Outlets are a new challenge to the retail industry after the continuous development of the market economy.However,academic research on outlets is very scarce.The purpose of this research is to study the relationship b...Outlets are a new challenge to the retail industry after the continuous development of the market economy.However,academic research on outlets is very scarce.The purpose of this research is to study the relationship between outlets'marketing methods and customer perception.This research cooperates with Shanghai International Fashion Education Center(SIFEC),and conducts convenience sampling on the research objects as the samples.By using quantitative research methods and questionnaire survey tools,the researchers studied the relationships among experience marketing,perceived value,customer satisfaction and loyalty of customers to outlets.The research found that outlets'experience marketing will influence customer perceived value effectively and affect consumer satisfaction and loyalty indirectly.展开更多
The study aimed at analyzing the most important factors affecting the retail marketing of honey in Saudi Arabia. Cross sectional survey was employed using field interview (direct contact) with a random sample of 343 r...The study aimed at analyzing the most important factors affecting the retail marketing of honey in Saudi Arabia. Cross sectional survey was employed using field interview (direct contact) with a random sample of 343 retail outlets represented all its forms and patterns in seven major cities in Saudi Arabia. Measurements like market share, Gini coefficient and Herfindahl Hirschman Index (HHI) were used to estimate the indicators of market structure and its performance. The result showed that the structure of honey retail market is generally closer to pure competition with a small concentration in some areas. Gini coefficients of concentration, as well as the values of the Herfindahl Hirschman Index (HHI) were relatively low for retailers. The average marketing margin was about SAR 6.4/Kg for local honey while the marketing margin of imported honey was about SAR 113/Kg. The high profit margin variation between local and imported honey is due to the high marketing costs, lower supplied quantity and higher demand for local honey. The estimated cost of marketing of onekilogram of honey was about 8 SAR at the retail level. From retailers’ point of view, low quality, lack of marketing services, improper display, high rental property, lack of knowledge and experience of the consumer about properties and quality characteristics honey, high prices and shortage of some varieties of honey in some specific season are the most important problems of honey marketing in the Saudi market. Setting priorities between different brands of honey plays a noticeable role in marketing. Some honey producers and traders were very concerned about unfair competition of honey market through high promotion as a brand based on their long history in the production and supply of high-quality varieties of honey from specific and well-known varieties. Hence, intensive awareness creation effort through training, exhibition, media and advertisement are required to improve the perception of consumers towards the local honey.展开更多
Sub-Saharan African cities are uniquely characterized by retail competition influencing outlet location.This work focused on revealing retail outlet location in Uyo and its relationship with distances from the Central...Sub-Saharan African cities are uniquely characterized by retail competition influencing outlet location.This work focused on revealing retail outlet location in Uyo and its relationship with distances from the Central Business Districts.Distance was measured along the six major arterial roads that link the city to the central business districts by the use of Google Map[5]Distance Calculator and itouch maps[7]technology.Six arteries were divided into four distinct spaces in kilometers namely 0-1km,1-2km,2-3km,3-4km.Retail Outlets were grouped into ten classes.Data was analysed using distance in kilometers from the Central Business District as variable Y1.The independent variables X1,X2,X3,X4,X5 and X6 were the six major arteries represented by the location of each specific retail outlet group.Utilising SPSS version 20 software the results reflected centre a 47.9 percent variation in retail outlets location with correlation coefficient(R)of 69.2%revealing a strong relationship between the distances from the Central Business Districts and the location of retail outlets located across the six major arteries.H1 was accepted which states a significant relationship in the location of retail outlets as distance increase from the city centre across the linkages.This confirms a strong intensity of location of retail outlets in the city centre with a gradual decline as distance increase from the centre.Although there was an increase in intensity of retail outlets in junctions away from the Central Business Districts according to multiple nuclei concept.It is recommended that urban expansion through growth poles.Aim:To access the relationship between retail outlets location and distance from central business district in a Uyo.Research Questions:This work provided answers to the following questions:1.Where are these retail outlets located in the city space?2.What is the relationship between Retail outlets and the distance from the City Centre?Objectives:1.To explain the distribution of location of retail outlets in city space.2.To reveal the relationship between Retail Outlets and distance from the City Centre.Hypothesis:There is no significant relationship between the distance from the central business district and the location of retail outlets.展开更多
Mixed convection of heat and mass transfer in an isosceles trapezoidal cavity has been studied numerically. Constant heat flux is imposed through four outlets and the grid is insulated. The inclined walls are maintain...Mixed convection of heat and mass transfer in an isosceles trapezoidal cavity has been studied numerically. Constant heat flux is imposed through four outlets and the grid is insulated. The inclined walls are maintained in natural convection while the lower horizontal wall is adiabatic. These conditions reflect the air draft zone of the ASUTO charcoal stove. The governing two-di- mensional flow equations have been solved by using the finite difference method and Thomas’s algorithm. The investigations are conducted for different values of Richardson (R<sub>i</sub>), Reynolds number (R<sub>e</sub>) and inclination angles of sidewalls. The results are presented in terms of streamlines, isotherms, moisture contours. It was found that for Reynolds number (R<sub>e</sub>) equal to 100, the flow pattern is strongly dependent on the inclination angle and Richardson number. Thus, for high Richardson number (R<sub>i</sub>) values (10, 100), the dominance of natural convection over the flow structure decreases with the decreasing of the inclination angle of sidewalls of the cavity. For R<sub>i</sub> = 1, an optimum air draft corresponds to an inclination angle in the vicinity of 22° while for R<sub>i</sub> = 10 or 100 (in dominance of natural convection), the optimum inclination angle for air draft is in the vicinity of 15°.展开更多
Snacks are an important part of the catering industry,whose spatial pattern distribution will directly affect the behavior of residents and tourists decision-making.Therefore,this paper chose 'Shaxian snacks' ...Snacks are an important part of the catering industry,whose spatial pattern distribution will directly affect the behavior of residents and tourists decision-making.Therefore,this paper chose 'Shaxian snacks' and 'Chengdu snacks' outlets in the downtown area of Beijing as the research object,taking POI data and GIS spatial data as data sources,using GIS spatial analysis and nuclear density estimation method,to make a comparative analysis of the spatial distribution characteristics of snack outlets in downtown of Beijing.The results showed that(1) distribution characteristics of snacks outlets in each district varied greatly.(2) Distribution differences of both snacks outlets in each circle was in significant.(3) Distribution of snacks outlets from the center to the periphery along the ring roads took on the "pyramid type".(4) Distribution of snacks outlet show stronger proximity to road than to subway.Distribution characteristics of the snack outlets included(1) Spatial distribution of the snacks outlets showed weak centrality.(2) The snacks outlets showed significant characteristics of spatial aggregation with great differences in internal structure.According to the above conclusions,combined with municipal planning,this paper according to the classification of the city,put forward suggestions on the distribution of snack outlets in Beijing,(1) Recombine the snack outlets in old urban districts.(2) According to the city functional orientation,redistribute the snack outlets in new urban districts.展开更多
BACKGROUND Mycobacterium tuberculosis(TB)is the causative agent of TB,a chronic granulo-matous illness.This disease is prevalent in low-income countries,posing a significant global health challenge.Gastrointestinal TB...BACKGROUND Mycobacterium tuberculosis(TB)is the causative agent of TB,a chronic granulo-matous illness.This disease is prevalent in low-income countries,posing a significant global health challenge.Gastrointestinal TB is one of the three forms.The disease can mimic other intra-abdominal conditions,leading to delayed diagnosis owing to the absence of specific symptoms.While gastric outlet obs-truction(GOO)remains a frequent complication,its incidence has declined with the advent of proton pump inhibitors and Helicobacter pylori eradication therapy.Gastroduodenal TB can cause upper gastrointestinal hemorrhage,obstruction,and malignancy-like tumors.CASE SUMMARY A 23-year-old male presented with recurrent epigastric pain,distension,nausea,vomiting,and weight loss,prompting a referral to a gastroenterologist clinic.Endoscopic examination revealed distorted gastric mucosa and signs of chronic inflammation.However,treatment was interrupted,possibly owing to vomiting or comorbidities such as human immunodeficiency virus infection or diabetes.Subsequent surgical intervention revealed a dilated stomach and diffuse thickening of the duodenal wall.Resection revealed gastric wall effacement with TB.CONCLUSION Primary gastric TB is rare,frequently leading to GOO.Given its rarity,suspicions should be promptly raised when encountering relevant symptoms,often requiring surgical intervention for diagnosis and treatment.展开更多
The performance of a water jet propulsion system is related to the inlet duct,rotor,stator,and nozzle.Generally,the flow inlet design must fit the bottom line of the hull,and the design of the inlet duct is often limi...The performance of a water jet propulsion system is related to the inlet duct,rotor,stator,and nozzle.Generally,the flow inlet design must fit the bottom line of the hull,and the design of the inlet duct is often limited by stern space.The entire section,from the rotor to the nozzle through the stator,must be designed based on system integration in that the individual performance of these three components will influence each other.Particularly,the section from the rotor to the nozzle significantly impacts the performance of a water jet propulsion system.This study focused on nozzle design and established referable analysis results to facilitate subsequent integrated studies on the design parameters regarding nozzle contour.Most existing studies concentrate on discussions on rotor design and the tip leakage flow of rotors or have replaced the existing complex computational domain with a simple flow field.However,research has yet to implement an integrated,optimal design of the section from the rotor to the nozzle.Given the above,our program conducted preliminary research on this system integration design issue,discussed the optimal nozzle for this section in-depth,and proposed design suggestions based on the findings.This program used an existing model as the design case.This study referred to the actual trial data as the design conditions for the proposed model.Unlike prior references’simple flow field form,this study added a jet ski geometry and free surface to the computational domain.After the linear hull shape was considered,the inflow in the inlet duct would be closer to the actual condition.Based on the numerical calculation result,this study recommends that the optimal nozzle outlet area should be 37%of the inlet area and that the nozzle contour should be linear.Furthermore,for the pump head,static pressure had a more significant impact than dynamic pressure.展开更多
Objective Bladder outlet obstruction(BOO)results in significant fibrosis in the chronic stage and elevated bladder pressure.Piezo1 is a type of mechanosensitive(MS)channel that directly responds to mechanical stimuli....Objective Bladder outlet obstruction(BOO)results in significant fibrosis in the chronic stage and elevated bladder pressure.Piezo1 is a type of mechanosensitive(MS)channel that directly responds to mechanical stimuli.To identify new targets for intervention in the treatment of BOO-induced fibrosis,this study investigated the impact of high hydrostatic pressure(HHP)on Piezo1 activity and the progression of bladder fibrosis.Methods Immunofluorescence staining was conducted to assess the protein abundance of Piezo1 in fibroblasts from obstructed rat bladders.Bladder fibroblasts were cultured under normal atmospheric conditions(0 cmH_(2)O)or exposed to HHP(50 cmH_(2)O or 100 cmH_(2)O).Agonists or inhibitors of Piezo1,YAP1,and ROCK1 were used to determine the underlying mechanism.Results The Piezo1 protein levels in fibroblasts from the obstructed bladder exhibited an elevation compared to the control group.HHP significantly promoted the expression of various pro-fibrotic factors and induced proliferation of fibroblasts.Additionally,the protein expression levels of Piezo1,YAP1,ROCK1 were elevated,and calcium influx was increased as the pressure increased.These effects were attenuated by the Piezo1 inhibitor Dooku1.The Piezo1 activator Yoda1 induced the expression of pro-fibrotic factors and the proliferation of fibroblasts,and elevated the protein levels of YAP1 and ROCK1 under normal atmospheric conditions in vitro.However,these effects could be partially inhibited by YAP1 or ROCK inhibitors.展开更多
In this editorial,we comment on an article published in a recent issue of the World Journal of Clinical Cases.There is a pressing need for reliable tools for diagnosing tuberculosis(TB)of the gastrointestinal tract.De...In this editorial,we comment on an article published in a recent issue of the World Journal of Clinical Cases.There is a pressing need for reliable tools for diagnosing tuberculosis(TB)of the gastrointestinal tract.Despite advancements in the diagnosis and treatment,TB remains a global health challenge.Ali et al demon-strated that TB may mimic gastrointestinal conditions,such as gastric outlet obstruction,causing a delay in the diagnosis.Furthermore,the latter complication is frequently observed during infections,including Helicobacter pylori,and rarely is related to TB,as in the presented case.In line with this,we think that laboratory tests based on interferon-gamma release assays can be a helpful tool for diagnosing latent TB paced in the gastrointestinal tract.Innovative strategies and approaches for diagnosing latent/active extra pulmonary TB are crucial for establishing the diagnosis early and enhancing treatment strategies to mitigate the global burden of TB.展开更多
Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.A...Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.As a peer-reviewer of World Journal of Clinical Cases,I would like to share my opinion on the article published by this journal.The patient had no family history of TB or contact with people with TB.Primary GD-TB presenting as gastric outlet obstruction and normal findings of thoracic computed tomography increased the difficulty of diagnosis and treatment in this patient.The diagnosis and treatment scheme of this typical case have reference value for the clinical treatment of GD-TB.展开更多
Malignant gastric outlet obstruction(mGOO)is a major condition affecting patients with periampullary tumors,including pancreatic cancer.The current treatment options include surgical gastroenterostomy,endoscopic stent...Malignant gastric outlet obstruction(mGOO)is a major condition affecting patients with periampullary tumors,including pancreatic cancer.The current treatment options include surgical gastroenterostomy,endoscopic stenting and more recently EUS-guided gastroenterostomy.Most studies comparing the outcomes of the three procedures focus on technical success,clinical success and safety.Several“occult”outcomes relevant to the patient’s viewpoints and perspective may ultimately impact on cancer-related and overall survival,such as body mass composition,nutritional biomarkers,chemotherapy tolerance and patient-reported quality of life.The aim of this review is to provide an overview of potential key outcomes that should be explored in future comparative research around mGOO treatment options.展开更多
Naixue,a popular brand of Chinese new-style tea,opened its first Singapore outlet at Jewel Changi Airport this July.It is the company’s second overseas store following a Bangkok branch that opened in December 2023.No...Naixue,a popular brand of Chinese new-style tea,opened its first Singapore outlet at Jewel Changi Airport this July.It is the company’s second overseas store following a Bangkok branch that opened in December 2023.Notably,Naixue’s previous attempts to establish a foothold in Singapore and Japan in 2018 were thwarted by the COVID-19 pandemic,leading to store closures.展开更多
Although some Western officials and media outlets have stepped up their smear campaign against China’s economy and have even sought to crack down on emerging Chinese industries,foreign businesses remain confident in ...Although some Western officials and media outlets have stepped up their smear campaign against China’s economy and have even sought to crack down on emerging Chinese industries,foreign businesses remain confident in the prospect of the Chinese economy and are committed to further expanding in the Chinese market.On May 13,the Global Trade and Investment Promotion Summit 2024 was held in Beijing.Chinese Vice President Han Zheng attended and addressed the opening ceremony.展开更多
This research delves into the hurdles and strategies aimed at augmenting the market involvement of smallholder carrot farmers in Nakuru County, Kenya. Employing a Multinomial Logit (MNL) model, it scrutinizes the fact...This research delves into the hurdles and strategies aimed at augmenting the market involvement of smallholder carrot farmers in Nakuru County, Kenya. Employing a Multinomial Logit (MNL) model, it scrutinizes the factors influencing the selection of marketing outlets among carrot farmers. The findings unveil that a significant majority (81%) of surveyed farmers actively participate in diverse market outlets, encompassing the farm gate, cleaning point, local market, external market, and export market. Notably, pivotal buyers include aggregators, brokers, wholesalers, retailers, and consumers, with transactions predominantly occurring at the farm level. Additionally, the analysis discerns substantial influences of socio-economic characteristics, experiential factors, and geographical proximity on farmers’ choices of market outlets. Specifically, gender, age, land size, farming experience, and distance to markets emerge as critical determinants. Moreover, the study delves into the examination of market margins along the carrot value chain, shedding light on the potential profitability of carrot farming in the region. Remarkably, higher average gross margins are identified in export and external markets, signaling lucrative prospects for farmers targeting these segments. However, disparities in profit distribution between farmers and traders underscore the necessity for interventions to ensure equitable value distribution throughout the value chain. These findings underscore the imperative for tailored interventions to tackle challenges and foster inclusive agricultural development. Strategies such as farmer organizations, contracting, and vertical integration are advocated to enhance market access and profitability for smallholder carrot farmers. Thus, this study enriches our comprehension of the dynamics within carrot value chains and provides valuable insights for policymakers and development practitioners aiming to uplift rural livelihoods and bolster food security.展开更多
BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)has recently emerged as an alternative treatment for gastric outlet obstruction(GOO)in selected patients.AIM To report the initial experience of EUS-GE ...BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)has recently emerged as an alternative treatment for gastric outlet obstruction(GOO)in selected patients.AIM To report the initial experience of EUS-GE in patients with GOO.METHODS This study was a retrospective,observational,multicenter study in which the data from 10 patients who underwent EUS-GE due to GOO between September 2021 and May 2023 were collected.We analyzed technical success,clinical success,adverse events,and survival.Technical success was defined as adequate positioning and deployment of the stent.Clinical success was defined as the patient’s ability to tolerate oral intake without vomiting 7 d after the procedure.Postprocedural adverse events were recorded.RESULTS Eleven procedures in 10 patients with GOO were included.The mean age of the patients was 67.5 years(range:56-77 years).Malignant GOO was present in 9 patients.Technical success was achieved in 9/11 procedures(82%).Among them,clinical success was achieved in 9 patients(100%).Adverse events occurred in 1 patient(9%).The median survival was 3 months(n=7;range:1-8 months).CONCLUSION EUS-GE is a feasible therapeutic option in the treatment of GOO.展开更多
The hydraulic characteristics at the side inlet/outlet of pumped storage plants is studied by numerical simulations,covering the flow distribution,head loss,vortex,and others.Based on the physical model test,the reali...The hydraulic characteristics at the side inlet/outlet of pumped storage plants is studied by numerical simulations,covering the flow distribution,head loss,vortex,and others.Based on the physical model test,the realizable k-εturbulence model is used in the 3-D simulation of the side inlet/outlet.A new scheme is suggested to obtain the uneven flow distribution over three branch orifices.The variation of the free surface with the reservoir water level under the pumped condition is simulated,with results consistent with the experimental results.展开更多
Standpipes,or downcomers,are commonly used in fluidized beds to transport particles.The outlet structure of the downcomer greatly affects the performance of flow from it and even overall reactor performance.In this st...Standpipes,or downcomers,are commonly used in fluidized beds to transport particles.The outlet structure of the downcomer greatly affects the performance of flow from it and even overall reactor performance.In this study,the hydrodynamics in commercial-scale internally circulating fluidized beds(ICFBs)with central downcomers having different outlet structures was investigated using computational fluid dynamics simulations with an energy minimization multi-scale drag model.The predicted results closely agreed with experimental data.Results showed that in an ICFB with a downcomer outlet directly open to the bed(model A),nearly 12.7%to 5.4%of the gas in the draft tube bypasses into the downcomer.In the ICFB models B and C with a conic baffle below the downcomer,the gas bypass is significantly weakened or even eliminated when the diameter of the conic baffle is 1.1 times that of the downcomer(model C).In addition,the solids circulation mass flux in ICFBs increased by about 62.5%,from 126.8 kg/(m2 s)in model A to 206 kg/(m2 s)in model C.展开更多
Since the 8th National Public Ice and Snow Season began,winter sports in Wuhan have significantly gained in popularity and attracted the attention of several state media outlets.
文摘Outlets are a new challenge to the retail industry after the continuous development of the market economy.However,academic research on outlets is very scarce.The purpose of this research is to study the relationship between outlets'marketing methods and customer perception.This research cooperates with Shanghai International Fashion Education Center(SIFEC),and conducts convenience sampling on the research objects as the samples.By using quantitative research methods and questionnaire survey tools,the researchers studied the relationships among experience marketing,perceived value,customer satisfaction and loyalty of customers to outlets.The research found that outlets'experience marketing will influence customer perceived value effectively and affect consumer satisfaction and loyalty indirectly.
文摘The study aimed at analyzing the most important factors affecting the retail marketing of honey in Saudi Arabia. Cross sectional survey was employed using field interview (direct contact) with a random sample of 343 retail outlets represented all its forms and patterns in seven major cities in Saudi Arabia. Measurements like market share, Gini coefficient and Herfindahl Hirschman Index (HHI) were used to estimate the indicators of market structure and its performance. The result showed that the structure of honey retail market is generally closer to pure competition with a small concentration in some areas. Gini coefficients of concentration, as well as the values of the Herfindahl Hirschman Index (HHI) were relatively low for retailers. The average marketing margin was about SAR 6.4/Kg for local honey while the marketing margin of imported honey was about SAR 113/Kg. The high profit margin variation between local and imported honey is due to the high marketing costs, lower supplied quantity and higher demand for local honey. The estimated cost of marketing of onekilogram of honey was about 8 SAR at the retail level. From retailers’ point of view, low quality, lack of marketing services, improper display, high rental property, lack of knowledge and experience of the consumer about properties and quality characteristics honey, high prices and shortage of some varieties of honey in some specific season are the most important problems of honey marketing in the Saudi market. Setting priorities between different brands of honey plays a noticeable role in marketing. Some honey producers and traders were very concerned about unfair competition of honey market through high promotion as a brand based on their long history in the production and supply of high-quality varieties of honey from specific and well-known varieties. Hence, intensive awareness creation effort through training, exhibition, media and advertisement are required to improve the perception of consumers towards the local honey.
文摘Sub-Saharan African cities are uniquely characterized by retail competition influencing outlet location.This work focused on revealing retail outlet location in Uyo and its relationship with distances from the Central Business Districts.Distance was measured along the six major arterial roads that link the city to the central business districts by the use of Google Map[5]Distance Calculator and itouch maps[7]technology.Six arteries were divided into four distinct spaces in kilometers namely 0-1km,1-2km,2-3km,3-4km.Retail Outlets were grouped into ten classes.Data was analysed using distance in kilometers from the Central Business District as variable Y1.The independent variables X1,X2,X3,X4,X5 and X6 were the six major arteries represented by the location of each specific retail outlet group.Utilising SPSS version 20 software the results reflected centre a 47.9 percent variation in retail outlets location with correlation coefficient(R)of 69.2%revealing a strong relationship between the distances from the Central Business Districts and the location of retail outlets located across the six major arteries.H1 was accepted which states a significant relationship in the location of retail outlets as distance increase from the city centre across the linkages.This confirms a strong intensity of location of retail outlets in the city centre with a gradual decline as distance increase from the centre.Although there was an increase in intensity of retail outlets in junctions away from the Central Business Districts according to multiple nuclei concept.It is recommended that urban expansion through growth poles.Aim:To access the relationship between retail outlets location and distance from central business district in a Uyo.Research Questions:This work provided answers to the following questions:1.Where are these retail outlets located in the city space?2.What is the relationship between Retail outlets and the distance from the City Centre?Objectives:1.To explain the distribution of location of retail outlets in city space.2.To reveal the relationship between Retail Outlets and distance from the City Centre.Hypothesis:There is no significant relationship between the distance from the central business district and the location of retail outlets.
文摘Mixed convection of heat and mass transfer in an isosceles trapezoidal cavity has been studied numerically. Constant heat flux is imposed through four outlets and the grid is insulated. The inclined walls are maintained in natural convection while the lower horizontal wall is adiabatic. These conditions reflect the air draft zone of the ASUTO charcoal stove. The governing two-di- mensional flow equations have been solved by using the finite difference method and Thomas’s algorithm. The investigations are conducted for different values of Richardson (R<sub>i</sub>), Reynolds number (R<sub>e</sub>) and inclination angles of sidewalls. The results are presented in terms of streamlines, isotherms, moisture contours. It was found that for Reynolds number (R<sub>e</sub>) equal to 100, the flow pattern is strongly dependent on the inclination angle and Richardson number. Thus, for high Richardson number (R<sub>i</sub>) values (10, 100), the dominance of natural convection over the flow structure decreases with the decreasing of the inclination angle of sidewalls of the cavity. For R<sub>i</sub> = 1, an optimum air draft corresponds to an inclination angle in the vicinity of 22° while for R<sub>i</sub> = 10 or 100 (in dominance of natural convection), the optimum inclination angle for air draft is in the vicinity of 15°.
基金Sponsored by Connotative Development-2018 Undergraduate Teaching Construction and Reform Project of College of Resource Environment and Tourism,Capital Normal University
文摘Snacks are an important part of the catering industry,whose spatial pattern distribution will directly affect the behavior of residents and tourists decision-making.Therefore,this paper chose 'Shaxian snacks' and 'Chengdu snacks' outlets in the downtown area of Beijing as the research object,taking POI data and GIS spatial data as data sources,using GIS spatial analysis and nuclear density estimation method,to make a comparative analysis of the spatial distribution characteristics of snack outlets in downtown of Beijing.The results showed that(1) distribution characteristics of snacks outlets in each district varied greatly.(2) Distribution differences of both snacks outlets in each circle was in significant.(3) Distribution of snacks outlets from the center to the periphery along the ring roads took on the "pyramid type".(4) Distribution of snacks outlet show stronger proximity to road than to subway.Distribution characteristics of the snack outlets included(1) Spatial distribution of the snacks outlets showed weak centrality.(2) The snacks outlets showed significant characteristics of spatial aggregation with great differences in internal structure.According to the above conclusions,combined with municipal planning,this paper according to the classification of the city,put forward suggestions on the distribution of snack outlets in Beijing,(1) Recombine the snack outlets in old urban districts.(2) According to the city functional orientation,redistribute the snack outlets in new urban districts.
文摘BACKGROUND Mycobacterium tuberculosis(TB)is the causative agent of TB,a chronic granulo-matous illness.This disease is prevalent in low-income countries,posing a significant global health challenge.Gastrointestinal TB is one of the three forms.The disease can mimic other intra-abdominal conditions,leading to delayed diagnosis owing to the absence of specific symptoms.While gastric outlet obs-truction(GOO)remains a frequent complication,its incidence has declined with the advent of proton pump inhibitors and Helicobacter pylori eradication therapy.Gastroduodenal TB can cause upper gastrointestinal hemorrhage,obstruction,and malignancy-like tumors.CASE SUMMARY A 23-year-old male presented with recurrent epigastric pain,distension,nausea,vomiting,and weight loss,prompting a referral to a gastroenterologist clinic.Endoscopic examination revealed distorted gastric mucosa and signs of chronic inflammation.However,treatment was interrupted,possibly owing to vomiting or comorbidities such as human immunodeficiency virus infection or diabetes.Subsequent surgical intervention revealed a dilated stomach and diffuse thickening of the duodenal wall.Resection revealed gastric wall effacement with TB.CONCLUSION Primary gastric TB is rare,frequently leading to GOO.Given its rarity,suspicions should be promptly raised when encountering relevant symptoms,often requiring surgical intervention for diagnosis and treatment.
基金the financial support from the National Science and Technology Council,Taiwan(Grant No.MOST 111-2221-E-019-035-).
文摘The performance of a water jet propulsion system is related to the inlet duct,rotor,stator,and nozzle.Generally,the flow inlet design must fit the bottom line of the hull,and the design of the inlet duct is often limited by stern space.The entire section,from the rotor to the nozzle through the stator,must be designed based on system integration in that the individual performance of these three components will influence each other.Particularly,the section from the rotor to the nozzle significantly impacts the performance of a water jet propulsion system.This study focused on nozzle design and established referable analysis results to facilitate subsequent integrated studies on the design parameters regarding nozzle contour.Most existing studies concentrate on discussions on rotor design and the tip leakage flow of rotors or have replaced the existing complex computational domain with a simple flow field.However,research has yet to implement an integrated,optimal design of the section from the rotor to the nozzle.Given the above,our program conducted preliminary research on this system integration design issue,discussed the optimal nozzle for this section in-depth,and proposed design suggestions based on the findings.This program used an existing model as the design case.This study referred to the actual trial data as the design conditions for the proposed model.Unlike prior references’simple flow field form,this study added a jet ski geometry and free surface to the computational domain.After the linear hull shape was considered,the inflow in the inlet duct would be closer to the actual condition.Based on the numerical calculation result,this study recommends that the optimal nozzle outlet area should be 37%of the inlet area and that the nozzle contour should be linear.Furthermore,for the pump head,static pressure had a more significant impact than dynamic pressure.
基金supported by grants from the National Natural Science Foundation of China(No.82270812)Medical Innovation and Transformation Incubation Project of Tongji Hospital(No.2022ZHFY11).
文摘Objective Bladder outlet obstruction(BOO)results in significant fibrosis in the chronic stage and elevated bladder pressure.Piezo1 is a type of mechanosensitive(MS)channel that directly responds to mechanical stimuli.To identify new targets for intervention in the treatment of BOO-induced fibrosis,this study investigated the impact of high hydrostatic pressure(HHP)on Piezo1 activity and the progression of bladder fibrosis.Methods Immunofluorescence staining was conducted to assess the protein abundance of Piezo1 in fibroblasts from obstructed rat bladders.Bladder fibroblasts were cultured under normal atmospheric conditions(0 cmH_(2)O)or exposed to HHP(50 cmH_(2)O or 100 cmH_(2)O).Agonists or inhibitors of Piezo1,YAP1,and ROCK1 were used to determine the underlying mechanism.Results The Piezo1 protein levels in fibroblasts from the obstructed bladder exhibited an elevation compared to the control group.HHP significantly promoted the expression of various pro-fibrotic factors and induced proliferation of fibroblasts.Additionally,the protein expression levels of Piezo1,YAP1,ROCK1 were elevated,and calcium influx was increased as the pressure increased.These effects were attenuated by the Piezo1 inhibitor Dooku1.The Piezo1 activator Yoda1 induced the expression of pro-fibrotic factors and the proliferation of fibroblasts,and elevated the protein levels of YAP1 and ROCK1 under normal atmospheric conditions in vitro.However,these effects could be partially inhibited by YAP1 or ROCK inhibitors.
基金The European Union-Next Generation EU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,Project,No.BG-RRP-2.004-0008.
文摘In this editorial,we comment on an article published in a recent issue of the World Journal of Clinical Cases.There is a pressing need for reliable tools for diagnosing tuberculosis(TB)of the gastrointestinal tract.Despite advancements in the diagnosis and treatment,TB remains a global health challenge.Ali et al demon-strated that TB may mimic gastrointestinal conditions,such as gastric outlet obstruction,causing a delay in the diagnosis.Furthermore,the latter complication is frequently observed during infections,including Helicobacter pylori,and rarely is related to TB,as in the presented case.In line with this,we think that laboratory tests based on interferon-gamma release assays can be a helpful tool for diagnosing latent TB paced in the gastrointestinal tract.Innovative strategies and approaches for diagnosing latent/active extra pulmonary TB are crucial for establishing the diagnosis early and enhancing treatment strategies to mitigate the global burden of TB.
基金Supported by Shenyang Science and Technology Plan Project,No.23-408-3-01The Natural Science Foundation of Liaoning Province,No.2022-MS-435.
文摘Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.As a peer-reviewer of World Journal of Clinical Cases,I would like to share my opinion on the article published by this journal.The patient had no family history of TB or contact with people with TB.Primary GD-TB presenting as gastric outlet obstruction and normal findings of thoracic computed tomography increased the difficulty of diagnosis and treatment in this patient.The diagnosis and treatment scheme of this typical case have reference value for the clinical treatment of GD-TB.
文摘Malignant gastric outlet obstruction(mGOO)is a major condition affecting patients with periampullary tumors,including pancreatic cancer.The current treatment options include surgical gastroenterostomy,endoscopic stenting and more recently EUS-guided gastroenterostomy.Most studies comparing the outcomes of the three procedures focus on technical success,clinical success and safety.Several“occult”outcomes relevant to the patient’s viewpoints and perspective may ultimately impact on cancer-related and overall survival,such as body mass composition,nutritional biomarkers,chemotherapy tolerance and patient-reported quality of life.The aim of this review is to provide an overview of potential key outcomes that should be explored in future comparative research around mGOO treatment options.
文摘Naixue,a popular brand of Chinese new-style tea,opened its first Singapore outlet at Jewel Changi Airport this July.It is the company’s second overseas store following a Bangkok branch that opened in December 2023.Notably,Naixue’s previous attempts to establish a foothold in Singapore and Japan in 2018 were thwarted by the COVID-19 pandemic,leading to store closures.
文摘Although some Western officials and media outlets have stepped up their smear campaign against China’s economy and have even sought to crack down on emerging Chinese industries,foreign businesses remain confident in the prospect of the Chinese economy and are committed to further expanding in the Chinese market.On May 13,the Global Trade and Investment Promotion Summit 2024 was held in Beijing.Chinese Vice President Han Zheng attended and addressed the opening ceremony.
文摘This research delves into the hurdles and strategies aimed at augmenting the market involvement of smallholder carrot farmers in Nakuru County, Kenya. Employing a Multinomial Logit (MNL) model, it scrutinizes the factors influencing the selection of marketing outlets among carrot farmers. The findings unveil that a significant majority (81%) of surveyed farmers actively participate in diverse market outlets, encompassing the farm gate, cleaning point, local market, external market, and export market. Notably, pivotal buyers include aggregators, brokers, wholesalers, retailers, and consumers, with transactions predominantly occurring at the farm level. Additionally, the analysis discerns substantial influences of socio-economic characteristics, experiential factors, and geographical proximity on farmers’ choices of market outlets. Specifically, gender, age, land size, farming experience, and distance to markets emerge as critical determinants. Moreover, the study delves into the examination of market margins along the carrot value chain, shedding light on the potential profitability of carrot farming in the region. Remarkably, higher average gross margins are identified in export and external markets, signaling lucrative prospects for farmers targeting these segments. However, disparities in profit distribution between farmers and traders underscore the necessity for interventions to ensure equitable value distribution throughout the value chain. These findings underscore the imperative for tailored interventions to tackle challenges and foster inclusive agricultural development. Strategies such as farmer organizations, contracting, and vertical integration are advocated to enhance market access and profitability for smallholder carrot farmers. Thus, this study enriches our comprehension of the dynamics within carrot value chains and provides valuable insights for policymakers and development practitioners aiming to uplift rural livelihoods and bolster food security.
文摘BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)has recently emerged as an alternative treatment for gastric outlet obstruction(GOO)in selected patients.AIM To report the initial experience of EUS-GE in patients with GOO.METHODS This study was a retrospective,observational,multicenter study in which the data from 10 patients who underwent EUS-GE due to GOO between September 2021 and May 2023 were collected.We analyzed technical success,clinical success,adverse events,and survival.Technical success was defined as adequate positioning and deployment of the stent.Clinical success was defined as the patient’s ability to tolerate oral intake without vomiting 7 d after the procedure.Postprocedural adverse events were recorded.RESULTS Eleven procedures in 10 patients with GOO were included.The mean age of the patients was 67.5 years(range:56-77 years).Malignant GOO was present in 9 patients.Technical success was achieved in 9/11 procedures(82%).Among them,clinical success was achieved in 9 patients(100%).Adverse events occurred in 1 patient(9%).The median survival was 3 months(n=7;range:1-8 months).CONCLUSION EUS-GE is a feasible therapeutic option in the treatment of GOO.
基金Project supported by the National Natural Science Foundation of China (Grant No. 50579048)
文摘The hydraulic characteristics at the side inlet/outlet of pumped storage plants is studied by numerical simulations,covering the flow distribution,head loss,vortex,and others.Based on the physical model test,the realizable k-εturbulence model is used in the 3-D simulation of the side inlet/outlet.A new scheme is suggested to obtain the uneven flow distribution over three branch orifices.The variation of the free surface with the reservoir water level under the pumped condition is simulated,with results consistent with the experimental results.
文摘Standpipes,or downcomers,are commonly used in fluidized beds to transport particles.The outlet structure of the downcomer greatly affects the performance of flow from it and even overall reactor performance.In this study,the hydrodynamics in commercial-scale internally circulating fluidized beds(ICFBs)with central downcomers having different outlet structures was investigated using computational fluid dynamics simulations with an energy minimization multi-scale drag model.The predicted results closely agreed with experimental data.Results showed that in an ICFB with a downcomer outlet directly open to the bed(model A),nearly 12.7%to 5.4%of the gas in the draft tube bypasses into the downcomer.In the ICFB models B and C with a conic baffle below the downcomer,the gas bypass is significantly weakened or even eliminated when the diameter of the conic baffle is 1.1 times that of the downcomer(model C).In addition,the solids circulation mass flux in ICFBs increased by about 62.5%,from 126.8 kg/(m2 s)in model A to 206 kg/(m2 s)in model C.
文摘Since the 8th National Public Ice and Snow Season began,winter sports in Wuhan have significantly gained in popularity and attracted the attention of several state media outlets.