期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes 被引量:7
1
作者 Bingbing Lin Hongying Su +7 位作者 Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai 《Science Bulletin》 SCIE EI CAS CSCD 2015年第14期1272-1280,共9页
Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanoc... Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles (SPIO) was prepared for drug delivery and magnetic resonance imaging (MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L^-1. Doxorubicin (DOX) and a cluster of the manganese-doped iron oxide nanoparticles (Mn-SPIO) nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplat- lk)rm for the delivery of anticancer drug DOX with a loading content (DLC) of 16 %. Confocal laser scanning microscopy reveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with flee DOX.HCI. Under a 3.0-T MRI scanner, Mn-SPIO/ DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation (T2) rate is also significantly higher than that of the control cells (33.9 versus 2.3 s^-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. 展开更多
关键词 Dextran micelle - Drug delivery systemSuperparamagnetic iron oxide Multifunctionalnanoparticles Magnetic resonance imaging
原文传递
Organic reactions in chiral micelles 7.The structural effects on the asymmetric oxidation of prochiral sulfides in chiral micelles
2
作者 ZHANG,Yong-Min FU,Chun-Ling FAN,Wei-Qiang Department of Chemistry,Hangzhou University,Hangzhou 310028 《Chinese Journal of Chemistry》 SCIE CAS CSCD 1990年第1期89-96,共0页
A variety of phenyl alkyl sulfides were oxidized enantioselectively with NaIO_4 in chiral micellar systems formed from eight chiral surfactants,to give optical active sulfoxides.The enantiomer excesses ranged from 1.6... A variety of phenyl alkyl sulfides were oxidized enantioselectively with NaIO_4 in chiral micellar systems formed from eight chiral surfactants,to give optical active sulfoxides.The enantiomer excesses ranged from 1.6 to 15.0%.To understand the mechanistic detail of this asymmetric oxi- dation in chiral micelle,the effects of structure both in substrates and surfactants on the optical yield of the oxidation were studied and discussed.Generally,increasing the alkyl chain length both in sur- factants and in substrates enhances the optical yield,also the surfactant with hydroxy group at its appropriate position gives better enantioselectivity,suggesting the enzymic characteristics of the chiral micelle. 展开更多
关键词 Organic reactions in chiral micelles 7.The structural effects on the asymmetric oxidation of prochiral sulfides in chiral micelles
全文增补中
上一页 1 下一页 到第
使用帮助 返回顶部