BACKGROUND Cardiogenic shock (CS) secondary to acute myocardial infarction (AMI) complicates management of the condition, and often leads to poor prognosis. Prompt and accurate monitoring of cardiovascular and accompa...BACKGROUND Cardiogenic shock (CS) secondary to acute myocardial infarction (AMI) complicates management of the condition, and often leads to poor prognosis. Prompt and accurate monitoring of cardiovascular and accompanying hemodynamic changes is crucial in achieving adequate management of the condition. Advances in technology has availed procedures such as pulse index continuous cardiac output (PiCCO), which can offer precise monitoring of cardiovascular functions and hemodynamic parameters. In this study, PiCCO is evaluated for its potential utility in improving management and clinical outcomes among elderly patients with AMI complicated by CS. AIM To assess whether use of the PiCCO system can improve clinical outcomes in elderly patients with AMI complicated by CS.METHODS Patients from emergency intensive care units (EICU) or coronary care units (CCU) were randomized to receive PiCCO monitoring or not. The APACHE II score, SOFA score, hs-TnI, NT-proBNP, PaO2/FiO2 ratio and lactate levels on day 1, 3 and 7 after treatment were compared. The infusion and urine volume at 0-24 h, 24-48 h and 48-72 h were recorded, as were the cardiac index (CI), extravascular lung water index (EVLWI), intrathoracic blood volume index (ITBVI) and global end diastolic volume index (GEDVI) at similar time intervals. RESULTS Sixty patients with AMI complicated by CS were included in the study. The PiCCO group had a significantly lower APACHE II score, SOFA score, hs-TnI and NT-proBNP levels on day 1, 3 and 7 after treatment. The infusion and urine volume during 0-24 h in the PiCCO group were significantly greater, and this group also showed significantly higher ADL scores. Furthermore, the PiCCO group spent lesser days on vasoactive agents, mechanical ventilation, and had a reduced length of stay in EICU/CCU. Additionally, the CI was significantly higher at 48 h and 72 h in the PiCCO group compared with that at 24 h, and the EVLWI, ITBVI and GEDVI were significantly decreased at 48 h and 72 h. CONCLUSION Applying the PiCCO system could improve the clinical outcomes of elderly patients with AMI complicated by CS.展开更多
<strong>Background</strong><strong>:</strong><b><span style="font-family:;" "=""> </span></b><span style="font-family:;" "=&qu...<strong>Background</strong><strong>:</strong><b><span style="font-family:;" "=""> </span></b><span style="font-family:;" "=""><span style="font-family:Verdana;">Septic shock is a rapidly changing and fatal syndrome that can </span><span style="font-family:Verdana;">cause comprehensive deterioration of cardiopulmonary and renal function and multiple organ failure. At the same time, septic shock has the complex clinical manifestations and hemodynamics. PiCCO can accurately </span><span style="font-family:Verdana;">monitor blood flow, physical and volume indicators, and active and effective fluid resuscitation are important measures to reduce the fatality rate of septic shock and improve the prognosis of patients. </span><b><span style="font-family:Verdana;">Objectives: </span></b><span style="font-family:Verdana;">To explore the application an</span><span style="font-family:Verdana;">d nursing of PiCCO in early fluid resuscitation in patie</span><span style="font-family:Verdana;">nts with septic shock. </span><b><span style="font-family:Verdana;">Me</span><span style="font-family:Verdana;">thods:</span></b><span style="font-family:Verdana;"> This was a retrospective observ</span><span style="font-family:Verdana;">ational study. The observation group and the control group each had 30 cases. The observation group used PiCCO to guide fluid resuscitation;the control group used conventional methods to guide fluid resuscitation.</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">The changes in CVP, HR, MAP, and urine volume per hour were observed in the two groups. The changes of various indicators before and after fluid resuscitation, the length of stay in ICU and the mortality rate were compared between the two groups. All the outcomes were collected from the electronic medical case system after patients’ discharge from the hospital. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">APACHE </span></span><span style="font-family:Verdana;">II</span><span style="font-family:;" "=""><span style="font-family:Verdana;">, CVP, HR, MAP were compared between th</span><span style="font-family:Verdana;">e obse</span><span style="font-family:Verdana;">rvation group and th</span></span><span style="font-family:;" "=""><span style="font-family:Verdana;">e control group, and the differences w</span><span><span style="font-family:Verdana;">ere statistically significant (</span><i><span style="font-family:Verdana;">P</span></i></span></span><i><span style="font-family:;" "=""> </span></i><span style="font-family:Verdana;"><</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.05). The blood volume of patients in the observatio</span><span style="font-family:;" "=""><span style="font-family:Verdana;">n group was significantly improved after fluid supplementation</span><span><span style="font-family:Verdana;"> (</span><i><span style="font-family:Verdana;">P</span></i></span></span><i><span style="font-family:;" "=""> </span></i><span style="font-family:Verdana;"><</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">0.05). Compared with the control group, the length of stay in ICU in the observation group was significantly shorter, and the mortality rate was also significantly reduced</span><span style="font-family:Verdana;"> (</span><i><span style="font-family:Verdana;">P</span></i></span><span> </span><span style="font-family:Verdana;"><</span><span> </span><span style="font-family:Verdana;">0.05</span><span><span style="font-family:Verdana;">). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> PiCCO can be better used in early fluid resuscitation of patients with septic shock.</span></span>展开更多
“双碳”目标下,各类可再生能源发电技术发展迅速,综合权衡不同可再生能源发电方案的综合效益对可再生能源的优化设计具有重要意义。综合考虑经济效益、环境效益、能源效益和社会效益4个层面,提出了一种基于模糊决策试验和评价实验(deci...“双碳”目标下,各类可再生能源发电技术发展迅速,综合权衡不同可再生能源发电方案的综合效益对可再生能源的优化设计具有重要意义。综合考虑经济效益、环境效益、能源效益和社会效益4个层面,提出了一种基于模糊决策试验和评价实验(decision making trial and evaluation laboratory,DEMATEL)与超效率数据包络分析(data envelopment analysis,DEA)模型的可再生能源发电技术综合效益评估方法。该方法分为投入-产出指标体系构建和综合评估2个阶段。首先,利用三角直觉模糊数处理模糊评价信息,将其与DEMATEL相结合量化各指标之间相互影响关系,基于指标间逻辑分析结果建立投入-产出评估指标体系。然后,基于超效率DEA模型对各可再生能源发电方案进行评估排序,结合投入冗余和产出不足分析结果给出各方案的针对性改善建议,以期为进一步选择和确定可再生能源产业发展战略提供参考。最后以某省10类可再生能源发电单元为研究对象,基于所提研究方法进行综合评估和分析,并与多准则妥协解排序法和熵权法进行对比分析,验证了所提方法的有效性。展开更多
文摘BACKGROUND Cardiogenic shock (CS) secondary to acute myocardial infarction (AMI) complicates management of the condition, and often leads to poor prognosis. Prompt and accurate monitoring of cardiovascular and accompanying hemodynamic changes is crucial in achieving adequate management of the condition. Advances in technology has availed procedures such as pulse index continuous cardiac output (PiCCO), which can offer precise monitoring of cardiovascular functions and hemodynamic parameters. In this study, PiCCO is evaluated for its potential utility in improving management and clinical outcomes among elderly patients with AMI complicated by CS. AIM To assess whether use of the PiCCO system can improve clinical outcomes in elderly patients with AMI complicated by CS.METHODS Patients from emergency intensive care units (EICU) or coronary care units (CCU) were randomized to receive PiCCO monitoring or not. The APACHE II score, SOFA score, hs-TnI, NT-proBNP, PaO2/FiO2 ratio and lactate levels on day 1, 3 and 7 after treatment were compared. The infusion and urine volume at 0-24 h, 24-48 h and 48-72 h were recorded, as were the cardiac index (CI), extravascular lung water index (EVLWI), intrathoracic blood volume index (ITBVI) and global end diastolic volume index (GEDVI) at similar time intervals. RESULTS Sixty patients with AMI complicated by CS were included in the study. The PiCCO group had a significantly lower APACHE II score, SOFA score, hs-TnI and NT-proBNP levels on day 1, 3 and 7 after treatment. The infusion and urine volume during 0-24 h in the PiCCO group were significantly greater, and this group also showed significantly higher ADL scores. Furthermore, the PiCCO group spent lesser days on vasoactive agents, mechanical ventilation, and had a reduced length of stay in EICU/CCU. Additionally, the CI was significantly higher at 48 h and 72 h in the PiCCO group compared with that at 24 h, and the EVLWI, ITBVI and GEDVI were significantly decreased at 48 h and 72 h. CONCLUSION Applying the PiCCO system could improve the clinical outcomes of elderly patients with AMI complicated by CS.
文摘<strong>Background</strong><strong>:</strong><b><span style="font-family:;" "=""> </span></b><span style="font-family:;" "=""><span style="font-family:Verdana;">Septic shock is a rapidly changing and fatal syndrome that can </span><span style="font-family:Verdana;">cause comprehensive deterioration of cardiopulmonary and renal function and multiple organ failure. At the same time, septic shock has the complex clinical manifestations and hemodynamics. PiCCO can accurately </span><span style="font-family:Verdana;">monitor blood flow, physical and volume indicators, and active and effective fluid resuscitation are important measures to reduce the fatality rate of septic shock and improve the prognosis of patients. </span><b><span style="font-family:Verdana;">Objectives: </span></b><span style="font-family:Verdana;">To explore the application an</span><span style="font-family:Verdana;">d nursing of PiCCO in early fluid resuscitation in patie</span><span style="font-family:Verdana;">nts with septic shock. </span><b><span style="font-family:Verdana;">Me</span><span style="font-family:Verdana;">thods:</span></b><span style="font-family:Verdana;"> This was a retrospective observ</span><span style="font-family:Verdana;">ational study. The observation group and the control group each had 30 cases. The observation group used PiCCO to guide fluid resuscitation;the control group used conventional methods to guide fluid resuscitation.</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">The changes in CVP, HR, MAP, and urine volume per hour were observed in the two groups. The changes of various indicators before and after fluid resuscitation, the length of stay in ICU and the mortality rate were compared between the two groups. All the outcomes were collected from the electronic medical case system after patients’ discharge from the hospital. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">APACHE </span></span><span style="font-family:Verdana;">II</span><span style="font-family:;" "=""><span style="font-family:Verdana;">, CVP, HR, MAP were compared between th</span><span style="font-family:Verdana;">e obse</span><span style="font-family:Verdana;">rvation group and th</span></span><span style="font-family:;" "=""><span style="font-family:Verdana;">e control group, and the differences w</span><span><span style="font-family:Verdana;">ere statistically significant (</span><i><span style="font-family:Verdana;">P</span></i></span></span><i><span style="font-family:;" "=""> </span></i><span style="font-family:Verdana;"><</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.05). The blood volume of patients in the observatio</span><span style="font-family:;" "=""><span style="font-family:Verdana;">n group was significantly improved after fluid supplementation</span><span><span style="font-family:Verdana;"> (</span><i><span style="font-family:Verdana;">P</span></i></span></span><i><span style="font-family:;" "=""> </span></i><span style="font-family:Verdana;"><</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">0.05). Compared with the control group, the length of stay in ICU in the observation group was significantly shorter, and the mortality rate was also significantly reduced</span><span style="font-family:Verdana;"> (</span><i><span style="font-family:Verdana;">P</span></i></span><span> </span><span style="font-family:Verdana;"><</span><span> </span><span style="font-family:Verdana;">0.05</span><span><span style="font-family:Verdana;">). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> PiCCO can be better used in early fluid resuscitation of patients with septic shock.</span></span>
文摘“双碳”目标下,各类可再生能源发电技术发展迅速,综合权衡不同可再生能源发电方案的综合效益对可再生能源的优化设计具有重要意义。综合考虑经济效益、环境效益、能源效益和社会效益4个层面,提出了一种基于模糊决策试验和评价实验(decision making trial and evaluation laboratory,DEMATEL)与超效率数据包络分析(data envelopment analysis,DEA)模型的可再生能源发电技术综合效益评估方法。该方法分为投入-产出指标体系构建和综合评估2个阶段。首先,利用三角直觉模糊数处理模糊评价信息,将其与DEMATEL相结合量化各指标之间相互影响关系,基于指标间逻辑分析结果建立投入-产出评估指标体系。然后,基于超效率DEA模型对各可再生能源发电方案进行评估排序,结合投入冗余和产出不足分析结果给出各方案的针对性改善建议,以期为进一步选择和确定可再生能源产业发展战略提供参考。最后以某省10类可再生能源发电单元为研究对象,基于所提研究方法进行综合评估和分析,并与多准则妥协解排序法和熵权法进行对比分析,验证了所提方法的有效性。