Organizing pneumonia secondary to pulmonary tuberculosis:A case report

BACKGROUND Organizing pneumonia secondary to pulmonary tuberculosis is rare.Moreover,the temporal boundary between pulmonary tuberculosis and secondary organizing pneumonia has not been defined.We report a case of secondary organizing pneumonia associated with pulmonary tuberculosis occurring after nine months of antituberculosis treatment.CASE SUMMARY A 54 years old man,previously diagnosed with pulmonary tuberculosis and tuberculous pleurisy,underwent nine months of antituberculosis treatment.Follow-up lung computed tomography revealed multiple new subpleural groundglass opacities in both lungs,and a lung biopsy confirmed organizing pneumonia.Treatment continued with anti-tuberculosis agents and hormone therapy,and subsequent dynamic pulmonary computed tomography exams demonstrated improvement in lesion absorption.No disease recurrence was observed after corticosteroid therapy discontinuation.CONCLUSION When treating patients with active pulmonary tuberculosis,if an increase in lesions is observed during anti-tuberculosis treatment,it is necessary to consider the possibility of tuberculosis-related secondary organizing pneumonia,timely lung biopsy is essential for early intervention.

Adult-Onset Still's Disease Misdiagnosed as Acute Fibrinous and Organizing Pneumonia: A Case Report and Literature Review

Adult-onset Stil's disease(AOSD)is a rare condition that lies between autoinflammatory syndrome and autoimmune disease.The main clinical manifestations include fever,chills,rash,joint swelling and pain,peripheral blood leukocytosis,splenomegaly,etc.It is a systemic disease affecting between 1 and 34 people per million.The average age of onset is 35 years old,with a slightly higher prevalence rate in women.Since AOSD lacks early specific symptoms and signs,non-specialist doctors have limited understanding of the disease,and patients are prone to clinical misdiagnosis,mistreatment,and delayed disease progression.This paper reports a patient whose AOSD was misdiagnosed as acute fibrinous and organizing pneumonia.

Organizing Pneumonia in A Patient Double-Positive for ANCA and Anti-GBM Antibodies:A Case Report

Both anti-glomerular basement membrane(GBM)disease and the anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis(AAV)are common causes of pulmonary-renal syndrome.Organizing pneumonia(OP),a special pattern of interstitial lung disease,is extremely rare either in AAV or anti-GBM disease.We report an old woman presented with OP on a background of co-presentation with both ANCA and anti-GBM antibodies.

Glucocorticoid pulse therapy in an elderly patient with post-COVID-19 organizing pneumonia:A case report

BACKGROUND Pulmonary fibrosis often occurs as a sequel of coronavirus disease 2019(COVID-19);however,in some cases,it can rapidly progress,similar to the acute exacerbation of interstitial lung disease.Glucocorticoids are the standard treatment for severe COVID-19 pneumonia requiring oxygen supply;however,the post-COVID-19 efficacy of high-dose steroid therapy remains unclear.Here,we presented a case of an 81-year-old man who developed acute respiratory failure after COVID-19 and was treated with glucocorticoid pulse therapy.CASE SUMMARY An 81-year-old man with no respiratory symptoms was admitted due to a diabetic foot.He had been previously treated for COVID-19 pneumonia six weeks prior.However,upon admission,he suddenly complained of dyspnea and required a high-flow oxygen supply.Initial simple chest radiography and computed tomography(CT)revealed diffuse ground-glass opacities and consolidation in both lungs.However,repeated sputum tests did not identify any infectious pathogens,and initial broad-spectrum antibiotic therapy did not result in any clinical improvement with the patient having an increasing oxygen demand.The patient was diagnosed with post-COVID-19 organizing pneumonia.Thus,we initiated glucocorticoid pulse therapy of 500 mg for three days followed by a tapered dose on hospital day(HD)9.After three days of pulse treatment,the patient's oxygen demand decreased.The patient was subsequently discharged on HD 41,and chest radiography and CT scans have almost normalized nine months after discharge.CONCLUSION Glucocorticoid pulse therapy may be considered when the usual glucocorticoid dose is ineffective for patients with COVID-19 sequelae.

Cryptogenic organizing pneumonia associated with pregnancy:A case report

BACKGROUND Cryptogenic organizing pneumonia(COP),formerly known as bronchiolitis obliterans organizing pneumonia,is an extremely rare disease in pregnancy.In this case,we report on COP diagnosed in recurrent pneumonia that does not respond to antibiotics in pregnant woman.CASE SUMMARY A 35-year-old woman with no prior lung disease presented with concerns of chest pain with cough,sputum,dyspnea,and mild fever at 11 wk’gestation.She was diagnosed with community-acquired pneumonia and treated with antibiotics;her symptoms improved temporarily.Four weeks after discharge,she was readmitted with aggravated symptoms.Chest computed tomography demonstrated multifocal patchy airspace consolidation and ground-glass opacities at the basal segments of the right lower lobe,at the lateral basal segment of the lower lobe,and at the lingular segment of the left upper lobe.Bronchoalveolar lavage revealed an increased lymphocyte count and a decreased CD4/CD8 ratio.Prednisolone(0.5 mg/kg/d)was administered for 10 d after the second admission.Dyspnea improved after 3 d of steroid treatment and other symptoms improved on the 5th day of steroid administration.Post-delivery transbronchial lung biopsy further revealed the presence of granulation tissue with fibroblasts in smallbronchiole lumens.CONCLUSION This case suggests that it is important to differentiate COP from atypical pneumonia in the deteriorated condition despite antibiotic treatment.

Successful steroid treatment for acute fibrinous and organizing pneumonia: A case report

BACKGROUND Since the acute fibrinous and organizing pneumonia(AFOP) was first described by Beasley in 2002, some case reports of patients aged from 38 d to 80 years have been published worldwide, but there is still no standard therapy for this disease and the treatment methods remain controversial. Both steroid and immunosuppressive agents, such as cyclophosphamide or mycophenolate mofetil, have been reported to be effective in some studies, but with many side effects, especially in patients of advanced age. CASE SUMMARY We herein report an 81-year-old female patient who was admitted to our hospital due to dry cough, and breathlessness for 1 mo. She was treated with broadspectrum antibiotics and anti-fungal therapy, but without improvement in both symptoms and radiological findings, and her respiratory status worsened, and she required bed rest almost the whole day. Computed tomography-guided percutaneous needle lung biopsy was performed and histopathology examination confirmed the diagnosis of AFOP. She was then successfully treated with a steroid monotherapy, which resulted in a satisfactory clinical outcome without serious complications. CONCLUSION We conclude that complete remission of AFOP can be achieved by steroid monotherapy in patients of advanced age.

An Analysis of the Party’s Mass Organizing Power Under the New Situation

The mass organizing power is a distinctive feature of the Communist Party of China,an important criterion to test the nature of the proletarian party,and an essential condition to transform the Party’s organizational advantages into strength superiority.In order to improve the mass organizing power,on the basis of giving full play to the traditional advantages,we’re required to carry out the mass line,and from the perspective of political construction,highlight political functions,strengthening work practices and organization system,taking advantage of technologies,promoting capacity,and intensifying the sense of responsibility,thus to provide a steady stream of power for the great rejuvenation of the Chinese nation.

Fractal Image Compression Using Self-Organizing Mapping

One of the main disadvantages of fractal image data compression is a loss time in the process of image compression (encoding) and conversion into a system of iterated functions (IFS). In this paper, the idea of the inverse problem of fixed point is introduced. This inverse problem is based on collage theorem which is the cornerstone of the mathematical idea of fractal image compression. Then this idea is applied by iterated function system, iterative system functions and grayscale iterated function system down to general transformation. Mathematical formulation form is also provided on the digital image space, which deals with the computer. Next, this process has been revised to reduce the time required for image compression by excluding some parts of the image that have a specific milestone. The neural network algorithms have been applied on the process of compression (encryption). The experimental results are presented and the performance of the proposed algorithm is discussed. Finally, the comparison between filtered ranges method and self-organizing method is introduced.

Application of Self-Organizing Map for Exploration of REEs’ Deposition

Varieties of approaches and algorithms have been presented to identify the distribution of elements. Previous researches based on the type of problem, categorized their data in proper clusters or classes. This means that the process of solution could be supervised or unsupervised. In cases, where there is no idea about dependency of samples to specific groups, clustering methods (unsupervised) are applied. About geochemistry data, since various elements are involved, in addition to the complex nature of geochemical data, clustering algorithms would be useful for recognition of elements distribution. In this paper, Self-Organizing Map (SOM) algorithm, as an unsupervised method, is applied for clustering samples based on REEs contents. For this reason the Choghart Fe-REE deposit (Bafq district, central Iran), was selected as study area and dataset was a collection of 112 lithology samples that were assayed with laboratory tests such as ICP-MS and XRF analysis. In this study, input vectors include 19 features which are coordinates x, y, z and concentrations of REEs as well as the concentration of Phosphate (P2O5) since the apatite is the main source of REEs in this particular research. Four clusters were determined as an optimal number of clusters using silhouette criterion as well as k-means clustering method and SOM. Therefore, using self-organizing map, study area was subdivided in four zones. These four zones can be described as phosphate type, albitofyre type, metasomatic and phosphorus iron ore, and Iron Ore type. Phosphate type is the most prone to rare earth elements. Eventually, results were validated with laboratory analysis.

Study on the Agile Virtual Enterprise′s Organizing Form and Running Environment

In this paper, we begin with the swift changes in the knowledge economy time,analyze the implication of the agility, and consider the agile virtual enterprise as the mainorganizational form for the manufacturing enterprises to realize agility. We classify the agilevirtual enterprises into products alliance style and knowledge alliance style, and compares theirmain features and profit distribution models. As a result, we give four basic structures for thebuilding and running of the agile virtual enterprises.

Two methods of lung biopsy for histological confirmation of acute fibrinous and organizing pneumonia:A case report

BACKGROUND Acute fibrinous and organizing pneumonia(AFOP)is a rare,noninfective lung disease,histologically characterized by a patchy distribution of intra-alveolar fibrin“balls”and organizing pneumonia.The clinical manifestations of AFOP are nonspecific.Diagnosis depends on pathology.Surgical lung biopsy is optimal for tissue sampling to diagnose AFOP.However,many patients have no tolerance to the operation,including mentally and physically.There is still no standard therapy for AFOP and the methods remain controversial.Therefore,further clinical attention and discussion are warranted.CASE SUMMARY A 53-year-old woman presented with fever,cough and dyspnea for 15 d.Antiinfective therapy was ineffective.Chest computed tomography showed bilateral patchy consolidation,especially in the lower lobes.We performed both ultrasound-guided transbronchial lung biopsy and ultrasound-guided percutaneous fine needle puncture at different lung lesion locations.Both samples supported the diagnosis of AFOP.The patient had a good clinical course after treatment with methylprednisolone,and no side effects of steroids.CONCLUSION Percutaneous needle biopsy combined with transbronchial lung biopsies may be a good choice in the absence of surgical biopsy.Methylprednisolone alone is effective in the treatment of idiopathic AFOP.

Factors Predicting the Relapse of Radiation-Induced Organizing Pneumonia after Breast-Conserving Therapy

We investigated the factors predicting radiation-induced organizing pneumonia (RIOP) relapse after tangential breast irradiation. The participants included 23 patients diagnosed with RIOP at the St. Marianna University School of Medicine Hospital between January 2008 and March 2015. Relapse was defined as the appearance of new lesions on diagnostic images during follow-up or after commencing treatment. The relapse-free survival rate and the following 9 parameters were compared between patients with and without RIOP relapse: 1) age (less than vs. equal to or more than the median);2) white blood cell count (less than vs. equal to or more than the median);3) C-reactive protein (CRP) level at the time of RIOP diagnosis (less than normal, more than normal/ less than borderline, and more than borderline);4) boost irradiation (yes vs. no);5) maximum lung depth on linacgraphy (less than vs. equal to or more than the median);6) hormone therapy (yes vs. no);7) chemotherapy (yes vs. no);8) RIOP ratio in the whole lung (less than vs. equal to or more than the median) at the time of RIOP diagnosis;and 9) use of corticosteroids (yes vs. no). The Kaplan-Meier method was used for statistical analysis, with relapse as the cutoff. The follow-up period spanned the date of RIOP onset to May 30, 2015. The level of significance for 2-sided tests was p < 0.05. Relapse was evident in 14 patients (60.8%). The relapse-free survival rate was significantly greater in the normal CRP group (less than 0.30 mg/dl) than in the abnormal CRP group (more than 0.36 mg/dl) (p = 0.044) and in the normal/borderline CRP group (less than 0.36 mg/dl) than in the high CRP group (more than 0.70 mg/dl) (p < 0.01). The CRP level at RIOP onset may be a useful predictor of relapse after breast-conserving therapy.We investigated the factors predicting radiation-induced organizing pneumonia (RIOP) relapse after tangential breast irradiation. The participants included 23 patients diagnosed with RIOP at the St. Marianna University School of Medicine Hospital between January 2008 and March 2015. Relapse was defined as the appearance of new lesions on diagnostic images during follow-up or after commencing treatment. The relapse-free survival rate and the following 9 parameters were compared between patients with and without RIOP relapse: 1) age (less than vs. equal to or more than the median);2) white blood cell count (less than vs. equal to or more than the median);3) C-reactive protein (CRP) level at the time of RIOP diagnosis (less than normal, more than normal/ less than borderline, and more than borderline);4) boost irradiation (yes vs. no);5) maximum lung depth on linacgraphy (less than vs. equal to or more than the median);6) hormone therapy (yes vs. no);7) chemotherapy (yes vs. no);8) RIOP ratio in the whole lung (less than vs. equal to or more than the median) at the time of RIOP diagnosis;and 9) use of corticosteroids (yes vs. no). The Kaplan-Meier method was used for statistical analysis, with relapse as the cutoff. The follow-up period spanned the date of RIOP onset to May 30, 2015. The level of significance for 2-sided tests was p < 0.05. Relapse was evident in 14 patients (60.8%). The relapse-free survival rate was significantly greater in the normal CRP group (less than 0.30 mg/dl) than in the abnormal CRP group (more than 0.36 mg/dl) (p = 0.044) and in the normal/borderline CRP group (less than 0.36 mg/dl) than in the high CRP group (more than 0.70 mg/dl) (p < 0.01). The CRP level at RIOP onset may be a useful predictor of relapse after breast-conserving therapy.

Clinical Utility of Procalcitonin for Differentiating between Cryptogenic Organizing Pneumonia and Community-Acquired Pneumonia

Background: Differentiating cryptogenic organizing pneumonia (COP) from community-acquired pneumonia (CAP) can be difficult in some cases. Objective: To clarify the clinical utility of procalcitonin (PCT) levels for differentiating between COP and CAP. Methods: Blood PCT levels, leukocyte count, C-reactive protein concentration, number of segments involved on computed tomography (CT) images, and pneumonia severity assessment scale were retrospectively investigated from clinical charts and chest CT images of COP and CAP patients who were admitted to our hospital from 2012 to 2014. The clinical characteristics of COP patients were compared to those of CAP patients for whom causative organisms were not detected. Results: There were 16 COP and 94 CAP patients for whom causative organisms were not detected. Blood PCT levels of all COP patients were less than 0.16 ng/dL, and significantly lower than those of CAP patients (p = 0.0004), while the number of involved segments was significantly higher than that of CAP patients (p = 0.0001). Blood PCT levels and the number of involved segments remained independently significant for differentiating between COP and CAP by multivariate analysis. Receiver operating characteristics curve analysis revealed that 7 was the best cut-off number for involved segments to differentiate between COP and CAP patients with low PCT levels (sensitivity 85.7%, specificity 94.7%). Conclusion: A combination of PCT levels and number of involved segments on CT images is useful for differentiation between COP and CAP.

Customer Segmentation of Credit Card Default by Self Organizing Map

In this paper we applied the technique of Self Organizing Map (SOM) to segment individuals based on their credit information. SOM is an unsupervised machine learning method that reduces data complexity and dimensionality while keeping sits original topology, which is superior to other dimension reduction methods especially when features in data have unclear nonlinear relations. Through this method we provide more clear and intuitive segmentation that other traditional methods cannot achieve.

Secondary Bacterial Organizing Pneumonia in a Patient Recovered from COVID-19 Disease: A Case Report

COVID-19 disease is a global pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) that mainly presents with pneumonia, but has variable multi-systemic manifestations. Concomitant bacterial infections associated with the acute stage of COVID-19 disease have been rarely reported in the literature. However, to our knowledge, post viral organizing pneumonia (OP) secondary to bacterial infection after recovery from SARS-CoV2 infection has not been noted before. We report a 27-year-old male patient with Type 1 Diabetes Mellitus who presented with fever post recovery from COVID-19 disease for seven weeks and was found to have OP secondary to Klebsiella pneumoniae. Furthermore, the bronchoalveolar lavage was positive for SARS-CoV2 by RT-PCR despite multiple negative nasopharyngeal RT-PCR. The patient was successfully treated with antibiotics only. Therefore, we conclude that early recognition of OP secondary to bacterial infection in patients with COVID-19 disease and prompt antibiotic treatment could avoid the use of a prolonged course of steroids.

The Art of Organizing a Piece of English Prose

ＴｈｅＡｒｔｏｆＯｒｇａｎｉｚｉｎｇａＰｉｅｃｅｏｆＥｎｇｌｉｓｈＰｒｏｓｅ￥ＬｉＷｅｎｚｈｉＡｂｓｔｒａｃｔ：ＡｐｉｅｃｅｏｆＥｎｇｌｉｓｈｐｒｏｓｅｉｓｕｓｕａｌｌｙｍａｄｅｕｐｏｆｔｈｒｅｅｍａｉｎｐａｒｔｓ：ｉｎｔｒｏｄｕｃｔｉｏｎ，ｂｏｄｙ...

11^(th) ICAM ORGANIZING SPONSORS

ICAM 2013 has been organized by the staff members of Southwest University of Science and Technology (SWUST).They have gratefully accepted the assistance and professional advice from their colleagues both locally and abroad,and employees of below instances have been members of the Organizing and Scientific Committees for ICAM2013.Southwest University of Science

ORGANIZING MACRO ECONOMIC REGIONS AND ENHANCING INTER-PROVINCIAL COORDINATION AND PLANNING IN CHINA

This paper elaborates upon the purpose of macro economicroponalization and inter-provincial planning and coordination under thesocialist market system. It descnbes the characteristics and orgarnzationalforms of macro economic regions and the principle of macro economic regionalization. The six macro economic regions-Northeast China, NorthChina, Northwest China, Middle-East China, Southwest China and South China-are divided in the paper. At the end, the paper describes somemajor programs, which requires cooperation among various involvedprovinces.

Research on Self Organizing of Internet of Things Nodes in Closed Area

In this paper, the intelligent application we designed focuses on a closed family area. ZigBee technology is mainly used to achieve the remote control. The most popular Android system is used in the design. The operation interface on the home intelligent gateway is completed through the designed system. It can allow people the full control by using smartphones. The system is operated and controlled through touch panel. Furthermore, it can be controlled remotely by using smartphones. ZigBee module is expected to be used to allow these devices to perform data transmission and collection. Some additional machinery, control circuits, and sensors will be designed for doors and windows. For example, a motor and a control circuit are installed to control doors and windows, and ZigBee is used to control the power input and drive the motor. Antitheft sensors, such as infrared sensors or light sensors, are installed to monitor the objects. Home gateway can collect ZigBee information on doors and windows, and an interactive mechanism is designed to take effective remote control.