Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease development.To do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of age.Twelve-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 mice.Notably,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 mice.These findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

China-U.S. Trade Balance from the National Income Perspective

This paper calculates the China-U.S. trade balance from the national income perspective based on an input-output model that differentiates domestic and foreign-invested companies. The result shows that due to different degrees of dependence of both countries on foreign production factors such as foreign capital for the manufacturing of export goods,only 87.7% of the domestic value-added created by China's exports to the U.S. in 2012 was China's national income, whereas 96.2% of value-added in U.S. exports to China was U.S.national income. In the comparison of total export volume and export value-added, the home country's national income created by exports can more realistically reflect a country's gains from trade. In 2012, China's trade surplus with the U.S. stood at 102.8 billion US dollars in national income terms, which is 61% and 22% smaller than the results in gross and value-added terms, respectively. The implication is that the traditional trade balance accounting method seriously exaggerates the China-U.S. trade imbalance.

‘Middle-Income Trap’ and ‘High-Income Waft＇： Challenges and Opportunities to China

The history of international industrialization shows that Latin American countries and former Soviet Union and Eastern European countries experienced a siginificant drop in economic growth and fell into the middle-income trap when their per capita GDP reached 4,000-7,000 international dollar （based on the 1990 prices） as a result of long-term implemented import-oriented strategy and planned economic system. Fortunately, China adopted reform and opening-up policy beginning at a lower development phase and achieved sustained high-speed growth for more than thirty years. Currently, China has surpassed the phase which the above-mentioned countries fell into the middle-income trap. On the other side, experiences of successful runner-ups show that when per capita GDP reached II,000 international dollar （based on the 1990 prices）, economic growth speed will present regularly ＂natural drop ＂. Without internal and external shocks, China＇s economy is expected to reach this level by 2015 and the potential growth rate will possibly drop significantly. In this regard, China＇s toughest challenges will be whether it can effectively prevent and solve the financial risks accumulated during high-speed growth and make a shift to innovation-driven growth model Time is pressing for addressing the above challenges. A fundamental change in the growth model depends on the intensification of reform, in particular, the promotion of an ＂participatory and facilitative reform ＂approach.

Group Purchasing Organizations (GPOs) in the U.S.: Development and Reform

Objective To study the characteristics, specific functions and policy improvement process of the Group Purchasing Organizations (GPOs) in the U.S. and to provide references for drug group purchasing practices in China. Methods Domestic and foreign relevant literatures, websites were reviewed or searched to analyze the functions and policy improvement process of the GPOs in the U.S. so as to provide references for drug group purchasing practices in China. Results and Conclusion As a third party in the U.S. GPOs has formed a relatively integrated business process and projects service system after long-term development. Supported by corresponding policies and industrial regulations, GPOs have made a great contribution to control the growth of medical and healthcare expenses and improve the efficiency of medical institutions, and its development experience can enlighten the practices in China.

The Function,Future and Support Elements of Farmer Cooperative Economy Organization

The nature of farmer cooperative economy organization( known as FCEO) determines the fact that the economic effects of farmer cooperative economy organization are as important as its social effects. Many experts,however,now would only focus on its economic function, and either neglect or weaken its social influence. Therefore,this paper introduces the theoretical foundation of the farmer cooperative economy organization,and studies the nature of cooperative economics. Based on those typical cases,the future of cooperative organization and four supporting elements were put forward in this paper.

Crohn’s disease in low and lower-middle income countries: A scoping review

BACKGROUND While Crohn’s disease has been studied extensively in high-income countries,its epidemiology and care in low and lower-middle income countries(LLMICs)is not well established due to a lack of disease registries and diagnostic capacity.AIM To describe the published burden,diagnostic/treatment capacity,service utilization,challenges/barriers to individuals with Crohn’s in LLMICs and their providers.METHODS We conducted a scoping review utilizing a full search strategy was developed and conducted in PubMed,Embase and World Health Organization Global Index Medicus.Two independent reviewers screened the titles and abstracts of all of the publications found in this search,reviewed selected publications,and extracted relevant data,which underwent descriptive review and was analyzed in Excel.RESULTS The database search yielded 4486 publications,216 of which were determined to be relevant to the research questions.Of all 79 LLMICs,only 21(26.6%)have publications describing individuals with Crohn’s.Overall,the highest number of studies came from India,followed by Tunisia,and Egypt.The mean number of Crohn’s patients reported per study is 57.84 and the median is 22,with a wide range from one to 980.CONCLUSION This scoping review has shown that,although there is a severe lack of populationbased data about Crohn’s in LLMICs,there is a signal of Crohn’s in these settings around the world.

An Analysis of Japanese Economy and Labor Market From Disparities by Gender and Employment Types of Lifetime and Annual Income,Public Pension Benefit and Redistribution

The purpose of this study is the maintenance of Japan’s economy by labor economics and public finance.I analyze(1)considering differences by gender and employment type by labor economics of applied microeconomics,and also(2)considering income,tax and social insurance obligations,and public pension benefits by public finance.1.In Japan,a regular employee has more men than women,and an irregular employee has more women than men.2.Japan’s current significant economic issues are rapidly decreasing population and other.3.All people from 20 years old pay the public pension insurance every month,and all people about from 70 years old can receive public pension benefit every month.4.The average lifespan is 100 years old,and a woman is higher than a man.Using individual data from the Japan’s Ministry of Internal Affairs and Communications'"National Survey of Income and Expenditure",I conducted an analysis on both an annual and lifetime basis of male and female workers from their 20s to 60s who are regular or irregular employees in the labor market.Furthermore,I studied men and women in from their 70s to 100 years old who receive public pension benefits.

Changes in Chinese People's Personal Incomes

Thegeneralsituationofpersonalincomesfrom1956to1978Itisnecessarytohaveknowledgeofthesituationofpersonalincomesfrom1956to1978beforewemakeasurveyofthepeople'sincomesatpresent.In1978Chinabeganintroducingthepolicyofreformandopeningtotheoutsideworld,thusus...

The Issue of Women＇s Social Organization to Participate in the Community Endowment Services

With the transformation of society and the deepening of reform, the government＇s emphasis on public service level gradually increased, arises at the historic moment of women in social organization to participate in social management and service ofgrassroots women play an important role on the stage. Women social organizations in jiangsu province to grow faster, quantity stability has increased year by year, widely participate in social services, in the ease of social contradictions, providing public services, safeguard women＇s rights has played a unique role. But at the same time also face the system is not sound, management is not standard, and all kinds of resources are scarce, etc. Women social organizations must through the standardization of the management and operation, actively integrating the resource of inside and outside the organization improve the survival and development environment, so as to promote their own development and perfection, a greater extent play a positive role in social and public services.

Impact of taxes on the 2030 Agenda for Sustainable Development:Evidence from Organization for Economic Cooperation and Development(OECD)countries

Multiple ecological and socioeconomic problems have occurred worldwide,raising the awareness of sustainability.This study aims to examine the impact of taxes on Sustainable Development Goals(SDGs)in the context of Organization for Economic Co-operation and Development(OECD)countries.This research used effective average tax(EAT),tax on personal income(TPI),tax on corporate profits(TCP),and tax on goods and services(TGS)as the variables of taxes,and employed secondary data from 38 OECD countries covering 2000–2021.The study also used Breusch-Pagan Lagrange Multiplier(LM),Pesaran Scaled LM,Bias-Corrected Scaled LM,and Pesaran Cross-sectional dependence(CSD)tests to analyze the existence of crosssectional dependency.Then,we established the stationarity of variables through second-generation panel unit root tests(Cross-sectional Augmented Dickey-Fuller(CADF)and Cross-sectional Im,Pesaran,and Shin(CIPS)),and confirmed the long-run cointegration of the variables by using secondgeneration panel cointegration test(Westerlund cointegration test).The results showed that EAT,TPI,TCP,and TGS are positively associated with SDGs.However,the change in TPI has a smaller effect on SDGs than the change in EAT or TCP or TGS.The result of panel causality indicated that EAT,TPI,and TGS have a unidirectional causal relationship with SDGs.The study also found that TCP has a bi-directional causal relationship with SDGs.Moreover,the finding indicated that the OECD countries need to focus on tax policies to achieve the 2030 Agenda for Sustainable Development.This study is based on the theory of optimal taxation(TOT),which suggests that tax systems should be designed to maximize social welfare.Finally,we suggests the importance of taking a comprehensive approach for the managers and policy-makers when analyzing the impact of taxes on SDGs.

Measuring Labor＇s Share of Income in China： 1993-2008

Accurately measuring labor＇s share of income is of great importance for China ＇S national policies, particularly its labor compensation policies during the 12th Five Year Plan period. This paper first analyses the measurement problems of labor＇s share of income from the perspectives of definition and data and their influences on the accuracy of the measurement results. Then it sums up and appraises several adjustment methods for existing measurement problems. Finally, the author estimates the operating surplus of private, unincorporated enterprises （OSPUE） in China using data from Urban household survey （UHS）, Rural household survey （RHS） and population survey, and further makes a correction to labor＇s share of income in China from 1993 to 2008 with data from flow of funds accounts. Finally, the author conducted trend analysis and international comparisons using the results obtained from the first part of the paper.

Women 's Organizations of China

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HANDICRAFTS BOOST VILLAGER’S INCOME IN MAINLING

Some Tibetan people regard it as a luxury or of high class to drink tea or wine in a silver-plated wooden bowl,with such bowls mostly made in Tibet’s places of lower attitude like in eastern Nyingchi City.Known as the Tibetan medicinal world,the region’s Mainling

The Income and Housing Problems of China's Teachers

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