To make the problems of existing high requirements of calibration tools, complex global calibration process addressed for monocular multi-view visual measurement system during measurement, in the paper, a global calib...To make the problems of existing high requirements of calibration tools, complex global calibration process addressed for monocular multi-view visual measurement system during measurement, in the paper, a global calibration method is proposed for the geometric properties of rotational correlation motion and the absolute orientation of the field of view without over lap. Firstly, a dual-camera system is constructed for photographing and collecting the rotating image sequence of two flat targets rigidly connected by a long rod at different positions, and based on the known parameters, such as, target feature image, world coordinates, camera internal parameters and so on, then the global PnP optimization method is used to solve the rotation axis and the reference point at different positions;Then, the absolute orientation matrix is constructed based on the parameters of rotation axis, reference point and connecting rod length obtained by this method. In the end, the singular value decomposition method is used to find the optimal rotation matrix, and then get the translation matrix. It’s shown based on simulation and actual tests that in comparison with the existing methods, the maximum attitude and pose errors is 0.0083˚ and 0.3657 mm, respectively, which improves the accuracy by 27.8% and 24.4%, respectively. The calibration device in this paper is simple, and there are no parallel, vertical and coplanar requirements between multiple rotating positions. At the same time, in view of the calibration accuracy, the accuracy requirements of most application scenarios can be met.展开更多
In this paper,DOA and subarray-interval estimation are considered and applied to arbitrarily distributed unmanned aerial vehicle(UAV)swarm system,in which multiple small UAVs containing uniform linear array(ULA)are di...In this paper,DOA and subarray-interval estimation are considered and applied to arbitrarily distributed unmanned aerial vehicle(UAV)swarm system,in which multiple small UAVs containing uniform linear array(ULA)are divided by unknown intervals because of dynamic moving.Three parameters are taken to indicate the steering vector,namely,the direction of arrivals(DOAs)of target users,the intervals of UAVs,and the orientation angles of UAVs.The orientation angles are first estimated with an auxiliary user and the DOAs are obtained through a search free rooting method,despite the intervals among the UAVs.Afterwards,the intervals among UAVs can also be calculated via exhaustive when the number of target users are no less than three.We further develop a low-complex method to reduce the computational complexity during subarray-interval estimation.The deterministic Cramér-Rao bound(CRB)of the DOA,orientation angle and subarray-interval can be inferred in a closed form.Eventually,numerical instances are cited to verify the research results.展开更多
The prominence of Renewable Energy Sources(RES)in the process of power generation is exponentially increased in the recent days since these sources assist in minimizing the environmental contamination.A grid-tied DFIG...The prominence of Renewable Energy Sources(RES)in the process of power generation is exponentially increased in the recent days since these sources assist in minimizing the environmental contamination.A grid-tied DFIG(Doubly Fed Induction Generator)based WECS(Wind Energy Conversion System)is introduced in this work,in which a Landsman converter is implemented to impro-vise the output voltage of PV without anyfluctuations.A novel GA(Genetic Algorithm)assisted ANN(Artificial Neural Network)is employed for tracking the Maximum power from PV.Among the rotor and grid side controllers,the for-mer is implemented by combining the statorflux with d-q reference frame and the latter is realized by the PI controller.The proposed approach delivers better per-formance in the compensation of real and reactive power along with the DC link voltage control.The controlling mechanism is verified in both MATLAB and experimental bench setupby using an emulated wind turbine for the concurrent control of DC link potential,active and reactive powers.The source current THD is observed as 1.93%and 2.4%for simulation and hardware implementation respectively.展开更多
This review explores entrepreneurial orientation and innovation ecosystems in the industrial sector of the Central Region, Kampala, Uganda, through an analysis of ten scholarly articles. The study contextualizes the r...This review explores entrepreneurial orientation and innovation ecosystems in the industrial sector of the Central Region, Kampala, Uganda, through an analysis of ten scholarly articles. The study contextualizes the research within the regional landscape and establishes a theoretical framework through a focused literature review. Key findings highlight the intersection of entrepreneurial activities and innovation dynamics, emphasizing the region’s unique contributions to the broader field. Discussions on discrepancies and unexplored territories within the articles offer insights into limitations and research gaps. The manuscript concludes by identifying future research avenues, providing a roadmap for ongoing inquiry into the entrepreneurial and innovative dimensions of the Central Region’s industrial sector. This synthesis underscores the importance of cultivating an entrepreneurial mindset and collaborative innovation strategies for sustainable industrial development in the region.展开更多
The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,sp...The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.展开更多
The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic ducts.The disease is more prevalent in Asia,mainly owing to socioeconomic ...The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic ducts.The disease is more prevalent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prevalence of biliary parasites.In the last century,owing to migration,its global incidence has increased.The main pathophysiological mechanisms involve cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for development of intrahepatic cholangiocarcinoma.Various classifications have aimed at providing useful insight of clinically relevant aspects and guidance for treatment.The management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interventional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prevent the development of more serious complications.This comprehensive review provides insight on various aspects of hepatolithiasis,with a focus on epidemiology,new evidence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.展开更多
Linear dichroism (LD) spectroscopy is an important technique in the study of the orientation and organization of pigments in the photosynthetic membrane complexes in vivo and in vitro . In this work, the orient...Linear dichroism (LD) spectroscopy is an important technique in the study of the orientation and organization of pigments in the photosynthetic membrane complexes in vivo and in vitro . In this work, the orientation of the pigments in the isolated photosystem Ⅱ (PSⅡ) sub_core reaction center complexes was analyzed and characterized by means of low temperature absorption and LD spectroscopy. The preparations containing different amounts of CP47 isolated from spinach (Spinacia oleracea L.) chloroplast were used in order to investigate the orientation of pigments in the PSⅡ sub_core CP47/D1/D2/Cyt b_559 (CP47/D1/D2) complexes. Chlorophyll a (Chl a) absorbing at 680 nm in CP47/D1/D2/Cyt b_559 complex showed an orientation of the Q y transition parallel to the membrane plane. It is proposed that there are two forms of β_carotene (β_Car) in CP47/D1/D2/Cyt b_559 complex, denoted as β_Car (Ⅰ) and β_Car (Ⅱ), with different orientations, β_Car (Ⅰ) at 470 and 505 nm is roughly parallel to the membrane plane, and β_Car (Ⅱ) at 460 and 490 nm seems to be perpendicular orientation. Upon the photoinhibitory experiment β_Car (Ⅱ) was found to be photosensitive and easily photodamaged. It also showed that the positive LD signal observed at 680 nm was quite complicated. This signal is tentatively attributed to P680 and some Chl a of antenna in CP47 protein based upon our measurements.展开更多
In order to solve existing problems about the method of establishing traditional system structure of decision support system(DSS), O S chart is applied to describe object oriented system structure of general DSS, an...In order to solve existing problems about the method of establishing traditional system structure of decision support system(DSS), O S chart is applied to describe object oriented system structure of general DSS, and a new method of eight specific steps is proposed to establish object oriented system structure of DSS by using the method of O S chart, which is applied successfully to the development of the DSS for the energy system ecology engineering research of the Wangheqiu country. Supplying many scientific effective computing models, decision support ways and a lot of accurate reliable decision data, the DSS plays a critical part in helping engineering researchers to make correct decisions. Because the period for developing the DSS is relatively shorter, the new way improves the efficiency of establishing DSS greatly. It also makes the DSS of system structure more flexible and easy to expand.展开更多
Low-temperature,ambient processing of high-quality CsPbBr_(3)films is demanded for scalable production of efficient,low-cost carbon-electrode perovskite solar cells(PSCs).Herein,we demonstrate a crystal orientation en...Low-temperature,ambient processing of high-quality CsPbBr_(3)films is demanded for scalable production of efficient,low-cost carbon-electrode perovskite solar cells(PSCs).Herein,we demonstrate a crystal orientation engineering strategy of PbBr_(2)precursor film to accelerate its reaction with CsBr precursor during two-step sequential deposition of CsPbBr_(3)films.Such a novel strategy is proceeded by adding CsBr species into PbBr_(2)precursor,which can tailor the preferred crystal orientation of PbBr_(2)film from[020]into[031],with CsBr additive staying in the film as CsPb_(2)Br_(5)phase.Theoretical calculations show that the reaction energy barrier of(031)planes of PbBr_(2)with CsBr is lower about 2.28 eV than that of(O2O)planes.Therefore,CsPbBr_(3)films with full coverage,high purity,high crystallinity,micro-sized grains can be obtained at a low temperature of 150℃.Carbon-electrode PSCs with these desired CsPbBr_(3)films yield the record-high efficiency of 10.27%coupled with excellent operation stability.Meanwhile,the 1 cm^(2)area one with the superior efficiency of 8.00%as well as the flexible one with the champion efficiency of 8.27%and excellent mechanical bending characteristics are also achieved.展开更多
Based on the theory of elastic mechanics and material mechanics, the orientation precision of the hohl schaft kegel(HSK) tooling system in static and dynamic states is theoretically and experimentally studied. The r...Based on the theory of elastic mechanics and material mechanics, the orientation precision of the hohl schaft kegel(HSK) tooling system in static and dynamic states is theoretically and experimentally studied. The relation between the clamping force and the shank taper is obtained. And a proper clamping force is found to be essential to assure the axial and radial orientation precisions of the HSK tooling system in high speed machining (HSM). Analytical results show that the reason why the HSK tooling system can keep high precision at the high rotational speed is that the actual axial clamping force keeps the two surfaces of the shank and the spindle in contact all the time.展开更多
Climate change and extreme weather pose significant challenges to the traditional viticulture regions.Emerging high-altitude grape-producing regions with diverse orientations have shown great potential in coping with ...Climate change and extreme weather pose significant challenges to the traditional viticulture regions.Emerging high-altitude grape-producing regions with diverse orientations have shown great potential in coping with this challenge.Stable,high-quality wine grape production may be achieved by synchronizing the meso-and microclimate.To clarify the role of high altitude and row orientation in meso-and microclimate and the response of berries to it,we evaluated seven years(2012-2018)of climate data,two years of basic grape(Cabernet Sauvignon,Vitis vinifera L.)quality,and one-year microclimate from veraison to harvest.By comparing two locations(Sidon 2047 m,Sinon 2208 m)in Yunnan Province,China,we found that the average temperature has been stable at approximately 15℃ for seven years,with no extreme weather or,noticeable global warming.The light intensity(LI)in the north-south(NS)was more balanced than the east-west(EW)direction,and the east-west to the south(EW-S)canopy side was almost higher than the other sides.High LI was associated with high photosynthetically active radiation(PAR),ultraviolet(UV),and infrared(IR)light and vice versa.The north-south to the east(NS-E)and east-west to the north(EWN)sides were characterized by lower LI and higher UV and IR light,and higher total anthocyanin content.Most anthocyanin synthesis-related genes,for example,VvF3'H and VvF3'5'H,were highly expressed in NS-E from veraison to maturity.Perhaps UV and IR light induced their expression.This study provides new insights on the role of differently orientated rows in controlling grape quality due to varied light quality.The findings are globally significant,particularly in the context of climate change,and offer fresh insights into berry physiological responses and decision-making for the management of existing vineyards.展开更多
Preferential orientation control of metal—organic framework(MOF)films is advantageous for maximizing pore uniformity and minimizing grain-boundary defects.Nonetheless,the preparation of MOF films with both in-plane a...Preferential orientation control of metal—organic framework(MOF)films is advantageous for maximizing pore uniformity and minimizing grain-boundary defects.Nonetheless,the preparation of MOF films with both in-plane and out-of-plane orientations remains a grand challenge.In this study,we reported the preparation of three-dimensionally oriented MIL-96 layers through combining morphology control of MIL-96 seeds with addition of polyvinylpyrrolidone surfactants and arachidonic acids.The three-dimensionally oriented MIL-96 film was readily obtained through in-plane epitaxial growth.It is anticipated that the aforementioned protocol can be effective for obtaining diverse MOF films with a three-dimensionally oriented organization.展开更多
In perovskite solar cells(PSCs),the inherent defects of perovskite film and the random distribution of excess lead iodide(PbI_(2))prevent the improvement of efficiency and stability.Herein,natural cellulose is used as...In perovskite solar cells(PSCs),the inherent defects of perovskite film and the random distribution of excess lead iodide(PbI_(2))prevent the improvement of efficiency and stability.Herein,natural cellulose is used as the raw material to design a series of cellulose derivatives for perovskite crystallization engineering.The cationic cellulose derivative C-Im-CN with cyano-imidazolium(Im-CN)cation and chloride anion prominently promotes the crystallization process,grain growth,and directional orientation of perovskite.Meanwhile,excess PbI_(2)is transferred to the surface of perovskite grains or formed plate-like crystallites in local domains.These effects result in suppressing defect formation,decreasing grain boundaries,enhancing carrier extraction,inhibiting non-radiative recombination,and dramatically prolonging carrier lifetimes.Thus,the PSCs exhibit a high power conversion efficiency of 24.71%.Moreover,C-Im-CN has multiple interaction sites and polymer skeleton,so the unencapsulated PSCs maintain above 91.3%of their initial efficiencies after 3000 h of continuous operation in a conventional air atmosphere and have good stability under high humidity conditions.The utilization of biopolymers with excellent structure-designability to manage the perovskite opens a state-of-the-art avenue for manufacturing and improving PSCs.展开更多
A new rhombohedral phase(termed R′)in a solution-aging-treated titanium alloy(Ti-4.5Al-6.5Mo-2Cr-2Nb-1V-1Sn-1Zr,wt.%)was identified.Its accurate Bravais lattice parameters were determined by a novel unit cell reconst...A new rhombohedral phase(termed R′)in a solution-aging-treated titanium alloy(Ti-4.5Al-6.5Mo-2Cr-2Nb-1V-1Sn-1Zr,wt.%)was identified.Its accurate Bravais lattice parameters were determined by a novel unit cell reconstruction method based on conventional selected-area electron diffraction(SAED)technique.The orientation relationship between R'phase and BCC phase was revealed.The results show that the R′phase is found to have 48crystallographically equivalent variants,resulting in rather complicated SAED patterns with high-order reflections.A series of in-situ SAED patterns were taken along both low-and high-index zone axes,and all weak and strong reflections arising from the 48 variants were properly explained and directly assigned with self-consistent Miller indices,confirming the presence of the rhombohedral phase.Additionally,some criteria were also proposed for evaluating the indexed results,which together with the Bravais lattice reconstruction method shed light on the microstructure characterization of even unknown phases in other alloys.展开更多
Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tes...Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were conducted.The rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of corrosion.In air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking paths.Compared with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack tip.The corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of specimen.However,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic dissolution.Owing to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.展开更多
Extreme droughts are increasing in frequency and severity globally as a result of climate change.Developing understanding of species’responses to drought is crucial for their conservation,especially in regions experi...Extreme droughts are increasing in frequency and severity globally as a result of climate change.Developing understanding of species’responses to drought is crucial for their conservation,especially in regions experi-encing increased aridity.Although numerous studies have investigated birds’responses to drought,the emphasis has primarily been on landbirds.Drought can significantly alter the wetland environments that waterbirds inhabit,but the response of waterbirds to drought remains understudied.In this study,we surveyed the distri-bution and behavior of Oriental Storks(Ciconia boyciana)in Poyang Lake,which is the largest freshwater lake in China.Results indicate that drought-induced catchment areas at the lowest water level limited the total popu-lation size of Oriental Storks in the sub-lakes.Sub-lakes with large catchment areas at the lowest water level demonstrated a capacity to support a larger population of wintering Oriental Storks.Over time,Oriental Storks exhibited a gradual concentration in Changhu Lake,characterized by larger catchments,after resource depletion in sub-lakes with smaller catchments.Additionally,the duration of Oriental Storks’vigilance and moving be-haviors decreased significantly compared with that observed before the drought.After the drought,Oriental Storks increased their foraging efforts,as evidenced by increased presence in deeper water and reaching their heads and necks into deeper water to forage,higher search rates,but lower foraging rates.In accordance with area-restricted search theory,reductions in habitat quality resulting from drought,including extensive fish die-offs,forced Oriental Storks to increase their foraging efforts.Sustaining a specific water area in sub-lakes during droughts can preserve resource availability,which is crucial for the conservation of Oriental Storks.Imple-menting measures such as water level control and micro-modification of lake bottoms in sub-lakes might mitigate the impact of drought on the piscivorous Oriental Storks.展开更多
Based on the building principle of additive manufacturing,printing orientation mainly determines the tribological properties of joint prostheses.In this study,we created a polyether-ether-ketone(PEEK)joint prosthesis ...Based on the building principle of additive manufacturing,printing orientation mainly determines the tribological properties of joint prostheses.In this study,we created a polyether-ether-ketone(PEEK)joint prosthesis using fused filament fabrication and investigated the effects of printing orientation on its tribological properties using a pin-on-plate tribometer in 25% newborn calf serum.An ultrahigh molecular weight polyethylene transfer film is formed on the surface of PEEK due to the mechanical capture of wear debris by the 3D-printed groove morphology,which is significantly impacted by the printing orientation of PEEK.When the printing orientation was parallel to the sliding direction of friction,the number and size of the transfer film increased due to higher steady stress.This transfer film protected the matrix and reduced the friction coefficient and wear rate of friction pairs by 39.13%and 74.33%,respectively.Furthermore,our findings provide a novel perspective regarding the role of printing orientation in designing knee prostheses,facilitating its practical applications.展开更多
文摘To make the problems of existing high requirements of calibration tools, complex global calibration process addressed for monocular multi-view visual measurement system during measurement, in the paper, a global calibration method is proposed for the geometric properties of rotational correlation motion and the absolute orientation of the field of view without over lap. Firstly, a dual-camera system is constructed for photographing and collecting the rotating image sequence of two flat targets rigidly connected by a long rod at different positions, and based on the known parameters, such as, target feature image, world coordinates, camera internal parameters and so on, then the global PnP optimization method is used to solve the rotation axis and the reference point at different positions;Then, the absolute orientation matrix is constructed based on the parameters of rotation axis, reference point and connecting rod length obtained by this method. In the end, the singular value decomposition method is used to find the optimal rotation matrix, and then get the translation matrix. It’s shown based on simulation and actual tests that in comparison with the existing methods, the maximum attitude and pose errors is 0.0083˚ and 0.3657 mm, respectively, which improves the accuracy by 27.8% and 24.4%, respectively. The calibration device in this paper is simple, and there are no parallel, vertical and coplanar requirements between multiple rotating positions. At the same time, in view of the calibration accuracy, the accuracy requirements of most application scenarios can be met.
基金supported by National Natural Science Foundation of China(No.62101601)。
文摘In this paper,DOA and subarray-interval estimation are considered and applied to arbitrarily distributed unmanned aerial vehicle(UAV)swarm system,in which multiple small UAVs containing uniform linear array(ULA)are divided by unknown intervals because of dynamic moving.Three parameters are taken to indicate the steering vector,namely,the direction of arrivals(DOAs)of target users,the intervals of UAVs,and the orientation angles of UAVs.The orientation angles are first estimated with an auxiliary user and the DOAs are obtained through a search free rooting method,despite the intervals among the UAVs.Afterwards,the intervals among UAVs can also be calculated via exhaustive when the number of target users are no less than three.We further develop a low-complex method to reduce the computational complexity during subarray-interval estimation.The deterministic Cramér-Rao bound(CRB)of the DOA,orientation angle and subarray-interval can be inferred in a closed form.Eventually,numerical instances are cited to verify the research results.
文摘The prominence of Renewable Energy Sources(RES)in the process of power generation is exponentially increased in the recent days since these sources assist in minimizing the environmental contamination.A grid-tied DFIG(Doubly Fed Induction Generator)based WECS(Wind Energy Conversion System)is introduced in this work,in which a Landsman converter is implemented to impro-vise the output voltage of PV without anyfluctuations.A novel GA(Genetic Algorithm)assisted ANN(Artificial Neural Network)is employed for tracking the Maximum power from PV.Among the rotor and grid side controllers,the for-mer is implemented by combining the statorflux with d-q reference frame and the latter is realized by the PI controller.The proposed approach delivers better per-formance in the compensation of real and reactive power along with the DC link voltage control.The controlling mechanism is verified in both MATLAB and experimental bench setupby using an emulated wind turbine for the concurrent control of DC link potential,active and reactive powers.The source current THD is observed as 1.93%and 2.4%for simulation and hardware implementation respectively.
文摘This review explores entrepreneurial orientation and innovation ecosystems in the industrial sector of the Central Region, Kampala, Uganda, through an analysis of ten scholarly articles. The study contextualizes the research within the regional landscape and establishes a theoretical framework through a focused literature review. Key findings highlight the intersection of entrepreneurial activities and innovation dynamics, emphasizing the region’s unique contributions to the broader field. Discussions on discrepancies and unexplored territories within the articles offer insights into limitations and research gaps. The manuscript concludes by identifying future research avenues, providing a roadmap for ongoing inquiry into the entrepreneurial and innovative dimensions of the Central Region’s industrial sector. This synthesis underscores the importance of cultivating an entrepreneurial mindset and collaborative innovation strategies for sustainable industrial development in the region.
基金the Natural Science Foundation of China(Grant Nos.82072413,82101649)National Key Research and Development Program of China(Grant Nos.2021YFE0105400).
文摘The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.
文摘The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic ducts.The disease is more prevalent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prevalence of biliary parasites.In the last century,owing to migration,its global incidence has increased.The main pathophysiological mechanisms involve cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for development of intrahepatic cholangiocarcinoma.Various classifications have aimed at providing useful insight of clinically relevant aspects and guidance for treatment.The management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interventional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prevent the development of more serious complications.This comprehensive review provides insight on various aspects of hepatolithiasis,with a focus on epidemiology,new evidence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.
基金Commissaire Energie de Atomique de Francethe 9th Five-Year Major Program of the National Natural Science Foundation of China(39890390)+1 种基金the State Key Basic Research Development Plan of China(973)(G1998010100)Innovation of Laboratory of Photosynthests Basic Research,Institute of Botany,The Chinese Acadeny of Sciences
文摘Linear dichroism (LD) spectroscopy is an important technique in the study of the orientation and organization of pigments in the photosynthetic membrane complexes in vivo and in vitro . In this work, the orientation of the pigments in the isolated photosystem Ⅱ (PSⅡ) sub_core reaction center complexes was analyzed and characterized by means of low temperature absorption and LD spectroscopy. The preparations containing different amounts of CP47 isolated from spinach (Spinacia oleracea L.) chloroplast were used in order to investigate the orientation of pigments in the PSⅡ sub_core CP47/D1/D2/Cyt b_559 (CP47/D1/D2) complexes. Chlorophyll a (Chl a) absorbing at 680 nm in CP47/D1/D2/Cyt b_559 complex showed an orientation of the Q y transition parallel to the membrane plane. It is proposed that there are two forms of β_carotene (β_Car) in CP47/D1/D2/Cyt b_559 complex, denoted as β_Car (Ⅰ) and β_Car (Ⅱ), with different orientations, β_Car (Ⅰ) at 470 and 505 nm is roughly parallel to the membrane plane, and β_Car (Ⅱ) at 460 and 490 nm seems to be perpendicular orientation. Upon the photoinhibitory experiment β_Car (Ⅱ) was found to be photosensitive and easily photodamaged. It also showed that the positive LD signal observed at 680 nm was quite complicated. This signal is tentatively attributed to P680 and some Chl a of antenna in CP47 protein based upon our measurements.
文摘In order to solve existing problems about the method of establishing traditional system structure of decision support system(DSS), O S chart is applied to describe object oriented system structure of general DSS, and a new method of eight specific steps is proposed to establish object oriented system structure of DSS by using the method of O S chart, which is applied successfully to the development of the DSS for the energy system ecology engineering research of the Wangheqiu country. Supplying many scientific effective computing models, decision support ways and a lot of accurate reliable decision data, the DSS plays a critical part in helping engineering researchers to make correct decisions. Because the period for developing the DSS is relatively shorter, the new way improves the efficiency of establishing DSS greatly. It also makes the DSS of system structure more flexible and easy to expand.
基金the financial support from the National Key R&D program of China(2021YFF0500501 and 2021YFF0500504)the Fundamental Research Funds for the Central Universities(YJS2213 and JB211408)+1 种基金the National Natural Science Foundation of China(61874083)the Joint Research Funds of Department of Science&Technology of Shaanxi Province and Northwestern Polytechnical University(No.2020GXLH-Z-014)
文摘Low-temperature,ambient processing of high-quality CsPbBr_(3)films is demanded for scalable production of efficient,low-cost carbon-electrode perovskite solar cells(PSCs).Herein,we demonstrate a crystal orientation engineering strategy of PbBr_(2)precursor film to accelerate its reaction with CsBr precursor during two-step sequential deposition of CsPbBr_(3)films.Such a novel strategy is proceeded by adding CsBr species into PbBr_(2)precursor,which can tailor the preferred crystal orientation of PbBr_(2)film from[020]into[031],with CsBr additive staying in the film as CsPb_(2)Br_(5)phase.Theoretical calculations show that the reaction energy barrier of(031)planes of PbBr_(2)with CsBr is lower about 2.28 eV than that of(O2O)planes.Therefore,CsPbBr_(3)films with full coverage,high purity,high crystallinity,micro-sized grains can be obtained at a low temperature of 150℃.Carbon-electrode PSCs with these desired CsPbBr_(3)films yield the record-high efficiency of 10.27%coupled with excellent operation stability.Meanwhile,the 1 cm^(2)area one with the superior efficiency of 8.00%as well as the flexible one with the champion efficiency of 8.27%and excellent mechanical bending characteristics are also achieved.
文摘Based on the theory of elastic mechanics and material mechanics, the orientation precision of the hohl schaft kegel(HSK) tooling system in static and dynamic states is theoretically and experimentally studied. The relation between the clamping force and the shank taper is obtained. And a proper clamping force is found to be essential to assure the axial and radial orientation precisions of the HSK tooling system in high speed machining (HSM). Analytical results show that the reason why the HSK tooling system can keep high precision at the high rotational speed is that the actual axial clamping force keeps the two surfaces of the shank and the spindle in contact all the time.
基金supported by the National Natural Science Foundation of China(Grant No.31772258)the National Key Research and Development Program(Grant No.2019YFD1000102-11)。
文摘Climate change and extreme weather pose significant challenges to the traditional viticulture regions.Emerging high-altitude grape-producing regions with diverse orientations have shown great potential in coping with this challenge.Stable,high-quality wine grape production may be achieved by synchronizing the meso-and microclimate.To clarify the role of high altitude and row orientation in meso-and microclimate and the response of berries to it,we evaluated seven years(2012-2018)of climate data,two years of basic grape(Cabernet Sauvignon,Vitis vinifera L.)quality,and one-year microclimate from veraison to harvest.By comparing two locations(Sidon 2047 m,Sinon 2208 m)in Yunnan Province,China,we found that the average temperature has been stable at approximately 15℃ for seven years,with no extreme weather or,noticeable global warming.The light intensity(LI)in the north-south(NS)was more balanced than the east-west(EW)direction,and the east-west to the south(EW-S)canopy side was almost higher than the other sides.High LI was associated with high photosynthetically active radiation(PAR),ultraviolet(UV),and infrared(IR)light and vice versa.The north-south to the east(NS-E)and east-west to the north(EWN)sides were characterized by lower LI and higher UV and IR light,and higher total anthocyanin content.Most anthocyanin synthesis-related genes,for example,VvF3'H and VvF3'5'H,were highly expressed in NS-E from veraison to maturity.Perhaps UV and IR light induced their expression.This study provides new insights on the role of differently orientated rows in controlling grape quality due to varied light quality.The findings are globally significant,particularly in the context of climate change,and offer fresh insights into berry physiological responses and decision-making for the management of existing vineyards.
基金National Natural Science Foundation of China(22078039)Science Fund for Creative Research Groups of the National Natural Science Foundation of China(22021005)+1 种基金National Key Research and Development Program of China(2023YFB3810700)the Fundamental Research Funds for the Central Universities(DUT22LAB602)。
文摘Preferential orientation control of metal—organic framework(MOF)films is advantageous for maximizing pore uniformity and minimizing grain-boundary defects.Nonetheless,the preparation of MOF films with both in-plane and out-of-plane orientations remains a grand challenge.In this study,we reported the preparation of three-dimensionally oriented MIL-96 layers through combining morphology control of MIL-96 seeds with addition of polyvinylpyrrolidone surfactants and arachidonic acids.The three-dimensionally oriented MIL-96 film was readily obtained through in-plane epitaxial growth.It is anticipated that the aforementioned protocol can be effective for obtaining diverse MOF films with a three-dimensionally oriented organization.
基金supported by the National Natural Science Foundation of China(No.52173292 and U2004211)the Youth Innovation Promotion Association CAS(No.2018040).
文摘In perovskite solar cells(PSCs),the inherent defects of perovskite film and the random distribution of excess lead iodide(PbI_(2))prevent the improvement of efficiency and stability.Herein,natural cellulose is used as the raw material to design a series of cellulose derivatives for perovskite crystallization engineering.The cationic cellulose derivative C-Im-CN with cyano-imidazolium(Im-CN)cation and chloride anion prominently promotes the crystallization process,grain growth,and directional orientation of perovskite.Meanwhile,excess PbI_(2)is transferred to the surface of perovskite grains or formed plate-like crystallites in local domains.These effects result in suppressing defect formation,decreasing grain boundaries,enhancing carrier extraction,inhibiting non-radiative recombination,and dramatically prolonging carrier lifetimes.Thus,the PSCs exhibit a high power conversion efficiency of 24.71%.Moreover,C-Im-CN has multiple interaction sites and polymer skeleton,so the unencapsulated PSCs maintain above 91.3%of their initial efficiencies after 3000 h of continuous operation in a conventional air atmosphere and have good stability under high humidity conditions.The utilization of biopolymers with excellent structure-designability to manage the perovskite opens a state-of-the-art avenue for manufacturing and improving PSCs.
基金financial supports from the National Natural Science Foundation of China(No.51071125)the Major Project of Department of Education of Jiangxi Province,China(No.GJJ210605)。
文摘A new rhombohedral phase(termed R′)in a solution-aging-treated titanium alloy(Ti-4.5Al-6.5Mo-2Cr-2Nb-1V-1Sn-1Zr,wt.%)was identified.Its accurate Bravais lattice parameters were determined by a novel unit cell reconstruction method based on conventional selected-area electron diffraction(SAED)technique.The orientation relationship between R'phase and BCC phase was revealed.The results show that the R′phase is found to have 48crystallographically equivalent variants,resulting in rather complicated SAED patterns with high-order reflections.A series of in-situ SAED patterns were taken along both low-and high-index zone axes,and all weak and strong reflections arising from the 48 variants were properly explained and directly assigned with self-consistent Miller indices,confirming the presence of the rhombohedral phase.Additionally,some criteria were also proposed for evaluating the indexed results,which together with the Bravais lattice reconstruction method shed light on the microstructure characterization of even unknown phases in other alloys.
基金the National Natural Science Foundation of China(Nos.52175143 and 51571150)。
文摘Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were conducted.The rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of corrosion.In air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking paths.Compared with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack tip.The corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of specimen.However,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic dissolution.Owing to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.
基金funded by the National Natural Science Foundation of China(Grant No.32360142).
文摘Extreme droughts are increasing in frequency and severity globally as a result of climate change.Developing understanding of species’responses to drought is crucial for their conservation,especially in regions experi-encing increased aridity.Although numerous studies have investigated birds’responses to drought,the emphasis has primarily been on landbirds.Drought can significantly alter the wetland environments that waterbirds inhabit,but the response of waterbirds to drought remains understudied.In this study,we surveyed the distri-bution and behavior of Oriental Storks(Ciconia boyciana)in Poyang Lake,which is the largest freshwater lake in China.Results indicate that drought-induced catchment areas at the lowest water level limited the total popu-lation size of Oriental Storks in the sub-lakes.Sub-lakes with large catchment areas at the lowest water level demonstrated a capacity to support a larger population of wintering Oriental Storks.Over time,Oriental Storks exhibited a gradual concentration in Changhu Lake,characterized by larger catchments,after resource depletion in sub-lakes with smaller catchments.Additionally,the duration of Oriental Storks’vigilance and moving be-haviors decreased significantly compared with that observed before the drought.After the drought,Oriental Storks increased their foraging efforts,as evidenced by increased presence in deeper water and reaching their heads and necks into deeper water to forage,higher search rates,but lower foraging rates.In accordance with area-restricted search theory,reductions in habitat quality resulting from drought,including extensive fish die-offs,forced Oriental Storks to increase their foraging efforts.Sustaining a specific water area in sub-lakes during droughts can preserve resource availability,which is crucial for the conservation of Oriental Storks.Imple-menting measures such as water level control and micro-modification of lake bottoms in sub-lakes might mitigate the impact of drought on the piscivorous Oriental Storks.
基金This study was supported by the following funds:National Key R&D Program of China(No.2018YFE0207900)Program for Innovation Team of Shaanxi Province(No.2023-CXTD-17)+5 种基金Program of the National Natural Science Foundation of China(No.51835010)Key R&D Program of Guangdong Province(No.2018B090906001)Natural Science Basic Research Program of Shaanxi Province(No.2022JQ-378)China Postdoctoral Science Foundation(No.2020M683458)Fundamental Research Funds for the Central Universities(8)Youth Innovation Team of Shaanxi Universities.
文摘Based on the building principle of additive manufacturing,printing orientation mainly determines the tribological properties of joint prostheses.In this study,we created a polyether-ether-ketone(PEEK)joint prosthesis using fused filament fabrication and investigated the effects of printing orientation on its tribological properties using a pin-on-plate tribometer in 25% newborn calf serum.An ultrahigh molecular weight polyethylene transfer film is formed on the surface of PEEK due to the mechanical capture of wear debris by the 3D-printed groove morphology,which is significantly impacted by the printing orientation of PEEK.When the printing orientation was parallel to the sliding direction of friction,the number and size of the transfer film increased due to higher steady stress.This transfer film protected the matrix and reduced the friction coefficient and wear rate of friction pairs by 39.13%and 74.33%,respectively.Furthermore,our findings provide a novel perspective regarding the role of printing orientation in designing knee prostheses,facilitating its practical applications.