AIM: To evaluate the association between alcoholic liver disease(ALD) and bone fractures or osteoporosis. METHODS: Non-randomized studies were identified from databases(Pub Med, EMBASE, and the Cochrane Library). The ...AIM: To evaluate the association between alcoholic liver disease(ALD) and bone fractures or osteoporosis. METHODS: Non-randomized studies were identified from databases(Pub Med, EMBASE, and the Cochrane Library). The search was conducted using Boolean operators and keywords, which included "alcoholic liver diseases", "osteoporosis", or "bone fractures". The prevalence of any fractures or osteoporosis, and bone mineral density(BMD) were extracted and analyzed using risk ratios and standardized mean difference(SMD). A random effects model was applied. RESULTS: In total, 15 studies were identified and analyzed. Overall, ALD demonstrated a RR of 1.944(95%CI: 1.354-2.791) for the development of bone fractures. However, ALD showed a RR of 0.849(95%CI: 0.523-1.380) for the development of osteoporosis. BMD was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD(SMD in femur-BMD:-0.172, 95%CI:-0.453-0.110; SMD in spine-BMD:-0.169, 95%CI:-0.476-0.138). Sensitivity analyses showed consistent results. CONCLUSION: Current publications indicate significant associations between bone fractures and ALD, independent of BMD or the presence of osteoporosis.展开更多
目的调查北京城镇中老年人25-羟维生素D_3、甲状旁腺素、骨钙素与骨密度的相关性。方法采用美国DTX-200型双能X线骨密度仪,检测北京大兴区成年男性428例、女性778例的非优势前臂桡骨远端1/3处的骨密度。采用电化学发光免疫分析法测定25...目的调查北京城镇中老年人25-羟维生素D_3、甲状旁腺素、骨钙素与骨密度的相关性。方法采用美国DTX-200型双能X线骨密度仪,检测北京大兴区成年男性428例、女性778例的非优势前臂桡骨远端1/3处的骨密度。采用电化学发光免疫分析法测定25-羟维生素D_3[25(OH)D_3]、甲状旁腺素、血清骨钙素N端中分子片段(N-terminal-midfragment of osteocalcin,N-MID)。采用SPSS24.0统计学软件分析不同性别、年龄段组25(OH)D_3、甲状旁腺素、血清骨钙素N端中分子片段、非优势前臂桡骨远端1/3处的骨密度水平。结果 25(OH)D_3水平在不同性别间存在显著差异(P<0.01);甲状旁腺素性别间无统计学差异(P>0.05);血清骨钙素N端中分子片段50~69岁年龄段不同性别间存在显著差异(P<0.01);非优势手臂桡骨远端1/3处骨密度性别间无统计学差异(P>0.05);非优势手臂桡骨远端1/3处骨密度与25-羟维生素D_3[25(OH)D_3]、甲状旁腺素呈正相关,非优势手臂桡骨远端1/3处骨密度与年龄、血清骨钙素N端中分子片段呈负相关。结论北京中老年人女性普遍缺乏维生素D。25-羟维生素D_3[25(OH)D_3]、甲状旁腺素、血清骨钙素N端中分子片段与骨密度可综合评价骨质疏松症各阶段。展开更多
文摘目的:探讨老年男性慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并骨质疏松症患者血清睾酮水平的变化情况及其与病情严重程度的相关性。方法:选取2015年1至12月入院的117例稳定期COPD老年男性患者,并选择同期入院的非COPD患者40例为对照组。根据骨密度病情严重程度进行分组,比较不同组别间血清睾酮水平,并分析其与患者病情严重程度相关指标的相关性。结果:COPD组患者的血清睾酮水平明显低于对照组;骨质疏松组患者的睾酮水平明显低于骨量正常组和骨量减少组,骨量减少组的睾酮水平明显低于骨量正常组(P<0.05);随着COPD病情的加重,血清睾酮水平下降越明显(P<0.05);血清睾酮水平与患者的FEV1/FVC和FEV1%Pre呈正相关(r=0.267,r=0.291;P=0.011,P=0.009),与吸烟指数(r=-0.405,P=0.005)、体质指数(body mass index,BMI)(r=-0.304,P=0.006)、CAT评分(r=-0.583,P=0.000)、骨密度(bone mineral density,BMD)腰椎(r=-0.611,P=0.000)、BMD股骨颈(r=-0.382,P=0.002)呈负相关关系。结论:COPD合并骨质疏松症患者血清睾酮水平下降显著,且随病情严重程度呈递减状态。检测睾酮水平在一定程度上有助于COPD合并骨质疏松症患者病情严重程度的判断。
文摘AIM: To evaluate the association between alcoholic liver disease(ALD) and bone fractures or osteoporosis. METHODS: Non-randomized studies were identified from databases(Pub Med, EMBASE, and the Cochrane Library). The search was conducted using Boolean operators and keywords, which included "alcoholic liver diseases", "osteoporosis", or "bone fractures". The prevalence of any fractures or osteoporosis, and bone mineral density(BMD) were extracted and analyzed using risk ratios and standardized mean difference(SMD). A random effects model was applied. RESULTS: In total, 15 studies were identified and analyzed. Overall, ALD demonstrated a RR of 1.944(95%CI: 1.354-2.791) for the development of bone fractures. However, ALD showed a RR of 0.849(95%CI: 0.523-1.380) for the development of osteoporosis. BMD was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD(SMD in femur-BMD:-0.172, 95%CI:-0.453-0.110; SMD in spine-BMD:-0.169, 95%CI:-0.476-0.138). Sensitivity analyses showed consistent results. CONCLUSION: Current publications indicate significant associations between bone fractures and ALD, independent of BMD or the presence of osteoporosis.
文摘目的调查北京城镇中老年人25-羟维生素D_3、甲状旁腺素、骨钙素与骨密度的相关性。方法采用美国DTX-200型双能X线骨密度仪,检测北京大兴区成年男性428例、女性778例的非优势前臂桡骨远端1/3处的骨密度。采用电化学发光免疫分析法测定25-羟维生素D_3[25(OH)D_3]、甲状旁腺素、血清骨钙素N端中分子片段(N-terminal-midfragment of osteocalcin,N-MID)。采用SPSS24.0统计学软件分析不同性别、年龄段组25(OH)D_3、甲状旁腺素、血清骨钙素N端中分子片段、非优势前臂桡骨远端1/3处的骨密度水平。结果 25(OH)D_3水平在不同性别间存在显著差异(P<0.01);甲状旁腺素性别间无统计学差异(P>0.05);血清骨钙素N端中分子片段50~69岁年龄段不同性别间存在显著差异(P<0.01);非优势手臂桡骨远端1/3处骨密度性别间无统计学差异(P>0.05);非优势手臂桡骨远端1/3处骨密度与25-羟维生素D_3[25(OH)D_3]、甲状旁腺素呈正相关,非优势手臂桡骨远端1/3处骨密度与年龄、血清骨钙素N端中分子片段呈负相关。结论北京中老年人女性普遍缺乏维生素D。25-羟维生素D_3[25(OH)D_3]、甲状旁腺素、血清骨钙素N端中分子片段与骨密度可综合评价骨质疏松症各阶段。
