Summary: To investigate the expression of Toll-like receptor (TLR) 2 and 4 mRNA in local tissues of model of oropharyngeal candidiasis in mice and to explore the potential role of TLR2 and TLR4 in earlier period of im...Summary: To investigate the expression of Toll-like receptor (TLR) 2 and 4 mRNA in local tissues of model of oropharyngeal candidiasis in mice and to explore the potential role of TLR2 and TLR4 in earlier period of immune response, a murine model of oropharyngeal candidiasis inoculated by cotton wool balls saturated with candida albicans was established. Mice were sacrificed at the indicated time points and the oropharyngeal tissues were excised. The expression of TLR2 and TLR4 mRNA was detected by RT-PCR. The results showed that low level of TLR2/4 mRNA could be detected in oropharyngeal tissues, but they were markedly up-regulated 6 h after inoculation, peaking after 12-24 h. Tissue TLR4 mRNA was gradually down-regulated 24-48 h, while TLR2 mRNA levels remained high up to the 72nd h. These data suggested that oropharyngeal infection of Candida albicans could result in up-regulation of TLR2/4 mRNA expression in local tissues, which might play important roles in earlier period of immune response.展开更多
Lemierre’s syndrome is a rare and severe sepsis, capable of rapidly compromising the vital prognosis in the absence of early intervention, characterized by an oropharyngeal infection complicated by septic thrombosis ...Lemierre’s syndrome is a rare and severe sepsis, capable of rapidly compromising the vital prognosis in the absence of early intervention, characterized by an oropharyngeal infection complicated by septic thrombosis of the internal jugular vein and the formation of septic emboli primarily localized at the pulmonary level. We report the case of a 14-year-old boy, with no notable pathological history, who had presented for 15 days with unilateral orbital swelling which then became bilateral, all evolving in a context of fever.展开更多
文摘Summary: To investigate the expression of Toll-like receptor (TLR) 2 and 4 mRNA in local tissues of model of oropharyngeal candidiasis in mice and to explore the potential role of TLR2 and TLR4 in earlier period of immune response, a murine model of oropharyngeal candidiasis inoculated by cotton wool balls saturated with candida albicans was established. Mice were sacrificed at the indicated time points and the oropharyngeal tissues were excised. The expression of TLR2 and TLR4 mRNA was detected by RT-PCR. The results showed that low level of TLR2/4 mRNA could be detected in oropharyngeal tissues, but they were markedly up-regulated 6 h after inoculation, peaking after 12-24 h. Tissue TLR4 mRNA was gradually down-regulated 24-48 h, while TLR2 mRNA levels remained high up to the 72nd h. These data suggested that oropharyngeal infection of Candida albicans could result in up-regulation of TLR2/4 mRNA expression in local tissues, which might play important roles in earlier period of immune response.
文摘Lemierre’s syndrome is a rare and severe sepsis, capable of rapidly compromising the vital prognosis in the absence of early intervention, characterized by an oropharyngeal infection complicated by septic thrombosis of the internal jugular vein and the formation of septic emboli primarily localized at the pulmonary level. We report the case of a 14-year-old boy, with no notable pathological history, who had presented for 15 days with unilateral orbital swelling which then became bilateral, all evolving in a context of fever.
