A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ^1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacte...A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ^1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus（MRSA） and vancomycin-resistant Enterococcus（VRE） by minimum inhibitory concentration（MIC） assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.展开更多
文摘A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ^1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus（MRSA） and vancomycin-resistant Enterococcus（VRE） by minimum inhibitory concentration（MIC） assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.
