An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described.This cyclic reaction could be performed efficiently...An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described.This cyclic reaction could be performed efficiently under metal free conditions.Various products with functional groups could be obtained with moderate to high yields via radical mechanism.展开更多
Hydrazones of poorly studied fluorine-containing oxamic acid thiohydrazides were synthesized by the reaction with salicylaldehydes. Tests showed that the newly synthesized compounds were effective low-toxic inhibitors...Hydrazones of poorly studied fluorine-containing oxamic acid thiohydrazides were synthesized by the reaction with salicylaldehydes. Tests showed that the newly synthesized compounds were effective low-toxic inhibitors of type III secretion system in Chlamydia trachomatis.展开更多
基金supported by the National Natural Science Foundation of China(No.21772107)Shandong Province Key Research and Development Plan(No.2019GSF108017)。
文摘An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described.This cyclic reaction could be performed efficiently under metal free conditions.Various products with functional groups could be obtained with moderate to high yields via radical mechanism.
文摘Hydrazones of poorly studied fluorine-containing oxamic acid thiohydrazides were synthesized by the reaction with salicylaldehydes. Tests showed that the newly synthesized compounds were effective low-toxic inhibitors of type III secretion system in Chlamydia trachomatis.
