozone/aerosol concentration levels and dominant emission sources for ozone and SOA formation potential. 展开更多
关键词 Volatile organic compounds (VOCs)OzoneSecondary organic aerosol (SOA)Formation potentialControl strategy
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