4-Amino-5-pyridin-4-yl-s-triazole-3-thiol （1） was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-（4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl）-1-phenylpropan-1- one （2） followed by oximatio...4-Amino-5-pyridin-4-yl-s-triazole-3-thiol （1） was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-（4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl）-1-phenylpropan-1- one （2） followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-cbloromethanes to the corresponding oxime （3） and oxime-ethers （4a-e）, respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds （5a-e）. The antibacterial activity in vitro against Gram-postive （G^＋） and Gram negative （G） bacteria was primarily evaluated.展开更多
Twelve novel compounds of 2-acetyl-lH-benzimidazole oxime-ethers and 2-acetyl-6-chloro-1H-benzimidazole oxime-ethers were synthesized with o-phenylenediamine （or 4-chloro-o-phenylenediamine）, 2-hydroxypropyl acid, a...Twelve novel compounds of 2-acetyl-lH-benzimidazole oxime-ethers and 2-acetyl-6-chloro-1H-benzimidazole oxime-ethers were synthesized with o-phenylenediamine （or 4-chloro-o-phenylenediamine）, 2-hydroxypropyl acid, alkoxy （or benzyloxy） amines hydrochloride as starting materials. The structures of the target compounds were characterized by IR, 1H NMR spectra and elemental analyses. The in vitro fungicidal activities against Botrytis cinerea Pers and Alternaria alternata were also evaluated by mycelium growth rate method. The results indicate that the compounds 3b, 3c, 3f, 3g and 3h exhibit good activities against Botrytis cinerea Pers, while 3b and 3f possess excellent activities against Alternaria alternate, and their fungicidal activities are all higher than that of carbendazim.展开更多
基金the State Basic Research and Development Project （No. G 1998051112） the Science Foundation of Henan University （04ZDZR009）.
文摘4-Amino-5-pyridin-4-yl-s-triazole-3-thiol （1） was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-（4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl）-1-phenylpropan-1- one （2） followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-cbloromethanes to the corresponding oxime （3） and oxime-ethers （4a-e）, respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds （5a-e）. The antibacterial activity in vitro against Gram-postive （G^＋） and Gram negative （G） bacteria was primarily evaluated.
基金Project supported by Shandong Province Natural Science Foundation （No. ZR2009BM044）.
文摘Twelve novel compounds of 2-acetyl-lH-benzimidazole oxime-ethers and 2-acetyl-6-chloro-1H-benzimidazole oxime-ethers were synthesized with o-phenylenediamine （or 4-chloro-o-phenylenediamine）, 2-hydroxypropyl acid, alkoxy （or benzyloxy） amines hydrochloride as starting materials. The structures of the target compounds were characterized by IR, 1H NMR spectra and elemental analyses. The in vitro fungicidal activities against Botrytis cinerea Pers and Alternaria alternata were also evaluated by mycelium growth rate method. The results indicate that the compounds 3b, 3c, 3f, 3g and 3h exhibit good activities against Botrytis cinerea Pers, while 3b and 3f possess excellent activities against Alternaria alternate, and their fungicidal activities are all higher than that of carbendazim.
