We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group ...We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.展开更多
目的调查成人超重、肥胖的发生率,探讨体重指数(BMI)、体脂百分比(PBF)、腰臀比(WHR)与超重、肥胖之间的关系。方法对111名成人用In Body 3.0人体成分分析仪随机进行人体成分测试,分析他们体重指数、体脂分布、体脂百分比情况。结果男...目的调查成人超重、肥胖的发生率,探讨体重指数(BMI)、体脂百分比(PBF)、腰臀比(WHR)与超重、肥胖之间的关系。方法对111名成人用In Body 3.0人体成分分析仪随机进行人体成分测试,分析他们体重指数、体脂分布、体脂百分比情况。结果男女超重率63.06%,肥胖率19.82%。男女腰臀比及体脂肪比率超标分别占70.27%、72.07%。不同BMI和不同年龄的男性和女性腰臀比都有显著性差异(P<0.01)。不同BMI男性体脂百分比有显著差异(P<0.05),女性有显著性差异(P<0.01)。不同年龄男性和女性体脂百分比有差异(P<0.05)。结论体重指数的增加主要是脂肪增加造成的,而体内的脂肪又主要堆积在腹部。超重、肥胖情况较严重、体脂分布不合理、体内脂肪含量过高需引起重视,应采取各种措施以减少由超重带来的一系列问题。展开更多
基金supported by National High-Tech Research and Development Program of China (No.2006AA02A406)Natural Science Foundation of China (No.30871042)
文摘We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.
文摘目的调查成人超重、肥胖的发生率,探讨体重指数(BMI)、体脂百分比(PBF)、腰臀比(WHR)与超重、肥胖之间的关系。方法对111名成人用In Body 3.0人体成分分析仪随机进行人体成分测试,分析他们体重指数、体脂分布、体脂百分比情况。结果男女超重率63.06%,肥胖率19.82%。男女腰臀比及体脂肪比率超标分别占70.27%、72.07%。不同BMI和不同年龄的男性和女性腰臀比都有显著性差异(P<0.01)。不同BMI男性体脂百分比有显著差异(P<0.05),女性有显著性差异(P<0.01)。不同年龄男性和女性体脂百分比有差异(P<0.05)。结论体重指数的增加主要是脂肪增加造成的,而体内的脂肪又主要堆积在腹部。超重、肥胖情况较严重、体脂分布不合理、体内脂肪含量过高需引起重视,应采取各种措施以减少由超重带来的一系列问题。
