Prenatal alcohol exposure disrupts the development of normal fetal respiratory function, but whether it perturbs respiratory rhythmical discharge activity is unclear. Furthermore, it is unknown whether the 5-hydroxytr...Prenatal alcohol exposure disrupts the development of normal fetal respiratory function, but whether it perturbs respiratory rhythmical discharge activity is unclear. Furthermore, it is unknown whether the 5-hydroxytryptamine 2A receptor（5-HT2AR） is involved in the effects of prenatal alcohol exposure. In the present study, pregnant female rats received drinking water containing alcohol at concentrations of 0%, 1%, 2%, 4%, 8% or 10%（v/v） throughout the gestation period. Slices of the medulla from 2-day-old neonatal rats were obtained to record respiratory rhythmical discharge activity. 5-HT2 AR protein and m RNA levels in the pre-B？tzinger complex of the respiratory center were measured by western blot analysis and quantitative RT-PCR, respectively. Compared with the 0% alcohol group, respiratory rhythmical discharge activity in medullary slices in the 4%, 8% and 10% alcohol groups was decreased, and the reduction was greatest in the 8% alcohol group. Respiratory rhythmical discharge activity in the 10% alcohol group was irregular. Thus, 8% was the most effective alcohol concentration at attenuating respiratory rhythmical discharge activity. These findings suggest that prenatal alcohol exposure attenuates respiratory rhythmical discharge activity in neonatal rats by downregulating 5-HT2 AR protein and m RNA levels.展开更多
We study the photo-oxidation of bacteriochlorophylls （BChls） in peripheral light harvesting complexes （LH2） from rhodobacter sphaeroides by using the steady absorption and the femtosecond pump-probe measurement, t...We study the photo-oxidation of bacteriochlorophylls （BChls） in peripheral light harvesting complexes （LH2） from rhodobacter sphaeroides by using the steady absorption and the femtosecond pump-probe measurement, to realize the detailed dynamics of LH2 in the presence of photo-oxidation. The experimental results reveal that BChl-B850 radical cations may act as an additional channel to compete with the unoxidized BChl-B850 molecules for rapidly releasing the excitation energy, while the B800→B850 energy transfer rate is almost unaffected in the oxidation process.展开更多
The studies show that numerous complex networks have clustering effect.It is an indispensable step to identify node clusters in network,namely community,in which nodes are closely related,and in many applications such...The studies show that numerous complex networks have clustering effect.It is an indispensable step to identify node clusters in network,namely community,in which nodes are closely related,and in many applications such as identification of ringleaders in anti-criminal and anti-terrorist network,efficient storage of data in Wireless Sensor Network(WSN).At present,most of community identification methods still require the specifications of the number or the scale of community by user and still can not handle overlapping nodes.In an attempt to solve these problems,a network community identification method based on utility value is proposed,which is a function of each node's clustering coefficient and degree.This method makes use of individual-centered theory for reference and can automatically determine the number of communities.In addition,this method is an overlapping community identification method in nature.It is shown through contrastive experiments that this method is more efficient than other methods based on individual-centered theory when they control the same amount of information.Finally,a research direction is proposed for network community identification method based on the individual-centered theory.展开更多
基金the Natural Science Foundation of Henan Province in China,No.102102310156the Foundation of Xinxiang Technology Bureau in China,No.ZG14004
文摘Prenatal alcohol exposure disrupts the development of normal fetal respiratory function, but whether it perturbs respiratory rhythmical discharge activity is unclear. Furthermore, it is unknown whether the 5-hydroxytryptamine 2A receptor（5-HT2AR） is involved in the effects of prenatal alcohol exposure. In the present study, pregnant female rats received drinking water containing alcohol at concentrations of 0%, 1%, 2%, 4%, 8% or 10%（v/v） throughout the gestation period. Slices of the medulla from 2-day-old neonatal rats were obtained to record respiratory rhythmical discharge activity. 5-HT2 AR protein and m RNA levels in the pre-B？tzinger complex of the respiratory center were measured by western blot analysis and quantitative RT-PCR, respectively. Compared with the 0% alcohol group, respiratory rhythmical discharge activity in medullary slices in the 4%, 8% and 10% alcohol groups was decreased, and the reduction was greatest in the 8% alcohol group. Respiratory rhythmical discharge activity in the 10% alcohol group was irregular. Thus, 8% was the most effective alcohol concentration at attenuating respiratory rhythmical discharge activity. These findings suggest that prenatal alcohol exposure attenuates respiratory rhythmical discharge activity in neonatal rats by downregulating 5-HT2 AR protein and m RNA levels.
基金Supported by the National Natural Science Foundation of China under Grant Nos 10274013 and 10374020.
文摘We study the photo-oxidation of bacteriochlorophylls （BChls） in peripheral light harvesting complexes （LH2） from rhodobacter sphaeroides by using the steady absorption and the femtosecond pump-probe measurement, to realize the detailed dynamics of LH2 in the presence of photo-oxidation. The experimental results reveal that BChl-B850 radical cations may act as an additional channel to compete with the unoxidized BChl-B850 molecules for rapidly releasing the excitation energy, while the B800→B850 energy transfer rate is almost unaffected in the oxidation process.
基金Sponsored by the National Natural Science Foundation of China (Grant No. 61073041,60873037,61100008 and 61073043)the Natural Science Foundation of Heilongjiang Province (Grant No. F200901 and F201023 )+1 种基金the Harbin Special Funds for Technological Innovation Research (Grant No.2010RFXXG002 and 2011RFXXG015)the Fundamental Research Funds for the Central Universities of China(Grant No. HEUCF100602)
文摘The studies show that numerous complex networks have clustering effect.It is an indispensable step to identify node clusters in network,namely community,in which nodes are closely related,and in many applications such as identification of ringleaders in anti-criminal and anti-terrorist network,efficient storage of data in Wireless Sensor Network(WSN).At present,most of community identification methods still require the specifications of the number or the scale of community by user and still can not handle overlapping nodes.In an attempt to solve these problems,a network community identification method based on utility value is proposed,which is a function of each node's clustering coefficient and degree.This method makes use of individual-centered theory for reference and can automatically determine the number of communities.In addition,this method is an overlapping community identification method in nature.It is shown through contrastive experiments that this method is more efficient than other methods based on individual-centered theory when they control the same amount of information.Finally,a research direction is proposed for network community identification method based on the individual-centered theory.
