Studies on the Preparation of Bioactive Oligomerstilbene by Oxidative Coupling Reaction(Ⅰ)-Preparation of Shegansu B using Silver Oxide as Oxidant

篢he oxidative coupling reaction of isorhapontigenin using sliver oxide as oxidant afforded a major product, named shegansu B（2）， which was isolated from the roots of Belamcanda chinensis (L．)DC. Both the natural and synthetic Shegansu B have the same potent antagonism activities of leukotriene B4，D4 receptor．

Oxidative coupling of α-bromoarylacetonitriles and oxidative decyanation of diarylacetonitriles catalyzed by solid-liquid phase transfer

Oxidative coupling of α-bromoarylacetonitriles and oxidative decyanation of diarylacetonitriles are efficiently realized by solid-liquid phase transfer catalysis using anhydrous K 3 PO 4 as base and TBAB as catalyst in acetone at room temperature. In this mild and convenient method, α,β-dicyanostilbenes and diarylketones were prepared in good to excellent yields.

Synthesis of Amurensin H, a New Resveratrol Dimer from the Roots of Vitis Amurensis

Amurensin H(1) is a new resveratrol dimer isolated from the roots of Vitis amurensis Rupr. Its structure was determined by spectroscopic methods. II was synthesized from resveratrol with an oxidative coupling reaction as a key step.

Biomimetic synthesis of active stilbenolignan derivatives by oxidative coupling and acid-catalyzed polymerization

Two new stilbenolignans and one novel lactone stilbenolignan with a seven-membered ring were biomimetically synthesized by an oxidative coupling reaction and acid-catalyzed polymerization with either isorhapontigenin and ferulic acid or sinapinic acid,respectively,as the starting materials.The structures of the stilbenolignans were defined using spectral analysis and their mechanisms of formation are discussed.Anti-oxidant and anti-inflammatory activities of the novel stilbenolignans were tested,and the lactone stilbenolignan was observed to exhibit potent anti-oxidant activity.

The First Total Synthesis of the （±）-Palstatin

The first total synthesis of （±）-palstatin was achieved from commercially available 5-bromovanallin and 2,4,6-trihydroxyacetophenone. SeO2 promoted oxidative cyclization reaction and Ag20 catalyzed oxidative coupling reaction served as the key steps in the synthesis successfully.

Facile synthesis and excellent catalytic activity of gold nanoparticles on graphene oxide

For the first time,Au nanoparticles on graphene oxide（GO-AuNPs） were successfully fabricated without applying any additional reductants,just by the redox reaction between AuCl_4^（-1） and GO.Their structure was characterized by transmission electron microscopy and X-ray powder diffraction.The results show that flower-like AuNPs were successfully dispersed on GO surface.Importantly,they showed a high catalytic activity for the Suzuki-Miyaura coupling reaction in an aqueous medium.

First synthesis and in vitro biological assessment of isosideroxylin,6,8-dimethylgenistein and their analogues as nitric oxide production inhibition agents

A modular and efficient synthesis of the biologically significant C-methylisoflavones isosideroxylin（1）,6,8-dimethylgenistein（2） and their analogues（3-8） is established for the first time.The synthesis is realized in 7-8 steps in overall yields of 16%-24%from commercially inexpensive phloroglucinol and features a high yielding Vilsmeier-Haack reaction,Friedel-Crafts acylation,Gammill＇s protocol and Suzuki coupling as the pivotal transformations.Next,these compounds evaluated for their inhibitory potency on the production of nitric oxide（NO） in lipopolysaccharide（LPS）-activated RAW-264.7 cells as an indicator of anti-inflammatory activity.The results showed that all the compounds decreased NO production in a dose-dependent manner without marked cytotoxicity and IC_（50） values are found in the range of 10.17-33.88 μmol/L.Of note,compounds 3 followed by 1,7 and 8 show comparable inhibitory activity with positive control（N-monomethyl-L-arginine,L-NMMA）.