The contribution of steel wallposts to out-of-plane behavior of non-structural masonry walls

For years,non-structural masonry walls have received little attention by code developers and professional engineers.Recently,significant efforts have been made to shed more light on out-of-plane(OOP)behavior of non-structural masonry walls.In updated provisions of the Iranian seismic code,bed joint reinforcements(BJRs)and steel wallposts have been suggested for use.BJRs are horizontal reinforcements;steel wallposts are vertical truss-like elements intended to provide additional OOP restraints for a wall.The contribution of BJRs has previously been investigated by the authors.This study is devoted to investigating the contribution of steel wallposts to the OOP behavior of non-structural masonry walls.Using pre-validated 3D finite element(FE)models,the OOP behavior of 180 non-structural masonry walls with varying configurations and details are investigated.The OOP pressure-displacement curve,ultimate strength,the response modification factor,and the cracking pattern are among the results presented in this study.It is found that steel wallposts,especially those with higher rigidity,can improve the OOP strength of the walls.The contribution of wallposts in the case of shorter length walls and walls with an opening are more pronounced.Results also indicate that masonry walls with wallpost generally have smaller modification factors compared to similar walls without wallpost.

Wave nature of Rosensweig instability

The explicit analytical solution of Rosensweig instability spikes'shapes obtained by Navier-Stokes(NS)equation in diverse magnetic field H vertical to the flat free surface of ferrofluids are systematically studied experimentally and theoretically.After carefully analyzing and solving the NS equation in elliptic form,the force balanced surface equations of spikes in Rosensweig instability are expressed as cosine wave in perturbated magnetic field and hyperbolic tangent in large magnetic field,whose results both reveal the wave-like nature of Rosensweig instability.The results of hyperbolic tangent form are perfectly fitted to the experimental results in this paper,which indicates that the analytical solution is basically correct.Using the forementioned theoretical results,the total energy of the spike distribution pattern is calculated.By analyzing the energy components under different magnetic field intensities H,the hexagon-square transition of Rosensweig instability is systematically discussed and explained in an explicit way.

Theoretical analysis of the elastic Kelvin-Helmholtz instability in explosive weldings

By considering the joint effects of the Kelvin-Helmholtz(KH) and Rayleigh-Taylor(RT) instabilities, this paper presents an interpretation of the wavy patterns that occur in explosive welding. It is assumed that the elasticity of the material at the interface effectively determines the wavelength, because explosive welding is basically a solid-state welding process. To this end, an analytical model of elastic hydrodynamic instabilities is proposed, and the most unstable mode is selected in the solid phase. Similar approaches have been widely used to study the interfacial behavior of solid metals in high-energy-density physics. By comparing the experimental and theoretical results, it is concluded that thermal softening,which significantly reduces the shear modulus, is necessary and sufficient for successful welding. The thermal softening is verified by theoretical analysis of the increase in temperature due to the impacting and sliding of the flyer and base plates, and some experimental observations are qualitatively validated.In summary, the combined effect of the KH and RT instabilities in solids determines the wavy morphology, and our theoretical results are in good qualitative agreement with experimental and numerical observations.

Tendoscopic Surgery for Peroneal Tendons Instability: A Literature Review

Introduction: There has been a surge in the use of tendoscopic surgery for treating peroneal tendons instability. The novelty of this approach demanded a literature review of its indications, limitations, and clinical outcomes. Aim: a literature review of the clinical studies reporting on tendoscopic peroneal tendon stabilisation surgery along with its outcomes and complications. Methods: We carried out a comprehensive review of the literature up until September 2022 with an extensive search of the MEDLINE, Embase and Cochrane library databases. Results: Initial search resulted in 66 articles. Four duplicate articles were removed. Further 30 articles were excluded after title and abstract screening. Eight studies satisfied the inclusion criteria and were included in this review. Articles were analysed for outcomes and complications. Conclusion: The tendoscopic technique for peroneal tendon instability is an effective and safe surgical technique with very low failure rate. Levels of Evidence: Level IV.

Chronic Ankle Instability: Therapeutic Exercise and Data Analysis

Background and Objectives: Ankle injuries are the most common type of injury in healthy active individuals. If not treated properly, recurrent sprains can lead to a condition of chronic ankle instability (CAI). The present paper examines some subjects with a previous history of acute inversion ankle sprain who have developed a subsequent condition of instability, grouping them according to inclusion criteria and analyzing them through four field tests considered objective by the scientific literature: SEBT test, BEES test, TIBT test, SHT test. The data obtained were stored in order to compare them following a re-education protocol aimed at improving proprioception, balance, walking and strengthening the extrinsic and intrinsic muscles of the foot. per year. The subjects were then divided into two categories: subjects with CAI > 1 year and subjects with CAI ≤ 1 year. A protocol lasting 6 weeks was administered to both groups, trying to work on improving balance in single stance, improving static and dynamic stability, strengthening the gluteus medius and maximus (pelvis stabilizers) and strengthening of the intrinsic muscles of the foot. At the end of the protocol the subjects were all re-evaluated with the same field tests used previously and the data obtained were compared both with the pre-protocol data and with the data measured by the control subjects.

Parametric instability in the pure-quartic nonlinear Schrödinger equation

We study the nonlinear stage of modulation instability(MI)in the non-intergrable pure-quartic nonlinear Schrödinger equation where the fourth-order dispersion is modulated periodically.Using the three-mode truncation,we reveal the complex recurrence of parametric resonance(PR)breathers,where each recurrence is associated with two oscillation periods(PR period and internal oscillation period).The nonlinear stage of parametric instability admits the maximum energy exchange between the spectrum sidebands and central mode occurring outside the MI gain band.

Effect of external magnetic field on the instability of THz plasma waves in nanoscale graphene field-effect transistors

The instability of plasma waves in the channel of field-effect transistors will cause the electromagnetic waves with THz frequency.Based on a self-consistent quantum hydrodynamic model,the instability of THz plasmas waves in the channel of graphene field-effect transistors has been investigated with external magnetic field and quantum effects.We analyzed the influence of weak magnetic fields,quantum effects,device size,and temperature on the instability of plasma waves under asymmetric boundary conditions numerically.The results show that the magnetic fields,quantum effects,and the thickness of the dielectric layer between the gate and the channel can increase the radiation frequency.Additionally,we observed that increase in temperature leads to a decrease in both oscillation frequency and instability increment.The numerical results and accompanying images obtained from our simulations provide support for the above conclusions.

Growth mechanism and characteristics of electron drift instability in Hall thruster with different propellant types

The existence of a significant electron drift instability(EDI) in the Hall thruster is considered as one of the possible causes of the abnormal increase in axial electron mobility near the outlet of the channel. In recent years, extensive simulation research on the characteristics of EDI has been conducted, but the excitation mechanism and growth mechanism of EDI in linear stage and nonlinear stage remain unclear. In this work, a one-dimensional PIC model in the azimuthal direction of the thruster near-exit region is established to gain further insights into the mechanism of the EDI in detail, and the effects of different types of propellants on EDI characteristics are discussed. The changes in axial electron transport caused by EDI under different types of propellants and electromagnetic field strengths are also examined. The results indicate that EDI undergoes a short linear growth phase before transitioning to the nonlinear phase and finally reaching saturation through the ion Landau damping. The EDI drives a significant ion heating in the azimuthal direction through electron–ion friction before entering the quasi-steady state, which increases the axial mobility of the electrons. Using lighter atomic weight propellant can effectively suppress the oscillation amplitude of EDI, but it will increase the linear growth rate, frequency, and phase velocity of EDI. Compared with the classical mobility, the axial electron mobility under the EDI increases by three orders of magnitude, which is consistent with experimental phenomena. The change of propellant type is insufficient to significantly change the axial electron mobility. It is also found that the collisions between electrons and neutral gasescan significantly affect the axial electron mobility under the influence of EDI, and lead the strength of the electric field to increase and the strength of the magnetic field to decrease, thereby both effectively suppressing the axial transport of electrons.

Contrasts of bimodal tropical instability waves(TIWs)-induced wind stress perturbations in the Pacific Ocean among observations,ocean models,and coupled climate models

The coupling between wind stress perturbations and sea surface temperature(SST)perturbations induced by tropical instability waves(TIWs)in the Pacific Ocean has been revealed previously and proven crucial to both the atmosphere and ocean.However,an overlooked fact by previous studies is that the loosely defined“TIWs”actually consist of two modes,including the Yanai wave-based TIW on the equator(hereafter eTIW)and the Rossby wave-based TIW off the equator(hereafter vTIW).Hence,the individual feedbacks of the wind stress to the bimodal TIWs remain unexplored.In this study,individual coupling relationships are established for both eTIW and v TIW,including the relationship between the TIW-induced SST perturbations and two components of wind stress perturbations,and the relationship between the TIW-induced wind stress perturbation divergence(curl)and the downwind(crosswind)TIW-induced SST gradients.Results show that,due to different distributions of eTIW and vTIW,the coupling strength induced by the eTIW is stronger on the equator,and that by the vTIW is stronger off the equator.The results of any of eTIW and vTIW are higher than those of the loosely defined TIWs.We further investigated how well the coupling relationships remained in several widely recognized oceanic general circulation models and fully coupled climate models.However,the coupling relationships cannot be well represented in most numerical models.Finally,we confirmed that higher resolution usually corresponds to more accurate simulation.Therefore,the coupling models established in this study are complementary to previous research and can be used to refine the oceanic and coupled climate models.

Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer

In this editorial we comment on the article by Li published in the recent issue of the World Journal of Gastroenterology.We focus specifically on the application of immune checkpoint inhibitors(ICIs)and microsatellite instability(MSI)in gastric cancer(GC).The four pillars of GC management have long been considered,including surgery,chemotherapy,radiotherapy and targeted therapy.However,immunotherapy has recently emerged as a“fifth pillar”,and its use is rapidly expanding.There are four principal strategies for tumor immunotherapy:ICIs,tumor vaccines,adoptive immunotherapy and nonspecific immunomodulators.Of them,ICIs are the most advanced and widespread type of cancer immunotherapy for GC.Recent breakthrough results for ICIs have paved the way to a new era of cancer immunotherapy.In particular,inhibition of the PD-1/PD-L1 axis with ICIs,including nivolumab and pembrolizumab,has emerged as a novel treatment strategy for advanced GC.Unfortunately,these therapies are sometimes associated with often subtle,potentially fatal immune-related adverse events(irAEs),including dermatitis,diarrhea,colitis,endocrinopathy,hepatotoxicity,neuropathy and pneumonitis.We must be aware of these irAEs and improve the detection of these processes to prevent inappropriate discharges,emergency department revisits,and downstream complications.Recent studies have revealed that MSI-high or mismatch-repair-deficient tumors,regardless of their primary site,have a promising response to ICIs.So,it is important to detect MSI before applying ICIs for treatment of GC.

Homogeneity-Breaking Instability of Periodic Solutions of Gierer-Meindardt Model

The homogeneity-breaking instability of the periodic solutions triggered by Hopf bifurcations of a diffusive Gierer-Meinhart system is studied in this paper.Sufficient conditions on the diffusion coefficients and the cross diffusion coefficients were derived to guarantee the occurrence of the aforementioned homogeneity-breaking instability.

Construction and validation of somatic mutation-derived long noncoding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

BACKGROUND Long non-coding RNAs(LncRNAs)have been found to be a potential prognostic factor for cancers,including hepatocellular carcinoma(HCC).Some LncRNAs have been confirmed as potential indicators to quantify genomic instability(GI).Nevertheless,GI-LncRNAs remain largely unexplored.This study established a GI-derived LncRNA signature(GILncSig)that can predict the prognosis of HCC patients.AIM To establish a GILncSig that can predict the prognosis of HCC patients.METHODS Identification of GI-LncRNAs was conducted by combining LncRNA expression and somatic mutation profiles.The GI-LncRNAs were then analyzed for functional enrichment.The GILncSig was established in the training set by Cox regression analysis,and its predictive ability was verified in the testing set and TCGA set.In addition,we explored the effects of the GILncSig and TP53 on prognosis.RESULTS A total of 88 GI-LncRNAs were found,and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and GI.The GILncSig was constructed by 5 LncRNAs(miR210HG,AC016735.1,AC116351.1,AC010643.1,LUCAT1).In the training set,the prognosis of high-risk patients was significantly worse than that of low-risk patients,and similar results were verified in the testing set and TCGA set.Multivariate Cox regression analysis and stratified analysis confirmed that the GILncSig could be used as an independent prognostic factor.Receiver operating characteristic curve analysis of the GILncSig showed that the area under the curve(0.773)was higher than the two LncRNA signatures published recently.Furthermore,the GILncSig may have a better predictive performance than TP53 mutation status alone.CONCLUSION We established a GILncSig that can predict the prognosis of HCC patients,which will help to guide prognostic evaluation and treatment decisions.

Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status

BACKGROUND Immunotherapy have demonstrated promising outcomes in patients with high microsatellite instability(MSI)(MSI-H)metastatic colorectal cancer.However,the comparative effectiveness of Immunotherapy and chemotherapy for patients with low MSI(MSI-L),and microsatellite stable(MSS)metastatic colorectal cancer remains unclear.AIM To investigate immunotherapy vs chemotherapy for treatment of MSI-L/MSS metastatic colorectal cancer,and to evaluate the success of immunotherapy against chemotherapy in managing MSI-H metastatic colorectal cancer during a follow-up of 50 months.METHODS We conducted a retrospective cohort study using the National Cancer Database(NCDB)to evaluate the overall survival(OS)of patients with metastatic colorectal cancer treated with immunotherapy or chemotherapy.The study population was stratified by MSI status(MSI-H,MSI-L,and MSS).Multivariable Cox proportional hazard models were used to assess the association between treatment modality and OS,adjusting for potential confounders.RESULTS A total of 21951 patients with metastatic colorectal cancer were included in the analysis,of which 2358 were MSI-H,and 19593 were MSI-L/MSS.In the MSI-H cohort,immunotherapy treatment(n=142)was associated with a significantly improved median OS compared to chemotherapy(n=860).After adjusting for potential confounders,immunotherapy treatment remained significantly associated with better OS in the MSI-H cohort[adjusted hazard ratio(aHR):0.57,95%confidence interval(95%CI):0.43-0.77,P<0.001].In the MSS cohort,no significant difference in median OS was observed between immunotherapy treatment and chemotherapy(aHR:0.94,95%CI:0.69-1.29,P=0.715).CONCLUSION In this population-based study using the NCDB,immunotherapy treatment was associated with significantly improved OS compared to chemotherapy in patients with MSI-H metastatic colorectal cancer,but not in those with MSI-L/MSS metastatic colorectal cancer.Further studies are warranted to determine the optimal therapeutic approach for patients with MSI-L/MSS metastatic colorectal cancer.

Exact Solutions and Mode Transition for Out-of-Plane Vibrations of Non-uniform Beams with Variable Curvature

The two coupled governing differential equations for the out-of-plane vibrations of non-uniform beams with variable curvature are derived via the Hamilton’s principle.These equations are expressed in terms of flexural and torsional displacements simultaneously.In this study,the analytical method is proposed.Firstly,two physical parameters are introduced to simplify the analysis.One derives the explicit relations between the flexural and the torsional displacements which can also be used to reduce the difficulty in experimental measurements.Based on the relation,the two governing characteristic differential equations with variable coefficients can be uncoupled into a sixth-order ordinary differential equation in terms of the flexural displacement only.When the material and geometric properties of the beam are in arbitrary polynomial forms,the exact solutions with regard to the outof-plane vibrations of non-uniform beams with variable curvature can be obtained by the recurrence formula.In addition,the mode transition mechanism is revealed and the influence of several parameters on the vibration of the non-uniform beam with variable curvature is explored.

Out-of-plane (SH) soil-structure interaction： a shear wall with rigid and flexible ring foundation

Soil-structure interaction （SSI） of a building and shear wall above a foundation in an elastic half-space has long been an important research subject for earthquake engineers and strong-motion seismologists. Numerous papers have been published since the early 1970s; however, very few of these papers have analytic closed-form solu- tions available. The soil-structure interaction problem is one of the most classic problems connecting the two dis- ciplines of earthquake engineering and civil engineering. The interaction effect represents the mechanism of energy transfer and dissipation among the elements of the dynamic system, namely the soil subgrade, foundation, and super- structure. This interaction effect is important across many structure, foundation, and subgrade types but is most pro- nounced when a rigid superstructure is founded on a rela- tively soft lower foundation and subgrade. This effect may only be ignored when the subgrade is much harder than a flexible superstructure： for instance a flexible moment frame superstructure founded on a thin compacted soil layer on top of very stiff bedrock below. This paper will study the interaction effect of the subgrade and the super- structure. The analytical solution of the interaction of a shear wall, flexible-rigid foundation, and an elastic half- space is derived for incident SH waves with various angles of incidence. It found that the flexible ring （soft layer） cannot be used as an isolation mechanism to decouple asuperstructure from its substructure resting on a shaking half-space.

Variation of Out-of-Plane Constraint and Its Effects on Fracture

The limitations of using one-parameter to describe the crack-tip fields have prompted investigators to consider better descriptions of the crack tip fields. The two-parameter descriptions, such as J-Q theory, have been an important development in this field. But under the consideration of plane strain and three-dimensional problem, the effects of the out-of-plane stress can not be neglected In this paper, effects of the in-plane constraint as well as the out-of-plane constraint are studied by aid of the finite element method on the plane strain condition. It is obvious that both the in-plane constraint (Q factor) and the out-of-plane constraint (Tz = σzz/(σxx + σyy) ) affect the crack tip fields.Several important features of the out-of-plane constraint are described out based on the simulation results. At the end of this paper, a three-parameter formulation is proposed, in which both the in-plane constraint and the out-of-plane constraint are considered. Comparing with the results of the FEM numerical simulation, the three-parameter description can provide a better prediction near the crack tip.

OH…O Out-of-Plane Bending Band [γ(OH)] and Its Overtone Band of Dimethylol Propionic Acid(DMPA)

In the present paper are reported the OH…O out-of-plane bending band[γ(OH)] between 900—950 cm -1 of dimethylol propionic acid(DMPA), its dependence upon temperature and its overtone band investigated via FTIR spectroscopy. It has been found based on the crystal structure that the band [γ(OH)] may not certainly be the characteristic band of carboxylic dimers, it can also result from another H-bond formed between carboxylic carbonyl and the primary hydroxyl. In addition, the band [γ(OH)] is very sensitive to temperature change but its overtone band can only appear at a low temperature.

Transient out-of-plane distortion of multi-pass fillet welded tube to pipe T-joints

The out-of-plane distortion induced in a multi-pass circumferential fillet welding of tube to pipe under different weld sequences and directions was studied using Finite Element Method(FEM) based Sysweld software and verified experimentally. The FEM analyses consisted of thermal and mechanical analyses.Thermal analysis was validated with experimental transient temperature measurements. In the mechanical analysis, three different weld sequences and directions were considered to understand the mechanism of out-of-plane distortion in the tube to pipe T-joints. It was learnt that the welding direction plays a major role in minimizing the out-of-plane distortion. Further, during circumferential fillet welding of the tube to pipe component, the out-of-plane distortion generated in the x direction was primarily influenced by heat input due to the start and stop points, whereas the distortion in the z direction was influenced by time lag and welding direction. The FEM predicted distortion was compared with experimental measurements and the mechanism of out-of-plane distortion was confirmed.

Out-of-plane shear flow effects on fast magnetic reconnection in a two-dimensional hybrid simulation model

The effects of out-of-plane shear flows on fast magnetic reconnection are numerically investigated by a two- dimensional （2D） hybrid model in an initial Harris sheet equilibrium with flows. The equilibrium and driven shear flows out of the 2D reconnection plane with symmetric and antisymmetric profiles respectively are used in the simulation. It is found that the out-of-plane flows with shears in-plane can change the quadrupolar structure of the out-of-plane magnetic field and, therefore, modify the growth rate of magnetic reconnection. Furthermore, the driven flow varying along the anti-parallel magnetic field can either enhance or reduce the reconnection rate as the direction of flow changes. Secondary islands are also generated in the process with converting the initial X-point into an O-point.

Scalings for the Alfvén-cyclotron instability in a bi-kappa plasma

The particle velocity distribution in space plasma usually exhibits a non-Maxwellian high-energy tail that can be well modeled by kappa distributions.In this study,we focus on the growth rates of the Alfvén-cyclotron instability driven by ion temperature anisotropy in a kappa plasma.By solving the kinetic linear dispersion equation,we explore the sensitivity of growth rates to the spectral indexκof a bi-kappa distribution under different plasma conditions,including a variety of plasma beta β_(hp) and temperature anisotropy A_(hp) values of hot protons.Furthermore,a concise,analytic scaling formula is derived that relates the dimensionless maximum growth rate to three independent variables:the spectral index and the plasma beta and temperature anisotropy of hot protons.Our results show that as theκ-value increases,the instability bandwidth narrows and the maximum growth rate increases significantly.For higherβ_(hp)and A_(hp)′the maximum instability undergoes a sharp increase as well.When our fits of dimensionless maximum growth rates are compared with solutions to kinetic linear dispersion theory,the results generally exhibit good agreement between them.Especially under the circumstances of largeκ-values and highβ_(hp)and A_(hp)′the scalings of maximum growth rates primarily accurately model the numerical solutions.Our analytic expressions can readily be used in large-scale models of the Earth’s magnetosphere to understand wave generation due to the Alfvén-cyclotron instability.